DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mhcl and LOC100329748

DIOPT Version :9

Sequence 1:NP_732109.2 Gene:Mhcl / 41955 FlyBaseID:FBgn0026059 Length:2194 Species:Drosophila melanogaster
Sequence 2:XP_021326089.1 Gene:LOC100329748 / 100329748 -ID:- Length:1940 Species:Danio rerio


Alignment Length:1847 Identity:456/1847 - (24%)
Similarity:806/1847 - (43%) Gaps:376/1847 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   529 DEENKLSLRLLHNGEQ----------LTVDEDDVEKQNSPALDLVEDICELKYLNEASVLHCLRQ 583
            |||...:..:..:|::          :||.|.||..||.|..|.:||:....:|:|.:||..|::
Zfish    43 DEEYLKATVISRDGDKVTCETSKKTTVTVKECDVHPQNPPKFDKIEDMAMFTFLHEPAVLFNLKE 107

  Fly   584 RYASNLIHTKAGPTLLVVNPMAPLSLYSEKVVSMFRGCKTEDMPPHVYSLAQTAYRSLVETRRDQ 648
            |||:.:|:|.:|...:.|||...|.:|:::||..:||.|..:.|||::|::..||:.::..|.:|
Zfish   108 RYAAWMIYTYSGLFCVTVNPYKWLPVYNQEVVVAYRGKKRSEAPPHIFSISDNAYQYMLSDRENQ 172

  Fly   649 SLIFMGRSGSGKSTSFKHALNYLA-LAAGAYNNFINAEKVNAL------CT-ILEAFGNTKTCLN 705
            |::..|.||:||:.:.|..:.|.| :|||:.....::||...|      |. .||||||.||..|
Zfish   173 SILITGESGAGKTVNTKRVIQYFASIAAGSSKKDSSSEKKGTLEDQIIQCNPALEAFGNAKTIRN 237

  Fly   706 SNATRMTQLLSLDFDQTGQIASASLQVLLPERQRAGRRLGHEHSFHIMTRLLAGAAGLLQKELHL 770
            .|::|..:.:.:.|..:|::|||.::..|.|:.|...:|..|..:||..::|:      ||:..|
Zfish   238 DNSSRFGKFIRIHFAASGKLASADIETYLLEKSRVTFQLKAERDYHIFYQILS------QKKPEL 296

  Fly   771 ENITSEDSHP----FISLSQ----KLEDRHRAANDFMRTVQAFETLNIDAKAVRGIWSILAAIYH 827
            ..:....::|    |||..:    .::|    :::.|.|.:||:.|....:....|:.::.||.|
Zfish   297 LEMLLITANPYDYAFISQGETQVASIDD----SDELMATDEAFDVLGFTQEEKNSIYKLIGAIMH 357

  Fly   828 LGIAGVTKLGTGSTARTQFANPTA---ARKASGLLGVNLEDLSSAAFGLTQPNAPNGGLSPSKSP 889
            .|     .:......|.:.|....   |.|::.|:|:|..||..|   |..|..           
Zfish   358 YG-----NMKFKQKQREEQAEADGTEDADKSAYLMGLNSADLIKA---LCHPRV----------- 403

  Fly   890 TSDTGHEW---------AWECLEALVIGLYSEALAAVVALINRQICTSSHTIASIMLIDTPGFQ- 944
              ..|:||         .:..:.||...:|.:....:|..||:.:.|.......|.::|..||: 
Zfish   404 --KVGNEWVTKGQNVQQVYYAIGALSKSVYEKMFLWMVVRINQSLDTKQPRQYFIGVLDIAGFEI 466

  Fly   945 ---NPASCGQQVGATLADLRHNYLQERLQMLFHHTTLVAPRDRYAQ-----ELVEIEMDLASECH 1001
               |          |...|..|:..|:||..|:|...|..::.|.:     |.::..|||.: | 
Zfish   467 FDFN----------TFEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIDWEFIDFGMDLQA-C- 519

  Fly  1002 PGPLISLIDKAPQNHVVRSSQRDLREHDRRGMLWLLDEEAIYPNSNDDTFLERLF-SHYGDREHH 1065
                |.||:|.                  .|::.:|:||.::|.::|.||..:|: :|.|...:.
Zfish   520 ----IDLIEKP------------------MGIMSILEEECMFPKASDATFKAKLYDNHLGKSNNF 562

  Fly  1066 SLLRKCAGPRQ--FVLHHLQGTNPVLYAVDGWVRHSREHPGIRNAVSLLQDSSREEINRLYIGSL 1128
            ...|...|..:  |.|.|..||  |.|.::.|:..::: |.....|.|.|.|:.:.::.|:.|. 
Zfish   563 QKPRIVKGKPEAHFSLVHYAGT--VDYNINNWLVKNKD-PLNETVVGLYQKSTMKLLSNLFAGY- 623

  Fly  1129 TRGSGAMVFCGSFAGLEGTQSLRRVSSIRRSFTTAGVKRNSIMLQVKFTVDGIIDTLRRTGTHFV 1193
               :||........|.:|.:..::.||.:   |.:.:.|.::        :.::..||.|..|||
Zfish   624 ---AGAESAADGGGGGKGKEKKKKGSSFQ---TVSALHRENL--------NKLMTNLRSTHPHFV 674

  Fly  1194 HCYLLQHNAGKHTKYTANGSPSSAAGQVSSEEEMVNVPLLRSQLRGSQVLEAARLHRLGFPESVP 1258
            .|.:                    ..:..:...|.| ||:..|||.:.|||..|:.|.|||..:.
Zfish   675 RCII--------------------PNETKTPGAMEN-PLVMHQLRCNGVLEGIRICRKGFPNRIL 718

  Fly  1259 LLEFVRRFGLL------AGDLASNKDVSVEQILAVNELDVASYRIGPSQILFRSGVLSELEAKRD 1317
            ..:|.:|:.:|      .|....::. ..|::|...::|...||.|.:::.|::|:|..||..||
Zfish   719 YGDFKQRYRILNPAAIPEGQFIDSRK-GAEKLLGSLDIDHNQYRFGHTKVFFKAGLLGTLEEMRD 782

  Fly  1318 VLLSDRIIQLQAFCRGYLAR---KKMSQRRVQELAVRCIQRNVKAFLAVRDWPWWRLLVRVTPLL 1379
            ..|:..|..:||..||.|:|   :|:..||.   |:..||.||:||:.|::|||.:|..::.|||
Zfish   783 DRLALIITGIQARARGILSRIEFQKIVDRRD---ALLVIQWNVRAFMGVKNWPWMKLYFKIKPLL 844

  Fly  1380 NVHRTEEQLKTANEELLMLRAKLEKIECDRSEVK--------------------------AENQ- 1417
            .....|:::....||.|.|:....|.|..|.|::                          ||.: 
Zfish   845 RSAEAEKEMANMKEEFLKLKEAYAKSEARRKELEEKMVSLLQEKNDLQLAVQSEQDNLCDAEERC 909

  Fly  1418 --------KLEAKLSELTVDLAEERSTAHIATERLEAE-TAERLKLEKELGDQTNKVKNLQETTE 1473
                    :||||..|||..|.:|        |.:.|| ||::.|||.|..:....:.:|:.|..
Zfish   910 EGLIKNKIQLEAKAKELTERLEDE--------EEMNAELTAKKRKLEDECSELKKDIDDLELTLA 966

  Fly  1474 KLEMELICAKSDLNGISEDEDAENEDGVGGGVYKLKYERVA---------RELEFTKRRLHT--- 1526
            |:|.|....::.:..::|:..|.:|.     :.||..|:.|         .:|:..:.:::|   
Zfish   967 KVEKEKHATENKVKNLTEEMAALDEI-----IAKLTKEKKALQEAHQQTLDDLQSEEDKVNTLTK 1026

  Fly  1527 ------QHEHDLEQLVALKKHLEMKLSDA-----------YEEVVEQRQVVGQWKRKAQKMTNEM 1574
                  |...|||..:..:|.|.|.|..|           .|.|::......|.:.:.:|...|:
Zfish  1027 AKAKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLTQESVMDLENDKQQLEERLKKKDFEI 1091

  Fly  1575 NDLRMLLEEQNARNNLLEKKQRKFDAECQSLQDAVRQERQAKERYGREKDVLQAEKFTLEQTLAD 1639
            :.|...:|::.|....|:||.::..|..:.|::.:..||.|:.:..:::..|..|...:.:.|.:
Zfish  1092 SQLSSRIEDEQAMAAQLQKKLKELQARIEELEEELEAERAARAKVEKQRADLSRELEEISERLEE 1156

  Fly  1640 ----TRLDLEF---KEEKLASLQRELEEMTFG----------------GGTEEEFAQLRRSKNET 1681
                |...:|.   :|.:...|:|:|||.|..                ....|:...|:|.|.:.
Zfish  1157 AGGATAAQIEMNKKREAEFQKLRRDLEEATLQHEATASTLRKKHADSVSDLGEQIDNLQRVKQKL 1221

  Fly  1682 ERRAKEQEEELDEMAGQIQLLEQAKLRLE---MTLETMRKEARRESQQRDEELEEVRGNGYKKIK 1743
            |:...|...|||::...::.:.:||..||   .|||....|.|.:.::....:     |.:...|
Zfish  1222 EKEKSELRLELDDVVSNMEQIVKAKANLEKMCRTLEDQMSEYRTKYEEAQRSI-----NDFTMQK 1281

  Fly  1744 ALECQLETEHEERTLLLREKHELERRLS--------SMEDRDRVDRDAEEALN------QKLRRD 1794
            |   :|:||:.|.:..|.||..|..:|:        .:||..|...:..:|.|      |..|.|
Zfish  1282 A---KLQTENGELSRQLEEKDSLVSQLTRGKQSYTQQIEDLRRQLEEEVKAKNALAHAVQSARHD 1343

  Fly  1795 ---LRKYKALLKDAQTQLER--LKAD-------TPGKTLIRQLRNQLEDAESARSLAMK---ARQ 1844
               ||:.....::|:.:|:|  .||:       |..:|...|...:||||:  :.||.:   |.:
Zfish  1344 AELLREQYEEEQEAKAELQRSLSKANSEVAQWRTKYETDAIQRTEELEDAK--KKLAQRLQDAEE 1406

  Fly  1845 TAEAELTEVQAMFDESHRARNDAE------ERANAA---------HRDR--AELQAQIEENEEEL 1892
            ..||...:..::....||.:|:.|      ||:|||         :.|:  ||.:.:.||::.||
Zfish  1407 AVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKVLAEWKQKYEESQSEL 1471

  Fly  1893 GELMKKYSATVKQLNTEQINV----SEAEFKLNEMEAERNNLKEQVAELQHRL----DNVENLGD 1949
            ....|:    .:.|:||...:    .|:...|..|:.|..||:|::|:|..::    .|:..|..
Zfish  1472 ESSQKE----ARSLSTELFKLKNSYEESLDHLESMKRENKNLQEEIADLTEQIGESGKNIHELEK 1532

  Fly  1950 PSMAMMSKRLELRT--KELESRLELEQATRARLEVQVNRHKEALEK----LQNEVTQSKMREMQA 2008
            ....:..::.|::|  :|.|..||.|:....|.:::.|:.|..:|:    ...|:.|:|..:.:.
Zfish  1533 IRKQLEQEKAEIQTALEEAEGSLEHEEGKILRAQLEFNQVKADIERKLSEKDEEMEQAKRNQQRM 1597

  Fly  2009 QDVIKKSQKSLRDMREEFHAVSSREQESLTRRKDLEKKVEQMESEGAALKNDLRLALQRIADLQQ 2073
            .|.::.|.:|....|.|...:..:.:..|   .::|.::.|...:.:..:..|:.....:.|.|.
Zfish  1598 IDTLQSSLESETRSRNEALRLKKKMEGDL---NEMEIQLSQANRQASEAQKQLKGLHGHLKDAQL 1659

  Fly  2074 AMEE--EGEEELSES---------------DESLSSV-----------GSISDLEDRLRPVHVKR 2110
            .:::  .|.::|.|:               ||..|.|           ..:.|:.:|::.:|.:.
Zfish  1660 QLDDALRGNDDLKENIAIVERRNNLLQAELDELRSLVEQTERGRKLAEQELMDVSERVQLLHSQN 1724

  Fly  2111 SSQQSLNGSIGGGGGSVVSSTRTVVFE 2137
            :|..:....:.|....:.:.....|.|
Zfish  1725 TSLLNQKKKLEGDNTQLQTEVEEAVQE 1751

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MhclNP_732109.2 PDZ_signaling 339..426 CDD:238492
MYSc 556..1317 CDD:214580 211/806 (26%)
MYSc_Myo18 575..1305 CDD:276837 199/775 (26%)
GBP_C <1540..1750 CDD:303769 54/246 (22%)
COG1340 1565..1833 CDD:224259 76/319 (24%)
coiled coil 1723..1734 CDD:293879 0/10 (0%)
LOC100329748XP_021326089.1 Myosin_N 34..72 CDD:308391 5/28 (18%)
MYSc_class_II 99..770 CDD:276951 199/775 (26%)
SMC_N 850..1927 CDD:330553 207/932 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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