DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Myh7

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001348536.1 Gene:Myh7 / 140781 MGIID:2155600 Length:1935 Species:Mus musculus


Alignment Length:2091 Identity:481/2091 - (23%)
Similarity:806/2091 - (38%) Gaps:638/2091 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   461 LRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADV---ADASQPERVWLVHRGGFTAAIRLP 522
            ||:|..:|.:.|:|                ..||:.||   .|..:..:..:|.|.|...     
Mouse    16 LRKSEKERLEAQTR----------------PFDLKKDVFVPDDKEEFVKAKIVSREGGKV----- 59

  Fly   523 TASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQRYAS 587
            ||.:             .||:.:||.||.|.:||.|..|.:||:..|.:|:|.:||:.|::||||
Mouse    60 TAET-------------ENGKTVTVKEDQVMQQNPPKFDKIEDMAMLTFLHEPAVLYNLKERYAS 111

  Fly   588 NLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIF 652
            .:|:|.:|...:.|||...|.:|:.:||:.:||.|..:.|||::|::..||:.::..|.:||::.
Mouse   112 WMIYTYSGLFCVTVNPYKWLPVYNAEVVAAYRGKKRSEAPPHIFSISDNAYQYMLTDRENQSILI 176

  Fly   653 MGRSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTI----------LEAFGNTKTCLNSN 707
            .|.||:||:.:.|..:.|.|:.| |..:....::.....|:          ||||||.||..|.|
Mouse   177 TGESGAGKTVNTKRVIQYFAVIA-AIGDRSKKDQTPGKGTLEDQIIQANPALEAFGNAKTVRNDN 240

  Fly   708 ATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLEN 772
            ::|..:.:.:.|..||::|||.::..|.|:.|...:|..|..:||..::|:.....|...|.:.|
Mouse   241 SSRFGKFIRIHFGATGKLASADIETYLLEKSRVIFQLKAERDYHIFYQILSNKKPELLDMLLITN 305

  Fly   773 ITSEDSHPFISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGV 833
              :...:.|||..:    .::|    :.:.|.|..||:.|....:....|:.:..||.|.|    
Mouse   306 --NPYDYAFISQGETTVASIDD----SEELMATDSAFDVLGFTPEEKNSIYKLTGAIMHFG---- 360

  Fly   834 TKLGTGSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGH 895
             .:......|.:.|.|..   |.|::.|:|:|..||..   ||..|....|    ::..|.....
Mouse   361 -NMKFKQKQREEQAEPDGTEEADKSAYLMGLNSADLLK---GLCHPRVKVG----NEYVTKGQNV 417

  Fly   896 EWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGAT 956
            :.....:.||...:|.:....:|..||..:.|.......|.::|..||:    |          :
Mouse   418 QQVSYAIGALAKSVYEKMFNWMVTRINATLETKQPRQYFIGVLDIAGFEIFDFN----------S 472

  Fly   957 LADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNH 1016
            ...|..|:..|:||..|:|...|..::.|.:|     .::..|||.: |     |.||:|.    
Mouse   473 FEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWTFIDFGMDLQA-C-----IDLIEKP---- 527

  Fly  1017 VVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHHSLLRKCAGPRQ--FV 1078
                          .|::.:|:||.::|.:.|.||..:|: :|.|...:....|...|.::  |.
Mouse   528 --------------MGIMSILEEECMFPKATDMTFKAKLYDNHLGKSNNFQKPRNVKGKQEAHFS 578

  Fly  1079 LHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAG 1143
            |.|..||  |.|.:.||::.::: |.....|.|.|.||.:.::.|:..  ..|:.|....|....
Mouse   579 LVHYAGT--VDYNILGWLQKNKD-PLNETVVGLYQKSSLKLLSNLFAN--YAGADAPADKGKGKA 638

  Fly  1144 LEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKY 1208
            .:|: |.:.||::.|.                 .::.::..||.|..|||.|.:     ...|| 
Mouse   639 KKGS-SFQTVSALHRE-----------------NLNKLMTNLRSTHPHFVRCII-----PNETK- 679

  Fly  1209 TANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL---- 1269
                ||.           :::.||:..|||.:.|||..|:.|.|||..:...:|.:|:.:|    
Mouse   680 ----SPG-----------VMDNPLVMHQLRCNGVLEGIRICRKGFPNRILYGDFRQRYRILNPAA 729

  Fly  1270 --AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCR 1332
              .|....::. ..|::|...::|...|:.|.:::.|::|:|..||..||..||..|.::||..|
Mouse   730 IPEGQFIDSRK-GAEKLLGSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQAQSR 793

  Fly  1333 GYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEE 1394
            |.|:|   ||:.:||...|   .||.|::||:.|::|||.:|..::.|||....||:::.|..||
Mouse   794 GVLSRMEFKKLLERRDSLL---IIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAETEKEMATMKEE 855

  Fly  1395 LLMLRAKLEKIECDRSE------------------VKAENQ-----------------KLEAKLS 1424
            ...::..|||.|..|.|                  |:||..                 :||||:.
Mouse   856 FGRVKDALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVK 920

  Fly  1425 ELTVDLA-EERSTAHIATE--RLEAETAE-----------RLKLEKELGDQTNKVKNLQE----- 1470
            |:|..|. ||...|.:..:  :||.|.:|           ..|:|||.....||||||.|     
Mouse   921 EMTERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 985

  Fly  1471 ---------------------------------TTEKLEMELICAKSDLNGISEDE--------- 1493
                                             |..|.:::|.....||.|..|.|         
Mouse   986 DEIIVKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLER 1050

  Fly  1494 -----------------DAEN-------------------------EDGVGGGVYK--------- 1507
                             |.||                         |..:|..:.|         
Mouse  1051 AKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARI 1115

  Fly  1508 ------LKYERVA--------------------------------------RELEFTKRR----- 1523
                  |:.||.|                                      ||.||.|.|     
Mouse  1116 EELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEE 1180

  Fly  1524 -----------LHTQH------------------------------------------------- 1528
                       |..:|                                                 
Mouse  1181 ATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANL 1245

  Fly  1529 ------------EH------------DL------------------------------------E 1533
                        ||            ||                                    :
Mouse  1246 EKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQ 1310

  Fly  1534 QLVALKKHLEMK--------------------LSDAYEEVVE-----QRQV------VGQWKRKA 1567
            ||..||:.||.:                    |.:.|||..|     ||.:      |.||:.|.
Mouse  1311 QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY 1375

  Fly  1568 Q-------------------------------------------KMTNEMNDLRMLLEEQNARNN 1589
            :                                           ::.||:.||.:.:|..||...
Mouse  1376 ETDAIQRTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440

  Fly  1590 LLEKKQRKFD---AECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLE-FKEEK 1650
            .|:||||.||   ||.:...:..:.|.::.::..|.   |..|.|.|:....::...|| ||.|.
Mouse  1441 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARS---LSTELFKLKNAYEESLEHLETFKREN 1502

  Fly  1651 LASLQRELEEMTFG-GGTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLE 1714
             .:||.|:.::|.. |.|.:...:|.:.:.:.|....|.:..|:|....::..|...||.::...
Mouse  1503 -KNLQEEISDLTEQLGSTGKSIHELEKIRKQLEAEKLELQSALEEAEASLEHEEGKILRAQLEFN 1566

  Fly  1715 TMRKEARRESQQRDEELEEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDR 1778
            .::.|..|:..::|||:|:.:.|..:.:.:|:..|:.|...|...||.|.::|..|:.|| ....
Mouse  1567 QIKAEIERKLAEKDEEMEQAKRNHLRMVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631

  Fly  1779 VDRDAEEALNQKLRRDLRKYKALLKDAQTQLE---RLKADTPGKTLIRQLRNQLEDAESARSLAM 1840
            .:|.|.||     ::.::..::||||.|.||:   |...|......|.:.||.|           
Mouse  1632 ANRMAAEA-----QKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL----------- 1680

  Fly  1841 KARQTAEAELTEVQAMFDESHRARNDAE-------ERANAAH--------------RDRAELQAQ 1884
                 .:|||.|::|:.:::.|:|..||       ||....|              .|.::||.:
Mouse  1681 -----LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTE 1740

  Fly  1885 IEENEEELGELMKKYSATVKQLNTEQINVSEAEFKLNE-----MEAERNNLKEQVAELQHRLDNV 1944
            :||..:|.....:|    .|:..|:...::| |.|..:     :|..:.|:::.:.:||||||..
Mouse  1741 VEEAVQECRNAEEK----AKKAITDAAMMAE-ELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEA 1800

  Fly  1945 ENLGDPSMAMMSKRLELRTKELESRLELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQ 2009
            |.:.........::||.|.:|||:.||.||...|.....:.:.:..:::|..:..:.:...::.|
Mouse  1801 EQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQ 1865

  Fly  2010 DVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQA 2074
            |::.|.|..::..:.:......:...:|::.:.::.::::.|...       .:|..::..|:..
Mouse  1866 DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERA-------DIAESQVNKLRAK 1923

  Fly  2075 MEEEGEEELSE 2085
            ..:.|.:.|:|
Mouse  1924 SRDIGAKGLNE 1934

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 210/795 (26%)
MYSc_Myo18 575..1305 CDD:276837 197/764 (26%)
GBP_C <1540..1750 CDD:303769 62/288 (22%)
COG1340 1565..1833 CDD:224259 77/319 (24%)
coiled coil 1723..1734 CDD:293879 4/10 (40%)
Myh7NP_001348536.1 COG5022 37..1432 CDD:227355 344/1513 (23%)
MYSc_class_II 99..766 CDD:276951 197/764 (26%)
Actin-binding 655..677 7/26 (27%)
Actin-binding 757..771 3/13 (23%)
SMC_prok_B 1173..1930 CDD:274008 155/793 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1915..1935 4/20 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.