DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10185 and NWD2

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	NP_001138462.1	Gene:	NWD2 / 57495	HGNCID:	29229	Length:	1742	Species:	Homo sapiens

Alignment Length:	1828	Identity:	456/1828 - (24%)
Similarity:	777/1828 - (42%)	Gaps:	321/1828 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FLGSLESLPP---VSSKIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWG 71
            |.|:|.:||.   .:.:.||:|.|:...||..||..|....||:::::|||.:||||||:|:.||
Human    23 FSGNLTALPSHLVPAGRSVRVFISANPEDTGAERQALRENVYPKLREFCRENYGLEFQVIDLYWG 87

  Fly    72 VRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGV 136
            |.::..|.....:..|:.::||.:.|.||.|:..||:|||...||..:.:||..:|.:......:
Human    88 VEEDEWDSPELQKTRMKLLENCLKTSAGPCFVGLLGEKYGNIRIPGEVEASEFEMILDAAIEAKL 152

  Fly   137 DRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAAS 201
            :..:|:.||.:|.|:||....|:|.|.:|.:..|...|...||::..|.:..::::|:.:.|...
Human   153 ETKLLEEWYCRDENSVPAAYYLRPKSEMLRSNRNAMQPSTNAENEKTWQEISDEIKKIFKAAVKL 217

  Fly   202 LGASNKMSKEDVHNYFMSVTEREVINGILNVKNTK---NHCLSYVRYINNI-NLQNLKKASLFVD 262
            |....||.......|..|..|.|....:  .|.|.   ..|:.|:|.|.|| ....:.:...::|
Human   218 LHEKGKMKHSQAKRYLFSAIEDEFDFAL--GKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMD 280

  Fly   263 IINRS----LDTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHEEYLNHFI---- 319
            |....    .|.|:.:.|..|||..:|..:.:.|.:.||.  :....:.:...:|..||:|
Human   281 ITGTEPRIIRDPEAQEKLIKLRDEFIPTIVASSNLRVYTS--VTHCDMKLGYSQEIENHYIEGLG 343

  Fly   320 SHFYKNVVKLVDRAMRKEDSSAQGQIVTEILQHLHACNNSVKIFYGREESCERIKRYMLGDSD-- 382
            ..||::::.::...:::...:....:..|||||...|......:..:.||...:..|:|....
Human   344 KQFYEDMIDIIQATIQQNFDTETDTLYDEILQHSSLCKTYASFYEYKCESLNIVHNYILPSKAGH 408

  Fly   383 -KPLVLFGDGGCGKTSLLSKSVSLVATEWF-----AHVRPINVIRFLGTTPDSSALTATLISICQ 441
             .||:::|....|||.||:: |:..|..|.     ....|:.::||||||..||.|...|:|:|:
Human   409 INPLIIYGGPCTGKTLLLAE-VAKKAYGWLHEDTGPESDPVVIVRFLGTTDMSSDLRTLLLSVCE 472

  Fly   442 QISYNYMLPFENIPDDLVPLTAHFKQLLTYASPTQPLTIYLDSVDQLTGTQDSNKVSWIPTRLPP 506
            |::.||....::.|..:..|...|..||..:|..:||.|..|:::||:...|:.|:.|:|..||.
Human   473 QLAVNYRCLVQSYPKKIHDLCDLFINLLNESSLQRPLVIIFDALEQLSENDDARKLWWLPAHLPR 537

  Fly   507 HCKIIISCANEPANPTVSHEYHVLCK---MIDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNN 568
            ..:|::|        |:.:::.:|.|   :|..|:|:||:......:...|:|..:....|.:.:
Human   538 FVRIVLS--------TLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTS 594

  Fly   569 YQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERVEKQHGRILVF 633
            .|...|.||:|||:||:||.|.|.|:..|||:....|:.|:.||.:||..||..:||:.|:.||.
Human   595 GQQIYVNNALSKCTLPMFVNLTFREVRHWRSHKDVDESSLSVTVHESIEQLFWSLEKKCGQKLVS 659

  Fly   634 HALAYITASKSGLSESELEDLISLDDKVLDDVYQYHLPPT-RRIPPLLWTRIRNDLPNYLSEREA 697
            .||.|||.:|.||||.||||:::||:.|:.::.:...|.. .|:|.|...|::..|..||.||..
Human   660 RALGYITMAKMGLSEMELEDVLALDNSVMSELKENTRPSNPLRVPYLYIARLKEGLSGYLIERHV 724

  Fly   698 DGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIADYYLGIWGGGVPKPF-------------- 748
            ..|.::.|.:|..:..|::.|.::.|.....|:::|||:||:|.||..|.|
Human   725 KNVTLLVWANRHLQLIAQKLYLQDDNDLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLE 789

  Fly   749 --KFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRY--NLRKFGELPFHFVRSRRFKDL 809
              ...|.::|..    ::.|.||:.|.||.||.........:  |.||..||.:|..|..:..||
Human   790 NRSLLEEEKHFM----EQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYHLTRCGKTDDL 850

  Fly   810 FEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKEAKRELMLVSDALRLGGAILAIYPNMLA 874
            ...::.|:.||:..:.......||:|.|.|.:.:.:||.|    .:::.||.....:..:|..|:
Human   851 LYGIIMNFSWLYTMIKIGQFDKVLSDIELAYNYSQEKELK----FLANTLRSIKNKVTAFPGSLS 911

  Fly   875 PQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCALIPVNHCLHTPGGPLKYSLEG---HQFAVFAF 936
            .:|..||||.:...|.::.||..||:.|||.|:::|::..:.....|.:..|..   |...:...
Human   912 AELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSPERLPLSSSHLHVTEILPT 976

  Fly   937 CLTSDMRYMV---SISTHFITFDLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLL 998
            |..|.:...:   |||    |:|:.|..|.|.:... :.::..:.|:.|.|:....:.|| |:|:
Human   977 CNPSTVLTALENGSIS----TWDVETRQLLRQITTA-QSVILGMKLTSDEKYLVVATTNN-TLLI 1035

  Fly   999 -----NMLSSEFVVINSPFEESHGPVSGLYLLNQNLFITCKLRWAQFDTRGNLVDTFDVPGENKD 1058
                 :.|.||..:..:    .||. |..|:....|.....|.|.:               .:||
Human  1036 YDNVNSCLLSEVEIKGT----KHGS-SATYINGFTLSANHALAWLE---------------ASKD 1080

  Fly  1059 WEILTMEFFNPADYNVVFWSGSINDMRLRLDS----CRGGHYSNCQLLFSAMVMNKARTRAYGCA 1119
            ..::.:.:..|. |....|. .:..::..||.    |  |.|.|...:|......|.      |.
Human  1081 VTVIDLLYGWPL-YQFHCWY-EVTCVQCSLDGLYAFC--GQYLNTTTIFHLGSGEKL------CT 1135

  Fly  1120 NEENFE------VSVFDFIEDEVTGD-----ICWTLVE-SLPRFEND------DKEML-LQLRLD 1165
            ....|.      :.:.|..::.|..|     ..|...: |.|:..:|      |.|:: ::|..|
Human  1136 VTSEFSGGFVKFLLILDTAQEMVMVDSEGSLSVWNTEDISSPQLTDDFDCRREDSEVVSIELSED 1200

  Fly  1166 QHDRM--------LLGTAGKGFVIWDFGSKDKDAAEECRLREGALYLALPHGVRNITTRIMQSNS 1222
            |...:        ||.|.     :|       ..||:.|.:         |..|.|:. ::..|.
Human  1201 QSAVLICKALSIELLDTG-----LW-------KVAEKFRAK---------HNERFISA-VLSKNG 1243

  Fly  1223 IMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLEPLTIGNWNNLVTSSIDRSVKVW 1287
            ..:.:.::...|     ::.|...:||....|....|.|::|  :...:.|.|::.|....:.:|
Human  1244 DCIIATMENTSA-----VFFWRRDTGQCMASLQEISGSIVKL--VKSSHHNMLLSLSTSGVLSIW 1301

  Fly  1288 NINNIFEKVHVIDRHELQIDDISL---SEVDMAVTVTRSCVGVWETRSGRLLAKLADSPLGAIVT 1349
            :| :|...:..||:....|..:.|   .|:..::..: .||..|...||.:.|.....   .||.
Human  1302 DI-DIITAMSNIDKTGKPIQSLLLPARGEIIYSLDGS-DCVHKWNFSSGFIEAVFKHE---GIVE 1361

  Fly  1350 HAEITPDGRYIISS-ETGKFLVWNRVSEQVVFRDDQPGIQQITLMDYGYKVLTVSVPNINQRDIL 1413
            |..:|..|..:::| :.....||:..|.:.:||.:...|.|:.:......|:::...|
Human  1362 HCVLTSTGDIMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEEN------- 1419

  Fly  1414 AAAAGGSADEANRLTAITTMRSVPEGSIFFRFEFPIRMITGMPFRQSVITADNAYIVVVTVDK-- 1476
                      |:|:..:.|...|            ..::|.:  :.:.||:.|.::|.:|..|
Human  1420 ----------ASRVWRLATGHRV------------CNILTTL--QNAFITSANTFVVGMTKSKVL 1460

  Fly  1477 ---------SNKDC----------------------------LGVYSATNGAFVSKVLLKGCSIK 1504
                     :.|.|                            :.::|.|:.....:|.|....:|
Human  1461 AVSLWTGSITKKFCCEDGTTIVNFKLIPDCPDIIVFITSAETVNIWSLTDEVICRRVQLPNNFLK 1525

  Fly  1505 EVISLVPMPHKANQVAVISSEKGSVMDIKTKK----HVRSIAKWGGSITRDGKCGLYAPTRGGLE 1565
            .:......|:....:.....|..:|:|:.:.|    |...|. |...::|||:..:|...|.|.|
Human  1526 NLEDFEISPNGKLGIIARGDENINVLDLYSGKLRVVHASGII-WRQRLSRDGRYLVYICFRNGEE 1589

  Fly  1566 MLELRKGTTVKTFIPKVAEGVFSVICIFTENDEYVAYYHSGRKTIRVFRTADTEMIANYRLQAEL 1630
              |...|            .:||:|                     |.|.||.:.|....|....
Human  1590 --EDENG------------AIFSLI---------------------VMRLADGKNIGACSLYKTP 1619

  Fly  1631 TAIKSSKDGRAIVLGTVDGCMSVLAIVDPKKEEMNEYLNDLPSRDENWKAKLAKMKARVGFKAAI 1695
            |.:..|:....|::|..||.:.:..:||                             ||.....|
Human  1620 TFLALSQRHLNIIVGFDDGSIGIYTVVD-----------------------------RVDAALKI 1655

  Fly  1696 RVATISSR 1703
            ::||.:||
Human  1656 KIATSNSR 1663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934	41/132 (31%)
		WD40	1177..>1379	CDD:225201	42/205 (20%)
		WD40 repeat	1214..1256	CDD:293791	6/41 (15%)
		WD40	<1216..1380	CDD:295369	35/167 (21%)
		WD40 repeat	1261..1300	CDD:293791	8/38 (21%)
		WD40 repeat	1306..1341	CDD:293791	9/37 (24%)
		WD40 repeat	1348..1393	CDD:293791	12/45 (27%)
NWD2	NP_001138462.1	LRR 1	386..410		4/23 (17%)
		AAA_16	394..539	CDD:289934	47/145 (32%)
		LRR 2	677..698		6/20 (30%)
		LRR 3	724..747		5/22 (23%)
		LRR 4	883..906		5/26 (19%)
		WD40	<922..1207	CDD:225201	67/320 (21%)
		LRR 5	925..953		10/27 (37%)
		WD 1	963..1004		11/44 (25%)
		WD40	978..1302	CDD:295369	75/388 (19%)
		WD 2	1007..1046		8/40 (20%)
		WD40 repeat	1013..1051	CDD:293791	10/38 (26%)
		WD40 repeat	1056..1095	CDD:293791	9/55 (16%)
		WD40	1100..1435	CDD:225201	77/405 (19%)
		WD40 repeat	1102..1138	CDD:293791	9/43 (21%)
		WD 3	1140..1179		7/38 (18%)
		WD40 repeat	1145..1184	CDD:293791	7/38 (18%)
		WD40 repeat	1192..1228	CDD:293791	9/47 (19%)
		WD 4	1229..1271		8/56 (14%)
		WD40 repeat	1235..1257	CDD:293791	3/27 (11%)
		WD40	1259..1507	CDD:295369	52/285 (18%)
		WD 5	1272..1311		9/41 (22%)
		WD40 repeat	1277..1313	CDD:293791	8/38 (21%)
		WD40	1303..>1580	CDD:225201	57/313 (18%)
		WD 6	1314..1353		8/39 (21%)
		WD40 repeat	1320..1354	CDD:293791	8/34 (24%)
		WD 7	1355..1394		9/41 (22%)
		WD40 repeat	1360..1396	CDD:293791	10/35 (29%)
		WD 8	1396..1434		8/66 (12%)
		WD40 repeat	1400..1440	CDD:293791	9/70 (13%)
		WD40 repeat	1444..1469	CDD:293791	6/24 (25%)
		WD 9	1476..1516		2/39 (5%)
		WD 10	1522..1564		7/41 (17%)
		WD 11	1614..1653		11/67 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3602
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H14974
Inparanoid	1	1.050	458	1.000	Inparanoid score	I1581
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14491at33208
OrthoFinder	1	1.000	-	-		FOG0006917
OrthoInspector	1	1.000	-	-		oto88946
orthoMCL	1	0.900	-	-		OOG6_103490
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3466
SonicParanoid	1	1.000	-	-		X4387
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.760