DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10185 and LOC110438760

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_021327552.1	Gene:	LOC110438760 / 110438760	-ID:	-	Length:	745	Species:	Danio rerio

Alignment Length:	822	Identity:	174/822 - (21%)
Similarity:	299/822 - (36%)	Gaps:	232/822 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   667 QYHLPPTRRIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSM 731
            :|...|...:..||::     |.:|::|.|:|...|:.|.|.:|.....:||....:.....|:.
Zfish    13 EYSPVPYAFVAGLLYS-----LRDYMTEVESDDTWVLRWTHTEFCCVVLQRYAPTEDSRKAVHAD 72

  Fly   732 IADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRY--NLRKFG 794
            .|||:                           .|||......|||.:..|:...:.|  ||||..
Zfish    73 FADYF---------------------------NGSAPNSQVFQPLAWIRKERGRRCYVFNLRKLH 110

  Fly   795 ELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKEAKRELMLVSDAL 859
            .||:|::.|.:...|....||||::|..||....:..|..|.:.|.  ..||:. .::.:::..|
Zfish   111 CLPYHYIHSGQIIPLLTECLFNYEFLLHKLWGLSIYHVQEDLKAAV--IVDKDL-LDVAVLAQVL 172

  Fly   860 RLGGAILAIYPNMLAPQLVGRL-------LPEIGGNPN----IKMLLRACDRSG-PKDCALIPVN 912
            .|..::|...|..||.||:|||       .|...|:|.    :..||..|..|. |   .|:|..
Zfish   173 SLSHSVLLNDPCQLASQLLGRLEQIICQDKPVTSGDPRRFSFLHDLLAQCRSSSLP---VLVPSY 234

  Fly   913 HCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSIST----------------------HFITF 955
            .||..|||.:...|.||..||.|  |....|::||.|:                      |....
Zfish   235 TCLLPPGGLMHTLLSGHMSAVTA--LAHGGRHLVSCSSDGKLNLWRLDEQMRPVGALPRAHGCAV 297

  Fly   956 DLSTSDLT------------------RDVNPG----IEGIMQQLVLSP--DNKWAAA-YSNNNQT 995
            |.:...||                  |:|:.|    :|..:...|::.  |.:.... |...:..
Zfish   298 DWAADSLTLCLDDTVLVLQMGYCLQVREVHSGKVLYVEESLDVPVVTSACDGRLLVIFYDGCHMV 362

  Fly   996 VLLNMLSS---EFVV-INSPFEESHGPVSGLYLLNQNLFITCKL-------------RWAQFDTR 1043
            .:.|::||   .|.| :...||..|        .:|::.::.:.             ..|.|:.:
Zfish   363 KVFNLVSSCSLLFCVNLTLEFEPIH--------KDQSIVVSRQPAKDYVLFAYRNGGEAAVFNAK 419

  Fly  1044 GNLVDTFDVPGENKDWEILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGGHYSNCQL----LFS 1104
            |.:|.:             |::..:||   ....:..|:...|.| .||..:....::    |||
Zfish   420 GGVVSS-------------TLKAQHPA---AAIQAVEISSQYLLL-FCRYPYKRQSEIIHIELFS 467

  Fly  1105 AMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEMLL-QLRLDQHD 1168
            |......|: ..||:.         |:|...........:|...|...:...|::: .:..:.|.
Zfish   468 AESFQYLRS-ILGCSQ---------DYISQVTVAGGGSHIVAFCPAPHHGTTEIIIWNIETEDHK 522

  Fly  1169 RML----LGTAGK--------GFVI-------WDFGSKDKD--------------AAEECRLREG 1200
            .:.    |.|.|:        ||.:       |:.||:..|              .||...:::.
Zfish   523 HIARFPGLMTHGECSDLRFCVGFCVGERLLRMWNLGSRINDQTLTYNVHKAHIDGTAEIVTIQKN 587

  Fly  1201 ALYLAL----PHGVR--NITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFG 1259
            ..|:..    |..||  |:....::...:.|...|               ..|..:|.:.|.
Zfish   588 PRYVVCRSTRPGTVRIWNVARVRLKGRPVQVEHGL---------------FSSSDIALIRDL--- 634

  Fly  1260 RIIQLEPLTIGNWNNLVTSSIDRSVKVWNINNIFEKVHVIDRHELQI-----DDISL--SEVDMA 1317
            :|..|..||..|:.:   :::.:::.|:   ::.:|.::..:..|.|     .|..|  .|:.:.
Zfish   635 KIYILSDLTTSNFTD---AAVYQTLLVY---DLLKKSYIKKQTGLFIVPCPQQDYHLLEGEILLG 693

  Fly  1318 VTVTRSCVGVWETRS----GRLLAKLADSPLGAIVTHAEITP 1355
            ::.||..:.:|:..|    ||:.....:|.|.::.|.:.|.|
Zfish   694 LSETRDHLILWDLDSGYIKGRIKTSYKESLLLSMDTDSHIMP 735

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934
		WD40	1177..>1379	CDD:225201	41/225 (18%)
		WD40 repeat	1214..1256	CDD:293791	4/41 (10%)
		WD40	<1216..1380	CDD:295369	28/151 (19%)
		WD40 repeat	1261..1300	CDD:293791	7/38 (18%)
		WD40 repeat	1306..1341	CDD:293791	10/45 (22%)
		WD40 repeat	1348..1393	CDD:293791	3/8 (38%)
LOC110438760	XP_021327552.1	WD40	247..643	CDD:225201	79/450 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14491at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010