DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment sxe2 and Lipc

DIOPT Version :9

Sequence 1:	NP_001287352.1	Gene:	sxe2 / 41954	FlyBaseID:	FBgn0038398	Length:	387	Species:	Drosophila melanogaster
Sequence 2:	XP_006510879.1	Gene:	Lipc / 15450	MGIID:	96216	Length:	526	Species:	Mus musculus

Alignment Length:	394	Identity:	98/394 - (24%)
Similarity:	159/394 - (40%)	Gaps:	72/394 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MHISHWLLWTCLLLLGAAGTDASVDYFAYAPGKCEVSISDVIQGMITTEAGVILGRPRPSQTKLL 71
            :.||.:|::...:...|.|.....:.|..:.|              .|||...|.:|   :|:.|
Mouse     5 LQISIFLVFCIFIQSSACGQGVGTEPFGRSLG--------------ATEASKPLKKP---ETRFL 52

  Fly    72 RYDLYTPLNPEERQLLRPGDLTMLRNSHFNPKWPVRVSIHGWAG-KSVTCSNAAIKD-------- 127
               |:...|......|||.....|:...||...|:.:.||||:| :|.|....:..|
Mouse    53 ---LFQDENDRLGCRLRPQHPETLQECGFNSSQPLIMIIHGWSGSESATVGKDSDSDYQVDGLLE 114

  Fly   128 --------AYLSRGN--YNVIILDWSRQSLDISYPRVSKQLPS---IAANVAKMLRFLHDNTGVP 179
                    |..||.:  .||.::||    :.::|...:..:.:   :..:||.:|.:|.::....
Mouse   115 NWIWKIVSALKSRQSQPVNVGLVDW----ISLAYQHYTIAVQNTRIVGQDVAALLLWLEESAKFS 175

  Fly   180 YEQIYMIGHSAGSHISGLTGKLL-RPHRLGAIFALDPAGLTQLSLGPEERLDVNDALYVESIHT- 242
            ..::::||:|.|:|:||..|..: ..:::|.|..|||||.......|.|||..:||.:|::|||
Mouse   176 RSKVHLIGYSLGAHVSGFAGSSMDGKNKIGRITGLDPAGPMFEGTSPNERLSPDDANFVDAIHTF 240

  Fly   243 ---DLTLLGNPSTKLSHASFFANWGLGQPHC-----------PNATATEFDFVCDHFAAMFYFAE 293
               .:.|.......::|..|:.|.|..||.|           ....|......|.|..::..|.:
Mouse   241 TREHMGLSVGIKQPIAHYDFYPNGGSFQPGCHFLELYKHIAEHGLNAITQTIKCAHERSVHLFID 305

  Fly   294 SVRQPK-SFAALRCSSAKSVLSATC-NCNVGGSEKYAVNTCTGNEFMGGEPAVPKRGIFYLSTRP 356
            |::... .....:||...|.....| :|..|     ..|| .|.:.........||  .:|.||.
Mouse   306 SLQHSDLQSIGFQCSDMGSFSQGLCLSCKKG-----RCNT-LGYDIRKDRSGKSKR--LFLITRA 362

  Fly   357 QSPY 360
            |||:
Mouse   363 QSPF 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sxe2	NP_001287352.1	Lipase	53..360	CDD:278576	90/346 (26%)
sxe2	NP_001287352.1	Pancreat_lipase_like	72..356	CDD:238363	80/323 (25%)
Lipc	XP_006510879.1	Lipase	18..366	CDD:333880	94/379 (25%)
Lipc	XP_006510879.1	PLAT_LPL	369..504	CDD:238856
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835406
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N19
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11610
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840