Protein Alignment CG10185 and ttc41

DIOPT Version :10

• Sequence 1: NP_650521.1
• Gene: CG10185 / 41953
• FlyBaseID: FBgn0038397
• Length: 1732
• Species: Drosophila melanogaster
• Sequence 2: NP_001429318.1
• Gene: ttc41 / 101885759
• ZFINID: ZDB-GENE-110914-190
• Length: 1166
• Species: Danio rerio
• Alignment Length: 1374
• Identity: 251/1374 - (18%)
• Similarity: 438/1374 - (31%)
• Gaps: 529/1374 - (38%)

  Fly    57 EKHGLEFQVVDMRWGV--RDEATDDHMTTELCMREIK-NCQRLSMGPNFIVFLGQKYGY-RPIPT 117
            :..|..|:.:|::...  ||:|.:....::|..:::| :...:.....||..||..||. .|...
Zfish    46 QTRGTCFRPMDLQRSKQDRDDANNHKNDSDLFDQQLKISLDLVDRSSFFICLLGHSYGQCLPDIE 110

  Fly   118 YIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRV--------- 173
            ...|||:........|.|..      |..:|......::.|:...:..|  :|.|:
Zfish   111 SCSSSEVVRKLNIAASSGYP------WVLEDEYRTCSLTELEITKAAFI--DNHRLCFFYFKDYT 167

  Fly   174 PKLQ-------------AEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREV 225
            |:..             :|:.:::.|.|:|..:..|:....|                   :|.:
Zfish   168 PQDTEDDDDDDDNDDDGSEEMSIFLDMLSKQSQRERQRLRDL-------------------KRRI 213

  Fly   226 INGILNVKNTKNHCLSYVRYINNINLQNLKKASLFVDIINRSLDTESAKLLSDLRDVRLPAKIEA 290
            |          ||||....:.|...|..:.:.. :.::|:: :..:|..|:|..:|
Zfish   214 I----------NHCLPVRFFRNQYELGEMIRKD-WEEVISK-ISKDSKHLISGWQD--------- 257

  Fly   291 VNAQKYTVEWIGREGLDIETHEEYLNHFISHFYKNVVKLVDRAMRKEDSSAQGQIVTEIL----Q 351
                          ..|:.:|:.|.....:.|..:|.                  .||.|    :
Zfish   258 --------------SFDLHSHKSYSRALCNWFVPSVP------------------ATETLNAFDK 290

  Fly   352 HLHACNNSVKIFYGREESCERIKRYMLGDSDKP-LVLFGDGGCGKTSLLSKSVSLVATEW----F 411
            .||...::.| :....::...:....|.||:|. ||:.|:.||||::|.:         |    |
Zfish   291 FLHPVTHNAK-YETHAKNPGALFNSDLNDSEKSVLVISGERGCGKSTLAA---------WCLQTF 345

  Fly   412 AHVRP-INVIRFLGTTPDSSALTATLISICQ---QISYNYMLPFENIPDDLVPLTAHFK------ 466
            :...| :.|||....|..||....:|:.:|.   :.::|...|..   |:.:..|:.|:
Zfish   346 SEQNPDLPVIRHFCGTSTSSTDVRSLLRLCTAQLRKAHNGDSPDW---DESLENTSEFEYLHRAV 407

  Fly   467 QLLTYASPTQPLTIYLDSVDQLTGT-----QDSNKVSWIPTRLPPHCKIII------------SC 514
            |..|.|...:|..:.:|.:|.||.|     |:...:.|:|..|||.||:||            ||
Zfish   408 QAFTAALNLRPCILLIDGIDLLTETLGLSKQEVKSLQWLPAVLPPFCKMIITTTFTDLTHKSFSC 472

  Fly   515 ANE------PANPTVSHEYHVLCKMIDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNNYQWRL 573
            ..:      |..|..|.:..:|.|.:          .|......:|:...|...||  :.....|
Zfish   473 RTDVQILKCPPFPDPSVQLSILLKHL----------FLPSQEPPSVVLQRMVRKCR--SPAFLAL 525

  Fly   574 VANAISKC--------------------SLP-IFVKLVFAEICRW-RSYTRP-----------QE 605
            |...:..|                    |:| ::||::.    || :.|:|.           .|
Zfish   526 VGTELRTCGVLRKKEEEMELLKEYAEADSVPELWVKVIH----RWVKDYSRSAPSEDVTSSKVTE 586

  Fly   606 TH------LANTVMDSIMLLFERVEKQHGRILVFHALAYITASKSGLSESELEDLISLDDKVLDD 664
            ||      |:..|.|::.|:.........::||.                 ||||
Zfish   587 THTSPSEGLSGWVWDTLCLIHMSRALTEAQVLVL-----------------LEDL---------- 624

  Fly   665 VYQYHLPPTRRIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNMNMAI--- 726
            .|..||    |:..|.|.|:|:.:..::.|: |.|:.::..              |::::|:
Zfish   625 GYWGHL----RVQVLEWARLRSAIWPWIQEK-ASGLLIIKQ--------------KSLSLAMNLL 670

  Fly   727 --------YFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDG 783
                    .:|.::|.::.                                         .|...
Zfish   671 LNGTEGQNTYHQILATFFQ-----------------------------------------KSNSD 694

  Fly   784 LSKRYNLRKFGELPFHFVRSRRFKDLFEHVL--FNYDWLHAKLSSCP------------------ 828
            :|.   .:|..|:|:||:::..||:|.|.::  ...::|.:.|...|
Zfish   695 ISW---AQKMEEIPWHFIQTSSFKELHEFLINPATVEFLSSNLKRYPHLSTDVIHYWTLLRKKGF 756

  Fly   829 ---------LQAVLADFEDAS-------------------SNTD------DKEAKRELMLVSDAL 859
                     :....||..|.|                   ..|:      |:..::.:.|.||::
Zfish   757 DPVVSFQNLITQTYADTPDPSRLSRLSLFCSKVLLYMGEMRTTEEMLLQADQILQKTVELDSDSM 821

  Fly   860 RL----GGAILAIYPNMLAPQLV----------GRLLPE-----------IGGNPNIKMLLRACD 899
            ||    ...:..:|..|..|:.:          .|.|.|           :|     ::|.|.|
Zfish   822 RLQLNVQHMMAELYVQMHLPKDIEMFCHKGLETARSLTEAHLDSVEVKLIVG-----QLLCRLC- 880

  Fly   900 RSGPKDCALIPVNHCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSISTHFITFDLSTSDLTR 964
                  .||:.                ||..|||..  |..::|.....|.|
Zfish   881 ------MALLE----------------EGRLFAVPE--LFREIRSARYTSAH------------- 908

  Fly   965 DVNPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSEFVVINSPFEESHGPVSGLYLLNQNL 1029
               |..||.:  ::|...:|.:.....|.:..|.:.|.|.    ...:.:.|..|:.:..|..:|
Zfish   909 ---PCAEGTV--MILKAIHKLSFGELKNAERCLESALKSR----RRWYGQDHPLVAEVEELLADL 964

  Fly  1030 FITCKLRWAQFDTRGNLVDTFDVPGENKDWEILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGG 1094
                   ||...|             |.:|....|..|    |..|..|.....:.|:|...
Zfish   965 -------WANNQT-------------NTEWTRRRMVEF----YRHVISSKETEALTLQLPVL--- 1002

  Fly  1095 HYSNCQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEML 1159
            |:|     .:.::|...:.....|:..|..|  ..|.::...                    :..
Zfish  1003 HHS-----LAVVLMKLGKLLLCSCSTMERRE--GLDLLQRAA--------------------DTQ 1040

  Fly  1160 LQLRLDQHDRMLLGTAGKGFV-----------IWDFGSKDKDAAEECRLREGALYLALPHGVRNI 1213
            :||:..:|      ...||||           .|..|.|.....::      |.|...||    |
Zfish  1041 IQLQGSEH------LVTKGFVKVSKHDVIGQNKWSPGKKSNSGQQQ------ASYYYKPH----I 1089

  Fly  1214 TTRIMQSNS 1222
            |.::.:|.|
Zfish  1090 TPKLNRSYS 1098

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	P-loop containing Nucleoside Triphosphate Hydrolases	384..>514	CDD:476819	43/161 (27%)
		WD40 repeat	1214..1256	CDD:293791	3/9 (33%)
		WD40	<1232..1422	CDD:441893
		WD40 repeat	1261..1300	CDD:293791
		WD40 repeat	1306..1341	CDD:293791
		WD40 repeat	1348..1393	CDD:293791
ttc41	NP_001429318.1	None