DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10185 and TEP1

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	NP_009041.2	Gene:	TEP1 / 7011	HGNCID:	11726	Length:	2627	Species:	Homo sapiens

Alignment Length:	1767	Identity:	335/1767 - (18%)
Similarity:	580/1767 - (32%)	Gaps:	582/1767 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LPPVSS---KIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGVRDEATD 78
            |.|||.   :.:|:|.||||.|...||:.|:....|.::... ..|.:....:|:||||.:|.|.
Human   888 LAPVSQQGWRSIRLFISSTFRDMHGERDLLLRSVLPALQARA-APHRISLHGIDLRWGVTEEETR 951

  Fly    79 DHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGVDRAILDL 143
            .:...|:|:.|::|.|.      |:..||.:|||.| |:|.:......                .
Human   952 RNRQLEVCLGEVENAQL------FVGILGSRYGYIP-PSYNLPDHPHF----------------H 993

  Fly   144 WYKK--DSNAVPPISVLQPISSILINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAASLGASN 206
            |.::  ...:|..:.|:|     .:|.|.:..|..||              .:..:.::.|.:..
Human   994 WAQQYPSGRSVTEMEVMQ-----FLNRNQRLQPSAQA--------------LIYFRDSSFLSSVP 1039

  Fly   207 KMSKEDVHNYFMSVTEREVINGILNVKNTKNHCLSYVRYINNINLQNLKKASLFVDIINRSLDTE 271
            ...|.|    |:|.:|                                                |
Human  1040 DAWKSD----FVSESE------------------------------------------------E 1052

  Fly   272 SAKLLSDLRDVRLPAKIEAVNAQKYTVEW----IGRE---GLDIETHEEY-------LNHFISHF 322
            :|:.:|:|:...  ::.:.:..::|..||    .||.   ||     ||:       :.:.|...
Human  1053 AARRISELKSYL--SRQKGITCRRYPCEWGGVAAGRPYVGGL-----EEFGQLVLQDVWNMIQKL 1110

  Fly   323 Y---------------KNVVKLVDRAMRKEDSSAQGQIVTEILQHLHACNNSVKIFYGREESCER 372
            |               .::|:...:.::|..|.|:.:::.:.:|
Human  1111 YLQPGALLEQPVSIPDDDLVQATFQQLQKPPSPARPRLLQDTVQ--------------------- 1154

  Fly   373 IKRYMLGDSDKPLVLFGDGGCGKTSLLSKSVSLVATEWFAHVRPINVIRFLGTTPDSSALTATLI 437
              |.||......||. |..|.|||:.|:..||.:.....|.|..:....|.|..||.......|.
Human  1155 --RLMLPHGRLSLVT-GQSGQGKTAFLASLVSALQAPDGAKVASLVFFHFSGARPDQGLALTLLR 1216

  Fly   438 SICQQISYNYMLPFENIPDDLVPLTAHFKQLLTYAS-----PTQPLTIYLDSVDQLTGTQDSNKV 497
            .:|..:......| ..:|.....|....:|.|...|     |.|...:.:|..|:|. .|:...:
Human  1217 RLCTYLRGQLKEP-GALPSTYRSLVWELQQRLLPKSAESLHPGQTQVLIIDGADRLV-DQNGQLI 1279

  Fly   498 S-WIPTRLPPHCKIIISCANEPA-NPTV--SHEYHVLCKMIDVEENFIEVTALGEDLAMNVIKMW 558
            | |||.:||....:::|.:::.. ..|:  |...|||.  :...|.......:.|:||     ::
Human  1280 SDWIPKKLPRCVHLVLSVSSDAGLGETLEQSQGAHVLA--LGPLEASARARLVREELA-----LY 1337

  Fly   559 MKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERV 623
            .|.......|.|.||:. ...:...|::::||...:..:..|.:..|.  ..|:..::.||.:.:
Human  1338 GKRLEESPFNNQMRLLL-VKRESGRPLYLRLVTDHLRLFTLYEQVSER--LRTLPATVPLLLQHI 1399

  Fly   624 ----EKQHGRILVFHALAYITASKSGLSESELEDLISL------DDKVLDDVY-------QYHLP 671
                ||:||..::..||..:..::|||:..:|..::|:      ..|..::..       .|.:.
Human  1400 LSTLEKEHGPDVLPQALTALEVTRSGLTVDQLHGVLSVWRTLPKGTKSWEEAVAAGNSGDPYPMG 1464

  Fly   672 PTRRIPPLLWTRIRNDLPNYLSEREA------DGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHS 730
            |.    ..|...:|:.|.....||..      ||         ..|..||..|.|...:....|.
Human  1465 PF----ACLVQSLRSLLGEGPLERPGARLCLPDG---------PLRTAAKRCYGKRPGLEDTAHI 1516

  Fly   731 MIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRYNLRKFGE 795
            :||   ..:|        |..:        ||..|:. |..|.:.|                 |:
Human  1517 LIA---AQLW--------KTCD--------ADASGTF-RSCPPEAL-----------------GD 1544

  Fly   796 LPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVL---ADFEDASSNTDDKEAKRELMLVSD 857
            ||:|.::|.. :.|....|.|...:.|.|....:..:|   |.:..:....:.|..:.::.:...
Human  1545 LPYHLLQSGN-RGLLSKFLTNLHVVAAHLELGLVSRLLEAHALYASSVPKEEQKLPEADVAVFRT 1608

  Fly   858 ALRLGGAILAIYPNMLAPQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCALIPVN-HCLHTPGGP 921
            .||...:||:.||         ||||:...|..:...|  |.::     :|:... |..||
Human  1609 FLRQQASILSQYP---------RLLPQQAANQPLDSPL--CHQA-----SLLSRRWHLQHT---- 1653

  Fly   922 LKY-----SLEGHQFAVFAFCLTSDMRYMVSISTH------------FITFDLSTSDLTRDVNPG 969
            |::     :::..|.:..:..::|... .|:.||:            ....||.|....:.|..|
Human  1654 LRWLNKPRTMKNQQSSSLSLAVSSSPT-AVAFSTNGQRAAVGTANGTVYLLDLRTWQEEKSVVSG 1717

  Fly   970 IEGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSEFVVINSPFEESHG-----------PVSGLY 1023
            .:||...|.||.|..:..|:..     ||.:           ::..||           .::|..
Human  1718 CDGISACLFLSDDTLFLTAFDG-----LLEL-----------WDLQHGCRVLQTKAHQYQITGCC 1766

  Fly  1024 LL-NQNLFIT-----CKLRW-------------------AQFDTRGNLVDT-------------- 1049
            |. :..|..|     |...|                   ..|...|.::.|
Human  1767 LSPDCRLLATVCLGGCLKLWDTVRGQLAFQHTYPKSLNCVAFHPEGQVIATGSWAGSISFFQVDG 1831

  Fly  1050 ------------------FDVPG------------ENKDW------------------------- 1059
                              |:|||            |...|
Human  1832 LKVTKDLGAPGASIRTLAFNVPGGVVAVGRLDSMVELWAWREGARLAAFPAHHGFVAAALFLHAG 1896

  Fly  1060 -EILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGGHYSNCQLLFSAMV---------------- 1107
             ::||.    ..|..|..||||:...|        ||..:..|..:..|
Human  1897 CQLLTA----GEDGKVQVWSGSLGRPR--------GHLGSLSLSPALSVALSPDGDRVAVGYRAD 1949

  Fly  1108 ---MNKARTRAYGCANEE-NFEVSVFDFIEDEV------TGDI-CWTLVES-------LPRFEND 1154
               :.|..:.:.|...:. :..||...::..:|      .|.: .|.|.|.       |.||:
Human  1950 GIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECSLQSLWLLSRFQ-- 2012

  Fly  1155 DKEMLLQLRLDQHDRMLLGTAGKGFVI--W-------DFGSKDKDAAEECRLREGALYL------ 1204
              :.:|.|...|.   ||.:|.:.|.:  |       ...::|.....|.|..||.:..
Human  2013 --KPVLGLATSQE---LLASASEDFTVQLWPRQLLTRPHKAEDFPCGTELRGHEGPVSCCSFSTD 2072

  Fly  1205 --ALPHGVRN---------------------------ITTRIMQSNSIMVSSKLD---------- 1230
              :|..|.|:                           :|......:::::|...|
Human  2073 GGSLATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNLLISCSSDGSVGLWDPES 2137

  Fly  1231 --------------YAVAGVRKN---------LYVWCLQSGQLAKVLDAHFGRI----IQLEPLT 1268
                          .|||.|.::         |.||..|..:|..: .||.|.|    ..:||..
Human  2138 GQRLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSI-PAHSGPISHCAAAMEPRA 2201

  Fly  1269 IGNWNN---LVTSSIDRSVKVWNINNIFEKVHVIDRHELQIDDISLSEVD--MAVTVTRSCVGVW 1328
            .|...:   :||..:|.:.::|:...:.: .|.:..|...:...::||..  |........|.:|
Human  2202 AGQPGSELLVVTVGLDGATRLWHPLLVCQ-THTLLGHSGPVRAAAVSETSGLMLTASEDGSVRLW 2265

  Fly  1329 ETRSGRLLAKLADSPL----GAIVTHAEITPDGRYIIS-SETGKFLVWNRVSEQVVFRDDQPGIQ 1388
            :      :.|.||...    .|.||.....|||...:| ::.|:.::|...  :.|.....||..
Human  2266 Q------VPKEADDTCIPRSSAAVTAVAWAPDGSMAVSGNQAGELILWQEA--KAVATAQAPGHI 2322

  Fly  1389 QITLMDYGYKVLTVSV-PNINQRDI---LAAAAGGSADEANR-----LTAITTMRSVPEGSIFFR 1444
            ...:....:....:|. ..|::..:   ..:|.|..:...||     |..:|::...|:|.....
Human  2323 GALIWSSAHTFFVLSADEKISEWQVKLRKGSAPGNLSLHLNRILQEDLGVLTSLDWAPDGHFLIL 2387

  Fly  1445 FEFPIRMITGMP 1456
            .:..::::...|
Human  2388 AKADLKLLCMKP 2399

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934	31/129 (24%)
		WD40	1177..>1379	CDD:225201	52/292 (18%)
		WD40 repeat	1214..1256	CDD:293791	12/74 (16%)
		WD40	<1216..1380	CDD:295369	41/210 (20%)
		WD40 repeat	1261..1300	CDD:293791	9/45 (20%)
		WD40 repeat	1306..1341	CDD:293791	6/36 (17%)
		WD40 repeat	1348..1393	CDD:293791	11/45 (24%)
TEP1	NP_009041.2	TEP1 N-terminal 1	1..30
		TEP1_N	1..29	CDD:283129
		TEP1 N-terminal 2	31..60
		TEP1_N	31..59	CDD:283129
		TEP1 N-terminal 3	61..90
		TEP1_N	61..89	CDD:283129
		TEP1 N-terminal 4	91..120
		TEP1_N	91..119	CDD:283129
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	193..214
		TROVE	226..676	CDD:283406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	383..402
		DUF4062	908..1008	CDD:290011	29/123 (24%)
		NACHT	1162..1337	CDD:283404	46/184 (25%)
		WD 1	1411..1448		8/36 (22%)
		WD 2	1674..1713		7/39 (18%)
		WD40	1680..1955	CDD:295369	47/303 (16%)
		WD40	<1680..1824	CDD:225201	28/160 (18%)
		WD40 repeat	1680..1716	CDD:293791	7/36 (19%)
		WD 3	1716..1754		12/53 (23%)
		WD40 repeat	1722..1757	CDD:293791	9/50 (18%)
		WD 4	1757..1796		6/38 (16%)
		WD40 repeat	1762..1801	CDD:293791	6/38 (16%)
		WD 5	1798..1837		3/38 (8%)
		WD40	1799..2190	CDD:225201	65/410 (16%)
		WD40 repeat	1804..1840	CDD:293791	3/35 (9%)
		WD 6	1840..1879		6/38 (16%)
		WD40 repeat	1845..1881	CDD:293791	6/35 (17%)
		WD 7	1882..1921		9/50 (18%)
		WD40 repeat	1888..1923	CDD:293791	11/46 (24%)
		WD 8	1925..1964		4/38 (11%)
		WD 9	1967..2005		7/37 (19%)
		WD40	1972..2308	CDD:238121	67/350 (19%)
		WD40 repeat	1972..2013	CDD:293791	10/44 (23%)
		WD 10	2008..2047		11/45 (24%)
		WD40 repeat	2016..2059	CDD:293791	10/45 (22%)
		WD40	2022..2391	CDD:225201	69/381 (18%)
		WD 11	2059..2098		5/38 (13%)
		WD40 repeat	2064..2103	CDD:293791	3/38 (8%)
		WD 12	2105..2143		3/37 (8%)
		WD40 repeat	2111..2145	CDD:293791	3/33 (9%)
		WD 13	2146..2183		9/36 (25%)
		WD40 repeat	2151..2235	CDD:293791	21/85 (25%)
		WD 14	2185..2233		11/48 (23%)
		WD40	2231..>2391	CDD:295369	32/167 (19%)
		WD 15	2236..2275		9/44 (20%)
		WD40 repeat	2241..2280	CDD:293791	8/44 (18%)
		WD 16	2278..2317		10/40 (25%)
		WD40 repeat	2283..2307	CDD:293791	7/23 (30%)
		WD 17	2319..2355		4/35 (11%)
		WD40 repeat	2326..2359	CDD:293791	4/32 (13%)
		WD 18	2368..2417		5/32 (16%)
		WD40 repeat	2372..2418	CDD:293791	4/28 (14%)
		WD 19	2459..2500
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2506..2551
		WD 20	2553..2590
		WD 21	2592..2626
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	58	1.000	Domainoid score	I10829
eggNOG	1	0.900	-	-		E2759_KOG3602
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810