DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10185 and si:ch211-212k18.6

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_021333814.1	Gene:	si:ch211-212k18.6 / 101882836	ZFINID:	ZDB-GENE-130530-938	Length:	617	Species:	Danio rerio

Alignment Length:	756	Identity:	120/756 - (15%)
Similarity:	227/756 - (30%)	Gaps:	307/756 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   991 NNNQTVLLNMLSSEFVVINSPFEESH--GPVSGLYLLNQNLFITCKLRWAQFDTRGNLVDTFDVP 1053
            |..:..:.|   ::..|::|..:..|  |.:..:.:.:|.|.:.|:..:
Zfish     6 NGGEAAVFN---AKCGVVSSTLKAQHPAGAIQAVEISSQYLLLFCRYPY---------------- 51

  Fly  1054 GENKDWEILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGGHYSNCQLLFSAMVMNKARTRAYGC 1118
              .:..||:.:|.|:...:                           |.|.|.:          ||
Zfish    52 --KRQSEIIHIELFSAESF---------------------------QYLRSIL----------GC 77

  Fly  1119 ANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEMLL-QLRLDQHDRML----LGTAGK- 1177
            :.         |:|...........:|...|...:...|::: .:..:.|..:.    |.|.|:
Zfish    78 SQ---------DYISQVTVAGGGSHIVAFCPAPHHGTTEIIIWNIETEDHKHIARFPGLMTHGEC 133

  Fly  1178 -------GFVI-------WDFGSKDKD--------------AAEECRLREGALYLAL----PHGV 1210
                   ||.:       |:.||:..|              .||...:::...|:..    |..|
Zfish   134 SDLRFCVGFCVGERLLRMWNLGSRINDQTLTYNVHKVHIDGTAEIVTMQKNPRYVVCRSTRPGTV 198

  Fly  1211 R--NITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLEPLTIGNWN 1273
            |  |:....::...:.|...|               ..|..:|.:.|.   :|..|..||..|:.
Zfish   199 RIWNVARVRLKGRPVQVEHGL---------------FSSSDIALIRDL---KIYILSDLTTSNFT 245

  Fly  1274 NLVTSSIDRSVKVWNINNIFEKVHV-------------IDRHELQIDDISLSEVDMAVTVTRSCV 1325
            :   :::.:::.|:   ::.:|.::             .|.|.|:      .|:.:.::.||..:
Zfish   246 D---AAVYQTLLVY---DLLKKSYIKKQTGLFIVPCPQQDYHLLE------GEILLGLSETRDHL 298

  Fly  1326 GVWETRS----GRLLAKLADSPLGAIVTHAEITPDGRYIISSETGKFLVWNRVSEQVVFRDDQPG 1386
            .:|:..|    ||:.....:|.|.::.|.:.|.|.     ..:||..:.|:|.:|
Zfish   299 ILWDLDSGYIKGRIKTSYKESLLLSMDTDSHIMPS-----KEKTGLVMPWDRRTE---------- 348

  Fly  1387 IQQITLMDYGYKVLTVSVPNINQRDILAAAAGGSADEANRLTAITTMRSVPEGSIFFRFEFPIRM 1451
                          |.:...|.|.    ..|....||..|               |.|.:|
Zfish   349 --------------TQNAKRIRQE----REAKRKKDEQKR---------------FEREKF---- 376

  Fly  1452 ITGMPFRQSVITADNAYIVVVTVDKSNKDCLGVYSATNGAFVSKVLLKGCSIKEVISLVPMPHKA 1516
               ....|.:::.|...:|                              ||.        ..|..
Zfish   377 ---NSIDQYLLSGDEQVVV------------------------------CSY--------FAHHL 400

  Fly  1517 NQVAVISSEKGSVMDIKTKKHVRSIA-KWGGSITRDGKCGLYAPTRGGLEMLELRKGTTVKTFIP 1580
            |..:|||.|           |:.::. :|                    .:|.||...
Zfish   401 NVFSVISEE-----------HLHTLEDRW--------------------SLLSLRTAA------- 427

  Fly  1581 KVAEGVFSVICIFTENDEYVAYYHSGRKTIRVFRTA-DTEM-IANYRLQAE--LTAIKSSKDGRA 1641
                        .|.|.|::...:........|.|. ||:. :...||:.|  :..|..|.|...
Zfish   428 ------------ITHNGEHLVVSNYSEAQHAPFLTLWDTQRGMVRKRLKNEPGICCIAVSDDACR 480

  Fly  1642 IVLGTVDGCMSVLAIVDPKKEEMNEYLNDLPSRDENWKAKL 1682
            :|.|...  .:.|.:.||.:.: ::.::...|.:.||.::|
Zfish   481 VVFGIAG--FNKLKVWDPFRRK-HKNISGYGSLNLNWSSQL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934
		WD40	1177..>1379	CDD:225201	45/253 (18%)
		WD40 repeat	1214..1256	CDD:293791	4/41 (10%)
		WD40	<1216..1380	CDD:295369	32/180 (18%)
		WD40 repeat	1261..1300	CDD:293791	7/51 (14%)
		WD40 repeat	1306..1341	CDD:293791	7/38 (18%)
		WD40 repeat	1348..1393	CDD:293791	8/44 (18%)
si:ch211-212k18.6	XP_021333814.1	WD40	149..555	CDD:225201	91/546 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14491at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920