DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10185 and Tep1

DIOPT Version :9

Sequence 1:NP_650521.1 Gene:CG10185 / 41953 FlyBaseID:FBgn0038397 Length:1732 Species:Drosophila melanogaster
Sequence 2:NP_033377.1 Gene:Tep1 / 21745 MGIID:109573 Length:2629 Species:Mus musculus


Alignment Length:2013 Identity:379/2013 - (18%)
Similarity:653/2013 - (32%) Gaps:668/2013 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ESLP----PVSS---KIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCRE-KHGLEFQVVDMRWG 71
            |::|    |:|.   :.:|:|.||||.|...||:.||....|.::  .|. .|.:....:|:|||
Mouse   891 ENIPGPLGPISQHGWRNIRLFISSTFRDMHGERDLLMRSVLPALQ--ARVFPHRISLHAIDLRWG 953

  Fly    72 VRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGV 136
            :.:|.|..:...|:|:.|::|.|.      |:..||.:|||.| |:|                  
Mouse   954 ITEEETRRNRQLEVCLGEVENSQL------FVGILGSRYGYIP-PSY------------------ 993

  Fly   137 DRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAAS 201
                 ||                                  .:.....|                
Mouse   994 -----DL----------------------------------PDHPHFHW---------------- 1003

  Fly   202 LGASNKMSKEDVHNY--FMSVTEREVINGILNVKNTKNHCLSYVRYINNINLQNLKKASLFVDII 264
                       .|.|  ..||||.||:. .||...........:.|..:.:..:....:...|.|
Mouse  1004 -----------THEYPSGRSVTEMEVMQ-FLNRGQRSQPSAQALIYFRDPDFLSSVPDAWKPDFI 1056

  Fly   265 NRSLDTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHEEY---LNHFISHFYKNV 326
            :.|  .|:|..:|:|:  |...:.:.|..:.|:.||.|     :.....|   |..|.....::|
Mouse  1057 SES--EEAAHRVSELK--RYLHEQKEVTCRSYSCEWGG-----VAAGRPYTGGLEEFGQLVLQDV 1112

  Fly   327 VKLVDR-------AMRKEDSSAQGQIVTEILQHLHACNNSVKIFYGREESCERIKRYMLGDSDKP 384
            ..::.:       .:.:..|.::..::....|.|....:..             :..:|.|:.:.
Mouse  1113 WSMIQKQHLQPGAQLEQPTSISEDDLIQTSFQQLKTPTSPA-------------RPRLLQDTVQQ 1164

  Fly   385 LVL--------FGDGGCGKTSLLSKSVSLVATEWFAHVRPINVIRFLGTTPDSSALTATLISICQ 441
            |:|        .|..|.|||:.|:..||.:......:..|.....|....||.......|..:|.
Mouse  1165 LLLPHGRLSLVTGQAGQGKTAFLASLVSALKVPDQPNEPPFVFFHFAAARPDQCLALNLLRRLCT 1229

  Fly   442 QISYNYMLPFENIPDDLVPLTAHFKQ--LLTYA---SPTQPLTIYLDSVDQLTGTQDSNKVSWIP 501
            .:... :.....:|.....|....:|  ||.:|   .|.|.|.:.:|..|:|..........|||
Mouse  1230 HLRQK-LGELSALPSTYRGLVWELQQKLLLKFAQSLQPAQTLVLIIDGADKLVDRNGQLISDWIP 1293

  Fly   502 TRLPPHCKIIISCANEPA-NPTVSHEYHVLCKMIDVEENFIEVTALGE-------DLAMNVIKMW 558
            ..||....:::|.:::.. ..|:.            :.....|.|||.       .|....:.::
Mouse  1294 KSLPRRVHLVLSVSSDSGLGETLQ------------QSQGAYVVALGSLVPSSRAQLVREELALY 1346

  Fly   559 MKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLFERV 623
            .|.......|.|.||:. |....|||:::.||...:..:..|.:..|.  ..|:..::.||.:.:
Mouse  1347 GKRLEESPFNNQMRLLL-AKQGSSLPLYLHLVTDYLRLFTLYEQVSER--LRTLPATLPLLLQHI 1408

  Fly   624 ----EKQHGRILVFHALAYITASKSGLSESELEDLISL------DDKVLDDVY--QYHLPPTRRI 676
                |::||..::..||..:..::|||:..:|..::|.      :.|..::|.  .:...|....
Mouse  1409 LSTLEQEHGHDVLPQALTALEVTRSGLTVDQLHAILSTWLILPKETKSWEEVLAASHSGNPFPLC 1473

  Fly   677 P-PLLWTRIRNDLPNYLSERE------ADGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIAD 734
            | ..|...:|:.|.....||.      :||         ..|.|.|.||.|.:.:....|.:|| 
Mouse  1474 PFAYLVQSLRSLLGEGPVERPGARLCLSDG---------PLRTTIKRRYGKRLGLEKTAHVLIA- 1528

  Fly   735 YYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSAD-RKVPIQPLVFSSKDGLSKRYNLRKFGELPF 798
                                .|.:...|.:.|.. |..|.:.|    ||             ||:
Mouse  1529 --------------------AHLWKTCDPDASGTFRSCPPEAL----KD-------------LPY 1556

  Fly   799 HFVRSRRFKDLFE-----HVLFNYDWLHAKLSSCPLQA-VLADFEDASSNTDDKEAKRELMLVSD 857
            |.::|.....|.|     ||:..|  |...|....|:| ||  :..:....:.|....::.:...
Mouse  1557 HLLQSGNHGLLAEFLTNLHVVAAY--LEVGLVPDLLEAHVL--YASSKPEANQKLPAADVAVFHT 1617

  Fly   858 ALRLGGAILAIYPNMLAPQLVGRLLPEIGGNPNIKMLLRACDRSGPKDCALIPVNHCLHTPGGPL 922
            .||...::|..||.:|..|...:  ||                ..|..|.            .||
Mouse  1618 FLRQQASLLTQYPLLLLQQAASQ--PE----------------ESPVCCQ------------APL 1652

  Fly   923 KYSLEGHQFAVFAFCLTSDMRYMVSISTHFITFDLSTSDLTRDVNPGIEGIMQQLVLSPDNKWAA 987
            .......||.:........::...|:|            ||...:|                .|.
Mouse  1653 LTQRWHDQFTLKWINKPQTLKGQQSLS------------LTMSSSP----------------TAV 1689

  Fly   988 AYSNNNQTVLLNMLSSEFVVIN-SPFEESHGPVSG-------LYLLNQNLFIT------------ 1032
            |:|.|.|...:...|....::| ..::|....|||       .:|.:..||:|            
Mouse  1690 AFSPNGQRAAVGTASGTIYLLNLKTWQEEKAVVSGCDGISSFAFLSDTALFLTTFDGHLELWDLQ 1754

  Fly  1033 --CKLRWAQFDTRGN--------------LVDTFDVPGENKDWEI----LTMEFFNPADYNVV-- 1075
              |   |. |.|:.:              |:.|..:.|..|.|:.    |..::.:|...|.|  
Mouse  1755 HGC---WV-FQTKAHQYQITGCCLSPDRRLLATVCLGGYLKLWDTVRGQLAFQYTHPKSLNCVAF 1815

  Fly  1076 ----------FWSGSINDMR---LRLDSCRGG-HYSNCQLLFSAMVMNK---------------- 1110
                      .|:|||...:   |::....|. ..|.|.|.|     ||                
Mouse  1816 HPEGQVVATGSWAGSITFFQADGLKVTKELGAPGPSVCSLAF-----NKPGKIVAVGRIDGTVEL 1875

  Fly  1111 ------ARTRAY----GCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEML------ 1159
                  ||..|:    ||       ||...|:.   .||...|..|       |.|..|      
Mouse  1876 WAWQEGARLAAFPAQCGC-------VSAVLFLH---AGDRFLTAGE-------DGKAQLWSGFLG 1923

  Fly  1160 --------------LQLRLD-QHDRMLLGTAGKGFVIWDFGSKDKDAA-EECRLREGALYLALPH 1208
                          |.:.|: ..|::.:|....|..|:...|..:... :|..:...||      
Mouse  1924 RPRGCLGSLPLSPALSVALNPDGDQVAVGYREDGINIYKISSGSQGPQHQELNVAVSAL------ 1982

  Fly  1209 GVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAK--VLDAHFGRIIQLEPLTIGN 1271
                    :..|.|::||...|.::.|       |..:...|..  :|..:...::.|    ..:
Mouse  1983 --------VWLSPSVLVSGAEDGSLHG-------WMFKGDSLHSLWLLSRYQKPVLGL----AAS 2028

  Fly  1272 WNNLVTSSIDRSVKVWNINNIFE-KVHVID--------RHE-----------------------L 1304
            ...:..:|.|.:|::|....:.: .||.::        .||                       |
Mouse  2029 RELMAAASEDFTVRLWPRQLLTQPHVHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNL 2093

  Fly  1305 QIDDISLSEVDMAVTVTRSC------------------------VGVWETRSGRLLAKLA--DSP 1343
            ...|:.:::..:.:....||                        ||:|...:|:.|.:.:  .|.
Mouse  2094 LCWDMKIAQAPLLIHTFSSCHRDWITGCAWTKDNILVSCSSDGSVGLWNPEAGQQLGQFSGHQSA 2158

  Fly  1344 LGAIVTHAEITPDGRYIIS-SETGKFLVWNR--------------VSEQVVFRDDQPGIQQITLM 1393
            :.|:|...|      :|:| |..|...||:.              :|:.....:.:||.|.    
Mouse  2159 VSAVVAVEE------HIVSVSRDGTLKVWDHQGVELTSIPAHSGPISQCAAALEPRPGGQP---- 2213

  Fly  1394 DYGYKVLTVSVPNINQRDILAAAAGGSADEANRL---TAITTMRSVPEGSIFFRFEFPIRMITGM 1455
              |.::|.|:|               ..|.|.:|   ..:..:|::...|      .|:......
Mouse  2214 --GSELLVVTV---------------GLDGATKLWHPLLVCQIRTLQGHS------GPVTAAAAS 2255

  Fly  1456 PFRQSVITADNAYIVVVTVDKSNKDCLGVYSATNGAFVSKV--------LLKGCSIKEV------ 1506
            .....::|:|::.:.:..:.|...|.   |...:...::.|        ::.|....|:      
Mouse  2256 EASGLLLTSDDSSVQLWQIPKEADDS---YKPRSSVAITAVAWAPDGSMVVSGNEAGELTLWQQA 2317

  Fly  1507 --ISLVPMP--------HKANQVAVISS-----------EKGSVMDIKTKKHVRSIAK--WGG-- 1546
              ::....|        :.||...|:|:           .|||. ...:..|::.:.:  ||.  
Mouse  2318 KAVATAQAPGRVSHLIWYSANSFFVLSANENVSEWQVGLRKGST-STSSSLHLKRVLQEDWGVLT 2381

  Fly  1547 --SITRDGKCGLYAPTRGGLEMLELRKGTTVKTFIPKVAEGVF-SVICIFTENDEYVAYY----H 1604
              .:..||:..:.  .:..:|:||::.|:...:...:.  ||. |::|   .:.||..:|    .
Mouse  2382 GLGLAPDGQSLIL--MKEDVELLEMKPGSIPSSICRRY--GVHSSILC---TSKEYGLFYLQQGD 2439

  Fly  1605 SGRKTI-RVFRTADTEMIANYRLQ--------AELTAIKSSKDGRAIVLGTVDGCMSVLA----- 1655
            ||..:| ....:.:.|.|.::.|.        ..:|..|...:. :::..|.||.:..|:     
Mouse  2440 SGLLSILEQKESGEFEEILDFNLNLNNPNGSPVSITQAKPESES-SLLCATSDGMLWNLSECTSE 2503

  Fly  1656 ---IVD---------PKKEEMNEYLNDLPSRD---------ENWKAKLAKMKARVGFKAAIRV 1697
               |||         ||.:.:...|:.....|         .|.||:..| |..:|...|:.|
Mouse  2504 GEWIVDNIWQKKAKKPKTQTLETELSPHSELDFSIDCWIDPTNLKAQQCK-KIHLGSVTALHV 2565

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10185NP_650521.1 AAA_16 363..488 CDD:289934 29/137 (21%)
WD40 1177..>1379 CDD:225201 44/277 (16%)
WD40 repeat 1214..1256 CDD:293791 9/43 (21%)
WD40 <1216..1380 CDD:295369 38/238 (16%)
WD40 repeat 1261..1300 CDD:293791 7/39 (18%)
WD40 repeat 1306..1341 CDD:293791 8/60 (13%)
WD40 repeat 1348..1393 CDD:293791 12/59 (20%)
Tep1NP_033377.1 TEP1 N-terminal 1 1..30
TEP1_N 1..29 CDD:283129
TEP1 N-terminal 2 31..60
TEP1_N 31..59 CDD:283129
TEP1 N-terminal 3 61..90
TEP1_N 62..89 CDD:283129
TEP1 N-terminal 4 91..120
TEP1_N 91..119 CDD:283129
TROVE 230..685 CDD:283406
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 386..412
DUF4062 917..1017 CDD:290011 37/192 (19%)
NACHT 1171..1346 CDD:283404 38/187 (20%)
WD 1 1420..1462 9/41 (22%)
WD 2 1681..1720 10/54 (19%)
WD40 repeat 1687..1723 CDD:293791 8/35 (23%)
WD 3 1723..1761 8/41 (20%)
WD40 repeat 1729..1764 CDD:293791 8/38 (21%)
WD40 1763..2182 CDD:238121 82/471 (17%)
WD 4 1764..1803 6/38 (16%)
WD40 repeat 1769..1804 CDD:293791 6/34 (18%)
WD 5 1805..1844 8/38 (21%)
WD40 1806..2198 CDD:225201 77/444 (17%)
WD40 repeat 1811..1847 CDD:293791 7/35 (20%)
WD 6 1847..1886 8/43 (19%)
WD40 repeat 1852..1887 CDD:293791 7/39 (18%)
WD 7 1889..1930 12/57 (21%)
WD40 repeat 1895..1930 CDD:293791 9/44 (20%)
WD 8 1932..1971 7/38 (18%)
WD40 repeat 1937..2066 CDD:293791 26/153 (17%)
WD 9 1974..2013 11/59 (19%)
WD40 1979..2273 CDD:238121 55/351 (16%)
WD40 repeat 1979..2014 CDD:293791 10/55 (18%)
WD 10 2015..2054 6/42 (14%)
WD 11 2067..2106 4/38 (11%)
WD40 repeat 2072..2111 CDD:293791 2/38 (5%)
WD 12 2113..2151 6/37 (16%)
WD40 repeat 2118..2141 CDD:293791 2/22 (9%)
WD 13 2154..2191 10/42 (24%)
WD40 repeat 2159..2190 CDD:293791 9/36 (25%)
WD 14 2193..2241 11/68 (16%)
WD40 repeat 2198..2243 CDD:293791 12/65 (18%)
WD 15 2244..2282 6/46 (13%)
WD40 repeat 2250..2272 CDD:293791 2/21 (10%)
WD 16 2285..2324 3/38 (8%)
WD40 repeat 2290..2322 CDD:293791 3/31 (10%)
WD 17 2326..2362 8/36 (22%)
WD40 repeat 2330..2374 CDD:293791 8/44 (18%)
WD 18 2375..2424 11/52 (21%)
WD40 repeat 2380..2410 CDD:293791 6/31 (19%)
WD40 2408..>2625 CDD:225201 34/165 (21%)
WD40 repeat 2420..2465 CDD:293791 11/47 (23%)
WD 19 2467..2507 6/40 (15%)
WD40 repeat 2472..2495 CDD:293791 5/23 (22%)
WD40 <2534..>2602 CDD:295369 9/33 (27%)
WD 20 2555..2592 3/11 (27%)
WD 21 2594..2628
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I10781
eggNOG 1 0.900 - - E2759_KOG3602
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.810

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