DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myh7ba

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:NP_001311408.1 Gene:myh7ba / 100884147 ZFINID:ZDB-GENE-100914-2 Length:1938 Species:Danio rerio


Alignment Length:2036 Identity:485/2036 - (23%)
Similarity:840/2036 - (41%) Gaps:505/2036 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   493 DLE---ADVADASQPERVWLVHRGGFTAAIRLPTASSGRDE-ENKLSLRLLHNGEQLTVDEDDVE 553
            |||   |........:|.|:.........:.:......|.| |.|       :|:.|||.|||::
Zfish    21 DLELLAAQTVAFDGKKRAWIPDDKDAYIEVEIKQIDGDRVEVETK-------DGKCLTVKEDDIQ 78

  Fly   554 KQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMF 618
            :.|.|..||:||:..|.:|||||||..||:||:|.:|:|.:|...:.|||...|.:|:..||:.:
Zfish    79 QMNPPKFDLIEDMAMLTHLNEASVLFNLRRRYSSWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAY 143

  Fly   619 RGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALA-----AGAY 678
            :|.:..:.|||:||:|..||..::..|.:||::..|.||:||:.:.|..:.|.|:.     |.|.
Zfish   144 KGKRRSEAPPHIYSIADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGEAAAK 208

  Fly   679 NNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRR 743
            ......:::......:|||||.||..|.|::|..:.:.:.|..||::|||.:.:.|.|:.|...:
Zfish   209 KGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQ 273

  Fly   744 LGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPF--------ISLSQKLEDRHRAANDFMR 800
            ...|.|:||..::::      ||:..|.::....|:|:        ::..:.::|    ..:.|.
Zfish   274 QPGERSYHIYYQIMS------QKKPELLDMLLVSSNPYDYHFCSQGVTTVENMDD----GQELMA 328

  Fly   801 TVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLED 865
            |..|.:.|....:...|.:.|:.||.|.|.....:......|...  ...:|.|||.|:||:..|
Zfish   329 TDHAMDILGFTPEEKYGCYKIVGAIMHFGNMKFKQKQREEQAEAD--GTESADKASYLMGVSSAD 391

  Fly   866 LSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE---------CLEALVIGLYSEALAAVVALI 921
            |..   ||..|..             ..|:|:..:         .:.||....|......:|..|
Zfish   392 LIK---GLLHPRV-------------KVGNEYVVKGQNVEQVNYAVGALAKATYDRMFKWLVGRI 440

  Fly   922 NRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPR 982
            ||.:.|:......|.::|..||:    |          :...|..|:..|:||..|:|...:..:
Zfish   441 NRTLYTALPRQFFIGVLDIAGFEIFELN----------SFEQLCINFTNEKLQQFFNHHMFILEQ 495

  Fly   983 DRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAI 1042
            :.|.:|     .::..:||.: |     |.||:|.                  .|::.:|:||.:
Zfish   496 EEYKREGIEWTFIDFGLDLQA-C-----IDLIEKP------------------LGIMSILEEECM 536

  Fly  1043 YPNSNDDTFLERLFSHYGDREHHSLLRKCAG---PR---------QFVLHHLQGTNPVLYAVDGW 1095
            :|.:.|::|..:||.::        |.|.|.   ||         .|.|.|..|..|  |.:.||
Zfish   537 FPKATDNSFKAKLFDNH--------LGKSANFQKPRPDKKRKYEAHFELVHYAGVVP--YNIIGW 591

  Fly  1096 VRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSF 1160
            :..::: |.....|...|.||.:.:..||...::..|.:....|.....:...|.:.||.:.   
Zfish   592 LDKNKD-PLNETVVICFQKSSNKLLASLYEKYVSSDSASDPKTGGKEKRKKAASFQTVSQLH--- 652

  Fly  1161 TTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEE 1225
                          |..::.::..||.|..|||.|.:     ...||     :|.          
Zfish   653 --------------KENLNKLMTNLRSTQPHFVRCII-----PNETK-----TPG---------- 683

  Fly  1226 EMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-----AGDLASNKDVSVEQIL 1285
             :::..::..|||.:.|||..|:.|.|||..:...||.:|:.:|     ..|...:...:.|::|
Zfish   684 -IMDSFMVLHQLRCNGVLEGIRICRKGFPNRMLYAEFKQRYRILNPHAIPDDKFVDSRKAAEKLL 747

  Fly  1286 AVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAV 1350
            |..::|...||.|.:::.|::|:|.:||..||..|:..:..|||..||.:.|.::::...::.|:
Zfish   748 ASLDIDHNQYRFGHTKVFFKAGLLGQLEEMRDERLAKILTLLQAASRGKIMRMELNKMTQRKEAL 812

  Fly  1351 RCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVK-- 1413
            ..||.|::||..|::|||.:|..::.|||....||::|....||.|.|:..|||.|..|.|::  
Zfish   813 MIIQWNIRAFNIVKNWPWMKLFFKIKPLLRSAATEKELAALKEEFLKLKEALEKSEAKRKELEEK 877

  Fly  1414 ------------------------AENQ---------KLEAKLSELTVDLAEE---RSTAHIATE 1442
                                    ||::         :||||:.|:|..|.:|   .:|......
Zfish   878 QVSLIQEKNDLSLQLQAEQDNLADAEDRCDLLIKTKIQLEAKVKEMTERLEDEEEMNATVLAKKR 942

  Fly  1443 RLEAETAE-----------RLKLEKELGDQTNKVKN-------LQETTEKLEMELICAKSD---- 1485
            :||.|.||           ..|:|||.....|||||       |.||..||..|....:..    
Zfish   943 KLEDECAELKKDIDDLEITLAKVEKEKHATENKVKNLIEEMAALDETILKLTKEKKALQESHQQT 1007

  Fly  1486 LNGISEDEDAENE------------DGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVAL 1538
            |:.:..:||..|.            |.:.|.:.:.|  ::..:||.:||:|....:..:|.::.|
Zfish  1008 LDDLQTEEDKVNTLTKAKAKLEQQVDDLEGSLEQEK--KLRMDLERSKRKLEGDLKLSMESVMDL 1070

  Fly  1539 ---KKHLEMKLSDAYEEV------VEQRQV-VGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEK 1593
               |:.||.||.....|:      :|..|| :.|.::|.:::...:.:|...:|.:.:....:||
Zfish  1071 ENDKQQLEEKLKKKDFEMNQISSKIEDDQVLIIQLQKKIKELQARIEELEEEMEAERSTRAKMEK 1135

  Fly  1594 KQRKFDAECQSLQDAVRQ-------------ERQA---KERYGREKDVLQAEKFT--LEQTLADT 1640
            .:.....|.:.|.:.:.:             :|:|   |.|...|:.:|..|..|  |.:..||:
Zfish  1136 HRSDSSKELEELSERLEEAGGATSAQIEMNKKREADFLKLRRDLEEAILHHEAMTAALRKKHADS 1200

  Fly  1641 RLDLEFKEEKLASLQR---------------------ELEEMTFGGGTEEEFA-----QLRRSKN 1679
            .::|   .|::.||||                     .||::..|..|.|:..     |:..||.
Zfish  1201 VVEL---SEQIDSLQRVKQKLEKERSEAKMEADDLTSNLEQLAKGKATAEKTCRLYEDQMNESKA 1262

  Fly  1680 ETE-----------RRAKEQEE------ELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQ-- 1725
            :.|           :||:.|.|      :|:|....:..|:::|......:|.::|:...||:  
Zfish  1263 KVEELQRQLSDTNTQRARAQAESAELGRKLEEREALVSQLQRSKNTFSQNIEELKKQLEEESKSK 1327

  Fly  1726 ------------------------------------------------------QRDEELEEVRG 1736
                                                                  |:.|||||.:.
Zfish  1328 NALTHALQSSRHDCDLLREQYDEEQEGKSELQRALSKANAEVAQWRTKYETDAIQKTEELEEAKK 1392

  Fly  1737 NGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDRVDRDAEEALNQKLR---RDLRK 1797
            ....:::..|.|:|..:.:.:.|.:.||.|:..:..:. |.:| ...|..||::|.|   :.|.:
Zfish  1393 KLATRLQESEEQVEASNAKCSSLEKTKHRLQSEIEDLVLDLER-SNAAATALDKKQRQFDKILAE 1456

  Fly  1798 YKALLKDAQTQLERLKADTPG-KTLIRQLRNQLEDA----ESARSLAM----------------- 1840
            ::...::.|::||..:.::.. .|.:.:|:|..|:|    ||.:..:.                 
Zfish  1457 WRHKYEECQSELESSQKESRNLSTELFKLKNSYEEALDHLESIKRESKNLQEEISDLNDQISQGG 1521

  Fly  1841 -------KARQTAEAELTEVQAMFDESHRARNDAEERANAAHRD----RAELQAQIEENEEELGE 1894
                   |.::..:.|.||:||..:|:.......|.:......:    :|:...::.|.:||:..
Zfish  1522 KTIHELEKIKKGLDLEKTEIQAALEEAEGTLEHEESKTLRIQLELNQIKADTDRKLAEKDEEIDN 1586

  Fly  1895 LMKKYSATVKQ----LNTEQINVSEA-------EFKLNEMEAERN--------------NLKEQV 1934
            |.:.:...::.    |:.|..:.|||       |..|||||.:.|              ||:.|:
Zfish  1587 LRRNHQRALESMQATLDAEAKSRSEAIRVKKKMENDLNEMEVQLNHANWLATESQKMVRNLQTQI 1651

  Fly  1935 AELQHRLDNV----ENLGDPSMAMMSKRLELRTKELES-RLELEQATRAR-------LEV--QVN 1985
            .:||..||..    |.|.:.| |:..:|..|.|.|:|. |.:|||..|||       ||.  :||
Zfish  1652 KDLQMELDETVHQNEELKEQS-AVTERRNNLLTAEVEELRCQLEQNDRARKLAEFELLETTERVN 1715

  Fly  1986 ----------RHKEALEK----LQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQES 2036
                      ..|:.||.    |.:||..:......|::..||:......|.||.    .:||::
Zfish  1716 LLHSQNTSMLNQKKKLENDLATLSSEVDDAVQECRNAEEKAKKAITDAAMMAEEL----KKEQDT 1776

  Fly  2037 LTRRKDLEKKVEQM---------ESEGAAL---KNDLRLALQRIADLQQAMEEEGE--------- 2080
            ....:.::|.:||.         |:|..||   |..::....::.||:..:|.|.:         
Zfish  1777 SAHLERMKKNMEQTIKDLQLRLDEAEQIALKGGKKQIQKLESKVRDLESELESEQKKSNELQKGI 1841

  Fly  2081 -------EELS-ESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFE 2137
                   :||: :::|...::..:.:|.|:|: ..||...:|:.:..  ....|.::..:.:..|
Zfish  1842 RKYERRIKELTYQTEEDRKNIARLQELIDKLQ-AKVKTYKRQAEDAE--EQANSNLTKYKKIQHE 1903

  Fly  2138 KDDNSPRITVTSPSSPHIHKL 2158
            .||...|..:   :...::||
Zfish  1904 LDDAEERADI---AESQVNKL 1921

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 207/808 (26%)
MYSc_Myo18 575..1305 CDD:276837 192/777 (25%)
GBP_C <1540..1750 CDD:303769 62/333 (19%)
COG1340 1565..1833 CDD:224259 74/393 (19%)
coiled coil 1723..1734 CDD:293879 7/66 (11%)
myh7baNP_001311408.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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