DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sxe2 and LIPG

DIOPT Version :9

Sequence 1:	NP_001287352.1	Gene:	sxe2 / 41954	FlyBaseID:	FBgn0038398	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_005258447.1	Gene:	LIPG / 9388	HGNCID:	6623	Length:	536	Species:	Homo sapiens

Alignment Length:	348	Identity:	91/348 - (26%)
Similarity:	141/348 - (40%)	Gaps:	68/348 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 EAGVILGRPR-------PSQTKL---LRYDLYTPLNPE-ERQLLRPGDLTMLRNSHFNPKWPVRV 108
            |||..:.|||       .:||::   :|::|.|..:|| |...|..|....|.:..||.......
Human    59 EAGPSVRRPRDKLHKPKATQTEVKPSVRFNLRTSKDPEHEGCYLSVGHSQPLEDCSFNMTAKTFF 123

  Fly   109 SIHGWA---------GKSVTCSNAAIKDAYLSRGNYNVIILDWSRQSLDISYPRVSKQLPSIAAN 164
            .||||.         .|.|:..:...|||       ||:::||    |.:::     ||.:.|.|
Human   124 IIHGWTMSGIFENWLHKLVSALHTREKDA-------NVVVVDW----LPLAH-----QLYTDAVN 172

  Fly   165 --------VAKMLRFLHDNTGVPYEQIYMIGHSAGSHISGLTGKLLRPHRLGAIFALDPAGLTQL 221
                    :|:||.:|.:........:::||:|.|:|::|..|..:: ..:|.|..|||||....
Human   173 NTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGNFVK-GTVGRITGLDPAGPMFE 236

  Fly   222 SLGPEERLDVNDALYVESIHTDLTLLG---NPSTKLSHASFFANWGLGQPHC---------PNAT 274
            .....:||..:||.:|:.:||.....|   .....:.|...:.|.|..||.|         ...|
Human   237 GADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHIDIYPNGGDFQPGCGLNDVLGSIAYGT 301

  Fly   275 ATEFDFVCDHFAAMFYFAES-VRQPKSFAALRCSSAKSVLSATC-NCNVGGSEKYAVNTCTGNEF 337
            .||. ..|:|..|:..|.:| |.|.|...|.:|:.:.......| :|.        .|.|....:
Human   302 ITEV-VKCEHERAVHLFVDSLVNQDKPSFAFQCTDSNRFKKGICLSCR--------KNRCNSIGY 357

  Fly   338 MGGEPAVPKRGIFYLSTRPQSPY 360
            ...:....:....||.||...|:
Human   358 NAKKMRNKRNSKMYLKTRAGMPF 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sxe2	NP_001287352.1	Lipase	53..360	CDD:278576	90/346 (26%)
sxe2	NP_001287352.1	Pancreat_lipase_like	72..356	CDD:238363	81/315 (26%)
LIPG	XP_005258447.1	Pancreat_lipase_like	85..376	CDD:238363	81/316 (26%)
		lipo_lipase	86..521	CDD:132274	83/321 (26%)
		PLAT_LPL	383..519	CDD:238856
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940