Protein Alignment sxe2 and Lpl

DIOPT Version :10

• Sequence 1: NP_650522.1
• Gene: sxe2 / 41954
• FlyBaseID: FBgn0038398
• Length: 387
• Species: Drosophila melanogaster
• Sequence 2: NP_036730.1
• Gene: Lpl / 24539
• RGDID: 3017
• Length: 474
• Species: Rattus norvegicus
• Alignment Length: 367
• Identity: 89/367 - (24%)
• Similarity: 144/367 - (39%)
• Gaps: 71/367 - (19%)

  Fly    72 RYDLYTPLN-PEERQLLRPGDLTMLRNSHFNPKWPVRVSIHGW--AGKSVTCSNAAIKDAYLSRG 133
            ::.|.||.: .|:...|.||....:.|.|||......|.||||  .|...:.....:...|....
  Rat    40 KFALRTPEDTAEDTCHLIPGLADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREP 104

  Fly   134 NYNVIILDWSRQSLDISYPRVSKQLPSIAANVAKMLRFLHDNTGVPYEQIYMIGHSAGSHISGLT 198
            :.|||::||..::.. .||..:.....:..:||:.:.:|.:....|.:.::::|:|.|:|.:|:.
  Rat   105 DSNVIVVDWLYRAQQ-HYPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVA 168

  Fly   199 GKLLRPHRLGAIFALDPAGLTQLSLGPEERLDVNDALYVESIHTDLTLLGNPSTKL------SHA 257
            |.|.. .::..|..|||||..........||..:||.:|:.:||  ...|:|...:      .|.
  Rat   169 GSLTN-KKVNRITGLDPAGPNFEYAEAPSRLSPDDADFVDVLHT--FTRGSPGRSIGIQKPVGHV 230

  Fly   258 SFFANWGLGQPHCPNATAT---------EFDFV--CDHFAAMFYFAES-VRQPKSFAALRCSSAK 310
            ..:.|.|..||.|....|.         :.|.:  |.|..::..|.:| :.:.....|.||:|.:
  Rat   231 DIYPNGGTFQPGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKE 295

  Fly   311 SVLSATC-NC------NVGGSEKYAVNTCTGNEFMGGEPAVPKRGIFYLSTRPQSPY-------- 360
            :.....| :|      |||    |.:|          :....:....||.||.|.||
  Rat   296 AFEKGLCLSCRKNRCNNVG----YEIN----------KVRAKRSSKMYLKTRSQMPYKVFHYQVK 346

  Fly   361 ----GTSD-------------GLVHIKRPRPSTIRETANRRS 385
                ||.:             |.|......|.|:.|.|..::
  Rat   347 IHFSGTENDKQNNQAFEISLYGTVAESENIPFTLPEVATNKT 388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sxe2	NP_650522.1	Pancreat_lipase_like	72..356	CDD:238363	77/311 (25%)
Lpl	NP_036730.1	Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	32..53		4/12 (33%)
		lipo_lipase	33..472	CDD:132274	89/367 (24%)
		Essential for determining substrate specificity. /evidence=ECO:0000250|UniProtKB:P06858	243..266		3/22 (14%)
		Important for interaction with lipoprotein particles. /evidence=ECO:0000250|UniProtKB:P06858	417..421
		Important for heparin binding. /evidence=ECO:0000250|UniProtKB:P06858	430..434
		Interaction with GPIHBP1. /evidence=ECO:0000250|UniProtKB:P06858	443..467