DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and Patj

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_038965114.1 Gene:Patj / 140581 RGDID:1565362 Length:1858 Species:Rattus norvegicus


Alignment Length:2048 Identity:387/2048 - (18%)
Similarity:647/2048 - (31%) Gaps:652/2048 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LDEVRRSLKIRGRRKEKEKLP----------------------------SGITADYSADF-FA-- 87
            ||.:|..|:.:|...:.|||.                            |.|.:|.||:| |:  
  Rat    16 LDRLRGKLQEKGDTTQNEKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRK 80

  Fly    88 ALNADANGG-SNGGA------VGAADP---EQDRGNEEIVASVM-----THIE----SRASNGAG 133
            .|....:|. :||.|      :.|::.   .|..|||:..:.:.     .|||    .|.|.|  
  Rat    81 GLLVFTDGSITNGNAHRPCSSITASESLPWTQRSGNEDFTSVIQQMAQGRHIEYIDIERPSTG-- 143

  Fly   134 VSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRS---------------NMTNVHEEIS 183
             .:.:|.|.....|.||.:.|:..:.|         ||.:               |.|.:.:.||
  Rat   144 -GLGFSVVALRSQSLGLIDIFVKEVHP---------GSVADRDQRLKENDQILAINDTPLDQNIS 198

  Fly   184 FAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLR----------S 238
            ...:..        ||:..  ..||....||..|...|.:|......|..|::|          :
  Rat   199 HQQAIA--------LLQQA--TGSLRLVVAREVGHTQSRTSTSSADTTLPETVRWGHTEDVELIN 253

  Fly   239 DGEQ-----TGGQQRAMT----LPANA--RYGALPQGNSQGSHLHVLTSPSPSADSLT------- 285
            ||..     .||:...:.    :|...  |.|.|..|:      |:|...|.:...:|       
  Rat   254 DGSGLGFGIVGGKSSGVVVRTIVPGGLADRDGRLQTGD------HILKIGSTNVQGMTSEQVAQV 312

  Fly   286 --DTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQ 348
              :..||  .....:..||||..             |..|.|....|.||......:....||.:
  Rat   313 LRNCGNS--VRMLVARDPVGEIA-------------VTPPTPASLPVALPVVATRTLGSDSSPFE 362

  Fly   349 DFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGG--ATGLLPG------------DRLIKVNG 399
            .:...|.|    ...:||...|...|..|.||...|  ...::||            |:::.|:|
  Rat   363 TYNVELVK----KDGQSLGIRIVGYVGTAHPGEASGIYVKSIIPGSAAYHNGQIQVNDKIVAVDG 423

  Fly   400 TPVGELPREIIIEMIRNSGEAVTVEV-------------QP-----VAELVELSK--RCMAPSTA 444
            ..:.....:.::|::||:|:.|.:.:             ||     |||..|:.:  ..:.|.|.
  Rat   424 VNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASPFEQPSSREAVAEPPEVPELTGSLKPETN 488

  Fly   445 T---VEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKG-----VGHDLE------ 495
            :   .|||...:.|     ||:...:..::...:.....|..|...|.     :|.|.|      
  Rat   489 SRMEAEEIGERLDN-----LRKDTVQALEKPDVYPEDIPGCPENELKSRWENLLGPDYEVMVATL 548

  Fly   496 ----ADVADASQPERVWLVHRGGFTAAIRLPTASSGRDEENKLS----------LRLLH------ 540
                ||..:..:..::..:|      .:||.......|..:.:|          |.||.      
  Rat   549 DTQIADDEELQKYSKLLPIH------TLRLGMEVDSFDGHHYISSIAPGGPVDTLNLLQPEDELL 607

  Fly   541 --NGEQLTVDEDDVEKQNSPALDLVEDI--------CELKYLNEASVLHCLRQRYASNLIHTKAG 595
              ||.||      ..|....|:..::::        |...:.:||||..  .:....:|:..:..
  Rat   608 EVNGVQL------YGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDE--PRTVEPSLLEAEVD 664

  Fly   596 PTLLV--VNPMAPLSLYSE--KVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMG-- 654
            .::.|  .:....|:|:|.  |.|.:.:.||........|.......||::..|   ||:..|  
  Rat   665 RSVDVSTEDDDGELALWSPEVKTVELVKDCKGLGFSILDYQDPLDPMRSVIVIR---SLVADGVA 726

  Fly   655 -RSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTI---LEAFGNTKTCLNSNATRMTQLL 715
             |||.........::|..:|     :|...||.|..|..:   :...|..|..:........:..
  Rat   727 ERSGELLPGDRLVSVNEFSL-----DNATLAEAVEVLKAVPPGVVHLGICKPLVEEEKEEKEEHF 786

  Fly   716 SLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHP 780
            ....:..|..:.:      ||.         .|..|  :.|:..|....:.|.:||.:..|   |
  Rat   787 IFHSNNNGDNSES------PET---------VHEIH--SSLILEAPQGFRDEPYLEELVDE---P 831

  Fly   781 FISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQ 845
            |:.|.:.|:               |:..::|:.:  ..|.:     |                 :
  Rat   832 FLDLGKSLQ---------------FQQKDMDSSS--EAWEM-----H-----------------E 857

  Fly   846 FANPTAARKASGLLGVNLEDLSSAAFGLTQ---------PNAPNGGLSPSKSPTSD--TGHEWAW 899
            |.:|...|:     |...|.|....:.:.|         |..|:.....|.||..|  .|.:|  
  Rat   858 FLSPRLERR-----GEEREMLVDEEYEIYQDRLRDMEAHPPPPHIREPTSASPRLDLQAGPQW-- 915

  Fly   900 ECLEALVIG---LYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQN----PASCGQQVGATL 957
              |.|.:.|   |......:::....:::...|.:... |:.:|.|..:    |:|.|.......
  Rat   916 --LHADLSGGEILECHDTESMMTAYPQEMQDYSFSTTD-MMKETFGLDSRPPMPSSEGNGQHGRF 977

  Fly   958 ADLRHNYLQERLQMLFHH---TTLVAPRDRYAQELVEIEMDLAS-----ECHPGPLISL----ID 1010
            .||.|      |..|..|   ..::.|.|.....::   :||.:     |....||..|    :.
  Rat   978 DDLEH------LHSLVSHGLDLGMMTPSDLQGPGVL---VDLPAVTQRREQEELPLYRLPSARVV 1033

  Fly  1011 KAPQNHVVRSSQR------DLREHDRRGMLWLLDEEAIYPNSNDDTFLERLFSHYGDREHHSLLR 1069
            ..|.:||...|.|      :|.|.:.       .|....||          |||:|......:.|
  Rat  1034 TKPSSHVGMVSSRHANAACELPEREE-------GEGEETPN----------FSHWGPPRIVEIFR 1081

  Fly  1070 KCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLL-------QDSSREEINRLYIGS 1127
            :                                |.:...:|::       :..:.||:..::|..
  Rat  1082 E--------------------------------PNVSLGISIVGGQTVIKRLKNGEELKGIFIKQ 1114

  Fly  1128 LTRGSGAMVFCGSFAGLEGTQSLRRVSSI---RRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTG 1189
            :...|.|    |....|:....:..||.:   ..|...|.....|....|.|.|..:..|.|...
  Rat  1115 VLEDSPA----GKTKALKTGDKILEVSGVDLQNASHAEAVEAIKSAGNPVVFVVQSLSSTPRVIP 1175

  Fly  1190 THFVHCYLLQHNAGK-----------HTKYTANGS--------PSSAAGQVSSEEEMVNVPLLRS 1235
            :        .:|.||           ..|...:|:        |...|....:||...:..|...
  Rat  1176 S--------VNNKGKTPPQNQDQNTQEKKAKRHGTAPPPMKLPPPYRAPSADTEESEEDSALTDK 1232

  Fly  1236 QLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQILAVN-ELDVASYRIGP 1299
            ::|.........||         ::|..:....|...||.|||.|...|..|. ..|      ||
  Rat  1233 KIRQRYADLPGELH---------IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPD------GP 1282

  Fly  1300 SQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAF--LA 1362
            :....|..|..||....:.:|..|..|..:      |..|.:..||:.:.:    ||..|.  :|
  Rat  1283 AAADGRMRVGDELLEINNQILYGRSHQNAS------AIIKTAPTRVKLVFI----RNEDAVNQMA 1337

  Fly  1363 VRDWPWWRLLVRV-----TPLLNVHRTEEQLKTANEELLMLRAK-LEKIECDRSE---------V 1412
            |..:|       |     :|:.::..||   ..::||...:.|| |.:.|..:.|         :
  Rat  1338 VAPFP-------VPSHSPSPVEDLGGTE---PVSSEEDSSVDAKPLPERESSKPEDLTQAVDDSM 1392

  Fly  1413 KAENQKLEAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQE------- 1470
            .||.:|...........:.:...:|.:::...|..:|.....:....|.|.. .|.|.       
  Rat  1393 VAEQEKASESPDSAARQMKQPGYSAQVSSSSQEIPSAPAPLCQSTHADVTGS-GNFQAPLSVDPA 1456

  Fly  1471 --TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLE 1533
              :.:.....::..:..:..||:.........|||           ::.......|.|:      
  Rat  1457 PLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGG-----------KDTPLPGGSLPTK------ 1504

  Fly  1534 QLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLE--EQNAR--------- 1587
                                      ||.|::|.|:|.::  |..::.|  |:.|.         
  Rat  1505 --------------------------VGVWEKKLQEMMSQ--DAIVIHEVYEEGAAARDGRLWAG 1541

  Fly  1588 NNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLEFKEEK-- 1650
            :.:||  ....|....|.::|:...||..::.                .|...|.:.::::|:  
  Rat  1542 DQILE--VNGVDLRSSSHEEAITALRQTPQKV----------------RLVIYRDEAQYRDEENL 1588

  Fly  1651 ---LASLQRE-------------------LEEMTFGGGTEEEFAQLR----RSKNETERRAKEQE 1689
               |..||::                   :.::..||..:.:...:|    .|.|..:.|...||
  Rat  1589 EVFLVDLQKKTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLIRGDQILSVNGEDVRQASQE 1653

  Fly  1690 EE---LDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRD-------------EELEEVRGNG 1738
            ..   |..:.|.:| ||..:||......:.:.....:..|..             ..|:.:.|..
  Rat  1654 TVATILKCVQGLVQ-LEIGRLRAGSWASSRKTSQNSQGDQHSAHSSCRPSFAPVITSLQNLVGTK 1717

  Fly  1739 YKKIKALECQLETEHEERTLLLREKHELERRLS 1771
            .......:|   ||.|.||:      |:.|.||
  Rat  1718 RSSDPPQKC---TEEEPRTV------EIIRELS 1741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 22/113 (19%)
MYSc 556..1317 CDD:214580 157/844 (19%)
MYSc_Myo18 575..1305 CDD:276837 150/805 (19%)
GBP_C <1540..1750 CDD:303769 42/264 (16%)
COG1340 1565..1833 CDD:224259 48/262 (18%)
coiled coil 1723..1734 CDD:293879 2/23 (9%)
PatjXP_038965114.1 L27_2 8..65 CDD:312549 8/48 (17%)
PDZ_signaling 135..218 CDD:238492 20/104 (19%)
PDZ_signaling 248..325 CDD:238492 15/84 (18%)
PDZ_signaling 366..450 CDD:238492 20/87 (23%)
CtpA <391..>511 CDD:223864 25/124 (20%)
PDZ_signaling 572..636 CDD:238492 12/69 (17%)
PDZ 684..773 CDD:214570 22/96 (23%)
PDZ_signaling 1074..1165 CDD:238492 17/126 (13%)
PDZ 1244..1329 CDD:214570 26/109 (24%)
PDZ 1471..1578 CDD:214570 25/169 (15%)
PDZ_signaling 1590..1670 CDD:238492 15/80 (19%)
PDZ_signaling 1731..1816 CDD:238492 6/17 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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