DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and myh11

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_031748845.1 Gene:myh11 / 100490639 XenbaseID:XB-GENE-6459772 Length:1980 Species:Xenopus tropicalis


Alignment Length:1867 Identity:489/1867 - (26%)
Similarity:825/1867 - (44%) Gaps:359/1867 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   499 ADASQPERVWL-VHRGGFTAAIRLPTASSGRDEENKLSLRLLHNGEQLTVDEDDVEKQNSPALDL 562
            ||.:..:.||: ..:.||.|      ||...::.:::.:.:..||:::|:.:||::|.|.|....
 Frog    27 ADWTAKKLVWIPSEKHGFEA------ASIKEEKGDEVVVEMQENGKKITISKDDIQKMNPPKFSK 85

  Fly   563 VEDICELKYLNEASVLHCLRQRYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMP 627
            |||:.||..||||||||.||:||.|.||:|.:|...:||||...|.:||||::.|::|.|..:||
 Frog    86 VEDMAELTCLNEASVLHNLRERYFSGLIYTYSGLFCVVVNPYKALPIYSEKIIDMYKGKKRHEMP 150

  Fly   628 PHVYSLAQTAYRSLVETRRDQSLIFMGRSGSGKSTSFKHALNYLALAAGAYN-----------NF 681
            ||:|::|.|||||:::.|.|||::..|.||:||:.:.|..:.|||:.|.::.           :|
 Frog   151 PHIYAIADTAYRSMLQDREDQSILCTGESGAGKTENTKKVIQYLAVVASSHKGKKDTTITQGPSF 215

  Fly   682 INAEKVNALC---TILEAFGNTKTCLNSNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRR 743
            ...|....|.   .|||||||.||..|.|::|..:.:.::||.||.|..|:::..|.|:.||.|:
 Frog   216 AYGELEKQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQ 280

  Fly   744 LGHEHSFHIMTRLLAGAAGLLQKELHLENITSEDSHPFISLSQKLEDRHRAAND---FMRTVQAF 805
            ...|.:|||...|:.||....:::|.||..   .::.|:|.......   ||:|   |..|::|.
 Frog   281 ARDERTFHIFYYLIQGAKPAWREDLLLEGF---GNYTFLSYGYVPVP---AADDGDMFQETLEAM 339

  Fly   806 ETLNIDAKAVRGIWSILAAIYHLGIAGVTKLGTGSTARTQFANPTAARKASGLLGVNLEDLSSAA 870
            |.:.........:..:::::..||  .:......:|.:....:.|||:|...|.|:|:.|.:.. 
 Frog   340 EIMGFSEDEQLSMMRVVSSVLQLG--NIVFKKERNTDQASMPDDTAAQKVCHLAGINVTDFARC- 401

  Fly   871 FGLTQPNAPNGGLSPSKSPTSDTGHEWAWECLEALVIGLYSEALAAVVALINRQICTSSHTIASI 935
              :..|....|.....|:.|.    |.|...:|||....|......::..:|:.:..:....||.
 Frog   402 --ILTPRIKVGRDFVQKAQTK----EQADFAIEALAKATYERLFLWILNRVNKALDKTKRQGASF 460

  Fly   936 M-LIDTPGFQ----NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQE-----LV 990
            : ::|..||:    |          :...|..||..|:||.||:||..:..::.|.:|     .:
 Frog   461 LGILDIAGFEIFEVN----------SFEQLCINYTNEKLQQLFNHTMFILEQEEYQREGIEWNFI 515

  Fly   991 EIEMDLASECHPGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERL 1055
            :..:||.      |.|.||:               |.::..|:|.|||||..:|.:.|.:|:|::
 Frog   516 DFGLDLQ------PCIELIE---------------RPNNPPGILALLDEECWFPKATDVSFVEKV 559

  Fly  1056 FSHYGDREHHSLLRKCAGPRQFVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEI 1120
            ....|:.......::......|.|.|..|  .|.|....|:..:.: |...|..:||..||.:  
 Frog   560 IQEQGNHIKFQKTKQLKDKTIFTLVHYAG--KVDYDATSWLTKNMD-PLNDNVTALLNQSSDK-- 619

  Fly  1121 NRLYIGSLTRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTL 1185
               ::|.|.:....:|      ||:....:...|....|.|..|:.|....| .|..:..::.||
 Frog   620 ---FVGDLWKDVDRIV------GLDQMAKMTESSLPSASKTKKGMFRTVGQL-YKEQLTKLMTTL 674

  Fly  1186 RRTGTHFVHCYLLQH--NAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARL 1248
            |.|..:||.|.:..|  .:||                       ::..|:..|||.:.|||..|:
 Frog   675 RNTSPNFVRCIIPNHEKRSGK-----------------------LDAHLVLEQLRCNGVLEGIRI 716

  Fly  1249 HRLGFPESVPLLEFVRRFGLLAGDLASNKDVSVEQ----ILAVNELDVASYRIGPSQILFRSGVL 1309
            .|.|||..:...||.:|:.:|.........:..:|    ::...|||...||||.|::.||:|||
 Frog   717 CRQGFPNRIVFQEFRQRYEILTAGAIPKGFMDGKQSCMLMMKALELDTNLYRIGQSKVFFRTGVL 781

  Fly  1310 SELEAKRDVLLSDRIIQLQAFCRGYLARKKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVR 1374
            :.||.:||:.::|.||..||..||:||||..::|:.|..|::.||||..|:|.:|:|.||||..:
 Frog   782 AHLEEERDLKITDIIITFQALARGFLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTK 846

  Fly  1375 VTPLLNVHRTEEQLKTANEELLMLRAKLEKIECDRSEV--------------------------- 1412
            |.|||.|.|.||:::..:|||..:..|..|.|.:..|:                           
 Frog   847 VKPLLQVTRQEEEMQLKDEELQRVNEKFFKTEIELKEIQMKHIQLVEEKTLLQEQLQAETELYAE 911

  Fly  1413 --------KAENQKLEAKLSELTVDLAEERSTA--------------HIATERLEAETAERLKLE 1455
                    :|:.|:||..|.|:.|.|.||....              ....|:||.|.|.|.||:
 Frog   912 AEELRIRLQAKKQELEEVLHEMEVRLEEEEDRGQQLQAEKKKTLQQMQDLEEQLEEEEAARQKLQ 976

  Fly  1456 KELGDQTNKVKNLQE------------TTEKLEMELICAKSDLNGISEDEDAENEDGVGGGVYKL 1508
            .|......|:|.|::            |.||..:|........|...|:|.|:|...:     |.
 Frog   977 LEKVTAEAKIKKLEDDVLVMDDHHNKLTKEKKILEERVNDLTTNLAEEEEKAKNLTKL-----KN 1036

  Fly  1509 KYERVARELEFTKRRLHTQHEHDLEQLVALKKHLEMKLSDAYEEVVEQRQVVGQWKRKAQKMTNE 1573
            |:|.:..|||...::    .|...::|..:|:.||.:.:|..|::.:.:..:.:.|.:..|...|
 Frog  1037 KHESMISELEVRLKK----EEKGRQELEKVKRKLEGEANDLNEQIADLQAQIAELKMQLAKKEEE 1097

  Fly  1574 MNDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREK----DVLQAEKFTLE 1634
            :......||::.|:.|...||.|:.::....||:.:..|:.|:.:..:.|    :.|:|.|..||
 Frog  1098 LQAALARLEDETAQKNNALKKIRELESHISDLQEDLESEKSARNKAEKSKRDLGEELEALKTELE 1162

  Fly  1635 QTLADTRLDLEF---KEEKLASLQRELEEMTFGGGTE----------------EEFAQLRRSKNE 1680
            .||..|....|.   :|:::..|:|.|||.|....::                |:..|::|.:..
 Frog  1163 DTLDSTATQQELRAKREQEVTVLKRALEEETRSHESQVQEMRQKHTQAVEELTEQLEQVKRVRVT 1227

  Fly  1681 TERRAKEQEEELDEMAGQIQLLEQA-------KLRLEMTL----------ETMRKEARRESQQRD 1728
            .|:..:..|::..|:..:|:.|.||       |.:||..|          |.:|.|...:|.:..
 Frog  1228 LEKSKQALEKDNSELTIEIRSLNQAKQDVEHKKKKLESQLQELQSKYTDGERVRNELTEKSHRVQ 1292

  Fly  1729 EELE---------EVRGNGYKK-IKALECQLETEHE---ERTLLLREKHELERRLSSMED----- 1775
            .|||         |.:...:.| :..|..||:...|   |.|   |:|..:..:|..:||     
 Frog  1293 VELENVTVLLSEAETKSIKFSKDVAGLTAQLQDTQELLQEET---RQKLNVSTKLRQVEDERNSL 1354

  Fly  1776 RDRVDRDAEEALNQKLRRDLRKYKALLKDAQTQLERLKA-----DTPGKTLIRQLRN---QLEDA 1832
            ::::|.:.|  ..|.|.|.:......|.|::.:|:...|     :...|.|.|.:.:   |.|:.
 Frog  1355 QEQLDEETE--AKQTLERHISTLNIQLSDSKKKLQEFTATIESMEEGKKKLQRDIESATQQFEEK 1417

  Fly  1833 ESARSLAMKARQTAEAELTEVQAMFDESHRARNDAEERAN----------------AAHRDRAEL 1881
            .||.....|.:...:.||.::....|...:..::.|::..                |..|||||.
 Frog  1418 ASAYDKLEKTKNRLQQELDDLIVDLDNQRQLVSNLEKKQKKFDQMLAEEKTISSKYADERDRAEA 1482

  Fly  1882 QAQIEE---------------NEEELGELMKKYSATVKQLNTEQINVSEAEFKLNEMEAERNNLK 1931
            :|:.:|               ::|||....|...|.::.|.:.:.:|.:   .::::|..:..|:
 Frog  1483 EAREKETKALSLARALDEALQSKEELERTNKLLKAEMEDLVSSKDDVGK---NVHDLEKAKRGLE 1544

  Fly  1932 EQVAELQHRLDNVENLGDPSMAMMSKRLELRT----------KELESRLELEQATRARLEVQVNR 1986
            :||.|::.:|:.:|   |...|....:|.|..          ::|.:|.|..:..|.:|..||:.
 Frog  1545 QQVEEMKTQLEELE---DELQATEDAKLRLEVNMQALKAQFERDLLARDEQNEEKRRQLVKQVHE 1606

  Fly  1987 HKEALEKLQNEVT----QSKMREMQAQDV-----------------IKKSQKSLRDMREEFHAVS 2030
            ::..||..:.:.|    ..|..|:..:|:                 ::|.|..::|.:.:.....
 Frog  1607 YETELEDERKQRTVAAAAKKKLEVDLKDLEGQVDFASRARDEAIKQLRKLQGQMKDFQRDLDEAR 1671

  Fly  2031 SREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQAMEEEGEEELSESDESLSSV-- 2093
            :..:|.....::.|||.:.:|:|...|:.|| .|.:|.....:..:||..|||:.|....||:  
 Frog  1672 NAREEIFATARENEKKAKSLEAELIQLQEDL-AAAERARKQAELEKEELAEELAGSASGKSSLQD 1735

  Fly  2094 --------------------GSISDLEDRLRPVHVKRSSQQSLNGSI 2120
                                |::..:.||:|.. |:::.|  ||..:
 Frog  1736 EKRRLEARISQLEEELEEEQGNMEGMSDRMRKA-VQQAEQ--LNNEL 1779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 232/793 (29%)
MYSc_Myo18 575..1305 CDD:276837 215/762 (28%)
GBP_C <1540..1750 CDD:303769 60/259 (23%)
COG1340 1565..1833 CDD:224259 78/333 (23%)
coiled coil 1723..1734 CDD:293879 4/19 (21%)
myh11XP_031748845.1 Myosin_N 32..71 CDD:397036 10/44 (23%)
Motor_domain 98..777 CDD:419868 215/762 (28%)
Myosin_tail_1 854..1934 CDD:396244 209/950 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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