DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and PATJ

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_011538764.1 Gene:PATJ / 10207 HGNCID:28881 Length:1937 Species:Homo sapiens


Alignment Length:2302 Identity:415/2302 - (18%)
Similarity:704/2302 - (30%) Gaps:777/2302 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 STDEL--LR-LDEVRRSLKIRGRRKEKEKLP----------------------------SGITAD 80
            :||:|  |: ||.::..|:.:|...:.|||.                            :.|.:|
Human     6 ATDKLQVLQVLDRLKMKLQEKGDTSQNEKLSMFYETLKSPLFNQILTLQQSIKQLKGQLNHIPSD 70

  Fly    81 YSADFFAALNADANGGSNGGAVGAADPEQDRGNEEIVASVMTHIESRASNGAGVSVNYSEVTHSL 145
            .||:|         ..|..|.:...|.....||        .|   |.||.:.||          
Human    71 CSANF---------DFSRKGLLVFTDGSITNGN--------VH---RPSNNSTVS---------- 105

  Fly   146 LSGGLKNRFLPPIPPKPPKRG----------ILKGSRSNMTNVHEEISFAGSAGGAGGTPEMLLR 200
               ||.        |..||.|          :.:|.:....::...     |.||.|.:...|  
Human   106 ---GLF--------PWTPKLGNEDFNSVIQQMAQGRQIEYIDIERP-----STGGLGFSVVAL-- 152

  Fly   201 NTFQNESLYEGAARGAGSIGSNSSQHGTSFTSVESLRSDG----------EQTGGQQRAMTLPAN 255
               ::::|      |...|.....|.|:.....:.|:.:.          :|....|:|:     
Human   153 ---RSQNL------GKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQNISHQQAI----- 203

  Fly   256 ARYGALPQGNSQGSHLHVLTSP----SPSADSLTDTTNSSFATPPFSLSPVGESQGIDRWARVHA 316
                ||.|..:....|.|...|    |.::.||.|||......                |..|  
Human   204 ----ALLQQTTGSLRLIVAREPVHTKSSTSSSLNDTTLPETVC----------------WGHV-- 246

  Fly   317 FEDVELPLPPVQLVKLPPPRQLVIRRQKSPRQDFGFSLRKAICLDRTESLTSPIFRPVIFAEPGA 381
             |:|||                         .:.|..|...|...:|..:   :.|.::   ||.
Human   247 -EEVEL-------------------------INDGSGLGFGIVGGKTSGV---VVRTIV---PGG 279

  Fly   382 GGGATG-LLPGDRLIKVNGTPVGELPREIIIEMIRNSGEAVTVEV--QPVAELVELSKRCMAPST 443
            .....| |..||.::|:.||.|..:..|.:.:::||.|.:|.:.|  .|..   ::|....||:.
Human   280 LADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLRNCGNSVRMLVARDPAG---DISVTPPAPAA 341

  Fly   444 ATVEEIDHSITNGNCNTLRRSASKRFKRQSRHENGNGGGEEGGAKGVGHDLEADVADASQPERVW 508
            ..|             .|...||                     ||.|.|     :...:...|.
Human   342 LPV-------------ALPTVAS---------------------KGPGSD-----SSLFETYNVE 367

  Fly   509 LVHRGGFTAAIRLP--TASSGRDEENKLSLRLL-------HNGEQLTVDE----DDVEKQNSPAL 560
            ||.:.|.:..||:.  ..:|...|.:.:.::.:       |||.....|:    |.|..|.....
Human   368 LVRKDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANH 432

  Fly   561 DLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTED 625
            |:||.:     .|...|:|.       .|:..|...:   .:|:.|.|         .||...|.
Human   433 DVVEVL-----RNAGQVVHL-------TLVRRKTSSS---TSPLEPPS---------DRGTVVEP 473

  Fly   626 MPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYNNFINA-EKVNA 689
            :.|....|.     ..|||..:.         .|:....|..::.|.      |:.|.| ||:..
Human   474 LKPPALFLT-----GAVETETNV---------DGEDEEIKERIDTLK------NDNIQALEKLEK 518

  Fly   690 LCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQV-----------LLP-ERQRAGR 742
            :....|         |...:|...||..|::.  .:|:...|:           ||| ...|.|.
Human   519 VPDSPE---------NELKSRWENLLGPDYEV--MVATLDTQIADDAELQKYSKLLPIHTLRLGV 572

  Fly   743 RLGHEHSFHIMTRLLAG----AAGLLQKELHLENIT----------------SEDSHPF-ISLSQ 786
            .:......|.::.:::|    ..||||.|..|..:.                .|...|| :...:
Human   573 EVDSFDGHHYISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCR 637

  Fly   787 KLEDRHRAANDFMRTVQAFETLNIDAK----------AVRGIWSILAAIYHLGIAGVTKLGTGST 841
            :|.|...:.::..||..:.....:|..          ....:||....|..| :.....||....
Human   638 RLFDDEASVDEPRRTETSLPETEVDHNMDVNTEEDDDGELALWSPEVKIVEL-VKDCKGLGFSIL 701

  Fly   842 ARTQFANPTAARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALV 906
            ......:||.:     ::.:.    |..|.|:.:   .:|||.|.....|...:     ||:...
Human   702 DYQDPLDPTRS-----VIVIR----SLVADGVAE---RSGGLLPGDRLVSVNEY-----CLDNTS 749

  Fly   907 IGLYSEALAAV-VALINRQIC----------------TSS-----------HTIASIMLIDTP-G 942
            :....|.|.|| ..|::..||                :||           |.|.|.::::.| |
Human   750 LAEAVEILKAVPPGLVHLGICKPLVEDNEEESCYILHSSSNEDKTEFSGTIHDINSSLILEAPKG 814

  Fly   943 FQN-PASCGQQVGATLADL-------------------RHNYLQERLQMLFHHTTLVAPRDRYAQ 987
            |:: |....:.|.....||                   .|.:|..|||.:          |...:
Human   815 FRDEPYFKEELVDEPFLDLGKSFHSQQKEIEQSKEAWEMHEFLTPRLQEM----------DEERE 869

  Fly   988 ELVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFL 1052
            .||:.|.:|..:  |.|.:.|.   |.:|:..::..........|..||.|.|   |:.:.:.  
Human   870 ILVDEEYELYQD--PSPSMELY---PLSHIQEATPVPSVNELHFGTQWLHDNE---PSESQEA-- 924

  Fly  1053 ERLFSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSR 1117
                     |...::..:.|.|..:...::...|.|:.::          |.:.:          
Human   925 ---------RTGRTVYSQEAQPYGYCPENVMKENFVMESL----------PSVPS---------- 960

  Fly  1118 EEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGII 1182
                       |.|:...   |.|..||...||.: :|:........|:..|:::.:.....   
Human   961 -----------TEGNSQQ---GRFDDLENLNSLAK-TSLDLGMIPNDVQGPSLLIDLPVVAQ--- 1007

  Fly  1183 DTLRRTGTHFVHCYLLQHNA----GKHTKYTANGSPSSAAGQVSSE--EEMVNVPLLRSQLRGSQ 1241
               ||......   |.||.|    .|.:.||         |.:||.  .:...:| .|.:..|. 
Human  1008 ---RREQEDLP---LYQHQATRVISKASAYT---------GMLSSRYATDTCELP-EREEGEGE- 1055

  Fly  1242 VLEAARLHRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRS 1306
              |.......|.|.   ::|..|...:..|.........::::....||          :.:|..
Human  1056 --ETPNFSHWGPPR---IVEIFREPNVSLGISIVGGQTVIKRLKNGEEL----------KGIFIK 1105

  Fly  1307 GVLSELEAKRDVLL--SDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQR--NVKAFL--AVRD 1365
            .||.:..|.:...|  .|:|:::...         ..|......||..|:.  |...|:  ::..
Human  1106 QVLEDSPAGKTNALKTGDKILEVSGV---------DLQNASHSEAVEAIKNAGNPVVFIVQSLSS 1161

  Fly  1366 WPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVKAENQ-------KLEAKL 1423
            .|      ||.|  |||....:: |.|:..            |..|.|.:.|       ||....
Human  1162 TP------RVIP--NVHNKANKI-TGNQNQ------------DTQEKKEKRQGTAPPPMKLPPPY 1205

  Fly  1424 SELTVDLAEERSTAHIATERLEAETAER------LKLEKELGDQTNKVKNLQETTEKLEMELICA 1482
            ..||.|..|.........:::....|:.      ::|||   |:.....:|....::..|.:...
Human  1206 KALTDDSDENEEEDAFTDQKIRQRYADLPGELHIIELEK---DKNGLGLSLAGNKDRSRMSIFVV 1267

  Fly  1483 KSDLNGISEDEDAENEDGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLS 1547
                 ||:.:..|..:..:          |:..||.....::.....|.....:......::|| 
Human  1268 -----GINPEGPAAADGRM----------RIGDELLEINNQILYGRSHQNASAIIKTAPSKVKL- 1316

  Fly  1548 DAYEEVVEQRQVVGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQE 1612
                                           :.:..::|.|.:.........:...|::|....|
Human  1317 -------------------------------VFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTE 1350

  Fly  1613 RQAKERYGRE----KDVLQAEKFTLEQ--------TLADTRLDLEFKEEKLASLQRELEEMTFGG 1665
            ..:.|..|..    |.:.::|.|.||.        .:||.:..||:..:...|            
Human  1351 PISSEEDGSVEVGIKQLPESESFKLEDMSQVIGQGMVADQQKALEYPPDNAVS------------ 1403

  Fly  1666 GTEEEFAQLRRSKNETERRAKEQEEELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQQRDEE 1730
                   |:::.|..|:.....||..|                            ...|.....:
Human  1404 -------QMKQQKYPTKVSFSSQEIPL----------------------------APASSYHSTD 1433

  Fly  1731 LEEVRGNGYK---KIKALECQLETEHEERTLLLREKHELERRLSSMEDRDRVDR-DAEEALNQKL 1791
            .:.....|::   .:....|.:....|....:.:.:..|...:...:|.....| .:..|.:|.|
Human  1434 ADFTGYGGFQAPLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLFWRLGSPRAWSQHL 1498

  Fly  1792 RRDLRKYKALLKDAQTQLERLKADTPGKTLIRQLRNQLEDAESARSLAMKARQTAEAELTEVQAM 1856
            .|..     :|....|::|       |:..| .:....|:..:||.    .|..|..::.||..:
Human  1499 VRAF-----MLHHPVTEVE-------GQNAI-VIHEVYEEGAAARD----GRLWAGDQILEVNGV 1546

  Fly  1857 FDESHRARNDAEERANAAHRD----------RAELQAQIEENEEELG-ELMKKYS-----ATVKQ 1905
                 ..||.:.|.|..|.|.          |.|...:.|||.|... :|.||..     :.|.:
Human  1547 -----DLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGLGLSIVGK 1606

  Fly  1906 LNTEQINVSEAEFKLNEMEAERNNLKEQVAELQHRLDNVENLGDPSMAMMSKRLELRTKELESRL 1970
            .|...:.:|:.             :|...|:|..||..    ||..:::..:  ::|....|:..
Human  1607 RNGSGVFISDI-------------VKGGAADLDGRLIQ----GDQILSVNGE--DMRNASQETVA 1652

  Fly  1971 ELEQATRARLEVQVNRHKEALEKLQNEVTQSKMREMQAQDVIKKSQKSLR-DMREEFHAVSSREQ 2034
            .:.:..:..:::::.|.:      ....|.::.....:|.    ||:|.. .....|..|     
Human  1653 TILKCAQGLVQLEIGRLR------AGSWTSARTTSQNSQG----SQQSAHSSCHPSFAPV----- 1702

  Fly  2035 ESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSVGSISDL 2099
                                             |..||..:   |.:.:|:..:..|.    :|:
Human  1703 ---------------------------------ITGLQNLV---GTKRVSDPSQKNSG----TDM 1727

  Fly  2100 EDRLRPVHVKRSSQQSLNGSIGGGGGS 2126
            |.  |.|.:.|....:|..||.||.||
Human  1728 EP--RTVEINRELSDALGISIAGGRGS 1752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492 21/89 (24%)
MYSc 556..1317 CDD:214580 158/859 (18%)
MYSc_Myo18 575..1305 CDD:276837 150/828 (18%)
GBP_C <1540..1750 CDD:303769 28/224 (13%)
COG1340 1565..1833 CDD:224259 40/283 (14%)
coiled coil 1723..1734 CDD:293879 1/10 (10%)
PATJXP_011538764.1 L27_2 8..65 CDD:117611 10/56 (18%)
PDZ_signaling 135..218 CDD:238492 18/107 (17%)
PDZ_signaling 246..325 CDD:238492 25/112 (22%)
PDZ_signaling 366..450 CDD:238492 21/95 (22%)
PDZ_signaling 570..634 CDD:238492 12/63 (19%)
PDZ 683..772 CDD:214570 23/106 (22%)
PDZ_signaling 1066..1157 CDD:238492 19/112 (17%)
PDZ 1236..1321 CDD:214570 15/134 (11%)
PDZ 1459..1574 CDD:214570 26/136 (19%)
PDZ_signaling 1586..1666 CDD:238492 15/98 (15%)
PDZ_signaling 1729..1814 CDD:238492 10/26 (38%)
PDZ_signaling 1852..1936 CDD:238492
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3528
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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