DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10185 and Nwd1

DIOPT Version :9

Sequence 1:NP_650521.1 Gene:CG10185 / 41953 FlyBaseID:FBgn0038397 Length:1732 Species:Drosophila melanogaster
Sequence 2:XP_006531149.1 Gene:Nwd1 / 319555 MGIID:2442268 Length:1573 Species:Mus musculus


Alignment Length:1782 Identity:437/1782 - (24%)
Similarity:715/1782 - (40%) Gaps:399/1782 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 DTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIKNCQRLSMG 99
            ||  ||..|....||.::.:| ::|||.|:|||:|||:.:....|::|||||:.|::.||:.|:|
Mouse     2 DT--EREALQCTAYPEVQSFC-QRHGLAFEVVDLRWGIPNTQATDYLTTELCLEELERCQKTSIG 63

  Fly   100 PNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISSI 164
            |.|:..||.:||..|:|..|...|...:..:|||...|..::...:::|.|.:||..||||..|:
Mouse    64 PAFVALLGDQYGPCPVPRRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPSGSL 128

  Fly   165 LINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGI 229
            ::          ...::|.       :..:||..|........:|:|....|..||.|.|:..|:
Mouse   129 VV----------PGPEEAT-------LTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIELGL 176

  Fly   230 LNVKNTKNHCLSYVRYINNINLQNLKKASL-FVD-IINRSLDTESAKLLSDLRDVRLPAKIEAVN 292
            |:..........::|.:.::|...|...|| .|| :::..|||.:..|||.|:...|.|:..|: 
Mouse   177 LSSARGDQGATVFLRDVQDLNKHILDDCSLKMVDRLVDGCLDTNAQSLLSGLKGRILDAQPGAL- 240

  Fly   293 AQKYTVEWIGREGLDI-----ETHEEYLNHFISHFYKNVVKLVDRAMRKEDSSAQ--GQIVTEIL 350
             :.:.:.|    ..|:     :.|..||......|.......|...:|:.:.:.|  |.:..||.
Mouse   241 -KSHHLSW----SRDLVNPKNKAHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIR 300

  Fly   351 QHLHACNNSVKIFYGREESCERIKRYMLGDSDK---PLVLFGDGGCGKTSLLSKSVSLVATEWFA 412
            .||.....|.|:|.|.:|...::::.:..|..:   ||||||..|.|||||:.|....| .|...
Mouse   301 HHLWQSTESTKVFCGHQELLAQLRQQLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQV-PELLG 364

  Fly   413 HVRPINVIRFLGTTPDSSALTATLISICQQISYNYMLPFENIPDDLVPLTAH------FKQLLTY 471
            | :.:.|:|.|||:..|....:.|.|:..|:...|.||   :|...| |.||      |..||..
Mouse   365 H-KTVVVLRLLGTSKLSLDARSLLRSLSFQVCLAYGLP---LPPAQV-LEAHSRVGHFFHTLLHT 424

  Fly   472 ASPT--QPLTIYLDSVDQLTGTQDSNKVSWIPTRLPPHCKIIIS-CANEPANPTVSHEYHVLCKM 533
            .|..  :.|.:.|||||.|.....|.:|||:|.:.||...:|:| |:.:..       .|.|.:.
Mouse   425 VSQRNFESLVLLLDSVDDLDSICHSPRVSWLPLKCPPRVHLILSTCSGQQV-------LHNLQQT 482

  Fly   534 IDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWR 598
            :.....:.||.||........|::.:....|.|:..|..::..::.:|..|..::|.|.|..:|.
Mouse   483 LKDPSTYWEVKALSGSQGQEFIQLLLAAEKRMLSPGQRDVLWASLPECGHPGRLRLAFEEARKWA 547

  Fly   599 SYTRPQETHLANTVMDSIMLLFERVEKQHGRILVFHALAYITASKS----------GLSESELED 653
            |:|.|  ..||.|..::...|..|:|:.||.:||.|.|.||.:|:.          ||||:||:|
Mouse   548 SFTVP--VPLATTAEEATHQLCIRLEETHGALLVAHVLGYIVSSRDLDRTWILWRYGLSEAELKD 610

  Fly   654 LISLDDKVLDDVYQYHLPPTR---RIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAK 715
            ::||||:||..||:...||::   |.|||||.|:|.||.:.|..|..||..::...|||.....:
Mouse   611 VLSLDDEVLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCMLLAIAHRQLSQVIQ 675

  Fly   716 ERYFKNMNMAIYFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSS 780
            .||......| ..|.::|:::.|.|..|:.|.....        |..|..:.||||..|||.|||
Mouse   676 VRYLSGPERA-KRHGVLAEFFSGAWSQGIKKLITLP--------LVGKPLNLDRKVAPQPLWFSS 731

  Fly   781 KDGLSKRYNLRKFGELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDD 845
            ...     ||||..|||||.:.:.|.::|.:.||.|..|:..:..|..::.:|.||:..:.:.:.
Mouse   732 TVA-----NLRKLTELPFHLLHAGRLEELKQEVLGNMSWISCRGISGGIEVLLDDFDMCAPHMNS 791

  Fly   846 KEAKRELMLVSDALRLGGAIL--------AIYPNMLA---------PQLVGRLLPEIGGNPNIKM 893
            .|..    ||.:|::|.|..:        .:|..:||         |.::|:|..:      .:.
Mouse   792 PEVD----LVREAIQLCGPAVELRGLEKSVLYTELLARLLFFAASHPAMIGQLCQQ------AQS 846

  Fly   894 LLRACDRSGPKDCALIPVNHCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSISTH---FITF 955
            ..|||...     .|:|:...|..|||||:.:|.|....:.|...:.:.:.:| :.|.   .:.:
Mouse   847 WFRACPYP-----MLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLV-VGTQDGAMVVW 905

  Fly   956 DLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSE--FVVINSPFEESHGP 1018
            |:....:.. |..|....::.:.:......|.:.|.::...|.::||.:  ..:::...:....|
Mouse   906 DVEEQQVVH-VLMGHTAEVKCVRVFAQGTLAISASKDHTLRLWSLLSGQEKVTILDGGSQNPTEP 969

  Fly  1019 VSGLYLLNQNLFITCKLRW-AQFDTRGNLVDTFDVPGENKD-WEILTMEFFNPADYNVVFW-SGS 1080
            .|                | ...|.|.|:|  :...|...: |.:.|.:        :||. :|.
Mouse   970 QS----------------WDLHVDERNNVV--YSTSGARINMWNLETSK--------LVFCITGD 1008

  Fly  1081 IND----------MRLRLDSCRGGHYSNCQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDE 1135
            ::|          ..|.|...:||..|    |:|: .|.|.         :|..::|   .|::|
Mouse  1009 VSDPWVCVALLAAQGLLLALSKGGQVS----LWSS-AMGKL---------QEKHQLS---SIKEE 1056

  Fly  1136 VTGDICWTLVESLPRFENDDKEMLLQLRLDQHDRMLLGTAGKGFVIWDFGSKDKDAAEECRLREG 1200
            .  ..|...::|..|.                      .||     :..||....:|.|.||.| 
Mouse  1057 T--PTCAVSIQSRARL----------------------VAG-----FSSGSIALVSAGEDRLLE- 1091

  Fly  1201 ALYLALPHGVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLE 1265
                .||..|          ..::||......|||..:.:.::...|....:.:.:.......:|
Mouse  1092 ----KLPEAV----------GFLVVSEDDSLLVAGFGRFVRIFLADSQGFHRFMASDLEHEDMVE 1142

  Fly  1266 PLTIGNWNNL-VTSSIDRSVKVWNIN------NIFEKVHVIDRHELQIDDISL--SEVDMAVTVT 1321
            ...:|..||| :|.|.|..::||:::      |:.|.|..         .:||  ....:.|:.:
Mouse  1143 TAVLGPENNLIITGSRDALIQVWSLSEQGTLLNVLEGVGA---------PVSLLVRGGTLVVSAS 1198

  Fly  1322 R--SCVGVWETRSGRLLAK----LADSPLGAIVTHAEITPDGRYIISSETG---KFLVWN----- 1372
            |  |...||:.:|.:.|..    |..:.|.|:..|      |.::...:.|   |..:|:     
Mouse  1199 RKSSSFKVWDLKSTKKLQSPTPFLDRTGLAAVSHH------GSFVYFPKVGDKNKVTIWDLAEGE 1257

  Fly  1373 --------------RVSEQ--VVFRDDQPGIQQITLMDYGYKVLTVSVPNINQRDILAAAAGGSA 1421
                          .|:||  ::|.....||..:..::....||.:..|...:    |......:
Mouse  1258 EQDCLDTSNEVRCLEVAEQAKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEARK----AVNCMSLS 1318

  Fly  1422 DEANRLTA----ITTMRSVPEGSIFFRFEFPIRMITGMPFRQSVITADNAYIVVVTVDKSNKDCL 1482
            ...|||..    |..:..:..|.       |...|.|..:.......:....|.|..|       
Mouse  1319 KSENRLAIAYDNIVLVLDISPGD-------PCPAIEGPTYTFYTQLPETIVSVAVLAD------- 1369

  Fly  1483 GVYSATNGAFVSKVLLKGCSIKEV---------ISLVPMPHKANQVAVISSEKG--SVMDI---- 1532
              |....|.....:.|..|:..:|         :|.|.:.| :.|:||..:|..  .:.|:    
Mouse  1370 --YRVVYGMSDGSLFLYDCACSKVFPLEAHGSRVSCVEVSH-SEQLAVSGAEDALLCLWDLQACR 1431

  Fly  1533 ---------------------KTKKHV------RSIAKWGGSITRDGKC---------------- 1554
                                 :..|||      ||:..|.   |.||..                
Mouse  1432 GMFEMSYENSCCRGVRCACFSRDDKHVFAGMEDRSVTAWS---TVDGTLLAVQFVHAVINRIIPT 1493

  Fly  1555 --GLYAPTRGGLEMLELRKGTTVKTFIPKVAEGVFSVICIFTENDEYVAYYHSGRKTIRVFRTAD 1617
              |..|||..|..:.|..:..:|:.                ::.|....:    :|.:.:.:|  
Mouse  1494 SNGFMAPTSHGYLIRERFQCPSVRA----------------SQQDPLKNF----KKAVWLVKT-- 1536

  Fly  1618 TEMIANYRLQAELTAIKSSKDGRAIVL 1644
                   |.:.||.|.::|:|...:.:
Mouse  1537 -------RQREELAAAEASQDAEPVAV 1556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10185NP_650521.1 AAA_16 363..488 CDD:289934 47/135 (35%)
WD40 1177..>1379 CDD:225201 49/240 (20%)
WD40 repeat 1214..1256 CDD:293791 6/41 (15%)
WD40 <1216..1380 CDD:295369 39/202 (19%)
WD40 repeat 1261..1300 CDD:293791 13/45 (29%)
WD40 repeat 1306..1341 CDD:293791 10/42 (24%)
WD40 repeat 1348..1393 CDD:293791 11/68 (16%)
Nwd1XP_006531149.1 AAA 315..>361 CDD:99707 17/46 (37%)
P-loop_NTPase 337..504 CDD:393355 60/179 (34%)
WD40 870..1166 CDD:392136 71/384 (18%)
WD40 repeat 881..918 CDD:293791 5/38 (13%)
WD40 repeat 924..961 CDD:293791 5/36 (14%)
WD40 repeat 966..1006 CDD:293791 12/65 (18%)
WD40 repeat 1014..1051 CDD:293791 10/50 (20%)
WD40 1038..1471 CDD:225201 97/525 (18%)
WD40 repeat 1097..1134 CDD:293791 7/46 (15%)
WD40 repeat 1141..1165 CDD:293791 8/23 (35%)
WD40 repeat 1183..1216 CDD:293791 8/32 (25%)
WD40 repeat 1269..1307 CDD:293791 8/37 (22%)
WD40 repeat 1312..1347 CDD:293791 6/41 (15%)
WD40 repeat 1362..1393 CDD:293791 8/39 (21%)
WD40 repeat 1401..1439 CDD:293791 8/38 (21%)
WD40 repeat 1446..1483 CDD:293791 9/39 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG3602
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D14491at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103490
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3466
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.750

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