DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10185 and ttc41

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_005164667.3	Gene:	ttc41 / 101885759	ZFINID:	ZDB-GENE-110914-190	Length:	1167	Species:	Danio rerio

Alignment Length:	1430	Identity:	263/1430 - (18%)
Similarity:	463/1430 - (32%)	Gaps:	531/1430 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 EKHGLEFQVVDMRWGV--RDEATDDHMTTELCMREIK-NCQRLSMGPNFIVFLGQKYGY-RPIPT 117
            :..|..|:.:|::...  ||:|.:....::|..:::| :...:.....||..||..||. .|...
Zfish    46 QTRGTCFRPMDLQRSKQDRDDANNHKNDSDLFDQQLKISLDLVDRSSFFICLLGHSYGQCLPDIE 110

  Fly   118 YIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISSILINFNNKRV--------- 173
            ...|||:........|.|..      |..:|......::.|:...:..|  :|.|:
Zfish   111 SCSSSEVVRKLNIAASSGYP------WVLEDEYRTCSLTELEITKAAFI--DNHRLCFFYFKDYT 167

  Fly   174 PKLQ-------------AEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREV 225
            |:..             :|:.:::.|.|:|..:..|:....|                   :|.:
Zfish   168 PQDTEDDDDDDDNDDDGSEEMSIFLDMLSKQSQRERQRLRDL-------------------KRRI 213

  Fly   226 INGILNVKNTKNHCLSYVRYINNINLQNLKKASLFVDIINRSLDTESAKLLSDLRDVRLPAKIEA 290
            |          ||||....:.|...|.         ::|.:..:...:|:..|
Zfish   214 I----------NHCLPVRFFRNQYELG---------EMIRKDWEEGISKISKD------------ 247

  Fly   291 VNAQKYTVE-WIGREGLDIETHEEYLNHFISHFYKNVVKLVDRAMRKEDSSAQGQIVTEIL---- 350
               .|:.:. |  ::..|:.:|:.|.....:.|..:|.                  .||.|
Zfish   248 ---SKHLISGW--QDSFDLHSHKSYSRALCNWFVPSVP------------------ATETLNAFD 289

  Fly   351 QHLHACNNSVKIFYGREESCERIKRYMLGDSDKP-LVLFGDGGCGKTSLLSKSVSLVATEW---- 410
            :.||...::.| :....::...:....|.||:|. ||:.|:.||||::|.:         |
Zfish   290 KFLHPVTHNAK-YETHAKNPGALFNSDLNDSEKSVLVISGERGCGKSTLAA---------WCLQT 344

  Fly   411 FAHVRP-INVIRFLGTTPDSSALTATLISICQ---QISYNYMLPFENIPDDLVPLTAHFK----- 466
            |:...| :.|||....|..||....:|:.:|.   :.::|...|..   |:.:..|:.|:
Zfish   345 FSEQNPDLPVIRHFCGTSTSSTDVRSLLRLCTAQLRKAHNGDSPDW---DESLENTSEFEYLHRA 406

  Fly   467 -QLLTYASPTQPLTIYLDSVDQLTGT-----QDSNKVSWIPTRLPPHCKIII------------S 513
             |..|.|...:|..:.:|.:|.||.|     |:...:.|:|..|||.||:||            |
Zfish   407 VQAFTAAVNLRPCILLIDGIDLLTETLGLSKQEVKSLQWLPAVLPPFCKMIITTTFTDLTHKSFS 471

  Fly   514 CANE------PANPTVSHEYHVLCKMIDVEENFIEVTALGEDLAMNVIKMWMKTACRDLNNYQWR 572
            |..:      |..|..|.:..:|.|.:          :|......:|:...|
Zfish   472 CRTDVQILKCPPFPDPSVKLSILLKHL----------SLPSQEPPSVVLQRM------------- 513

  Fly   573 LVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHL--------ANTVMDSIMLLFERVEKQHGR 629
                 :.||..|.|:.||..|: |.....|.:|..:        |::|.:..:.:..|..|.:.|
Zfish   514 -----VHKCRSPAFLALVGTEL-RTCGVLRKKEEEMELLKEYAEADSVPELWVKVIHRWVKDYSR 572

  Fly   630 IL------------------------VFHALAYITASKSGLSESELEDLISLDDKVLDDVYQYHL 670
            ..                        |:..|..|..|::||:|:::  |:.|:|.    .|..||
Zfish   573 SAPSEDVTSSKVTETHTSPSEGLSGWVWDTLCLIHVSRAGLTEAQV--LVLLEDL----GYWGHL 631

  Fly   671 PPTRRIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNMNMAI--------- 726
                |:..|.|.|:|:.:..::.|: |.|:.::..              |::::|:
Zfish   632 ----RVQVLEWARLRSAIWPWIQEK-ASGLLIIKQ--------------KSLSLAMNLLLNGTEG 677

  Fly   727 --YFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRYN 789
              .:|.::|.::.                                         .|...:|.
Zfish   678 QNTYHQILATFFQ-----------------------------------------KSNSDISW--- 698

  Fly   790 LRKFGELPFHFVRSRRFKDLFEHVL--FNYDWLHAKLSSCP------------------------ 828
            .:|..|:|:||:::..||:|.|.::  ...::|.:.|...|
Zfish   699 AQKMEEIPWHFIQTSSFKELHEFLINPATVEFLSSNLKRYPHLSTDVIHYWTLLRKKGFDPVVSF 763

  Fly   829 ---LQAVLADFEDAS-------------------SNTD------DKEAKRELMLVSDALRL---- 861
               :....||..|.|                   ..|:      |:..::.:.|.||::||
Zfish   764 QNLITQTYADTPDPSRLSRLSLFCSKVLLYMGEMRTTEEMLLQADQILQKTVELDSDSMRLQLNV 828

  Fly   862 GGAILAIYPNMLAPQLV----------GRLLPE-----------IGGNPNIKMLLRACDRSGPKD 905
            ...:..:|..|..|:.:          .|.|.|           :|     ::|.|.|
Zfish   829 QHMMAELYVQMHLPKDIEMFCHKGLETARSLTEAHLDSVEVKLIVG-----QLLCRLC------- 881

  Fly   906 CALIPVNHCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSISTHFITFDLSTSDLTRDVNPGI 970
            .||:.                ||..|||..  |..::|.....|.|                |..
Zfish   882 MALLE----------------EGRLFAVPE--LFREIRSARYTSAH----------------PCA 912

  Fly   971 EGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSEFVVINSPFEESHGPVSGLYLLNQNLFITCKL 1035
            ||.:  ::|...:|.:.....|.:..|.:.|.|.    ...:.:.|..|:.:..|..:|
Zfish   913 EGTV--MILKAIHKLSFGELKNAERCLESALKSR----RRWYGQDHPLVAEVEELLADL------ 965

  Fly  1036 RWAQFDTRGNLVDTFDVPGENKDWEILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGGHYSNCQ 1100
             ||...|             |.:|....|..|    |..|..|.....:.|:|...   |:|
Zfish   966 -WANNQT-------------NTEWTRRRMVEF----YRHVISSKETEALTLQLPVL---HHS--- 1006

  Fly  1101 LLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEMLLQLRLD 1165
              .:.::|...:.....|:..|..|  ..|.::...                    :..:||:..
Zfish  1007 --LAVVLMKLGKLLLCSCSTMERRE--GLDLLQRAA--------------------DTQIQLQGS 1047

  Fly  1166 QHDRMLLGTAGKGFV-----------IWDFGSKDKDAAEECRLREGALYLALPHGVRNITTRIMQ 1219
            :|      ...||||           .|..|.|.....::      |.|...||    ||.:..:
Zfish  1048 EH------LVTKGFVKVSKHDVIGQNKWSLGKKLNSGQQK------ASYYYKPH----ITPKPNR 1096

  Fly  1220 SNS--IMVSSKLD-----------YAVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLEPLTIGN 1271
            |.|  ..:|.|.|           .:|.|::.::.. ..|.|: |..||.|.......|.::..|
Zfish  1097 SYSAETALSCKQDKTPKRSWTASRVSVFGLQSDINT-LPQKGK-AGWLDRHLSVTRSTEQVSQAN 1159

Fly 1272 1271
Zfish 1160 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934	34/139 (24%)
		WD40	1177..>1379	CDD:225201	28/119 (24%)
		WD40 repeat	1214..1256	CDD:293791	12/54 (22%)
		WD40	<1216..1380	CDD:295369	15/69 (22%)
		WD40 repeat	1261..1300	CDD:293791	2/11 (18%)
		WD40 repeat	1306..1341	CDD:293791
		WD40 repeat	1348..1393	CDD:293791
ttc41	XP_005164667.3	DUF4062	<79..108	CDD:315852	7/28 (25%)
		P-loop_NTPase	322..501	CDD:328724	50/200 (25%)
		TPR_12	915..>965	CDD:315987	9/55 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG3602
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900