DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10185 and Tep1

DIOPT Version :10

Sequence 1:NP_650521.1 Gene:CG10185 / 41953 FlyBaseID:FBgn0038397 Length:1732 Species:Drosophila melanogaster
Sequence 2:NP_072113.1 Gene:Tep1 / 64523 RGDID:3869 Length:2629 Species:Rattus norvegicus


Alignment Length:1985 Identity:364/1985 - (18%)
Similarity:635/1985 - (31%) Gaps:677/1985 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 PVSS---KIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCRE-KHGLEFQVVDMRWGVRDEATDD 79
            |:|.   :.:|:|.||||.|...||:.||....|.::  .|. .|.:....:|:|||:.:|.|..
  Rat   903 PISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQ--ARAFPHRISLHAIDLRWGITEEETRR 965

  Fly    80 HMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGVDRAILDL- 143
            :...|:|:.|::|.|.      |:..||.:|||.| |:|                       || 
  Rat   966 NRQLEVCLGEVENSQL------FVGILGSRYGYTP-PSY-----------------------DLP 1000

  Fly   144 ------WYKK--DSNAVPPISVLQ---------PISSILINFNNKRVPKLQAEDQAVWWDTLNKM 191
                  |.::  ...:|..:.|:|         |....||.|   |.|...:....||       
  Rat  1001 DHPHFHWTQRYPSGRSVTEMEVMQFLNRGQRSEPSDQALIYF---RDPGFLSSVPDVW------- 1055

  Fly   192 QKLLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGILNVKNTKNHCLSYVRYINNINLQNLKK 256
                              |.|    |:|.:|                                  
  Rat  1056 ------------------KPD----FISESE---------------------------------- 1064

  Fly   257 ASLFVDIINRSLDTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHEEY---LNHF 318
                          |:|..:|:|:  |...:.:.|..::|:.||.|     :.....|   |..|
  Rat  1065 --------------EAAHRVSELK--RFLQEQKEVTCRRYSCEWGG-----VAAGRPYTGGLEEF 1108

  Fly   319 ISHFYKNVVKLVDR-------AMRKEDSSAQGQIVTEILQHLHACNNSVKIFYGREESCERIKRY 376
            .....::|..::.:       .:.:..|.::..::....|.|.:..:..:    .....:.:::.
  Rat  1109 GQLVLQDVWSVIQKRYLQPGAQLEQPGSISEEDLIQASFQQLKSPPSPAR----PRLLQDTVQQL 1169

  Fly   377 MLGDSDKPLVLFGDGGCGKTSLLSKSVSLVATEWFAHVRPINVIRFLGTTPDSSALTATLISICQ 441
            ||......||: |..|.|||:.|:..||.:......:|.|.....|....||.......|..:|.
  Rat  1170 MLPHGRLSLVI-GQAGQGKTAFLASLVSALKVPDQPNVAPFVFFHFSAARPDQCLAFNLLRRLCT 1233

  Fly   442 QISYNYMLPFENIPDDLVPLTAHFKQLLTYAS-----PTQPLTIYLDSVDQLTGTQDSNKVSWIP 501
            .:......| ..:|.....|....:|.|...|     |.|.|.:.:|..|:|..........|||
  Rat  1234 HLHQKLGEP-SALPSTYRGLVWELQQKLLLKSAQWLQPGQTLVLIIDGADKLVDHNGQLISDWIP 1297

  Fly   502 TRLPPHCKIIISCANEPA-NPTVSHEYHVLCKMIDVEENFIEVTALGE-------DLAMNVIKMW 558
            ..||....:::|.:::.. ..|:.            :.....|.|||.       .|....:.::
  Rat  1298 KSLPRRVHLVLSVSSDSGLGETLQ------------QSQSAYVVALGSLVPSSRAQLVREELALY 1350

  Fly   559 MKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERV 623
            .|.......|.|.||:. |....|||:::.||...:..:..|.:..|.  ..|:..::.||.:.:
  Rat  1351 GKRLEESPFNNQMRLLL-AKQGSSLPLYLHLVTDYLRLFTLYEQVSER--LRTLPATLPLLLQHI 1412

  Fly   624 ----EKQHGRILVFHALAYITASKSGLSESELEDLISL------DDKVLDDVYQ-------YHLP 671
                |::||..::..||..:..:.|||:..:|..::|.      :.|..::...       |.|.
  Rat  1413 LSTLEQEHGHNVLPQALTALEVTHSGLTVDQLHAVLSTWLTLPKETKSWEEAVAASHSGNLYPLA 1477

  Fly   672 PTRRIPPLLWTRIRNDLPNYLSERE------ADGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHS 730
            |.    ..|...:|:.|.....||.      :||         ..|...|.||.|.:.:....|.
  Rat  1478 PF----AYLVQSLRSLLGEGPVERPGARLCLSDG---------PLRTAVKRRYGKRLGLEKTAHV 1529

  Fly   731 MIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSAD-RKVPIQPLVFSSKDGLSKRYNLRKFG 794
            :||                     .|.:.:.|.:.|.. |..|.:.|    ||            
  Rat  1530 LIA---------------------AHLWKMCDPDASGTFRSCPPEAL----KD------------ 1557

  Fly   795 ELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFE---DASSNTDDKEAKRELMLVS 856
             ||:|.::|.. ..|....|.|...:.|.|....:..:|..:|   .:....:.|..:.::.:..
  Rat  1558 -LPYHLLQSGN-HGLLAKFLTNLHVVAAYLEVGLVPDLLEAYELYASSKPEVNQKLPEADVAVFH 1620

  Fly   857 DALRLGGAILAIYPNML----------------APQLVGR----------------------LLP 883
            :.|:...::|..||.:|                ||.|..|                      .||
  Rat  1621 NFLKQQASLLTQYPLLLLQQAASQPEESPVCCQAPLLTQRWHNQCILKWINKPQTLKGQQSLSLP 1685

  Fly   884 ------EIGGNPN-----------------------IKMLLRACDRSGP----KDCALIPVNHCL 915
                  .:..:||                       .|.|:..||....    .|.||.     |
  Rat  1686 ISSSPTAVAFSPNGQRAAVGTAGGTIYLLNLRTWQEEKALVSGCDGISSFAFLSDTALF-----L 1745

  Fly   916 HTPGGPLK----------YSLEGHQFAVFAFCLTSDMRYMVSI---------------------- 948
            .|..|.|:          :..:.||:.:...||:.|.|.:.::                      
  Rat  1746 TTFDGLLELWDLQHGCWVFQTKAHQYQITGCCLSPDRRLLATVCLGGYVKLWDTVQGQLAFQYTH 1810

  Fly   949 --STHFITFD-----LSTSD--------------LTRDVN-------------PG-------IEG 972
              |.:.|||.     ::|.:              :|:::.             ||       |:|
  Rat  1811 PKSLNCITFHPEGQVVATGNWSGIVTFFQADGLKVTKELGGPGPSVRTLAFSAPGKVVALGRIDG 1875

  Fly   973 IMQQLVLSPDNKWAA--AYSNNNQTVLLNMLSSEFVVINSP---------FEESHGPVSGLYLLN 1026
            .::........:.||  |......|||.......|:.....         .....|.:..|| |:
  Rat  1876 TVELWAWQEGTRLAAFPAQCGGVSTVLFLHAGGRFLTAGEDGKAQLWSGFLGRPRGCLGSLY-LS 1939

  Fly  1027 QNLFITCKLRWAQFDT--RGNLVDTFDV---PGENKDWEILTMEFFNPADYNVVFWS-------- 1078
            ..|.:.......|...  ||:.:..:.:   |.|.:..|:      |.|...:|:.|        
  Rat  1940 PALSVALNPDGDQVAVGYRGDGIKIYRISSGPQEAQCQEL------NVAVSALVWLSPSVLVSGA 1998

  Fly  1079 --GSINDMRLRLDSCRGGHYSN-CQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDI 1140
              ||::...||.:|.:....|: ||    ..|:..|.::.:..:..|:|.|.:            
  Rat  1999 EDGSLHGWMLRRNSLQSLWLSSVCQ----KPVLGLAASQEFLASASEDFTVRL------------ 2047

  Fly  1141 CWT--------LVESLPRFENDDKEMLLQLRLDQ---------HDRMLLGTAG--KGFVIWD--- 1183
             |.        .||.||        ...:||..:         .|..:|.|||  :..:.||   
  Rat  2048 -WPRQLLTQPHAVEELP--------CAAELRGHEGPVCCCSFSPDGRILATAGRDRNLLCWDVKV 2103

  Fly  1184 ---------FGSKDKDAAEECR----------LREGALYLALPHGVRNITTRIMQSNSIMVSSKL 1229
                     |.|..:|....|.          ..:|::.|..|...:.:.......:::.....:
  Rat  2104 AQAPLLIHTFSSCHRDWITGCTWTKDNILISCSSDGSVGLWNPEAGQQLGQFPGHQSAVSAVVAV 2168

  Fly  1230 DYAVAGVRKN--LYVWCLQSGQLAKVLDAHFGRIIQ----LEPLTIGNWNN---LVTSSIDRSVK 1285
            :..:..|.::  |.||..|..:|..: .||.|.|.|    |||...|...:   :||..:|.:.|
  Rat  2169 EEHIVSVSRDGTLKVWDRQGVELTSI-PAHSGPISQCAAALEPRPAGQPGSELMVVTVGLDGATK 2232

  Fly  1286 VWNINNIFEKVHVIDRHELQIDDISLSEVD-MAVTVTRSCVGVWETRSGRLLAKLADSPL----G 1345
            :|:...:.: :|.:..|...:...:.||.. :.:|...|.|.:|:      :.|.||...    .
  Rat  2233 LWHPLLVCQ-IHTLQGHSGPVTAAAASEASGLLLTSDNSSVRLWQ------IPKEADDTCKPRSS 2290

  Fly  1346 AIVTHAEITPDGRYIIS-SETGKFLVWNRVSEQVVFRDDQPGIQQITLMDYGYKVLTVSVPNINQ 1409
            |::|.....|||..::| :|.|:..:|.:.                                  |
  Rat  2291 AVITAVAWAPDGSLVVSGNEAGELTLWQKA----------------------------------Q 2321

  Fly  1410 RDILAAAAGGSAD----EANRLTAITTMRSVPEGSIFFRFEFPIRMITGMPFRQSVITADNAYIV 1470
            ....|.|.|..:|    .||....::...:|.|..:..|             :.|..|....|: 
  Rat  2322 AVATARAPGRVSDLIWCSANAFFVLSANENVSEWQVELR-------------KGSTCTNFRLYL- 2372

  Fly  1471 VVTVDKSNKDCLGVYSATNGAFVSKVLLKGCSIKEVISLVPMPHKANQVAVISSEKGSVMDIKTK 1535
                                   .:||.:...:...::|.|    ..|..::..|          
  Rat  2373 -----------------------KRVLQEDLGVLTGMALAP----DGQSLILMKE---------- 2400

  Fly  1536 KHVRSIAKWGGSITRDGKCGLYAPTRGGLEMLELRKGTTVKTFIPKVAEGVFSVICIFTENDEYV 1600
                                       .:|:|:::.|:|..:...:.|.. .|::|  |..| |.
  Rat  2401 ---------------------------DVELLQMKPGSTPSSICRRYAVH-SSILC--TSKD-YG 2434

  Fly  1601 AYY----HSGRKTI-------RVFRTADTEMIANYRLQAELTAIKSS-KDGRAIVLGTVDGCMSV 1653
            .:|    :||..:|       :..:|.|..:..|....:.::..::. :.|.:::..|.||.:..
  Rat  2435 LFYLQQGNSGSLSILEQEESGKFEKTLDFNLNLNNPNGSPVSITQAEPESGSSLLCATSDGMLWN 2499

  Fly  1654 LAIVDPKKEEMNEYLNDLPSRDENWKAKLAKMKAR 1688
            |:...|:.|.:         .|..|:.|....|:|
  Rat  2500 LSECTPEGEWV---------VDNIWQKKSRNPKSR 2525

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10185NP_650521.1 P-loop containing Nucleoside Triphosphate Hydrolases 384..>514 CDD:476819 34/134 (25%)
WD40 repeat 1214..1256 CDD:293791 6/43 (14%)
WD40 <1232..1422 CDD:441893 44/204 (22%)
WD40 repeat 1261..1300 CDD:293791 12/45 (27%)
WD40 repeat 1306..1341 CDD:293791 7/35 (20%)
WD40 repeat 1348..1393 CDD:293791 8/45 (18%)
Tep1NP_072113.1 TEP1 N-terminal 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 1..30
TEP1_N 1..29 CDD:428450
TEP1 N-terminal 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 31..60
TEP1_N 31..59 CDD:428450
TEP1 N-terminal 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 61..90
TEP1_N 61..89 CDD:428450
TEP1 N-terminal 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00575, ECO:0000269|PubMed:10864046 91..120
TEP1_N 91..119 CDD:428450
TROVE 234..689 CDD:461724
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..416
DUF5920 700..900 CDD:466045
DUF4062 913..1021 CDD:463823 38/139 (27%)
NACHT 1175..1350 CDD:428606 41/188 (22%)
WD 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1424..1461 8/36 (22%)
WD40 <1674..1923 CDD:441893 38/253 (15%)
WD 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1685..1724 3/38 (8%)
WD40 repeat 1691..1727 CDD:293791 4/35 (11%)
WD 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1727..1765 9/42 (21%)
WD40 repeat 1733..1768 CDD:293791 7/39 (18%)
WD 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1768..1807 6/38 (16%)
WD40 repeat 1773..1812 CDD:293791 4/38 (11%)
WD 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1809..1848 6/38 (16%)
WD40 repeat 1815..1851 CDD:293791 5/35 (14%)
WD 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1851..1890 4/38 (11%)
WD40 repeat 1856..1896 CDD:293791 7/39 (18%)
WD40 1860..2318 CDD:441893 99/497 (20%)
WD 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1893..1934 6/40 (15%)
WD 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1936..1975 9/39 (23%)
WD40 repeat 1942..2000 CDD:293791 11/63 (17%)
WD 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 1978..2016 10/43 (23%)
WD 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2019..2058 9/55 (16%)
WD 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2070..2109 7/38 (18%)
WD40 repeat 2076..2113 CDD:293791 7/36 (19%)
WD 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2116..2154 5/37 (14%)
WD40 repeat 2121..2156 CDD:293791 4/34 (12%)
WD 13. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2157..2194 6/36 (17%)
WD40 2164..2586 CDD:441893 88/495 (18%)
WD40 repeat 2166..2195 CDD:293791 6/29 (21%)
WD 14. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2200..2244 11/44 (25%)
WD40 repeat 2201..2246 CDD:293791 12/45 (27%)
WD 15. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2247..2285 10/43 (23%)
WD 16. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2288..2327 10/72 (14%)
WD40 repeat 2293..2317 CDD:293791 7/23 (30%)
WD 17. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2329..2365 8/48 (17%)
WD40 repeat 2332..2355 CDD:293791 4/22 (18%)
WD 18. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2378..2427 10/90 (11%)
WD 19. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2470..2510 7/39 (18%)
WD 20. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2555..2592
WD 21. /evidence=ECO:0000255|PROSITE-ProRule:PRU00221, ECO:0000269|PubMed:10864046 2594..2628
Blue background indicates that the domain is not in the aligned region.

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