DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mhcl and PARD3B

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_011508854.1	Gene:	PARD3B / 117583	HGNCID:	14446	Length:	1213	Species:	Homo sapiens

Alignment Length:	413	Identity:	93/413 - (22%)
Similarity:	141/413 - (34%)	Gaps:	139/413 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KKSAGDEDKERRKREKKL--------RKEAKGTSGGPGMGGVTGVT--GSMSTDELLRLDEVRRS 60
            |:...:||.||:.::|..        :||.||     |.....|..  |.:..:||.::.|.|.
Human   863 KRKEENEDPERKIKKKGFGAMLRFGKKKEDKG-----GKAEQKGTLKHGGLREEELEKMKEERE- 921

  Fly    61 LKIRGRRKE-KEKLPSGITADYSADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHI 124
             :|..:.:| :||...|: .||:.                ||:|:.   .|..::|
Human   922 -RIGAKHQELREKQARGL-LDYAT----------------GAIGSV---YDMDDDE--------- 956

  Fly   125 ESRASNGAGVSVNYSEVTHSLLSGGLKNRFLPPIPPK-------------PPKRGILKGSRSNMT 176
                     :..||:.|.|........|.|..|.||:             .|:|..|:|..:.:.
Human   957 ---------MDPNYARVNHFREPCTSANVFRSPSPPRAGPFGYPRDGHPLSPERDHLEGLYAKVN 1012

  Fly   177 NVHEEISFAGSAGGAGGTPEML--LRNTF-----QNESLY---EGAAR----------GAGSIGS 221
            ..:..:..|.|....||:.:.:  ||..:     :...||   ||.||          |.|..|
Human  1013 KPYHPLVPADSGRPTGGSTDRIQKLRKEYYQARREGFPLYEDDEGRARPSEYDLLWVPGRGPDG- 1076

  Fly   222 NSSQHGTSFTSVESLRSDGEQTGGQQRAMTLPANAR----------Y-GALPQGNSQGSHLHVLT 275
              :.|...|..:|...:...:.|.......|||..|          | ||.|....:||:
Human  1077 --NAHNLRFEGMERQYASLPRGGPADPVDYLPAAPRGLYKERELPYYPGAHPMHPPKGSY----- 1134

  Fly   276 SPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQLVKLP------- 333
             |.|:...:.|........||    |..:.:|..|       :||. |.|| |..::|
Human  1135 -PRPTELRVADLRYPQHYPPP----PAPQHKGPFR-------QDVP-PSPP-QHQRMPAYQETGR 1185

  Fly   334 ------PPRQLVIR----RQKSP 346
                  .|.|...|    |||:|
Human  1186 PGPRGGSPDQYPYRTQDSRQKNP 1208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	5/12 (42%)
		MYSc	556..1317	CDD:214580
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
PARD3B	XP_011508854.1	DUF3534	<44..151	CDD:288873
		PDZ_signaling	209..296	CDD:238492
		PDZ_signaling	395..475	CDD:238492
		PDZ_signaling	509..597	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900