DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mhcl and Il16

DIOPT Version :9

Sequence 1:	NP_732109.2	Gene:	Mhcl / 41955	FlyBaseID:	FBgn0026059	Length:	2194	Species:	Drosophila melanogaster
Sequence 2:	XP_006229550.1	Gene:	Il16 / 116996	RGDID:	1583872	Length:	1425	Species:	Rattus norvegicus

Alignment Length:	663	Identity:	132/663 - (19%)
Similarity:	203/663 - (30%)	Gaps:	233/663 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 KERRKREKKLRKEAKGTSGGPGMGGVTGVTGSMSTDELLRL----DEVRRSL------------- 61
            |...:.:|||.::.|.|.    ..|.|..|.|..|.|||.|    |...|:|
  Rat   707 KNDSEPQKKLEEKEKVTD----PSGHTLPTCSQETRELLPLLLQEDTAGRTLCTAACCPGPAAST 767

  Fly    62 ----KIRG--RRKEKEKLPSG----------ITADYSAD----------------FFAALNADAN 94
                ...|  ||....:.|:.          ...|||.|                .|:.:.::.:
  Rat   768 QTSSSTEGEPRRSASPETPASPGKHPLLKRQARMDYSFDSTTEDPWVRISDCIKNLFSPIMSENH 832

  Fly    95 GGSNGGAVGAADPEQDRGNEEIVASVMTHIE---SRASNGAGVSVNYSEVTHSLLSGGLKNRFLP 156
            ...      ...|....|.|:   ....|.|   |:.....|....:.....|.:..|      |
  Rat   833 SHM------PLQPNASLGEED---GTQGHPEGGLSKMDTANGAPRIFKSADGSTVKKG------P 882

  Fly   157 PIPPKPP-KRGILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLRNTFQNESLYEGAARGAGSIG 220
            |:.|||. .|..|||.|:.:.....             .||  :.:..|...:...|: |..|..
  Rat   883 PVAPKPAWFRQSLKGLRNRVPETRR-------------APE--VASAIQTTPVSRDAS-GPQSQA 931

  Fly   221 SNSS--QHGTSF--------------------TSVESLRSDGEQTGGQQRAMTLPANARYGALPQ 263
            |:||  |..:||                    ||.|:.|..|:|..|           |:..||.
  Rat   932 SSSSIRQRISSFENFGSSQLPDRGVQRLSLQPTSGETTRLPGKQDEG-----------RFSGLPA 985

  Fly   264 GNSQGSHLHVLTSPSPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHAFEDVELPLPPVQ 328
            ..::.:..|..|...|  .|.|...:|....|..|.||                       ||.|
  Rat   986 QGTKVTAKHRQTEVEP--PSTTFPNSSEVGDPDMSESP-----------------------PPGQ 1025

  Fly   329 LVKLPPPRQL-------VIRRQKSPRQDFGFSL----RKAICLDRTES----------------- 365
               .|.|:.|       ::..|....|..||.:    .::..|.||:|
  Rat  1026 ---RPNPKALSPDPLLRLLTTQTEDTQGPGFKMPSQRARSFPLTRTQSYETKLLDEKSSKLYSIS 1087

  Fly   366 --LTSPIFRPVIFAEPGAGGGATGLLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEV--- 425
              |:|.:.:.::.....|..|....:|.:|:     :|..........|   ..||||..:.
  Rat  1088 SQLSSAVMKSLLCLPSSASCGQITCIPKERV-----SPKSPCNNSAAAE---GFGEAVASDTGFS 1144

  Fly   426 QPVAELVELSKRCMAPSTATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGV 490
            ..::||.|.|:....|  ...|:.:|..:....:.:...:::..|:...
  Rat  1145 LNLSELREYSEGLTEP--GETEDRNHCSSQAGQSVISLLSAEELKKLIE---------------- 1191

  Fly   491 GHDLEADVADASQPERVWLVH-------RG---GFTAAIRLPTASSGRDEENKLSL--RLLHNGE 543
                |..|.|.:..:::..:|       .|   ||:.|       .|.|.|||:..  |:..||
  Rat  1192 ----EVRVLDEATLKQLDSIHVTVLHKEEGAGLGFSLA-------GGADLENKVITVHRVFPNG- 1244

  Fly   544 QLTVDEDDVEKQN 556
             |...|..::|.|
  Rat  1245 -LASQEGTIQKGN 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_signaling	339..426	CDD:238492	20/112 (18%)
		MYSc	556..1317	CDD:214580	1/1 (100%)
		MYSc_Myo18	575..1305	CDD:276837
		GBP_C	<1540..1750	CDD:303769
		COG1340	1565..1833	CDD:224259
		coiled coil	1723..1734	CDD:293879
Il16	XP_006229550.1	PDZ_signaling	316..391	CDD:238492
		PDZ_signaling	454..536	CDD:238492
		PDZ_signaling	1207..1284	CDD:238492	17/59 (29%)
		PDZ	1329..1413	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900