DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mhcl and Patj

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_766284.2 Gene:Patj / 12695 MGIID:1277960 Length:1834 Species:Mus musculus


Alignment Length:2055 Identity:380/2055 - (18%)
Similarity:659/2055 - (32%) Gaps:690/2055 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    54 LDEVRRSLKIRGRRKEKEKLP----------------------------SGITADYSADF-FA-- 87
            ||.:|..|:.:|...:.|||.                            |.|.:|.||:| |:  
Mouse    16 LDRLRGKLQEKGDTTQNEKLSAFYETLKSPLFNQILTLQQSIKQLKGQLSHIPSDCSANFDFSRK 80

  Fly    88 ALNADANGG-SNGGA------VGAAD--PEQDRGNEEIVASVM------THIE----SRASNGAG 133
            .|....:|. :||.|      |.|::  |...:...|...||:      .|:|    .|.|.|  
Mouse    81 GLLVFTDGSITNGNAQRPCSNVTASELLPWTQKSASEDFNSVIQQMAQGRHVEYIDIERPSTG-- 143

  Fly   134 VSVNYSEVTHSLLSGGLKNRFLPPIPPKPPKRGILKGSRS---------------NMTNVHEEIS 183
             .:.:|.|.....|.||.:.|:..:.|         ||.:               |.|.:.:.||
Mouse   144 -GLGFSVVALRSQSLGLIDIFVKEVHP---------GSVADRDHRLKENDQILAINDTPLDQNIS 198

  Fly   184 F---------------------AGSAGGAGGT-------PEMLL-RNTFQNESLYEGAARGAGSI 219
            .                     .|...|...|       ||.:. .:|.:.|.:.:|:..|.|.:
Mouse   199 HQQAIALLQQATGSLRLVVAREVGHTQGRASTSSADTTLPETVCWGHTEEVELINDGSGLGFGIV 263

  Fly   220 GSNSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANA--RYGALPQGNS----QGSHLHVLTSPS 278
            |..||  |....::                  :|...  |.|.|..|:.    .|:::..:|| .
Mouse   264 GGKSS--GVVVRTI------------------VPGGLADRDGRLQTGDHILKIGGTNVQGMTS-E 307

  Fly   279 PSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQL-VKLPPPRQLVIRR 342
            ..|..|.:..||  .....:..||||.              ...|..||.| |.||......:..
Mouse   308 QVAQVLRNCGNS--VRMLVARDPVGEI--------------AVTPPTPVSLPVALPAVATRTLDS 356

  Fly   343 QKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGAGGG--ATGLLPG------------DR 393
            .:||.:.:...|.|    ...:||...|...|..|.||...|  ...::||            |:
Mouse   357 DRSPFETYSVELVK----KDGQSLGIRIVGYVGTAHPGEASGIYVKSIIPGSAAYHNGQIQVNDK 417

  Fly   394 LIKVNGTPVGELPREIIIEMIRNSGEAVTVEV------------------QPVAELVELSKRCMA 440
            ::.|:|..:.....:.::|::||:|:.|.:.:                  :.|||..::.:|..:
Mouse   418 IVAVDGVNIQGFANQDVVEVLRNAGQVVHLTLVRRKTSLSASPFEHSSSRETVAEPPKVPERAGS 482

  Fly   441 PS-----TATVEEIDHSITNGNCNTLRR-----------SASKRFKRQSRHENGNGGGEEGGAKG 489
            |.     :...|||...:.|...||::.           ..|...:.:||.||..|...|    .
Mouse   483 PKPEANLSVEAEEIGERLDNLKNNTVQALEKPDVYPEKVPGSPENELKSRWENLLGPDYE----V 543

  Fly   490 VGHDLEADVADASQPE---RVWLVHRGGFTAAIRLPTASSGRDEENKLS----------LRLLH- 540
            :...|:|.:||..:.:   ::..:|      .:||.......|..:.:|          |.||. 
Mouse   544 MVATLDAQIADDEELQKYSKLLPIH------TLRLGMEVDSFDGHHYISSVAPGGPVDTLNLLQP 602

  Fly   541 -------NGEQLTVDEDDVEKQNSPALDLVEDI--------CELKYLNEASVLHCLRQRYASNLI 590
                   ||.||      ..|....|:..::::        |...:.:||||........|  |:
Mouse   603 EDELLEVNGMQL------YGKSRREAVSFLKEVPPPFTLVCCRRLFDDEASVDEPRTMEPA--LL 659

  Fly   591 HTKAGPTL---LVVNPMAPLSLYSE--KVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQSL 650
            ..:...::   :..:....|:|:|.  |.|.:.:.||........|.......||::..|   ||
Mouse   660 EAEVDHSVDVNIEDDDDGELALWSPEVKTVELVKDCKGLGFSILDYQDPLDPTRSVIVIR---SL 721

  Fly   651 IFMG---RSGSGKSTSFKHALNYLALAAGAYNNFINAEKVNALCTILEAFGNTKTCLNSNATRMT 712
            :..|   |||.........::|..:|     :|...||.|..|..:.....:...|.........
Mouse   722 VADGVAERSGELLPGDRLVSVNEFSL-----DNATLAEAVEVLKAVPPGVVHLGICKPLVEDEKE 781

  Fly   713 QLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHLENITSED 777
            :..||..:..|..:..:..|               |..|  :.|:..|....:.|.:||.:..| 
Mouse   782 ERFSLHSNNNGDSSEPADAV---------------HEIH--SSLILEAPQGFRDEPYLEELVDE- 828

  Fly   778 SHPFISLSQKLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTA 842
              ||:.|.:.|:               |:..::|:.:  ..|.:     |               
Mouse   829 --PFLDLGKSLQ---------------FQQKDVDSSS--EAWEM-----H--------------- 854

  Fly   843 RTQFANPTAARKASGLLGVNLEDLSSAAFGLTQ---------PNAPNGGLSPSKSPTSD--TGHE 896
              :|.:|....:     |...|.|....:.|.|         |..|:...:...||..:  .|.:
Mouse   855 --EFLSPPLDGR-----GEEREMLVDEEYELYQDHLRAMESNPPPPHIREAAPASPVLELQAGTQ 912

  Fly   897 WAWECLEALVIG---LYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQN----PASCGQQVG 954
            |    |.|.:.|   |......::::...:::...|::.|. |:.:|.|..:    |:|.|....
Mouse   913 W----LHANLSGGERLECHDAESMMSAYPQEMQQYSYSTAD-MMEETFGLDSRAPIPSSEGNGQH 972

  Fly   955 ATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQELVEIEMDLASECH-PGPLISL---------- 1008
            ....|:.|          .|..|         ...:::.|.:.|:.. ||.|:.|          
Mouse   973 GRFDDMGH----------LHSLT---------SSSLDLGMMIPSDLQGPGVLVDLPAVAQRREQE 1018

  Fly  1009 -----------IDKAPQNHVVRSSQR------DLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF 1056
                       :...|.:|:...|.|      :|.|.:.       .|....||          |
Mouse  1019 DLPLYRLPSARVVTKPSSHMGLVSSRHANAACELPEREE-------GEGEETPN----------F 1066

  Fly  1057 SHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEIN 1121
            ||:|......:.|:   |...:...:.|...|:..    :::..|..|| ....:|:||...:.|
Mouse  1067 SHWGPPRIVEIFRE---PNVSLGISIVGGQTVIKR----LKNGEELKGI-FIKQVLEDSPAGKTN 1123

  Fly  1122 RLYIG-SLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTL 1185
            .|..| .:...||        ..|:.......|.:|:    :||   |.::    |.|..:..|.
Mouse  1124 ALKTGDKILEVSG--------VDLQNASHAEAVEAIK----SAG---NPVV----FVVQSLSSTP 1169

  Fly  1186 RRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEE----------MVNVPLLR---SQL 1237
            |...|        .:|.||        :|:....|.:.|.:          |...|..|   :.:
Mouse  1170 RVIPT--------VNNKGK--------TPAPNQDQNTQERKAKRHGTAPPPMKLPPPYRAPSADM 1218

  Fly  1238 RGSQ-----VLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDVASYRI 1297
            .||:     ..:..|......|..:.::|..:....|...||.|||.|...|..|          
Mouse  1219 EGSEEDCALTDKKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVV---------- 1273

  Fly  1298 GPSQILFRSGVLSELEAKRD--VLLSDRIIQLQ---AFCRGY---LARKKMSQRRVQELAVRCIQ 1354
                     |:..|..|..|  :.:.|.::::.   .:.|.:   .|..|.:..||:.:.:|  .
Mouse  1274 ---------GINPEGPAAADGRMRIGDELLEINNQILYGRSHQNASAIIKTAPTRVKLVFIR--N 1327

  Fly  1355 RNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQKL 1419
            .:..:.:||..:|  .|....:|:.::..||  |.::.||..:....|.:.|..:.|        
Mouse  1328 EDAVSQMAVAPFP--ELSHSPSPVEDLGGTE--LVSSEEESSVDAKHLPEPESSKPE-------- 1380

  Fly  1420 EAKLSELTVDLAEERSTAHIATERLEAETAERLKLEKELGDQTNKVKNLQETTEKLEMELIC--A 1482
                     ||::......:|.::.|:|:.:....:.:....:.:|.:..:.:......| |  |
Mouse  1381 ---------DLSQVVDDNMVAEQQKESESPDSAACQIKQQTYSTQVSSSSQDSPSSPAPL-CQSA 1435

  Fly  1483 KSDLNG--------------ISED--------------EDAENEDGVG----GGVYKLKYERVAR 1515
            .:|:.|              :|.|              |.::...|:|    ||           
Mouse  1436 HADVTGSGNFQAPLPVDPAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGG----------- 1489

  Fly  1516 ELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRML 1580
                        .:..|:.:|         :.:.|||....|                  |.|:.
Mouse  1490 ------------KDTPLDAIV---------IHEVYEEGAAAR------------------DGRLW 1515

  Fly  1581 LEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLADTRLDLE 1645
            ..:|     :||  ....|....|.::|:...||..::.                .|...|.:.:
Mouse  1516 AGDQ-----ILE--VNGVDLRSSSHEEAITALRQTPQKV----------------RLVVYRDEAQ 1557

  Fly  1646 FKEEK-----LASLQRE-------------------LEEMTFGGGTEEEFAQLR----RSKNETE 1682
            :::|:     |..||::                   :.::..||..:.:...:|    .|.|..:
Mouse  1558 YRDEENLEVFLVDLQKKTGRGLGLSIVGKRSGSGVFISDIVKGGAADLDGRLIRGDQILSVNGED 1622

  Fly  1683 RRAKEQEEE---LDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRD-------------EEL 1731
            .|...||..   |..:.|.:| ||..:||......:.:.....:..|..             ..|
Mouse  1623 MRHASQETVATILKCVQGLVQ-LEIGRLRAGSWAASRKTSQNSQGDQHSAHSSCRPSFAPVITSL 1686

  Fly  1732 EEVRGNGYKKIKALECQLETEHEERTLLLREKHELERRLS 1771
            :.:.|.........:|   ||.|.||:      |:.|.||
Mouse  1687 QNLVGTKRSSDPPQKC---TEEEPRTV------EIIRELS 1717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 22/118 (19%)
MYSc 556..1317 CDD:214580 153/841 (18%)
MYSc_Myo18 575..1305 CDD:276837 147/802 (18%)
GBP_C <1540..1750 CDD:303769 39/253 (15%)
COG1340 1565..1833 CDD:224259 44/251 (18%)
coiled coil 1723..1734 CDD:293879 2/23 (9%)
PatjNP_766284.2 L27_2 8..65 CDD:312549 8/48 (17%)
PDZ_signaling 135..218 CDD:238492 16/94 (17%)
PDZ_signaling 248..325 CDD:238492 20/99 (20%)
PDZ_signaling 363..450 CDD:238492 20/90 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..488 5/31 (16%)
PDZ_signaling 572..636 CDD:238492 12/69 (17%)
PDZ 685..774 CDD:214570 22/96 (23%)
PDZ_signaling 1072..1163 CDD:238492 22/117 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1171..1219 10/63 (16%)
PDZ 1242..1327 CDD:214570 21/105 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1340..1453 22/134 (16%)
MPDZ_u10 <1453..1468 CDD:374710 2/14 (14%)
PDZ 1469..1554 CDD:214570 22/157 (14%)
PDZ_signaling 1566..1646 CDD:238492 15/80 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1657..1676 1/18 (6%)
PDZ_signaling 1707..1792 CDD:238492 6/17 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1811..1834
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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