DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10185 and NWD1

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_011526231.1	Gene:	NWD1 / 284434	HGNCID:	27619	Length:	1564	Species:	Homo sapiens

Alignment Length:	1792	Identity:	433/1792 - (24%)
Similarity:	717/1792 - (40%)	Gaps:	427/1792 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 KCYPRIKDYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKY 110
            ||    :.:| ::|||.|:|||:|||:|:....||:|||||:.|:..|.:.|:||.|:..:|.:|
Human    14 KC----QTFC-QRHGLMFEVVDLRWGIRNIEATDHLTTELCLEEVDRCWKTSIGPAFVALIGDQY 73

  Fly   111 GYRPIPTYIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVP- 174
            |...||:.|...|..::.:.||:...|..::..::::|.||.||..|||             .|
Human    74 GPCLIPSRIDEKEWEVLRDHLTARPSDLELVARYFQRDENAFPPTYVLQ-------------APG 125

  Fly   175 ---KLQAEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGILNVKNTK 236
               ..:.|:..        :..:||..|........:::|...:|..||.|.|:...:|:.::.:
Human   126 TGEACEPEEAT--------LTSVLRSGAQEARRLGLITQEQWQHYHRSVIEWEIERSLLSSEDRE 182

  Fly   237 NHCLSYVRYINNINLQNLKKASL-FVD-IINRSLDTESAKLLSDLR----DV--------RLPAK 287
            .....::|.|.:::...|:..:| .|| :.:..||.::..|||.|:    |:        |||..
Human   183 QGATVFLREIQDLHKHILEDCALRMVDRLADGCLDADAQNLLSSLKSHITDMHPGVLKTHRLPWS 247

  Fly   288 IEAVNAQKYTVEWIGREGLDIETHEEYLNHFISHFYKNVVKLVDRAMRKEDSSAQ--GQIVTEIL 350
            .:.||.:.             :||..||......|.......|...:|:.|::.|  ..:..||.
Human   248 RDLVNPKN-------------KTHACYLKELGEQFVVRANHQVLTRLRELDTAGQELAWLYQEIR 299

  Fly   351 QHLHACNNSVKIFYGREESCERIKRYMLGDSDK---PLVLFGDGGCGKTSLLSKSVSLVATEWFA 412
            .||...:..::.|.||:|...|:.:.:..|..|   ||||||..|.|||:|:.|....: .....
Human   300 HHLWQSSEVIQTFCGRQELLARLGQQLRHDDSKQHTPLVLFGPPGIGKTALMCKLAEQM-PRLLG 363

  Fly   413 HVRPINVIRFLGTTPDSSALTATLISICQQISYNYMLPFENIPDDLVPLTAH------FKQLLTY 471
            | :.:.|:|.|||:..||.....|.|||.|:...|.||   :|...| |.||      |..||..
Human   364 H-KTVTVLRLLGTSQMSSDARGLLKSICFQVCLAYGLP---LPPAQV-LDAHTRVVQFFHTLLHT 423

  Fly   472 AS--PTQPLTIYLDSVDQLTGTQDSNKVSWIPTRLPPHCKIIISCANEPANPTVSHEYHVLCKMI 534
            .|  ..:.|.:.||::|.|...:.:.:|.|:|...||...:|:|..:....     ....|.:::
Human   424 VSCRNFESLVLLLDAMDDLDSVRHARRVPWLPLNCPPRVHLILSACSGALG-----VLDTLQRVL 483

  Fly   535 DVEENFIEVTALGEDLAMNVIKMWMKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRS 599
            ...|.:.||..|..:....:|::.:..|.|.|:.....|:..::.:|..|..::|.|.|..:|.|
Human   484 LDPEAYWEVKPLSGNQGQQMIQLLLAAARRTLSPVHTDLLWASLPECGNPGRLRLAFEEARKWAS 548

  Fly   600 YTRPQETHLANTVMDSIMLLFERVEKQHGRILVFHALAYITASKSGLSESELEDLISLDDKVLDD 664
            :|.|  ..||.|..::...|..|:|:.||::||.|.|.||.:|:.||||:||:|::||||:||.|
Human   549 FTVP--VPLATTAEEATHQLCTRLEQTHGQLLVAHVLGYIVSSRHGLSEAELKDVLSLDDEVLQD 611

  Fly   665 VYQYHLPPTR---RIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNMNMAI 726
            ||:...||::   |.|||||.|:|.||..||:.|..||..::...|||..:..:|||......|
Human   612 VYRDWTPPSKELLRFPPLLWVRLRRDLGYYLARRPVDGFTLLAIAHRQLVEVVRERYLSGSERA- 675

  Fly   727 YFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRYNLR 791
            ..|.::||::.|.|..|..|.....        |..|..:.||||..|||.||....     |||
Human   676 KRHGVLADFFSGTWSQGTKKLITLP--------LVGKPLNLDRKVAPQPLWFSHTVA-----NLR 727

  Fly   792 KFGELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKE---AKRELM 853
            |..|||:|.:.|.|.::|.:.||.:..|:..:..|..::.:|.||:..:.:.|..|   .:..|.
Human   728 KLKELPYHLLHSGRLEELKQEVLGSMSWISCRGISGGIEDLLDDFDLCAPHLDSPEVGLVREALQ 792

  Fly   854 LVSDALRLGGAILA-IYPNMLA---------PQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCA- 907
            |...|:.|.|...: :|..:||         |.|||:|..:.              :|..:.||
Human   793 LCRPAVELRGMERSLLYTELLARLHFFATSHPALVGQLCQQA--------------QSWFQLCAH 843

  Fly   908 --LIPVNHCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSISTHFITFDLSTSDLTRDVNPGI 970
              |:|:...|..|||||:.:|.|....:.|.....:.:.:|          :.|.|
Human   844 PVLVPLGGFLQPPGGPLRATLSGCHKGITAMAWGVEEKLLV----------IGTQD--------- 889

  Fly   971 EGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSEFVVINSPFEESHGPVSGLYLLNQNLFITCKL 1035
             |||            |.:....|.| ::||:..                           |.::
Human   890 -GIM------------AVWDMEEQHV-IHMLTGH---------------------------TGEV 913

  Fly  1036 RWAQFDTRGNLVDTFDVPGENKD-----WEILT-MEFF--------NPADYNVVFWSGSINDMRL 1086
            |..:...:|.|.::     .:||     |.:|: .|.|        |||:..:  |:       |
Human   914 RCVKIFAKGTLANS-----ASKDYTLHLWNLLSGQEKFTIWDGGSKNPAEPQI--WN-------L 964

  Fly  1087 RLDSCRGGHYSNCQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDICWTLVESLPRF 1151
            .:|...       ::::||   :.::..|:.....|    .||..:.|.....:|..::.|
Human   965 HVDEAH-------KVVYSA---SGSKINAWNLETAE----PVFHILGDASDPWMCMAVLAS---- 1011

  Fly  1152 ENDDKEMLLQLRLDQHDRMLLGTAGKGFV-IWDFG----------SKDKDAAEECRL---REGAL 1202
                            ...||..:..|.| :|...          |..|:....|.:   ::|.|
Human  1012 ----------------QATLLTVSRDGVVSLWSSATGKLQGKQHMSSIKEETPTCAVSVQKQGKL 1060

  Fly  1203 YLALPHGVRNITT----RIMQS-----NSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHF 1258
            .....:|..::.:    |:::.     ..::||.......||..:::.::...|....:.:....
Human  1061 VTGFSNGSISLVSSKGDRLLEKLPDAVRFLVVSEDESLLAAGFGRSVRIFLADSRGFRRFMAMDL 1125

  Fly  1259 GRIIQLEPLTIGNWNNL-VTSSIDRSVKVWNINNIFEKVHVIDRHELQIDDISLSEVDMAVTVT- 1321
            .....:|....|..||| :|.|:|..::||:::   |:..::|..|.....:||.....|:..:
Human  1126 EHEDMVETAVFGTENNLIITGSLDALIQVWSLS---EQGTLLDILEGVGAPVSLLARGGALVASA 1187

  Fly  1322 ---RSCVGVW---ETRSGRLLAKLADSPLGAIVTHAEITPDGRYIISSETG---KFLVWN----- 1372
               .|...||   :....|:.|...|......|:|     :|.|:...:.|   |..:|:
Human  1188 SPQSSSFKVWDLSDAHRSRVPAPFLDRTGLTAVSH-----NGSYVYFPKIGDKNKVTIWDLAEGE 1247

  Fly  1373 --------------RVSEQ--VVFRDDQPGIQQITLMDYGYKVLTVSVPNINQ----------RD 1411
                          .|:||  ::|.....|:..:..::....|:.:..|...:          .|
Human  1248 EQDSLDTSSEIRCLEVAEQRKLLFTGLVSGVVLVFPLNSRQDVICIPPPEARKAINCMSLSKCED 1312

  Fly  1412 ILAAAAGGSADEANRLTAITTMRSVP--EGSIFFRFEFPIRMITGMPFRQSVITADNAYIVVVTV 1474
            .||.|    .|....:..||:....|  :|.   |:.|    .|.:|...|.:.....|.|
Human  1313 RLAIA----YDNIVLVLDITSGDPCPVIDGP---RYTF----YTQLPETLSSVAILTDYRV---- 1362

  Fly  1475 DKSNKDCLGVYSATNGAFVSKVLLKGCSIKEV---------ISLVPMPHKANQVAVISSEKGSVM 1530
                     |||.|||    .:.|..|:..:.         ::.|.:.|| .|:.|..||..
Human  1363 ---------VYSMTNG----DLFLYECATSKAFPLETHRSRVACVEVSHK-EQLVVSGSEDA--- 1410

  Fly  1531 DIKTKKHVRSIAKWGGSITRDGKCGLYAPTRGGLEMLELRKGTTVKTFIPKVAEGVFSVICIFTE 1595
                     .:..|.                     |:.||.....::......|| ...| |::
Human  1411 ---------LLCLWD---------------------LQARKWKFEMSYTSSYCRGV-QCAC-FSK 1443

  Fly  1596 NDEYVAYYHSGRKTIRVFRTADTEMIANYRLQAELTAIKSSKDGRAIVLGTVDG--------CMS 1652
            :|:|| |.....::|.|:...|..::....:.|.:..|..:..|  .:..|..|        |:|
Human  1444 DDKYV-YVGLKDRSILVWSVLDGTLLTVQFVHAVVNRIIPTTSG--FIAPTRHGYLIRENFQCLS 1505

  Fly  1653 VLAI-VDPKKEEMNEYLNDLPSRDENWKAKLAKMKAR 1688
            ..|. .||.|               |:|..:..:|:|
Human  1506 AKASPQDPLK---------------NFKKAMWMVKSR 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934	48/135 (36%)
		WD40	1177..>1379	CDD:225201	47/256 (18%)
		WD40 repeat	1214..1256	CDD:293791	6/50 (12%)
		WD40	<1216..1380	CDD:295369	38/200 (19%)
		WD40 repeat	1261..1300	CDD:293791	11/39 (28%)
		WD40 repeat	1306..1341	CDD:293791	8/41 (20%)
		WD40 repeat	1348..1393	CDD:293791	12/68 (18%)
NWD1	XP_011526231.1	AAA	314..>399	CDD:99707	32/86 (37%)
		WD40	860..1156	CDD:295369	66/403 (16%)
		WD40 repeat	871..908	CDD:293791	12/69 (17%)
		WD40	906..1286	CDD:225201	77/462 (17%)
		WD40 repeat	914..952	CDD:293791	9/42 (21%)
		WD40 repeat	961..996	CDD:293791	9/57 (16%)
		WD40 repeat	1004..1041	CDD:293791	7/56 (13%)
		WD40 repeat	1087..1124	CDD:293791	5/36 (14%)
		WD40	1127..1461	CDD:295369	81/406 (20%)
		WD40 repeat	1131..1155	CDD:293791	8/23 (35%)
		WD40 repeat	1259..1297	CDD:293791	6/37 (16%)
		WD40 repeat	1302..1337	CDD:293791	8/38 (21%)
		WD40 repeat	1352..1383	CDD:293791	11/47 (23%)
		WD40 repeat	1391..1429	CDD:293791	11/71 (15%)
		WD40 repeat	1436..1462	CDD:293791	9/28 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3602
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14491at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103490
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3466
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750