Protein Alignment CG10185 and CG10132

DIOPT Version :10

• Sequence 1: NP_650521.1
• Gene: CG10185 / 41953
• FlyBaseID: FBgn0038397
• Length: 1732
• Species: Drosophila melanogaster
• Sequence 2: NP_609979.2
• Gene: CG10132 / 35239
• FlyBaseID: FBgn0032798
• Length: 1361
• Species: Drosophila melanogaster
• Alignment Length: 1567
• Identity: 289/1567 - (18%)
• Similarity: 505/1567 - (32%)
• Gaps: 531/1567 - (33%)

  Fly    11 LGSLESLPPVSSKIVR-----IFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDM-- 68
            |..|:..||...||.|     ::..:..:....:...::...|...|..|:.: |.:|.:.|:
  Fly   117 LSVLQGKPPPGRKIERDKKIVVYILADNSTEYKKHKRVVHSLYKHFKSKCQSR-GFDFIIADVHD 180

  Fly    69 -----------------------RWGVRD-EATDDHMTTELCMREIKNCQRLSMGPNFI--VFLG 107
                                   ||.... ||...|.....|:.||   .|.|.|...|  :|||
  Fly   181 SEPETEPGNGNARKDFSRLQEAKRWTQTPLEAQGGHEEAANCLCEI---TRHSAGAYMIPVLFLG 242

  Fly   108 QKYGYRPIPTYIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVL-----QPISSILIN 167
            ...|...:|..|.|.:...:..  |:...:|.:|:.||..|::..|....|     .|.||
  Fly   243 ATLGTPMLPLTIESQDFTSVLG--TASEEERLLLEKWYTIDNSYQPMCHRLHAQQVDPYSS---- 301

  Fly   168 FNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDV-HNYFMSVTEREVINGILN 231
                   ::..|        ||::..:|.          ::..:|| .:|..:|.|:|:.|.:|.
  Fly   302 -------QVNGE--------LNELLAVLL----------RLFSDDVKDSYLTTVVEQEINNTVLM 341

  Fly   232 VKNTKNHCLSYVRYINNINLQNLKKASLFVDIINR-------------------------SLDTE 271
            .:.....|: :::..:.:...:...:.|.:::..|                         .||.|
  Fly   342 SQELAKRCI-WIQTGSQVARPSENASPLELEVQRRLSHVYSGLKSQLSEKNLIRLLPTMSILDEE 405

  Fly   272 SAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHEEYLNHFISHFYKNVVKLVDRAMRK 336
            .:.::..|.|..| |.|...:.||.::.: ...|:|....||.  ..:.|:.|.:.:
  Fly   406 LSAVIESLLDKTL-AGIFEEHQQKNSIPY-NTLGVDRVLLEEL--RLVGHYSKLLAQ-------- 458

  Fly   337 EDSSAQGQIVTEILQHLHACNNSVKIFYGREESCERIKRYMLGDSDKPLVLFGDGGCGKTSLLSK 401
              :||...|:.:                        :|||:...:.:|||:.|..|.||:.|:||
  Fly   459 --NSANFDIMND------------------------VKRYIRDSTAQPLVVSGARGSGKSVLVSK 497

  Fly   402 SVSLVATEWFAHVRPINVIRFLGTTPDSSALTATLISICQQISYNYMLPFENIPDDLVPLTAHFK 466
            .:..| ..|....:.|  :|:...:..||.||:.|.|:..|:|.........:|..|...:...:
  Fly   498 IMENV-HRWKPEAQLI--LRYANLSARSSDLTSLLGSMANQMSVLETGHQCQVPHTLEGYSRVIR 559

  Fly   467 QLLTYASPTQPLTIYLDSVDQLTGTQDSNKVSWIPTRLPPHCKIIISCANEPANPTVSHEYHVLC 531
            ::|.  ...:...:.:|.||:|   |....:.|:|.:| ...|:|:         |||
  Fly   560 EILD--RQQRFFVLIIDGVDEL---QRDELLDWLPQQL-GSAKMIL---------TVS------- 602

  Fly   532 KMIDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNNYQWRLVANAISKCSLP--IFVKLVFAEI 594
            ::.|..|: ::.|..|:...|                      ..|:::..:|  .|::|
  Fly   603 ELADEGED-VDGTEAGDSFDM----------------------LAALAQLGIPQRCFLRL----- 639

  Fly   595 CRWRSYTRPQ----------ETHLANTVMDSIMLLFERVEKQHGRILVFHA-----LAYITASKS 644
               |.:|..|          :.:.||    ..:.|.:..:..||: ..:||     ||::.....
  Fly   640 ---RQFTERQWHDILSSGGGDFYAAN----GALKLPDDWKTLHGK-TPYHAKSLWWLAWLGHVAQ 696

  Fly   645 GLSESELEDLIS-----LDDKVLDDVYQYHLPPTRRIPPLLWTRIRNDLPNYLSEREADGVNV-- 702
            .:  ||:.|:.|     |:.|...|..:..|...|..|   |           ..||:|.:.|
  Fly   697 PI--SEIGDISSRILQVLESKFATDQVELLLLIVRLSP---W-----------GIRESDCLGVFQ 745

  Fly   703 -MNWYHRQFRDTAKERY----------FKNMNMA--IYFHSMIADYYLGIWGGGVPKPFKFTEIQ 754
             |.....|.......::          .||:.:|  .:..:::|.|        ..|.:...|..
  Fly   746 KMTQLEAQVAFKVWSKFCWLMGPMLLGLKNIRIADKSFGRAVLARY--------AQKQWLVHEAL 802

  Fly   755 RHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRYNLRKFGELPFHFVRSRRFKDLFE-------- 811
            |..|...|.|             |....| :..||.:|:.:||:|     .|..:.|
  Fly   803 RDYFDRQDSE-------------FKGSQG-ANTYNYQKYLKLPYH-----HFCAVIEDNPAPHKI 848

  Fly   812 HVLFN------YDWLHAKLSSCPLQAVLADFEDA-----SSNTDDKEAKRELMLVSDALRL---- 861
            .:|||      ..|:..|:.:...:.:|.|...|     |...:...|...:..:...|..
  Fly   849 DILFNCFYFTDLQWIANKVHATGPEHLLNDILQAEWLAKSGGENCPTAYVHICFLKQFLEQYLHE 913

  Fly   862 ----GGAILAIYPNMLAPQLVGRLLPEIGGNPNIKM--------------LLRA---------CD 899
                |.....:....|..:.  |..||:..:..|:.              :|.|         .:
  Fly   914 LSYDGQQFYTLMKYYLKTRF--REAPELKDDEKIRSWWEYTNELEFAFLEILNADLDAENGNQAE 976

  Fly   900 RSGPKDCAL---IPVNHC-----LHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSIST---HFI 953
            :..|.|.|:   :||...     |..||                 |      |:.|:.|   ...
  Fly   977 QEKPSDDAVPSSVPVKGYDVLMNLPQPG-----------------C------YVASMCTDRSEIC 1018

  Fly   954 TFDLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSEFVVINSPFEESHGP 1018
            .:|:......|:    ::||.|...:.|...:.||.....:..::|:...:|.|..........|
  Fly  1019 IWDVKNCCRIRE----LQGIQQPTAMCPVGNYEAAVLCRREIRVINLDEGKFKVTLKGVMNQKMP 1079

  Fly  1019 VSGLYLLNQNLFITCKLRWAQFDT-----RGNLVDTFDVPGENKDWEILTMEFFNPADYNVVFWS 1078
            ..||:  :|| .:.|..|...:..     .|:.|.||.. ||::        |.|
  Fly  1080 YFGLH--DQN-HLVCLSRNRMYVNLMNLESGDCVTTFKA-GEDR--------FLN---------- 1122

  Fly  1079 GSINDMRLRLDSCRGGHYSNCQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDICWT 1143
                                     |.:|....|....|...::.|.:.|             |.
  Fly  1123 -------------------------SLLVSGDGRILVCGDETQKPFPLLV-------------WH 1149

  Fly  1144 LVESLPRFENDDKEMLLQLRLDQHDRMLLGTAGKGFVIWDFGSKDKDAAEECR------------ 1196
            |         ..:::|..||:..||.:...:|     |...||.....|:|..
  Fly  1150 L---------SQRKLLYDLRIPHHDFITSLSA-----ITHEGSYVCVVAKELNEPTTPNFIVVYD 1200

  Fly  1197 LREGALYLALPHGVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFGRI 1261
            |:.|.|:.........::..|.|.|:.:::...|       ..:.:|.|.:|.....|..|...:
  Fly  1201 LQSGTLFKKWKPACNTVSLAISQVNACVIAGLED-------AKILIWDLVTGNCKSTLIGHNAPV 1258

  Fly  1262 --IQLEPLTIGNWNNLVTSSIDRSVKVWNINNIFEKVHVIDRHELQIDDISLSEVDMAVTVTRSC 1324
              ::|:||      ..|..|.|:..:                                    .|.
  Fly  1259 TFLKLDPL------GKVLLSYDKEGR------------------------------------DSA 1281

  Fly  1325 VGVWETRSGRLLAKLADSPLGAIVTHAEITPDGRYIISSETGKFLVWNRVSEQVVFRDDQPGIQQ 1389
            |.:||..|.:.||.....   |.|:..||.|:|.::                 |:...|:..:..
  Fly  1282 VRMWELNSAKSLAVFKPP---AQVSTCEILPNGAFV-----------------VLALKDRNSLLT 1326

  Fly  1390 ITLMDYG 1396
            :.|.:||
  Fly  1327 LALKNYG 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	P-loop containing Nucleoside Triphosphate Hydrolases	384..>514	CDD:476819	35/129 (27%)
		WD40 repeat	1214..1256	CDD:293791	8/41 (20%)
		WD40	<1232..1422	CDD:441893	29/167 (17%)
		WD40 repeat	1261..1300	CDD:293791	6/40 (15%)
		WD40 repeat	1306..1341	CDD:293791	7/34 (21%)
		WD40 repeat	1348..1393	CDD:293791	7/44 (16%)
CG10132	NP_609979.2	AAA_22	474..599	CDD:379165	34/133 (26%)
		WD40 repeat	1039..1072	CDD:293791	6/32 (19%)
		WD40	<1042..1321	CDD:441893	72/421 (17%)
		WD40 repeat	1079..1114	CDD:293791	10/37 (27%)
		WD40 repeat	1122..1160	CDD:293791	10/94 (11%)
		WD40 repeat	1167..1252	CDD:293791	16/96 (17%)
		WD40 repeat	1258..1294	CDD:293791	11/77 (14%)