Protein Alignment Mhcl and myh7ba

DIOPT Version :10

• Sequence 1: NP_732109.2
• Gene: Mhcl / 41955
• FlyBaseID: FBgn0026059
• Length: 2194
• Species: Drosophila melanogaster
• Sequence 2: NP_001311408.1
• Gene: myh7ba / 100884147
• ZFINID: ZDB-GENE-100914-2
• Length: 1938
• Species: Danio rerio
• Alignment Length: 2036
• Identity: 485/2036 - (23%)
• Similarity: 840/2036 - (41%)
• Gaps: 505/2036 - (24%)

  Fly   493 DLE---ADVADASQPERVWLVHRGGFTAAIRLPTASSGRDE-ENKLSLRLLHNGEQLTVDEDDVE 553
            |||   |........:|.|:.........:.:......|.| |.|       :|:.|||.|||::
Zfish    21 DLELLAAQTVAFDGKKRAWIPDDKDAYIEVEIKQIDGDRVEVETK-------DGKCLTVKEDDIQ 78

  Fly   554 KQNSPALDLVEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMF 618
            :.|.|..||:||:..|.:|||||||..||:||:|.:|:|.:|...:.|||...|.:|:..||:.:
Zfish    79 QMNPPKFDLIEDMAMLTHLNEASVLFNLRRRYSSWMIYTYSGLFCVTVNPYKWLPVYTAPVVAAY 143

  Fly   619 RGCKTEDMPPHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALA-----AGAY 678
            :|.:..:.|||:||:|..||..::..|.:||::..|.||:||:.:.|..:.|.|:.     |.|.
Zfish   144 KGKRRSEAPPHIYSIADNAYNDMLRNRENQSMLITGESGAGKTVNTKRVIQYFAIVAALGEAAAK 208

  Fly   679 NNFINAEKVNALCTILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRR 743
            ......:::......:|||||.||..|.|::|..:.:.:.|..||::|||.:.:.|.|:.|...:
Zfish   209 KGGTLEDQIIEANPAMEAFGNAKTLRNDNSSRFGKFIRIHFGPTGKLASADIDIYLLEKSRVIFQ 273

  Fly   744 LGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPF--------ISLSQKLEDRHRAANDFMR 800
            ...|.|:||..::::      ||:..|.::....|:|:        ::..:.::|    ..:.|.
Zfish   274 QPGERSYHIYYQIMS------QKKPELLDMLLVSSNPYDYHFCSQGVTTVENMDD----GQELMA 328

  Fly   801 TVQAFETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLED 865
            |..|.:.|....:...|.:.|:.||.|.|.....:......|...  ...:|.|||.|:||:..|
Zfish   329 TDHAMDILGFTPEEKYGCYKIVGAIMHFGNMKFKQKQREEQAEAD--GTESADKASYLMGVSSAD 391

  Fly   866 LSSAAFGLTQPNAPNGGLSPSKSPTSDTGHEWAWE---------CLEALVIGLYSEALAAVVALI 921
            |..   ||..|..             ..|:|:..:         .:.||....|......:|..|
Zfish   392 LIK---GLLHPRV-------------KVGNEYVVKGQNVEQVNYAVGALAKATYDRMFKWLVGRI 440

  Fly   922 NRQICTSSHTIASIMLIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPR 982
            ||.:.|:......|.::|..||:    |          :...|..|:..|:||..|:|...:..:
Zfish   441 NRTLYTALPRQFFIGVLDIAGFEIFELN----------SFEQLCINFTNEKLQQFFNHHMFILEQ 495

  Fly   983 DRYAQE-----LVEIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAI 1042
            :.|.:|     .::..:||.: |     |.||:|.                  .|::.:|:||.:
Zfish   496 EEYKREGIEWTFIDFGLDLQA-C-----IDLIEKP------------------LGIMSILEEECM 536

  Fly  1043 YPNSNDDTFLERLFSHYGDREHHSLLRKCAG---PR---------QFVLHHLQGTNPVLYAVDGW 1095
            :|.:.|::|..:||.::        |.|.|.   ||         .|.|.|..|..|  |.:.||
Zfish   537 FPKATDNSFKAKLFDNH--------LGKSANFQKPRPDKKRKYEAHFELVHYAGVVP--YNIIGW 591

  Fly  1096 VRHSREHPGIRNAVSLLQDSSREEINRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSF 1160
            :..::: |.....|...|.||.:.:..||...::..|.:....|.....:...|.:.||.:.
Zfish   592 LDKNKD-PLNETVVICFQKSSNKLLASLYEKYVSSDSASDPKTGGKEKRKKAASFQTVSQLH--- 652

  Fly  1161 TTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFVHCYLLQHNAGKHTKYTANGSPSSAAGQVSSEE 1225
                          |..::.::..||.|..|||.|.:     ...||     :|.
Zfish   653 --------------KENLNKLMTNLRSTQPHFVRCII-----PNETK-----TPG---------- 683

  Fly  1226 EMVNVPLLRSQLRGSQVLEAARLHRLGFPESVPLLEFVRRFGLL-----AGDLASNKDVSVEQIL 1285
             :::..::..|||.:.|||..|:.|.|||..:...||.:|:.:|     ..|...:...:.|::|
Zfish   684 -IMDSFMVLHQLRCNGVLEGIRICRKGFPNRMLYAEFKQRYRILNPHAIPDDKFVDSRKAAEKLL 747

  Fly  1286 AVNELDVASYRIGPSQILFRSGVLSELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAV 1350
            |..::|...||.|.:::.|::|:|.:||..||..|:..:..|||..||.:.|.::::...::.|:
Zfish   748 ASLDIDHNQYRFGHTKVFFKAGLLGQLEEMRDERLAKILTLLQAASRGKIMRMELNKMTQRKEAL 812

  Fly  1351 RCIQRNVKAFLAVRDWPWWRLLVRVTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEVK-- 1413
            ..||.|::||..|::|||.:|..::.|||....||::|....||.|.|:..|||.|..|.|::
Zfish   813 MIIQWNIRAFNIVKNWPWMKLFFKIKPLLRSAATEKELAALKEEFLKLKEALEKSEAKRKELEEK 877

  Fly  1414 ------------------------AENQ---------KLEAKLSELTVDLAEE---RSTAHIATE 1442
                                    ||::         :||||:.|:|..|.:|   .:|......
Zfish   878 QVSLIQEKNDLSLQLQAEQDNLADAEDRCDLLIKTKIQLEAKVKEMTERLEDEEEMNATVLAKKR 942

  Fly  1443 RLEAETAE-----------RLKLEKELGDQTNKVKN-------LQETTEKLEMELICAKSD---- 1485
            :||.|.||           ..|:|||.....|||||       |.||..||..|....:..
Zfish   943 KLEDECAELKKDIDDLEITLAKVEKEKHATENKVKNLIEEMAALDETILKLTKEKKALQESHQQT 1007

  Fly  1486 LNGISEDEDAENE------------DGVGGGVYKLKYERVARELEFTKRRLHTQHEHDLEQLVAL 1538
            |:.:..:||..|.            |.:.|.:.:.|  ::..:||.:||:|....:..:|.::.|
Zfish  1008 LDDLQTEEDKVNTLTKAKAKLEQQVDDLEGSLEQEK--KLRMDLERSKRKLEGDLKLSMESVMDL 1070

  Fly  1539 ---KKHLEMKLSDAYEEV------VEQRQV-VGQWKRKAQKMTNEMNDLRMLLEEQNARNNLLEK 1593
               |:.||.||.....|:      :|..|| :.|.::|.:::...:.:|...:|.:.:....:||
Zfish  1071 ENDKQQLEEKLKKKDFEMNQISSKIEDDQVLIIQLQKKIKELQARIEELEEEMEAERSTRAKMEK 1135

  Fly  1594 KQRKFDAECQSLQDAVRQ-------------ERQA---KERYGREKDVLQAEKFT--LEQTLADT 1640
            .:.....|.:.|.:.:.:             :|:|   |.|...|:.:|..|..|  |.:..||:
Zfish  1136 HRSDSSKELEELSERLEEAGGATSAQIEMNKKREADFLKLRRDLEEAILHHEAMTAALRKKHADS 1200

  Fly  1641 RLDLEFKEEKLASLQR---------------------ELEEMTFGGGTEEEFA-----QLRRSKN 1679
            .::|   .|::.||||                     .||::..|..|.|:..     |:..||.
Zfish  1201 VVEL---SEQIDSLQRVKQKLEKERSEAKMEADDLTSNLEQLAKGKATAEKTCRLYEDQMNESKA 1262

  Fly  1680 ETE-----------RRAKEQEE------ELDEMAGQIQLLEQAKLRLEMTLETMRKEARRESQ-- 1725
            :.|           :||:.|.|      :|:|....:..|:::|......:|.::|:...||:
Zfish  1263 KVEELQRQLSDTNTQRARAQAESAELGRKLEEREALVSQLQRSKNTFSQNIEELKKQLEEESKSK 1327

  Fly  1726 ------------------------------------------------------QRDEELEEVRG 1736
                                                                  |:.|||||.:.
Zfish  1328 NALTHALQSSRHDCDLLREQYDEEQEGKSELQRALSKANAEVAQWRTKYETDAIQKTEELEEAKK 1392

  Fly  1737 NGYKKIKALECQLETEHEERTLLLREKHELERRLSSME-DRDRVDRDAEEALNQKLR---RDLRK 1797
            ....:::..|.|:|..:.:.:.|.:.||.|:..:..:. |.:| ...|..||::|.|   :.|.:
Zfish  1393 KLATRLQESEEQVEASNAKCSSLEKTKHRLQSEIEDLVLDLER-SNAAATALDKKQRQFDKILAE 1456

  Fly  1798 YKALLKDAQTQLERLKADTPG-KTLIRQLRNQLEDA----ESARSLAM----------------- 1840
            ::...::.|::||..:.::.. .|.:.:|:|..|:|    ||.:..:.
Zfish  1457 WRHKYEECQSELESSQKESRNLSTELFKLKNSYEEALDHLESIKRESKNLQEEISDLNDQISQGG 1521

  Fly  1841 -------KARQTAEAELTEVQAMFDESHRARNDAEERANAAHRD----RAELQAQIEENEEELGE 1894
                   |.::..:.|.||:||..:|:.......|.:......:    :|:...::.|.:||:..
Zfish  1522 KTIHELEKIKKGLDLEKTEIQAALEEAEGTLEHEESKTLRIQLELNQIKADTDRKLAEKDEEIDN 1586

  Fly  1895 LMKKYSATVKQ----LNTEQINVSEA-------EFKLNEMEAERN--------------NLKEQV 1934
            |.:.:...::.    |:.|..:.|||       |..|||||.:.|              ||:.|:
Zfish  1587 LRRNHQRALESMQATLDAEAKSRSEAIRVKKKMENDLNEMEVQLNHANWLATESQKMVRNLQTQI 1651

  Fly  1935 AELQHRLDNV----ENLGDPSMAMMSKRLELRTKELES-RLELEQATRAR-------LEV--QVN 1985
            .:||..||..    |.|.:.| |:..:|..|.|.|:|. |.:|||..|||       ||.  :||
Zfish  1652 KDLQMELDETVHQNEELKEQS-AVTERRNNLLTAEVEELRCQLEQNDRARKLAEFELLETTERVN 1715

  Fly  1986 ----------RHKEALEK----LQNEVTQSKMREMQAQDVIKKSQKSLRDMREEFHAVSSREQES 2036
                      ..|:.||.    |.:||..:......|::..||:......|.||.    .:||::
Zfish  1716 LLHSQNTSMLNQKKKLENDLATLSSEVDDAVQECRNAEEKAKKAITDAAMMAEEL----KKEQDT 1776

  Fly  2037 LTRRKDLEKKVEQM---------ESEGAAL---KNDLRLALQRIADLQQAMEEEGE--------- 2080
            ....:.::|.:||.         |:|..||   |..::....::.||:..:|.|.:
Zfish  1777 SAHLERMKKNMEQTIKDLQLRLDEAEQIALKGGKKQIQKLESKVRDLESELESEQKKSNELQKGI 1841

  Fly  2081 -------EELS-ESDESLSSVGSISDLEDRLRPVHVKRSSQQSLNGSIGGGGGSVVSSTRTVVFE 2137
                   :||: :::|...::..:.:|.|:|: ..||...:|:.:..  ....|.::..:.:..|
Zfish  1842 RKYERRIKELTYQTEEDRKNIARLQELIDKLQ-AKVKTYKRQAEDAE--EQANSNLTKYKKIQHE 1903

  Fly  2138 KDDNSPRITVTSPSSPHIHKL 2158
            .||...|..:   :...::||
Zfish  1904 LDDAEERADI---AESQVNKL 1921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mhcl	NP_732109.2	PDZ_canonical	337..426	CDD:483948
		COG5022	541..2019	CDD:227355	442/1814 (24%)
		MYSc_Myo18	575..1305	CDD:276837	192/777 (25%)
myh7ba	NP_001311408.1	Myosin_N	33..77	CDD:460670	12/50 (24%)
		MYSc_Myh7b	100..767	CDD:276953	192/777 (25%)
		Myosin_tail_1	847..1924	CDD:460256	237/1092 (22%)