Protein Alignment CG10185 and Nwd1

DIOPT Version :10

• Sequence 1: NP_650521.1
• Gene: CG10185 / 41953
• FlyBaseID: FBgn0038397
• Length: 1732
• Species: Drosophila melanogaster
• Sequence 2: XP_006531149.1
• Gene: Nwd1 / 319555
• MGIID: 2442268
• Length: 1573
• Species: Mus musculus
• Alignment Length: 1782
• Identity: 437/1782 - (24%)
• Similarity: 715/1782 - (40%)
• Gaps: 399/1782 - (22%)

  Fly    35 DTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIKNCQRLSMG 99
            ||  ||..|....||.::.:| ::|||.|:|||:|||:.:....|::|||||:.|::.||:.|:|
Mouse     2 DT--EREALQCTAYPEVQSFC-QRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIG 63

  Fly   100 PNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISSI 164
            |.|:..||.:||..|:|..|...|...:..:|||...|..::...:::|.|.:||..||||..|:
Mouse    64 PAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSL 128

  Fly   165 LINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGI 229
            ::          ...::|.       :..:||..|........:|:|....|..||.|.|:..|:
Mouse   129 VV----------PGPEEAT-------LTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGL 176

  Fly   230 LNVKNTKNHCLSYVRYINNINLQNLKKASL-FVD-IINRSLDTESAKLLSDLRDVRLPAKIEAVN 292
            |:..........::|.:.::|...|...|| .|| :::..|||.:..|||.|:...|.|:..|:
Mouse   177 LSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGAL- 240

  Fly   293 AQKYTVEWIGREGLDI-----ETHEEYLNHFISHFYKNVVKLVDRAMRKEDSSAQ--GQIVTEIL 350
             :.:.:.|    ..|:     :.|..||......|.......|...:|:.:.:.|  |.:..||.
Mouse   241 -KSHHLSW----SRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIR 300

  Fly   351 QHLHACNNSVKIFYGREESCERIKRYMLGDSDK---PLVLFGDGGCGKTSLLSKSVSLVATEWFA 412
            .||.....|.|:|.|.:|...::::.:..|..:   ||||||..|.|||||:.|....| .|...
Mouse   301 HHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQV-PELLG 364

  Fly   413 HVRPINVIRFLGTTPDSSALTATLISICQQISYNYMLPFENIPDDLVPLTAH------FKQLLTY 471
            | :.:.|:|.|||:..|....:.|.|:..|:...|.||   :|...| |.||      |..||..
Mouse   365 H-KTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLP---LPPAQV-LEAHSRVGHFFHTLLHT 424

  Fly   472 ASPT--QPLTIYLDSVDQLTGTQDSNKVSWIPTRLPPHCKIIIS-CANEPANPTVSHEYHVLCKM 533
            .|..  :.|.:.|||||.|.....|.:|||:|.:.||...:|:| |:.:..       .|.|.:.
Mouse   425 VSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQV-------LHNLQQT 482

  Fly   534 IDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWR 598
            :.....:.||.||........|::.:....|.|:..|..::..::.:|..|..::|.|.|..:|.
Mouse   483 LKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWA 547

  Fly   599 SYTRPQETHLANTVMDSIMLLFERVEKQHGRILVFHALAYITASKS----------GLSESELED 653
            |:|.|  ..||.|..::...|..|:|:.||.:||.|.|.||.:|:.          ||||:||:|
Mouse   548 SFTVP--VPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRDLDRTWILWRYGLSEAELKD 610

  Fly   654 LISLDDKVLDDVYQYHLPPTR---RIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAK 715
            ::||||:||..||:...||::   |.|||||.|:|.||.:.|..|..||..::...|||.....:
Mouse   611 VLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQ 675

  Fly   716 ERYFKNMNMAIYFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSS 780
            .||......| ..|.::|:::.|.|..|:.|.....        |..|..:.||||..|||.|||
Mouse   676 VRYLSGPERA-KRHGVLAEFFSGAWSQGIKKLITLP--------LVGKPLNLDRKVAPQPLWFSS 731

  Fly   781 KDGLSKRYNLRKFGELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDD 845
            ...     ||||..|||||.:.:.|.::|.:.||.|..|:..:..|..::.:|.||:..:.:.:.
Mouse   732 TVA-----NLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNS 791

  Fly   846 KEAKRELMLVSDALRLGGAIL--------AIYPNMLA---------PQLVGRLLPEIGGNPNIKM 893
            .|..    ||.:|::|.|..:        .:|..:||         |.::|:|..:      .:.
Mouse   792 PEVD----LVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQ------AQS 846

  Fly   894 LLRACDRSGPKDCALIPVNHCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSISTH---FITF 955
            ..|||...     .|:|:...|..|||||:.:|.|....:.|...:.:.:.:| :.|.   .:.:
Mouse   847 WFRACPYP-----MLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLV-VGTQDGAMVVW 905

  Fly   956 DLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSE--FVVINSPFEESHGP 1018
            |:....:.. |..|....::.:.:......|.:.|.::...|.::||.:  ..:::...:....|
Mouse   906 DVEEQQVVH-VLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEP 969

  Fly  1019 VSGLYLLNQNLFITCKLRW-AQFDTRGNLVDTFDVPGENKD-WEILTMEFFNPADYNVVFW-SGS 1080
            .|                | ...|.|.|:|  :...|...: |.:.|.:        :||. :|.
Mouse   970 QS----------------WDLHVDERNNVV--YSTSGARINMWNLETSK--------LVFCITGD 1008

  Fly  1081 IND----------MRLRLDSCRGGHYSNCQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDE 1135
            ::|          ..|.|...:||..|    |:|: .|.|.         :|..::|   .|::|
Mouse  1009 VSDPWVCVALLAAQGLLLALSKGGQVS----LWSS-AMGKL---------QEKHQLS---SIKEE 1056

  Fly  1136 VTGDICWTLVESLPRFENDDKEMLLQLRLDQHDRMLLGTAGKGFVIWDFGSKDKDAAEECRLREG 1200
            .  ..|...::|..|.                      .||     :..||....:|.|.||.|
Mouse  1057 T--PTCAVSIQSRARL----------------------VAG-----FSSGSIALVSAGEDRLLE- 1091

  Fly  1201 ALYLALPHGVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLE 1265
                .||..|          ..::||......|||..:.:.::...|....:.:.:.......:|
Mouse  1092 ----KLPEAV----------GFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVE 1142

  Fly  1266 PLTIGNWNNL-VTSSIDRSVKVWNIN------NIFEKVHVIDRHELQIDDISL--SEVDMAVTVT 1321
            ...:|..||| :|.|.|..::||:::      |:.|.|..         .:||  ....:.|:.:
Mouse  1143 TAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGA---------PVSLLVRGGTLVVSAS 1198

  Fly  1322 R--SCVGVWETRSGRLLAK----LADSPLGAIVTHAEITPDGRYIISSETG---KFLVWN----- 1372
            |  |...||:.:|.:.|..    |..:.|.|:..|      |.::...:.|   |..:|:
Mouse  1199 RKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHH------GSFVYFPKVGDKNKVTIWDLAEGE 1257

  Fly  1373 --------------RVSEQ--VVFRDDQPGIQQITLMDYGYKVLTVSVPNINQRDILAAAAGGSA 1421
                          .|:||  ::|.....||..:..::....||.:..|...:    |......:
Mouse  1258 EQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARK----AVNCMSLS 1318

  Fly  1422 DEANRLTA----ITTMRSVPEGSIFFRFEFPIRMITGMPFRQSVITADNAYIVVVTVDKSNKDCL 1482
            ...|||..    |..:..:..|.       |...|.|..:.......:....|.|..|
Mouse  1319 KSENRLAIAYDNIVLVLDISPGD-------PCPAIEGPTYTFYTQLPETIVSVAVLAD------- 1369

  Fly  1483 GVYSATNGAFVSKVLLKGCSIKEV---------ISLVPMPHKANQVAVISSEKG--SVMDI---- 1532
              |....|.....:.|..|:..:|         :|.|.:.| :.|:||..:|..  .:.|:
Mouse  1370 --YRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSH-SEQLAVSGAEDALLCLWDLQACR 1431

  Fly  1533 ---------------------KTKKHV------RSIAKWGGSITRDGKC---------------- 1554
                                 :..|||      ||:..|.   |.||..
Mouse  1432 GMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWS---TVDGTLLAVQFVHAVINRIIPT 1493

  Fly  1555 --GLYAPTRGGLEMLELRKGTTVKTFIPKVAEGVFSVICIFTENDEYVAYYHSGRKTIRVFRTAD 1617
              |..|||..|..:.|..:..:|:.                ::.|....:    :|.:.:.:|
Mouse  1494 SNGFMAPTSHGYLIRERFQCPSVRA----------------SQQDPLKNF----KKAVWLVKT-- 1536

  Fly  1618 TEMIANYRLQAELTAIKSSKDGRAIVL 1644
                   |.:.||.|.::|:|...:.:
Mouse  1537 -------RQREELAAAEASQDAEPVAV 1556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	P-loop containing Nucleoside Triphosphate Hydrolases	384..>514	CDD:476819	53/138 (38%)
		WD40 repeat	1214..1256	CDD:293791	6/41 (15%)
		WD40	<1232..1422	CDD:441893	44/228 (19%)
		WD40 repeat	1261..1300	CDD:293791	13/45 (29%)
		WD40 repeat	1306..1341	CDD:293791	10/42 (24%)
		WD40 repeat	1348..1393	CDD:293791	11/68 (16%)
Nwd1	XP_006531149.1	ExeA	315..>421	CDD:442498	37/111 (33%)
		WD40	<864..1211	CDD:441893	86/444 (19%)
		WD40 repeat	881..918	CDD:293791	5/38 (13%)
		WD40 repeat	924..961	CDD:293791	5/36 (14%)
		WD40 repeat	966..1006	CDD:293791	12/65 (18%)
		WD40 repeat	1014..1051	CDD:293791	10/50 (20%)
		WD40	1061..1428	CDD:441893	84/444 (19%)
		WD40 repeat	1097..1134	CDD:293791	7/46 (15%)
		WD40 repeat	1141..1165	CDD:293791	8/23 (35%)
		WD40 repeat	1183..1216	CDD:293791	8/32 (25%)
		WD40 repeat	1269..1307	CDD:293791	8/37 (22%)
		WD40 repeat	1312..1347	CDD:293791	6/41 (15%)
		WD40 repeat	1362..1393	CDD:293791	8/39 (21%)
		WD40 repeat	1401..1439	CDD:293791	8/38 (21%)
		WD40 repeat	1446..1483	CDD:293791	9/39 (23%)