DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10185 and Nwd1

DIOPT Version :9

Sequence 1:	NP_650521.1	Gene:	CG10185 / 41953	FlyBaseID:	FBgn0038397	Length:	1732	Species:	Drosophila melanogaster
Sequence 2:	XP_038950913.1	Gene:	Nwd1 / 100364350	RGDID:	2321209	Length:	1563	Species:	Rattus norvegicus

Alignment Length:	1686	Identity:	418/1686 - (24%)
Similarity:	682/1686 - (40%)	Gaps:	350/1686 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 DTTMERNTLMAKCYPRIKDYCREKHGLEFQVVDMRWGVRDEATDDHMTTELCMREIKNCQRLSMG 99
            ||  ||..|....||.::.:| :||||.|:.||:|||:.:....|::|||||:.|::.||:.|:|
  Rat     2 DT--EREALQCTAYPEVQSFC-QKHGLAFEAVDLRWGIPNTQATDYLTTELCLEELERCQKTSVG 63

  Fly   100 PNFIVFLGQKYGYRPIPTYIVSSELALICEELTSMGVDRAILDLWYKKDSNAVPPISVLQPISSI 164
            |.|:..||.:||..|:|..|...|...:..:|||...|..::...:::|.|.:||..||||..|.
  Rat    64 PAFVALLGDQYGPCPVPQRIEEKEWEALRAQLTSRPRDLELVTRHFQRDDNTIPPTYVLQPPGSG 128

  Fly   165 LINFNNKRVPKLQAEDQAVWWDTLNKMQKLLRKAAASLGASNKMSKEDVHNYFMSVTEREVINGI 229
            ::          ...::|.       :..:||..|........:|:|....|..||.|.|:.:|:
  Rat   129 VV----------PGPEEAT-------LTSVLRGGAQEAWRLGLISQEQWMCYHRSVIEWEIEHGL 176

  Fly   230 LNVKNTKNHCLSYVRYINNINLQNLKKASL-FVD-IINRSLDTESAKLLSDLRDVRLPAKIEAVN 292
            ||..........::|.:.:::...|....| .|| :.:..|||.:..|||.|:...|.|:..|:
  Rat   177 LNSARGDQGATVFLRDVQDLSKHILDDCCLKMVDRLADGCLDTNAQSLLSGLKGRILDAQPGAL- 240

  Fly   293 AQKYTVEWIGREGLDI-----ETHEEYLNHFISHFYKNVVKLVDRAMRKEDSSAQ--GQIVTEIL 350
             :.:.:.|    ..|:     :||..||......|.......|...:|:.:.:.|  |.:..||.
  Rat   241 -KSHHLPW----SRDLVNPKNKTHARYLKQLSEQFVARTNHQVLEQLRELELARQELGWLYQEIR 300

  Fly   351 QHLHACNNSVKIFYGREESCERIKRYMLGDSDK---PLVLFGDGGCGKTSLLSKSVSLVATEWFA 412
            .||.....|.|:|.|.:|...::|:.:..|..:   ||||||..|.|||||:.|....| .|...
  Rat   301 HHLWQSTESTKVFCGHQELLAQLKQRLRQDESRTHTPLVLFGPPGIGKTSLMCKLAQQV-PELLG 364

  Fly   413 HVRPINVIRFLGTTPDSSALTATLISICQQISYNYMLPFENIPDDLVPLTAH------FKQLLTY 471
            | :.:.|:|.|||:..|....:.|.|:..|:...|.||   :|...| |.||      |..||..
  Rat   365 H-KTVAVLRLLGTSKLSLDARSLLRSLSFQLCLAYGLP---LPPAQV-LEAHSRVGHFFHILLHT 424

  Fly   472 ASPT--QPLTIYLDSVDQLTGTQDSNKVSWIPTRLPPHCKIIIS-CANEPANPTVSHEYHVLCKM 533
            .|..  :.|.:.|||||.|...:.:.:|||:|.:.||...:|:| |:.:          .|||.:
  Rat   425 VSQRNFESLVLLLDSVDDLDSIRHTPRVSWLPLKCPPRVHLILSACSGQ----------QVLCNL 479

  Fly   534 IDVEEN---FIEVTALGEDLAMNVIKMWMKTACRDLNNYQWRLVANAISKCSLPIFVKLVFAEIC 595
            ....::   :.||.||........|::.:....|.|:..|..::..::.:|..|..::|.|.|..
  Rat   480 QQTLKDPSAYWEVKALSGSQGQEFIQLLLAAERRMLSPGQRDVLWASLPECGHPGRLRLAFEEAR 544

  Fly   596 RWRSYTRPQETHLANTVMDSIMLLFERVEKQHGRILVFHALAYITASKSGLSESELEDLISLDDK 660
            :|.|:|.|  ..||.|..::......|:|:.||::||...|.||.:|:.||||:||:|::||||:
  Rat   545 KWASFTVP--VPLATTAEEATHQFCIRLEETHGQLLVARVLGYIVSSRYGLSEAELKDVLSLDDE 607

  Fly   661 VLDDVYQYHLPPTR---RIPPLLWTRIRNDLPNYLSEREADGVNVMNWYHRQFRDTAKERYFKNM 722
            ||..||:...||::   |.|||||.|:|.||.:.|..|..||..::...|||.....:.||....
  Rat   608 VLQAVYRDWTPPSKELLRFPPLLWVRLRRDLGHCLVRRPVDGCILLAIAHRQLSQVIQVRYLSGP 672

  Fly   723 NMAIYFHSMIADYYLGIWGGGVPKPFKFTEIQRHRFGLADKEGSADRKVPIQPLVFSSKDGLSKR 787
            ..| ..|.::|:::.|.|..|:.|.....        |..|..:.||||..|||.||....
  Rat   673 ERA-KRHGVLAEFFSGAWSQGIKKLITLP--------LVGKPLNLDRKVAPQPLWFSGTVA---- 724

  Fly   788 YNLRKFGELPFHFVRSRRFKDLFEHVLFNYDWLHAKLSSCPLQAVLADFEDASSNTDDKE---AK 849
             |.||..|||||.:.:...::|.:.||.|..|:..:..|..::.:|.||:..:.:.|..|   .:
  Rat   725 -NWRKLTELPFHLLHAGCLEELKQEVLGNMSWISCRGISGGIEDLLDDFDMCAPHMDSPEVYLVR 788

  Fly   850 RELMLVSDALRLGGAILAI-YPNMLA---------PQLVGRLLPEIGGNPNIKMLLRACDRSGPK 904
            ..:.|...|:.|.|...:| |..:||         |.::|:|..:      .:...|||...
  Rat   789 EAIQLCRPAVELRGLEKSILYTELLARLLFFATSHPAMIGQLCQQ------AQSWFRACPYP--- 844

  Fly   905 DCALIPVNHCLHTPGGPLKYSLEGHQFAVFAFCLTSDMRYMVSISTH---FITFDLSTSDLTRDV 966
              .|:|:...|..|||||:.:|.|....:.|...:.:.:.:| :.|.   .:.:|:....:.. |
  Rat   845 --MLVPLAGFLQPPGGPLRATLTGCHKGITAIAWSLEEKLLV-VGTQDGTMVVWDVEEQQVVH-V 905

  Fly   967 NPGIEGIMQQLVLSPDNKWAAAYSNNNQTVLLNMLSSEFVVINSPFEESHGPVSGLYLLNQNLFI 1031
            ..|....::.:.:......|.:.|.::...|.::||.:
  Rat   906 LMGHTAEVRCVRVFAQGTLAISASKDHTLRLWSLLSGQ--------------------------- 943

  Fly  1032 TCKLRWAQFDTRGNLVDTFDV-PGENKDWEILTMEFFNPADYNVVF-WSGS-INDMRL---RLDS 1090
                      .:..::|.... |.|.:.|::...|.     .|||: .||: ||...|   :|..
  Rat   944 ----------EKATILDGGSPNPTEQQGWDLHVDEI-----KNVVYSTSGTKINVWDLETSKLVF 993

  Fly  1091 CRGGHYSN---CQLLFSAMVMNKARTRAYGCANEENFEVSVFDFIEDEVTGDICWTLVESLPRFE 1152
            |..|..|:   |..|.:|..:..|.|        |..:||::    ....|.:
  Rat   994 CITGDASDPWVCVALLAAQGLLLALT--------EGGQVSLW----SSAVGKL------------ 1034

  Fly  1153 NDDKEMLLQLR---------LDQHDRMLLGTAGKGFVIWDFGSKDKDAAEECRLREGALYLALPH 1208
             .:|..|..::         :....|:::|        :..||.....|.|.||.|     .||.
  Rat  1035 -QEKHQLCSIKEETPTCAVSIQTRARLVVG--------FSSGSVALVCAGEDRLLE-----KLPE 1085

  Fly  1209 GVRNITTRIMQSNSIMVSSKLDYAVAGVRKNLYVWCLQSGQLAKVLDAHFGRIIQLEPLTIGNWN 1273
            .|..:.  :.:.:|::        ..|..:.:.|:...|....:.:.........:|...:|..|
  Rat  1086 AVGFLA--VSEDDSLL--------AVGFGRCVRVFLADSQDFHRFMATDLEHEDVVETAVLGPEN 1140

  Fly  1274 NL-VTSSIDRSVKVWNINNIFEKVHVIDRHELQIDDISLSEVDMAVTVT--RSCVGVWETRSGRL 1335
            || :|:|.|..::||:::.....:.|.:........:.|.|. :.|:.:  .|....|:.||
  Rat  1141 NLIITASRDALIQVWSLSEQGTLLSVFESAGAPASLLVLCET-LVVSASWKSSSFKAWDLRS--- 1201

  Fly  1336 LAKLADSPLG-------AIVTHAEITPDGRYIISSETG---KFLVWN------------------ 1372
             .:...||..       |.|:|     .|.|:...:.|   |..:|:
  Rat  1202 -TQKPPSPTPFLDRTGLATVSH-----HGSYVYFPKVGDKNKVTIWDLAEGEEQDSLDTSNEVCC 1260

  Fly  1373 -RVSEQ--VVFRDDQPGIQQITLMDYGYKVLTVSVPNINQRDILAAAAGGSADE-ANRLTAITTM 1433
             .|:||  ::|.....||..:..::....||.:..|.. ::.:...:...|.|. |.....|..:
  Rat  1261 LEVAEQTKLLFTGLVSGIVLVFPLNSRQDVLCIPPPEA-RKAVNCMSVSKSEDRLAIAYDNIVLV 1324

  Fly  1434 RSVPEGSIFFRFEFP-IRMITGMPFRQSVITADNAYIVVVTVDKSNKDCLGVYSATNGAFVSKVL 1497
            ..:..|.:....|.| ....|.:|  ::::.      |.|..|         |....|.....:.
  Rat  1325 LDISPGDLCPAIEGPTYTFYTQLP--ETIVR------VAVLAD---------YRVVYGMSDGSLF 1372

  Fly  1498 LKGCSIKEV---------ISLVPMPHKANQVAVISSEKG--SVMDI------------------- 1532
            |..|:..:|         :|.|.:.|: .|:||..:|..  .:.|:
  Rat  1373 LYDCAQSKVFPLEAHGSRVSCVEVSHR-EQLAVSGAEDALLCLWDLQACREKFKMSYESSYCRGV 1436

  Fly  1533 ------KTKKHV------RSIAKWGGSITRDGKC------------------GLYAPTRGG 1563
                  |..|||      |||..|.   ..||..                  |..|||..|
  Rat  1437 RCACFSKDDKHVFTGMEDRSIIAWS---ALDGTLLAVQFVHAVVNRIIPTSNGFMAPTSHG 1494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10185	NP_650521.1	AAA_16	363..488	CDD:289934	48/135 (36%)
		WD40	1177..>1379	CDD:225201	45/235 (19%)
		WD40 repeat	1214..1256	CDD:293791	4/41 (10%)
		WD40	<1216..1380	CDD:295369	35/197 (18%)
		WD40 repeat	1261..1300	CDD:293791	11/39 (28%)
		WD40 repeat	1306..1341	CDD:293791	7/36 (19%)
		WD40 repeat	1348..1393	CDD:293791	13/68 (19%)
Nwd1	XP_038950913.1	AAA	315..>361	CDD:99707	18/46 (39%)
		YlqF_related_GTPase	<333..>421	CDD:424112	34/93 (37%)
		WD40	860..1156	CDD:421866	67/387 (17%)
		WD40 repeat	871..908	CDD:293791	5/38 (13%)
		WD40 repeat	914..956	CDD:293791	6/78 (8%)
		WD40 repeat	961..996	CDD:293791	12/39 (31%)
		WD40 repeat	1004..1041	CDD:293791	10/61 (16%)
		WD40 repeat	1087..1123	CDD:293791	5/45 (11%)
		WD40	1127..1461	CDD:421866	69/362 (19%)
		WD40 repeat	1130..1155	CDD:293791	8/24 (33%)
		WD40 repeat	1259..1297	CDD:293791	8/37 (22%)
		WD40 repeat	1302..1337	CDD:293791	5/34 (15%)
		WD40 repeat	1352..1383	CDD:293791	8/45 (18%)
		WD40 repeat	1391..1429	CDD:293791	8/38 (21%)
		WD40 repeat	1436..1473	CDD:293791	10/39 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D14491at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103490
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820