DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10185 and nwd1

DIOPT Version :9

Sequence 1:NP_650521.1 Gene:CG10185 / 41953 FlyBaseID:FBgn0038397 Length:1732 Species:Drosophila melanogaster
Sequence 2:XP_002934424.2 Gene:nwd1 / 100492543 XenbaseID:XB-GENE-985040 Length:1615 Species:Xenopus tropicalis


Alignment Length:1782 Identity:473/1782 - (26%)
Similarity:773/1782 - (43%) Gaps:375/1782 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDDRTIDSIFLGSLESLPPVSSKIVRIFTSSTFTDTTMERNTLMAKCYPRIKDYCREKHGLEFQV 65
            ||.:....|..|...|||...|..||:|.||||:|...|||.||...||.|:.:| :||||.|:|
 Frog     1 MDSQGFKDILRGKETSLPTEPSNTVRLFISSTFSDMAEERNALMEFAYPDIQAFC-QKHGLGFEV 64

  Fly    66 VDMRWGVRDEATDDHMTTELCMREIKNCQRLSMGPNFIVFLGQKYGYRPIPTYIVSSELALICEE 130
            |||||||||.||.||.|.|||::||..||:.||||:||..:|.:||:||||..|...|..::..:
 Frog    65 VDMRWGVRDYATVDHRTKELCLKEIDFCQKTSMGPSFIALVGNRYGFRPIPRVISEEEFNILFSK 129

  Fly   131 LTSMGVDRAILDLWYKKDSNAVPPISVLQPISSILINF--NNKRVPKLQAEDQAVWWDTLNKMQK 193
            :.|...|..:|..|:.||.|.:||..|||||::.|.::  .|....:|||::...|.:|..::.|
 Frog   130 IQSNESDAQLLTKWFWKDMNTIPPTYVLQPITTHLPHYAATNPSFAELQAQEYKEWRNTEKQLTK 194

  Fly   194 LLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGILNVKNTKNHCLSYVRYINNINLQNLKKAS 258
            .||.||........::.|..|.||.||||.|:..|:|.....|.....::|.:.::|...:   |
 Frog   195 ALRLAALEAQIEGLITLEQKHKYFKSVTESEIECGLLACGANKEGSTIFLREVKDLNQCQI---S 256

  Fly   259 LFVDI-INRSLDTESAKLLSDLRDVRLPAKIEAVNAQKYTVEWIGREGLDIETHE-EYLNHFISH 321
            ..:|: .:.|.|||:..||.:|::..|....:.|  :.:.||      :.|:.:: .||:     
 Frog   257 GLLDVREDGSTDTEAQDLLQNLKNRILTDHKDCV--KTHVVE------MSIQKNKMAYLH----- 308

  Fly   322 FYKNVVKLVDRAMR----------------KEDSSAQ----GQIVTEILQHLHACNNSVKIFYGR 366
                  ||.|:|:.                :..|..|    |.:..|::.||.:.....::|.||
 Frog   309 ------KLCDQAIAVVNHQILKCLPSGNAGQSQSENQHPWLGWLRQEVIHHLSSSQKKSQVFSGR 367

  Fly   367 EESCERIKRYMLGDSDK---PLVLFGDGGCGKTSLLSKSVSLVATEWFAHVRPIN------VIRF 422
            ::..::|..|:.....:   ||::.|..|.|||:|:.|:        |..::..|      |:|.
 Frog   368 QDLLQKIMSYIQERHSQVYPPLIIHGVSGSGKTALMCKA--------FEMLKQTNNGSSLMVLRL 424

  Fly   423 LGTTPDSSALTATLISICQQ--ISYNYMLPFENIPDDLVPLTAHFKQLLTYAS--PTQPLTIYLD 483
            |||:|.||.:...|.|||.|  |:.....|...|.:........|.||||..|  ..:.|.::.|
 Frog   425 LGTSPQSSEIHDVLKSICYQLCIALELQPPSSQITNIYNETVRFFHQLLTTVSERKVENLVLFFD 489

  Fly   484 SVDQLTGTQDSNKVSWIPTRLPPHCKIIISCANEPANPTVSHEYHVLCKMIDV---EENFIEVTA 545
            |:|||:.::.::::.|:|...|.:..|::|        |:..|..:|..:.|.   .|.:|||..
 Frog   490 SLDQLSPSEGAHRLHWLPKECPANVCIVVS--------TLPEEGGILKTLKDSVTDPECYIEVKP 546

  Fly   546 LGEDLAMNVIKMWMKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEICRWRSYTRPQETHLAN 610
            |..:....:|:|.|.:|.|.|.|.|..:|..:..||..|:.:||.|.|..||.|||...|..:|.
 Frog   547 LSAEQGSQMIEMLMASAGRRLTNDQQEIVLGSFRKCGQPLLLKLAFDEAKRWSSYTPITELMIAT 611

  Fly   611 TVMDSIMLLFERVEKQHGRILVFHALAYITASKSGLSESELEDLISLDDKVLDDVYQYHLPPTR- 674
            :..:::.||::.:|:.||::||.|||.||.||:|||||:||:|::||||:||.|:|||..||:. 
 Frog   612 STKEAVSLLYQCLEQLHGKLLVSHALGYIVASRSGLSEAELKDILSLDDEVLADIYQYWAPPSND 676

  Fly   675 --RIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNMNMAIYFHSMIADYYL 737
              |.|.|.|||:||||..||.||:|||..|:..|||||.:.|::.|..|...: ..|..:|||::
 Frog   677 LIRFPTLPWTRLRNDLEGYLVERQADGSTVLGLYHRQFIEVARDTYLTNTEKS-NRHGTLADYFM 740

  Fly   738 GIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKRYNLRKFGELPFHFVR 802
            |.|..|..:|....        |.:|..:|||||..|||.||  |.:..|   ||..|||:|.:.
 Frog   741 GKWSMGTKRPILLP--------LINKSLNADRKVASQPLWFS--DNMPNR---RKMSELPYHLLN 792

  Fly   803 SRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKEAKRELMLVSDALRL------ 861
            :....:|...:|.|.||:.:|:.||.:|:|:.|||.:....    :.||:||:.|.|||      
 Frog   793 AGCIDELQGEILGNMDWISSKIVSCGIQSVIKDFEMSVKLI----SSREIMLLRDTLRLFQPTIN 853

  Fly   862 --GGAI--LAIYPNMLAP----QLVGRLLPEIGGNPNIKMLLRACDRSGPKDC----------AL 908
              .|.|  :.::..|||.    ||..||:.|:            |     :.|          ..
 Frog   854 FIEGVIDPVIVFTEMLARMHFFQLSYRLIDEL------------C-----QQCTGWLHQYPHPTF 901

  Fly   909 IPVNHCLHTPGGPLKYSLEGHQ--FAVFAFCLTSDMRYMVSISTHFITFDLSTSDLTRDVNPGIE 971
            ||.......|||||:.::.|.:  ..|...|...|:..:.|.....|.:::...::...:....:
 Frog   902 IPTCGFFQPPGGPLQTTVTGFKKGVTVMELCPDHDLLVVGSEDGIMIVWNIKDIEVIHTLTGHND 966

  Fly   972 GIMQQLVLSPDNKWAAAYSNN-NQTVLL-NMLS-SEFVVINSPFEESHGPVSGLYLLNQNLFITC 1033
            ||.   .:....|...|.|.: :.|:|| |::: .:::.|:    |.|......||         
 Frog   967 GIR---CIKMFEKGTRAVSGSLDHTLLLWNLVTGKQYLCIH----EDHTTYENAYL--------- 1015

  Fly  1034 KLRWAQFDTRGNLVDTFDVPGENKDWEILTMEFFNPADYNVVFWSGSINDMRLRLDSCRGGHYSN 1098
                 ..|.:.:::                   ::.|...|..|         :::|  |....|
 Frog  1016 -----HVDEKNSII-------------------YSAAGSQVYAW---------KIES--GAPLLN 1045

  Fly  1099 CQLLFSAMVMNKARTRAYGCANE------ENFEVSVFDFIEDEVTGDICWTLVESLPRFENDDKE 1157
                .|..|.|.....|..||::      |...|.::|....|:.|.      ..||....:|..
 Frog  1046 ----LSPGVPNFPLQAAVFCAHQLLITVTEGGTVHLWDSATGELKGS------RQLPGVGGEDAN 1100

  Fly  1158 MLLQLRLDQHDRMLLGTAGKGFVIWDFGSKDKDAAEECRLREGALYLALPHGVRNITTRIMQSNS 1222
            .:....:.:|.:|::|                       ...|  :||:......::|..|.|..
 Frog  1101 PVCSCFIPRHGKMVVG-----------------------FENG--FLAVISSGGGVSTEKMSSAV 1140

  Fly  1223 IMVSSKLDYAV--AGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLEPLTIGNWNNLV-TSSIDRSV 1284
            :.|....|.::  ||..|.:.::...|..|...||:.......::.:.|.|..|:: |.|.|.::
 Frog  1141 VFVVPSEDESLFAAGFGKQVQIFRADSNALRTFLDSPLEHEDFVKSVVINNGRNIILTGSQDETI 1205

  Fly  1285 KVWNI--------------------------------NNIFEKVHVID---RHEL------QIDD 1308
            ::|::                                |..:.|:..:|   :|:.      :...
 Frog  1206 RIWSLSHRGTLLDTFYGMGVSVTSLALHGGTLISSSKNAYYLKLWTLDYDQQHKTLTPFQERSGC 1270

  Fly  1309 ISLSEVDMAV----TVTRSCVGVWETRSGRLLAKLADSPLGAIVTHAEITPDGRYI-ISSETGKF 1368
            ::||:....|    |..:..:.||:::.|| :|.:.::  .|.|...|:..:.|.: :...:|..
 Frog  1271 VALSDAGNRVYFPKTGDKHKIVVWDSKQGR-MADIVEA--SAEVKCLEVAENSRILFVGLTSGTV 1332

  Fly  1369 LVWNRVSEQVVFRDDQPGIQQITLMDYGYKVLTVSVPNINQRDILAAAAGGSADEANRLTA---- 1429
            |.:....:|.|.....||                     |..:::..:.   :.:.|||..    
 Frog  1333 LAFPLDQKQDVACIPPPG---------------------NNMEVVCLSL---SKQENRLAVAYHN 1373

  Fly  1430 ITTMRSVPEGSIFFRFEFPIRMITGMPFRQSVITADNAYIVVVTVDKSNKDCLGVYSATNGAFVS 1494
            :..:..|.:|.       |:.::.| |. .||.....:.|....|.:..:...|:.|       .
 Frog  1374 LILLYDVTKGD-------PLPVLDG-PI-HSVHPGSTSSICKTAVLEDQRLLYGMAS-------G 1422

  Fly  1495 KVLLKGCSIKEVISLVPMPHKANQVAVISSEKGSVMDIKTKKHVRSIAKWG--GSITRDGKCGLY 1557
            ::.|..|.:.....|.|.......:...:||              ::|..|  .|:.|       
 Frog  1423 EIYLFNCEMDNTCQLEPHERCITCLETSNSE--------------TLALSGCEDSVQR------- 1466

  Fly  1558 APTRGGLEMLELRKGTTVKTFIPKVAEGVF--SVIC-IFTENDEYVAYYHSGRKTIRVFRTADTE 1619
                    :..:..|..|.....|   |.|  .|.| .|:::|.:: :..|..:.|:.:..:...
 Frog  1467 --------LWNIDSGQWVHEMCYK---GFFFQGVDCACFSKDDRFI-FTGSQDRAIKAWDVSSGS 1519

  Fly  1620 MIANYRLQAELTAIKSSKDGRAIVLGT 1646
            ::|...:.|.:|.:..:.:|   .:||
 Frog  1520 LLAVQYVYASVTRLLPTAEG---FIGT 1543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10185NP_650521.1 AAA_16 363..488 CDD:289934 42/137 (31%)
WD40 1177..>1379 CDD:225201 42/250 (17%)
WD40 repeat 1214..1256 CDD:293791 11/43 (26%)
WD40 <1216..1380 CDD:295369 38/212 (18%)
WD40 repeat 1261..1300 CDD:293791 9/71 (13%)
WD40 repeat 1306..1341 CDD:293791 9/38 (24%)
WD40 repeat 1348..1393 CDD:293791 9/45 (20%)
nwd1XP_002934424.2 WD40 repeat 1444..1482 CDD:293791 8/66 (12%)
WD40 repeat 1489..1513 CDD:293791 6/24 (25%)
DUF4062 26..122 CDD:379095 57/96 (59%)
P-loop_NTPase 388..557 CDD:393355 53/184 (29%)
WD40 918..1295 CDD:392136 75/462 (16%)
WD40 repeat 926..963 CDD:293791 5/36 (14%)
WD40 repeat 969..1012 CDD:293791 10/49 (20%)
WD40 repeat 1055..1092 CDD:293791 8/42 (19%)
WD40 repeat 1140..1179 CDD:293791 9/38 (24%)
WD40 1180..1514 CDD:392136 66/409 (16%)
WD40 repeat 1184..1208 CDD:293791 6/23 (26%)
WD40 repeat 1262..1306 CDD:293791 9/44 (20%)
WD40 repeat 1311..1347 CDD:293791 7/35 (20%)
WD40 repeat 1356..1390 CDD:293791 6/43 (14%)
WD40 repeat 1401..1438 CDD:293791 6/43 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 121 1.000 Domainoid score I5645
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 498 1.000 Inparanoid score I1343
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D14491at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - oto102815
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.970

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