DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10185 and Nwd2

DIOPT Version :9

Sequence 1:NP_650521.1 Gene:CG10185 / 41953 FlyBaseID:FBgn0038397 Length:1732 Species:Drosophila melanogaster
Sequence 2:XP_038948680.1 Gene:Nwd2 / 289633 RGDID:1563065 Length:1742 Species:Rattus norvegicus


Alignment Length:1854 Identity:460/1854 - (24%)
Similarity:783/1854 - (42%) Gaps:300/1854 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 FLGSLESLPP---VSSKIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWG 71
            |.|:|.:||.   .:.:.||:|.|:...||..||..|....||:::::|||.:||||||:|:.||
  Rat    23 FSGNLTALPSHLVPAGRSVRVFISANPEDTGAERQALRETVYPKLREFCRENYGLEFQVIDLYWG 87

  Fly    72 VRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGV 136
            |.::..|.....::.|:.::.|.:.|.||.|:..||:|||...||..:.:||..:|.:......:
  Rat    88 VEEDEWDSPELQKMRMKLLEECLKSSAGPCFVGLLGEKYGNIRIPGQVEASEFEMILDAAVEAKL 152

  Fly   137 DRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAAS 201
            :..:|:.||.:|.|:||....|:|...:.....|...|....|.:..|.:..::::.:.:.|...
  Rat   153 ETKLLEDWYCRDENSVPAAYYLRPRLEVPRTNKNSTQPSATGEHERPWQEISDEIKTIFKAATKL 217

  Fly   202 LGASNKMSKEDVHNYFMSVTEREVINGILNVKNTK---NHCLSYVRYINNI-NLQNLKKASLFVD 262
            |....||.......|..|..|.|....:  .|.|.   ..|:.|:|.|.|| ....:.:...::|
  Rat   218 LHEQGKMKLSQAKRYLFSAIEDEFDFAL--GKQTPAFLKKCVCYIRKIANIERFVKIPEMGKYMD 280

  Fly   263 IINRS----LDTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHEEYLNHFI---- 319
            |....    .|.|:.:.|..|||..:|..:.:.|.:.||.  :....:.:...:|..||:|    
  Rat   281 ITGTDPRIIRDPEAQEKLIKLRDEFIPTIVASSNLRVYTS--VTHCDMKLGYSQEIENHYIEGLG 343

  Fly   320 SHFYKNVVKLVDRAMRKEDSSAQGQIVTEILQHLHACNNSVKIFYGREESCERIKRYMLGDSD-- 382
            ..||::::.::...:::...:....:..|||||...|......:..:.||...:.:|:|....  
  Rat   344 KQFYEDMIDIIQATVQQNFDTETDTLYDEILQHSSLCKTYASFYEYKCESLNILHKYILPSKTGH 408

  Fly   383 -KPLVLFGDGGCGKTSLLSKSVSLVATEWF-----AHVRPINVIRFLGTTPDSSALTATLISICQ 441
             .||:::|....|||.||:: |:..|..|.     ....|:.::||||||..|..|...|:|:|:
  Rat   409 INPLIVYGGPCTGKTLLLAE-VAKKAYGWLHEDTGPDSDPVVIVRFLGTTDMSIDLRTLLLSVCE 472

  Fly   442 QISYNYMLPFENIPDDLVPLTAHFKQLLTYASPTQPLTIYLDSVDQLTGTQDSNKVSWIPTRLPP 506
            |::.||....::.|..:..|...|..||..:|..:||.|..|:::||:.|.::.|:.|:|..||.
  Rat   473 QLAVNYRCLVQSFPKKIHDLRDLFINLLNESSLQRPLVIIFDALEQLSETDEARKLWWLPAHLPR 537

  Fly   507 HCKIIISCANEPANPTVSHEYHVLCK---MIDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNN 568
            ..:||:|        |:.:::.:|.|   :|..|:|:||:......:...|:|..:....|.:.:
  Rat   538 FVRIILS--------TLPNKHGILQKLRCLIHEEDNYIELIPRDRKMCSQVLKHQLLRVKRKVTS 594

  Fly   569 YQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERVEKQHGRILVF 633
            .|...|.||.|||:||:||.|.|.|:..|||:....|:.|..||.:||..||..:||:.|:.||.
  Rat   595 GQQIYVNNAFSKCTLPMFVNLTFREVRHWRSHKDVNESSLCVTVHESIEQLFWSLEKKCGQKLVS 659

  Fly   634 HALAYITASKSGLSESELEDLISLDDKVLDDVYQYHLPPT-RRIPPLLWTRIRNDLPNYLSEREA 697
            .||.|||.:|.||||.||||:::||:.|::::.:...|.. .|:|.|...|::..|..||.||..
  Rat   660 RALGYITMAKMGLSEMELEDVLALDNSVMNELIENTRPSNPLRVPYLYIARLKEGLNGYLIERHV 724

  Fly   698 DGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIADYYLGIWGGGVPKPF-------------- 748
            ..|.::.|.:|..:..|::.|.:..:.....|:::|||:||:|.||..|.|              
  Rat   725 KNVTLLVWANRHLQLIAQKLYLQEDSNLREMHTILADYFLGVWSGGRRKAFCLEDPYLNGCLDLE 789

  Fly   749 --KFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRY--NLRKFGELPFHFVRSRRFKDL 809
              ...|.::|..    ::.|.||:.|.||.||.........:  |.||..||.:|..|..:..||
  Rat   790 NRSLLEEEKHFI----EQASFDRQAPDQPWVFQCNPLEPDIFFVNHRKMSELLYHLTRCGKTDDL 850

  Fly   810 FEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKEAKRELMLVSDALRLGGAILAIYPNMLA 874
            ...::.|:.||:..:.......||||.|.|.:.:.:||.|   .|.|....:...::. :|..|:
  Rat   851 LYGIIMNFSWLYTMIKIGQFDKVLADIELAYNYSQEKELK---FLASTLRGIRNKVIT-FPGSLS 911

  Fly   875 PQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCALIPVNHCLHTPGGPLKYSLEG---HQFAVFAF 936
            .:|..||||.:...|.::.||..||:.|||.|:::|::..:.....|.:..|..   |...:...
  Rat   912 AELQQRLLPVVSSLPKLRHLLLECDKDGPKYCSIVPLHSSMDVTYSPERLPLASSHLHVTEILPT 976

  Fly   937 CLTSDMRYMV---SISTHFITFDLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLL 998
            |..|.:...:   |||    |:|:.|..|.|.:... :.::..:.|:.|.|:....:.|| |:|:
  Rat   977 CNPSTVLTALENGSIS----TWDVETRQLLRQITTA-QSVILGMKLTSDEKYLVVATTNN-TLLI 1035

  Fly   999 -----NMLSSEFVVINSPFEESHGPVSGLYLLNQNLFITCKLRWAQFDTRGNLVDTFDVPGENKD 1058
                 :.|.||..:..:    .||. |..|:....|.|...|.|.:               .:||
  Rat  1036 YDNVNSCLLSEVEIKGT----KHGS-SPTYINGFTLSINHALAWLE---------------ASKD 1080

  Fly  1059 WEILTMEFFNPADYNVVFWSGSINDMRLRLDS----CRGGHYSNCQLLFSAMVMNKARTRAYGCA 1119
            ..::.:.:..|. |....|. .:..::..||.    |  |.|.|...:|......|.      |.
  Rat  1081 VTVIDLLYGWPL-YQFHCWY-EVTCVQCSLDGVYAFC--GQYLNNTTIFHLGSGEKI------CT 1135

  Fly  1120 NEENFE------VSVFDFIEDEVTGD-----ICWTLVE-SLPRFEND------DKEMLLQLRLDQ 1166
            ....|.      :.:.|..::.|..|     ..|...: |.|:...|      |.| ::.:.|.:
  Rat  1136 VTSEFSGGFVKFLLILDTAQEMVMIDSEGSLSVWNTEDISSPQLTEDFDCRKEDSE-VVSIELSE 1199

  Fly  1167 HDRMLLGTAGKGFVIWDFGSKDKDAAEECRLREGALYLALPHGVRNITTRIMQSNSIMVSSKLDY 1231
            ....:|........:.|.|.  ...||:.|.|         |..|.|:. ::..|...:.:.::.
  Rat  1200 DQSAILICKALSIELLDTGM--WKVAEKFRAR---------HNERFISA-VLSKNGDCIIATMEN 1252

  Fly  1232 AVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLEPLTIGNWNNLVTSSIDRSVKVWNINNIFEKV 1296
            ..|     ::.|...:||....|....|.|::|  :...:.|.|::.|....:.:|:| :|...:
  Rat  1253 TPA-----VFFWRRDTGQCMASLKEISGTIVKL--VKSSHHNMLLSLSTSGVLSIWDI-DIITAM 1309

  Fly  1297 HVIDRHELQIDDISL---SEVDMAVTVTRSCVGVWETRSGRLLAKLADSPLGAIVTHAEITPDGR 1358
            ..||:....|..:.|   .|:..::..: .||..|...||.:.|.....   .||.|..:|..|.
  Rat  1310 SNIDKTGKPIQSLVLPARGEIIYSLDGS-DCVHKWNFSSGFIEAVFKHE---GIVEHCVLTSAGD 1370

  Fly  1359 YIISS-ETGKFLVWNRVSEQVVFRDDQPGIQQITLMDYGYKVLTVSVPNINQRDILAAAAGGSAD 1422
            .:::| :.....||:..|.:.:||.:...|.|:.:......|:::...|                
  Rat  1371 IMVTSDDKSSQYVWHTSSGENLFRINGQRISQLLITHNDQFVVSLCEEN---------------- 1419

  Fly  1423 EANRLTAITTMRSVPEGSIFFRFEFPIRMITGMPFRQSVITADNAYIVVVTVDK----------- 1476
             |:|:..:.|...|            ..::|.:  :.:.||:.|.::|.:|..|           
  Rat  1420 -ASRVWRLATGHRV------------CNILTTL--QNAFITSANTFVVGMTKSKVLAVSLWTGSI 1469

  Fly  1477 SNKDC----------------------------LGVYSATNGAFVSKVLLKGCSIKEVISLVPMP 1513
            :.|.|                            :.::|.|:.....:|.|....:|.:......|
  Rat  1470 TKKFCCEDGITIVNFKLIPDCPDIIVFITSAETVNLWSLTDEVICRRVQLPSNFLKNLEDFEISP 1534

  Fly  1514 HKANQVAVIS--SEKGSVMDIKTKK----HVRSIAKWGGSITRDGKCGLYAPTRGGLEMLELRKG 1572
            :  .::.:||  .|..:|:|:.:.|    |...:. |...::|||:..:|...:.|.|..|   .
  Rat  1535 N--GKLGIISRGDENINVLDLHSGKLRVVHASGVI-WRQRLSRDGRYLVYICFQNGEEEEE---N 1593

  Fly  1573 TTVKTFIPKVAEGVFSVICIFTENDEYVAYYHSGRKTIRVFRTADTEMIANYRLQAELTAIKSSK 1637
            .||.:.|                                |.|.||.:.|....|....|.:..|:
  Rat  1594 DTVSSLI--------------------------------VMRLADGKNIGACSLYKTPTFLALSQ 1626

  Fly  1638 DGRAIVLGTVDGCMSVLAIVDPKKEEMNEYLNDLPSRDENWKAKLAKMKARVGFKAAIRVATISS 1702
            ....|::|..||.:.:..:||              ..|...|.|:|...:|..|..    ||.:|
  Rat  1627 RHLNIIVGFDDGSIGIYTVVD--------------RVDAALKIKIATSNSRQIFSN----ATQTS 1673

  Fly  1703 RYAKTSKGGEDGEEELLTEITE----DIVVPVAD 1732
            |....|...:...:.|..|.||    |..:.|:|
  Rat  1674 RPKSNSYSFKVSVDCLWRESTEVFARDSPITVSD 1707

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10185NP_650521.1 AAA_16 363..488 CDD:289934 40/132 (30%)
WD40 1177..>1379 CDD:225201 44/205 (21%)
WD40 repeat 1214..1256 CDD:293791 6/41 (15%)
WD40 <1216..1380 CDD:295369 35/167 (21%)
WD40 repeat 1261..1300 CDD:293791 8/38 (21%)
WD40 repeat 1306..1341 CDD:293791 9/37 (24%)
WD40 repeat 1348..1393 CDD:293791 12/45 (27%)
Nwd2XP_038948680.1 AAA_16 394..523 CDD:404141 40/129 (31%)
WD40 <922..1207 CDD:225201 67/321 (21%)
WD40 repeat 1013..1063 CDD:293791 14/55 (25%)
WD40 repeat 1068..1095 CDD:293791 7/42 (17%)
WD40 1100..1435 CDD:225201 75/396 (19%)
WD40 repeat 1102..1137 CDD:293791 9/42 (21%)
WD40 repeat 1145..1184 CDD:293791 7/38 (18%)
WD40 repeat 1278..1324 CDD:293791 10/48 (21%)
WD40 repeat 1361..1393 CDD:293791 7/31 (23%)
WD40 repeat 1444..1469 CDD:293791 6/24 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 352 1.000 Domainoid score I980
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H14974
Inparanoid 1 1.050 352 1.000 Inparanoid score I2196
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D14491at33208
OrthoFinder 1 1.000 - - FOG0006917
OrthoInspector 1 1.000 - - oto96080
orthoMCL 1 0.900 - - OOG6_103490
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X4387
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
98.870

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