DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10185 and Tep1

DIOPT Version :10

Sequence 1:NP_650521.1 Gene:CG10185 / 41953 FlyBaseID:FBgn0038397 Length:1732 Species:Drosophila melanogaster
Sequence 2:NP_033377.1 Gene:Tep1 / 21745 MGIID:109573 Length:2629 Species:Mus musculus


Alignment Length:2013 Identity:379/2013 - (18%)
Similarity:653/2013 - (32%) Gaps:668/2013 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ESLP----PVSS---KIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCRE-KHGLEFQVVDMRWG 71
            |::|    |:|.   :.:|:|.||||.|...||:.||....|.::  .|. .|.:....:|:|||
Mouse   891 ENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQ--ARVFPHRISLHAIDLRWG 953

  Fly    72 VRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGV 136
            :.:|.|..:...|:|:.|::|.|.      |:..||.:|||.| |:|                  
Mouse   954 ITEEETRRNRQLEVCLGEVENSQL------FVGILGSRYGYIP-PSY------------------ 993

  Fly   137 DRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAAS 201
                 ||                                  .:.....|                
Mouse   994 -----DL----------------------------------PDHPHFHW---------------- 1003

  Fly   202 LGASNKMSKEDVHNY--FMSVTEREVINGILNVKNTKNHCLSYVRYINNINLQNLKKASLFVDII 264
                       .|.|  ..||||.||:. .||...........:.|..:.:..:....:...|.|
Mouse  1004 -----------THEYPSGRSVTEMEVMQ-FLNRGQRSQPSAQALIYFRDPDFLSSVPDAWKPDFI 1056

  Fly   265 NRSLDTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHEEY---LNHFISHFYKNV 326
            :.|  .|:|..:|:|:  |...:.:.|..:.|:.||.|     :.....|   |..|.....::|
Mouse  1057 SES--EEAAHRVSELK--RYLHEQKEVTCRSYSCEWGG-----VAAGRPYTGGLEEFGQLVLQDV 1112

  Fly   327 VKLVDR-------AMRKEDSSAQGQIVTEILQHLHACNNSVKIFYGREESCERIKRYMLGDSDKP 384
            ..::.:       .:.:..|.::..::....|.|....:..             :..:|.|:.:.
Mouse  1113 WSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPA-------------RPRLLQDTVQQ 1164

  Fly   385 LVL--------FGDGGCGKTSLLSKSVSLVATEWFAHVRPINVIRFLGTTPDSSALTATLISICQ 441
            |:|        .|..|.|||:.|:..||.:......:..|.....|....||.......|..:|.
Mouse  1165 LLLPHGRLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLALNLLRRLCT 1229

  Fly   442 QISYNYMLPFENIPDDLVPLTAHFKQ--LLTYA---SPTQPLTIYLDSVDQLTGTQDSNKVSWIP 501
            .:... :.....:|.....|....:|  ||.:|   .|.|.|.:.:|..|:|..........|||
Mouse  1230 HLRQK-LGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQTLVLIIDGADKLVDRNGQLISDWIP 1293

  Fly   502 TRLPPHCKIIISCANEPA-NPTVSHEYHVLCKMIDVEENFIEVTALGE-------DLAMNVIKMW 558
            ..||....:::|.:::.. ..|:.            :.....|.|||.       .|....:.::
Mouse  1294 KSLPRRVHLVLSVSSDSGLGETLQ------------QSQGAYVVALGSLVPSSRAQLVREELALY 1346

  Fly   559 MKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERV 623
            .|.......|.|.||:. |....|||:::.||...:..:..|.:..|.  ..|:..::.||.:.:
Mouse  1347 GKRLEESPFNNQMRLLL-AKQGSSLPLYLHLVTDYLRLFTLYEQVSER--LRTLPATLPLLLQHI 1408

  Fly   624 ----EKQHGRILVFHALAYITASKSGLSESELEDLISL------DDKVLDDVY--QYHLPPTRRI 676
                |::||..::..||..:..::|||:..:|..::|.      :.|..::|.  .:...|....
Mouse  1409 LSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHSGNPFPLC 1473

  Fly   677 P-PLLWTRIRNDLPNYLSERE------ADGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIAD 734
            | ..|...:|:.|.....||.      :||         ..|.|.|.||.|.:.:....|.:|| 
Mouse  1474 PFAYLVQSLRSLLGEGPVERPGARLCLSDG---------PLRTTIKRRYGKRLGLEKTAHVLIA- 1528

  Fly   735 YYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSAD-RKVPIQPLVFSSKDGLSKRYNLRKFGELPF 798
                                .|.:...|.:.|.. |..|.:.|    ||             ||:
Mouse  1529 --------------------AHLWKTCDPDASGTFRSCPPEAL----KD-------------LPY 1556

  Fly   799 HFVRSRRFKDLFE-----HVLFNYDWLHAKLSSCPLQA-VLADFEDASSNTDDKEAKRELMLVSD 857
            |.::|.....|.|     ||:..|  |...|....|:| ||  :..:....:.|....::.:...
Mouse  1557 HLLQSGNHGLLAEFLTNLHVVAAY--LEVGLVPDLLEAHVL--YASSKPEANQKLPAADVAVFHT 1617

  Fly   858 ALRLGGAILAIYPNMLAPQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCALIPVNHCLHTPGGPL 922
            .||...::|..||.:|..|...:  ||                ..|..|.            .||
Mouse  1618 FLRQQASLLTQYPLLLLQQAASQ--PE----------------ESPVCCQ------------APL 1652

  Fly   923 KYSLEGHQFAVFAFCLTSDMRYMVSISTHFITFDLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAA 987
            .......||.:........::...|:|            ||...:|                .|.
Mouse  1653 LTQRWHDQFTLKWINKPQTLKGQQSLS------------LTMSSSP----------------TAV 1689

  Fly   988 AYSNNNQTVLLNMLSSEFVVIN-SPFEESHGPVSG-------LYLLNQNLFIT------------ 1032
            |:|.|.|...:...|....::| ..::|....|||       .:|.:..||:|            
Mouse  1690 AFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTTFDGHLELWDLQ 1754

  Fly  1033 --CKLRWAQFDTRGN--------------LVDTFDVPGENKDWEI----LTMEFFNPADYNVV-- 1075
              |   |. |.|:.:              |:.|..:.|..|.|:.    |..::.:|...|.|  
Mouse  1755 HGC---WV-FQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYTHPKSLNCVAF 1815

  Fly  1076 ----------FWSGSINDMR---LRLDSCRGG-HYSNCQLLFSAMVMNK---------------- 1110
                      .|:|||...:   |::....|. ..|.|.|.|     ||                
Mouse  1816 HPEGQVVATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAF-----NKPGKIVAVGRIDGTVEL 1875

  Fly  1111 ------ARTRAY----GCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEML------ 1159
                  ||..|:    ||       ||...|:.   .||...|..|       |.|..|      
Mouse  1876 WAWQEGARLAAFPAQCGC-------VSAVLFLH---AGDRFLTAGE-------DGKAQLWSGFLG 1923

  Fly  1160 --------------LQLRLD-QHDRMLLGTAGKGFVIWDFGSKDKDAA-EECRLREGALYLALPH 1208
                          |.:.|: ..|::.:|....|..|:...|..:... :|..:...||      
Mouse  1924 RPRGCLGSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSAL------ 1982

  Fly  1209 GVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAK--VLDAHFGRIIQLEPLTIGN 1271
                    :..|.|::||...|.::.|       |..:...|..  :|..:...::.|    ..:
Mouse  1983 --------VWLSPSVLVSGAEDGSLHG-------WMFKGDSLHSLWLLSRYQKPVLGL----AAS 2028

  Fly  1272 WNNLVTSSIDRSVKVWNINNIFE-KVHVID--------RHE-----------------------L 1304
            ...:..:|.|.:|::|....:.: .||.::        .||                       |
Mouse  2029 RELMAAASEDFTVRLWPRQLLTQPHVHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNL 2093

  Fly  1305 QIDDISLSEVDMAVTVTRSC------------------------VGVWETRSGRLLAKLA--DSP 1343
            ...|:.:::..:.:....||                        ||:|...:|:.|.:.:  .|.
Mouse  2094 LCWDMKIAQAPLLIHTFSSCHRDWITGCAWTKDNILVSCSSDGSVGLWNPEAGQQLGQFSGHQSA 2158

  Fly  1344 LGAIVTHAEITPDGRYIIS-SETGKFLVWNR--------------VSEQVVFRDDQPGIQQITLM 1393
            :.|:|...|      :|:| |..|...||:.              :|:.....:.:||.|.    
Mouse  2159 VSAVVAVEE------HIVSVSRDGTLKVWDHQGVELTSIPAHSGPISQCAAALEPRPGGQP---- 2213

  Fly  1394 DYGYKVLTVSVPNINQRDILAAAAGGSADEANRL---TAITTMRSVPEGSIFFRFEFPIRMITGM 1455
              |.::|.|:|               ..|.|.:|   ..:..:|::...|      .|:......
Mouse  2214 --GSELLVVTV---------------GLDGATKLWHPLLVCQIRTLQGHS------GPVTAAAAS 2255

  Fly  1456 PFRQSVITADNAYIVVVTVDKSNKDCLGVYSATNGAFVSKV--------LLKGCSIKEV------ 1506
            .....::|:|::.:.:..:.|...|.   |...:...::.|        ::.|....|:      
Mouse  2256 EASGLLLTSDDSSVQLWQIPKEADDS---YKPRSSVAITAVAWAPDGSMVVSGNEAGELTLWQQA 2317

  Fly  1507 --ISLVPMP--------HKANQVAVISS-----------EKGSVMDIKTKKHVRSIAK--WGG-- 1546
              ::....|        :.||...|:|:           .|||. ...:..|::.:.:  ||.  
Mouse  2318 KAVATAQAPGRVSHLIWYSANSFFVLSANENVSEWQVGLRKGST-STSSSLHLKRVLQEDWGVLT 2381

  Fly  1547 --SITRDGKCGLYAPTRGGLEMLELRKGTTVKTFIPKVAEGVF-SVICIFTENDEYVAYY----H 1604
              .:..||:..:.  .:..:|:||::.|:...:...:.  ||. |::|   .:.||..:|    .
Mouse  2382 GLGLAPDGQSLIL--MKEDVELLEMKPGSIPSSICRRY--GVHSSILC---TSKEYGLFYLQQGD 2439

  Fly  1605 SGRKTI-RVFRTADTEMIANYRLQ--------AELTAIKSSKDGRAIVLGTVDGCMSVLA----- 1655
            ||..:| ....:.:.|.|.::.|.        ..:|..|...:. :::..|.||.:..|:     
Mouse  2440 SGLLSILEQKESGEFEEILDFNLNLNNPNGSPVSITQAKPESES-SLLCATSDGMLWNLSECTSE 2503

  Fly  1656 ---IVD---------PKKEEMNEYLNDLPSRD---------ENWKAKLAKMKARVGFKAAIRV 1697
               |||         ||.:.:...|:.....|         .|.||:..| |..:|...|:.|
Mouse  2504 GEWIVDNIWQKKAKKPKTQTLETELSPHSELDFSIDCWIDPTNLKAQQCK-KIHLGSVTALHV 2565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10185NP_650521.1 P-loop containing Nucleoside Triphosphate Hydrolases 384..>514 CDD:476819 33/142 (23%)
WD40 repeat 1214..1256 CDD:293791 9/43 (21%)
WD40 <1232..1422 CDD:441893 40/264 (15%)
WD40 repeat 1261..1300 CDD:293791 7/39 (18%)
WD40 repeat 1306..1341 CDD:293791 8/60 (13%)
WD40 repeat 1348..1393 CDD:293791 12/59 (20%)
Tep1NP_033377.1 TEP1 N-terminal 1 1..30
TEP1_N 1..29 CDD:428450
TEP1 N-terminal 2 31..60
TEP1_N 31..59 CDD:428450
TEP1 N-terminal 3 61..90
TEP1_N 61..89 CDD:428450
TEP1 N-terminal 4 91..120
TEP1_N 91..119 CDD:428450
TROVE 230..685 CDD:461724
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..412
DUF5920 696..898 CDD:466045 2/6 (33%)
DUF4062 909..1017 CDD:463823 43/200 (22%)
NACHT 1031..>1466 CDD:444362 91/472 (19%)
NACHT 1171..1346 CDD:428606 38/187 (20%)
WD 1 1420..1462 9/41 (22%)
WD 2 1681..1720 10/54 (19%)
WD40 1683..2099 CDD:441893 86/482 (18%)
WD40 repeat 1687..1723 CDD:293791 8/35 (23%)
WD 3 1723..1761 8/41 (20%)
WD40 repeat 1729..1764 CDD:293791 8/38 (21%)
WD 4 1764..1803 6/38 (16%)
WD40 repeat 1769..1804 CDD:293791 6/34 (18%)
WD 5 1805..1844 8/38 (21%)
WD40 repeat 1811..1847 CDD:293791 7/35 (20%)
WD 6 1847..1886 8/43 (19%)
WD40 repeat 1852..1887 CDD:293791 7/39 (18%)
WD40 1856..2275 CDD:441893 81/498 (16%)
WD 7 1889..1930 12/57 (21%)
WD40 repeat 1895..1930 CDD:293791 9/44 (20%)
WD 8 1932..1971 7/38 (18%)
WD40 repeat 1937..2066 CDD:293791 26/153 (17%)
WD 9 1974..2013 11/59 (19%)
WD40 repeat 1979..2014 CDD:293791 10/55 (18%)
WD 10 2015..2054 6/42 (14%)
WD 11 2067..2106 4/38 (11%)
WD40 repeat 2072..2111 CDD:293791 2/38 (5%)
WD 12 2113..2151 6/37 (16%)
WD40 repeat 2118..2141 CDD:293791 2/22 (9%)
WD 13 2154..2191 10/42 (24%)
WD40 repeat 2159..2190 CDD:293791 9/36 (25%)
WD 14 2193..2241 11/68 (16%)
WD40 repeat 2198..2243 CDD:293791 12/65 (18%)
WD 15 2244..2282 6/46 (13%)
WD40 repeat 2250..2272 CDD:293791 2/21 (10%)
WD 16 2285..2324 3/38 (8%)
WD40 repeat 2290..2322 CDD:293791 3/31 (10%)
WD 17 2326..2362 8/36 (22%)
WD40 repeat 2330..2374 CDD:293791 8/44 (18%)
WD 18 2375..2424 11/52 (21%)
WD40 repeat 2380..2410 CDD:293791 6/31 (19%)
WD40 repeat 2420..2465 CDD:293791 11/47 (23%)
WD 19 2467..2507 6/40 (15%)
WD40 repeat 2472..2495 CDD:293791 5/23 (22%)
WD 20 2555..2592 3/11 (27%)
WD 21 2594..2628
Blue background indicates that the domain is not in the aligned region.

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