DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sxe2 and PNLIPRP2

DIOPT Version :9

Sequence 1:	NP_001287352.1	Gene:	sxe2 / 41954	FlyBaseID:	FBgn0038398	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	NP_005387.3	Gene:	PNLIPRP2 / 5408	HGNCID:	9157	Length:	469	Species:	Homo sapiens

Alignment Length:	373	Identity:	111/373 - (29%)
Similarity:	156/373 - (41%)	Gaps:	62/373 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WTCLLLLGAAGTDASVDYFAYAPGKCEVSISDVIQGMITTE---AGVILGRPRPSQTKLL----- 71
            ||..|||           .|...|| ||....:  |..:.|   ||. |.||    .|||
Human     5 WTLGLLL-----------LATVRGK-EVCYGQL--GCFSDEKPWAGT-LQRP----VKLLPWSPE 50

  Fly    72 ----RYDLYTPLNPEERQLLRPGDLTMLRNSHFNPKWPVRVSIHGWAGKSVTCSNAAIKDAYLSR 132
                |:.|||..||...||:...:...:..|:|......|..|||:..|:.....:.:.......
Human    51 DIDTRFLLYTNENPNNFQLITGTEPDTIEASNFQLDRKTRFIIHGFLDKAEDSWPSDMCKKMFEV 115

  Fly   133 GNYNVIILDWSRQSLDISYPRVSKQLPSIAANVAKMLRFLHDNTGVPYEQIYMIGHSAGSHISGL 197
            ...|.|.:|| |......|.:..:.:..:.|..|.:::.|....|...|.:::||||.|:|.:..
Human   116 EKVNCICVDW-RHGSRAMYTQAVQNIRVVGAETAFLIQALSTQLGYSLEDVHVIGHSLGAHTAAE 179

  Fly   198 TGKLLRPHRLGAIFALDPAGLTQLSLGPEERLDVNDALYVESIHTD----LTLLG-NPSTKLSHA 257
            .|:.| ..|:|.|..|||||........|.|||.:||::|:.||||    :..|| ..|.|:.|.
Human   180 AGRRL-GGRVGRITGLDPAGPCFQDEPEEVRLDPSDAVFVDVIHTDSSPIVPSLGFGMSQKVGHL 243

  Fly   258 SFFANWGLGQPHCPN---ATATEFD--------FV-CDHFAAMFYFAESVRQPKSFAALRCSSAK 310
            .||.|.|...|.|..   :|.|:.|        || |:|..:..|::.||..|..|....|:|..
Human   244 DFFPNGGKEMPGCKKNVLSTITDIDGIWEGIGGFVSCNHLRSFEYYSSSVLNPDGFLGYPCASYD 308

  Fly   311 SVLSATC-NCNVGGSEK---YAVNTCTGNEFMGGEPAVPKRGIFYLST 354
            ....:.| .|...|..|   ||      ::|.|...||.:  .|:|:|
Human   309 EFQESKCFPCPAEGCPKMGHYA------DQFKGKTSAVEQ--TFFLNT 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sxe2	NP_001287352.1	Lipase	53..360	CDD:278576	100/335 (30%)
sxe2	NP_001287352.1	Pancreat_lipase_like	72..356	CDD:238363	91/304 (30%)
PNLIPRP2	NP_005387.3	Lipase	18..354	CDD:395099	104/349 (30%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	93..105		4/11 (36%)
		Required for galactolipase activity. /evidence=ECO:0000269\|PubMed:26494624	257..279		4/21 (19%)
		PLAT_PL	357..469	CDD:238857
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145345
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940