DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10185 and LOC101730828

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_031751296.1	Gene:	LOC101730828 / 101730828	-ID:	-	Length:	2018	Species:	Xenopus tropicalis

Alignment Length:	1822	Identity:	436/1822 - (23%)
Similarity:	724/1822 - (39%)	Gaps:	449/1822 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 IFLGSLESLPPVSSK-IVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGV 72
            |..|.|: ||....| :..|:....:.|:..|||:|....||.:..|.:|: |.:|::.|:|||:
Frog   268 IIQGLLQ-LPCTDRKRVFMIYICGGYQDSYPERNSLFQSVYPDLYIYFKER-GFDFRMFDLRWGL 330

  Fly    73 RDEATDDHMTTELCMREIKNCQRLSMGPN-FIVFLGQKYGYRPIP------TYIV---------- 120
            .|..:::|..|.|.:..:||||  ..|.. |..|:||||....||      |:.|
Frog   331 NDGVSNNHGFTSLHLNTLKNCQ--DTGHKAFFCFMGQKYDQITIPVTFAKETFEVITATVEMRRK 393

  Fly   121 ----SSELALIC---EELTSMGVD----------------------------------------- 137
                :|..|:|.   |:....|.|
Frog   394 EAKQNSVTAIIVMPPEDPAPSGKDDKEHNGTVFQQKTLEHDTLQTTNTETNHFANGSAKFKKKSS 458

  Fly   138 ------RAILDLWYKKDSNAVPPISVLQPISSILINFNNKRVPKLQAEDQAVWWDTLNKMQKLLR 196
                  ..:|..||..|.||.|.:..|||||::..:..: |.|..:.:.:..|.:||.|:..:|:
Frog   459 AKYDKELELLTRWYLLDENADPSVYRLQPISTVYGDIFS-RDPARRQQAKTKWLNTLRKLYDILQ 522

  Fly   197 K-AAASLGASNKMSKEDVHNYFMSVTEREVINGILNVKNTKN---HC----LSYVRYINNINLQN 253
            : ...:.|      ||...:...:|.::| |:....|..|..   ||    :|.|:|    ||.:
Frog   523 EYMTLAFG------KEMTDSVLKTVVQQE-IDQAFQVAGTPEDYFHCFKRIISDVKY----NLTS 576

  Fly   254 LKKASLFVDI------INRSL-DTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLD---I 308
             .:.|.::|:      ||::| |.:...:.|      :..::...|..:|.|.| |.:|::   .
Frog   577 -NRVSEYIDVLPTKSEINKTLFDAQQGVIQS------IHQRLRHTNISEYIVSW-GWDGINPVSN 633

  Fly   309 ETHEEYL----NHF----ISHFYK--NVVKLVDRAMRKEDSSAQGQIVTEILQHLHACNNSVKIF 363
            .:|..||    |.|    |:||.:  |.:...:::..:.| |.:.||..|||:|...|:..|..|
Frog   634 RSHAYYLERLGNDFRKKVIAHFNRITNYLNETEKSCTRRD-SIRNQIKEEILEHAKHCHTLVNCF 697

  Fly   364 YGREESCERIKRYMLGDSDKPLVLFGDGGCGKTSLLSKSVSLVATEWFAHVRPINVI-RFLGTTP 427
            .|||...:.::..:...:.:.:|:.|:.|.||:|:::| ::.:|::|..  |.|.|: ||:|.|.
Frog   698 MGRESFLQELQDCITSANKQLVVVHGESGSGKSSIIAK-IATLASQWIG--RDIRVVTRFIGRTG 759

  Fly   428 DSSALTATLISICQQIS--YNYMLPFENIPDDLVPLTAHFKQLLTYASPTQPLTIYLDSVDQLTG 490
            :|......|.|:|.||:  ||..:.|.   :||..|...|..||.:|:..:||.:.:|.:|:|:.
Frog   760 ESRNPRMLLYSLCFQIAEIYNITMDFS---EDLKGLINEFSTLLEFANKCRPLMVAVDGIDELSV 821

  Fly   491 TQDSNKVSWIPTRLPPHCKIIISCANEPANPTVSHEYHVLCKMIDVEENFIEVTALGEDLAMNVI 555
            .:||  :||||..||.|...|:..:.|.|    ...:..|.| :.:::|..::..|..:...|:|
Frog   822 HEDS--LSWIPRVLPRHVYFIVCASTESA----CSSFRTLQK-LTMQQNVHQIPPLDSEEIRNMI 879

  Fly   556 KMWMKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLANTVMDSIMLLF 620
            ::||:...|.|...|.:::.:|.:.|.||::|...:.|.|.|.||:...:::|...:......:.
Frog   880 EVWMERDNRRLTGRQKKVLFDACAACPLPLYVVSSYMESCLWTSYSSESDSYLQPNLHKLYSAVL 944

  Fly   621 ERVEKQHGRILVFHALAYITASKSGLSESELEDLISLDDKVLDDVYQYHLPPTRRIPPLLWTRIR 685
            .|:||.||..::....:||:.||:|::..||.||:|||..|:.:|.||........|..||.:::
Frog   945 GRLEKSHGEQVMKMVASYISLSKNGVTLEELLDLLSLDLGVMQEVKQYQNITVSVFPEALWIKLQ 1009

  Fly   686 NDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIADYYLGIWGGGVPKPFKF 750
            ||:..:|.|:..|...|:||.|..||.....||.|:..:.:..||..|:|||
Frog  1010 NDIGTHLVEQRTDNTYVINWAHALFRVVCINRYLKSKELQLSVHSAFANYYL------------- 1061

  Fly   751 TEIQRHRFGLADKEGSADRKVPI-QPLVFSSKDGLSKR--YNLRKFGELPFHFVRSRRFKDLFEH 812
            ....||         :...||.: .||:::   |..::  :||||...:..|.:.|.:|..|...
Frog  1062 ESKSRH---------NHPEKVSLMMPLMWT---GTHRKPVFNLRKILGISHHLIHSNQFPRLITE 1114

  Fly   813 VLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKEAKRELMLVSDALRLGGAILAIYPNMLAPQL 877
            .||||::|..|:.:   .:|:...||..:..:.:....:|.|:|:||:|...:|...|..||.||
Frog  1115 CLFNYEYLLHKVWA---TSVVGLQEDIKAAINPERPAPDLNLLSEALQLSTKVLLRDPTQLASQL 1176

  Fly   878 VGRL-------LPEIGGNPNIK-----MLLRACDRSG-PKDCALIPVNHCLHTPGGPLKYSLEGH 929
            .|||       .|...|:| ||     .||..|.:|. |   ..:|...||..|||.|...|.||
Frog  1177 KGRLHQIEMLDKPVAPGDP-IKYPLLPTLLNQCHQSSIP---VFLPSFTCLLPPGGLLFDMLSGH 1237

  Fly   930 QFAVFAFCLTSDMRYMVSISTH--FITFDLSTSDL---TRDVNPGIEGI---MQQLVLSPDNKWA 986
            ..|:.|.....:....|:.|..  ...:||||...   ...|...|:.|   ||
Frog  1238 TEAITAVAELQNGLQAVTASKDGTLKVWDLSTGKFIYTLHGVGKNIDSITVCMQ----------- 1291

  Fly   987 AAYSNNNQTVLLNMLSSEFVVINSPFEESHGPVSGLYLLNQNLFITCKLRWAQFDTRGNLVDTFD 1051
                  ||.|.|.              |.|.  ..::.|.....|.|       |.     ||.|
Frog  1292 ------NQIVALT--------------EDHS--FQIWDLTSRKVIYC-------DN-----DTLD 1322

  Fly  1052 VP--GENKDWEILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGGHYSNCQLLFSAMVMNKARTR 1114
            :|  ....|.::| :.||:.:....||      |:   .||||    ..||:...|
Frog  1323 IPILTSAMDGQLL-LAFFDGSHLVKVF------DL---ADSCR----LVCQVAIPA--------- 1364

  Fly  1115 AYGCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKEMLLQLRLDQHDRMLLGTAGKGF 1179
                               ||.......:::.|    .|..||.:|.......:.|:| .|.||.
Frog  1365 -------------------DEAPVHKNHSILVS----RNSVKEYVLFAYRSGKEAMVL-NARKGI 1405

  Fly  1180 VIWDFGSKDKDAAEECRLREGALYLALPHGVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWC 1244
            |:....::|..|:.:                                     .||...:...|.|
Frog  1406 VVAKLTAQDPVASVQ-------------------------------------GVAVTNEYFLVIC 1433

  Fly  1245 LQSGQLAKVLDAHFGRIIQLEPLTIGNWNNLVTSSIDRSVKVWNINNIFEKVHVIDRHELQIDDI 1309
            ....     |..|  .|:.:|..::.      |.:..|:||  ..:|.|.....::|....:  :
Frog  1434 RYPS-----LKMH--DIVHIELFSVN------TFAYIRTVK--GCSNDFICQIAVNRQGSHV--V 1481

  Fly  1310 SLSEVDMAVTVTRSCVGVW--ETRSGRLLAKLADSPLGAIVTHAEITPDGRYIISSETGKFLV-- 1370
            :.|::....|..   :.:|  ||...:.:......|.|.|..      |.||.::...|:..:
Frog  1482 AFSQIPNTNTTE---IVLWNLETEDHKHIVTFPSIPRGGICC------DLRYCLAFCDGENYLRS 1537

  Fly  1371 W---NRVSEQVVF-------RDDQPGIQQ-ITLMDY-GYKVLTVSVPN-INQRDILAAAAGGSAD 1422
            |   ||:::|.:.       |.|  |||: ||:.:: .|.:.....|. |...:|:.:...|||.
Frog  1538 WNLVNRINDQTLSMNINRLKRTD--GIQEIITMKNFPRYAICRSMKPGLITVWNIVKSKCKGSAV 1600

  Fly  1423 EANR-LTAITTMRSVPEGSIFFRFEFPIRMI--TGMPFRQSVITAD-----------NAYIVVV- 1472
            ...| |...|.:..|.:..:|...:..:...  |..|..|:::|.|           ..||:..
Frog  1601 RVERGLVESTDIVLVRDMKLFILTDRGMASFTETPRPIFQTLLTYDMLKKKYVRKQSGLYIIPCP 1665

  Fly  1473 -----TVD-------KSNKDCLGVYSATNGAFVSKVLLKGCSIKEVISLVPMP----HKAN--QV 1519
                 .:|       ..|:|...:::...| |:.:.|......:....|:|.|    .|.|  ::
Frog  1666 KHEYRVLDGGLLLGLSENRDHFVIWNMDTG-FIKERLRPKYKERNATDLLPEPDGCKEKLNKEEL 1729

  Fly  1520 AVISSEKGSVM--------DIKTKKHVRSIAKWGGSITRDGKCGLYAPTRGGLEMLELRKGTTVK 1576
            .....:||:|:        :.||.|..|...:....:.:             ::.|...|...:.
Frog  1730 HQQKKQKGTVLLTPWERRNETKTAKRRRLDVEMKQEVEK-------------MQHLLNEKNNAID 1781

  Fly  1577 TFIPKVAEGVFSV------ICIFT----------ENDEYVAYYHSGRKT-----IRVFRTADTEM 1620
            .::....|.|...      :|:|:          |:.|.:.:.||...|     :.:....|.|.
Frog  1782 QYLLSEDEKVIVCSYYAHHLCVFSLETMTHLSTLEDTESMLFLHSAALTSNGSFLALSNYCDAEK 1846

  Fly  1621 IA 1622
            |:
Frog  1847 IS 1848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934	40/127 (31%)
		WD40	1177..>1379	CDD:225201	36/208 (17%)
		WD40 repeat	1214..1256	CDD:293791	5/41 (12%)
		WD40	<1216..1380	CDD:295369	31/170 (18%)
		WD40 repeat	1261..1300	CDD:293791	8/38 (21%)
		WD40 repeat	1306..1341	CDD:293791	5/36 (14%)
		WD40 repeat	1348..1393	CDD:293791	15/57 (26%)
LOC101730828	XP_031751296.1	AAA_16	699..833	CDD:404141	46/141 (33%)
		WD40	<1234..1432	CDD:421866	61/326 (19%)
		WD40 repeat	1242..1278	CDD:293791	7/35 (20%)
		WD40 repeat	1283..1340	CDD:293791	21/102 (21%)
		WD40 repeat	1348..1411	CDD:293791	22/108 (20%)
		WD40 repeat	1419..1455	CDD:293791	9/85 (11%)
		WD40 repeat	1468..1512	CDD:293791	6/48 (13%)
		WD40	<1770..1999	CDD:225201	14/79 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14491at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920