|
Fly 1 MAEDTEYKKLPVEERCVHKLWKARVDGYEEAAKIFRELDDEKSPEWSKFAGLIKKMVVDSNALAQ 65
|.:|:|:.||||:::|.|||||||:.|||||.|||:::.||||||||||.|||||.|.||||:.|
Human 1 MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQ 65
Fly 66 EKGLEAALIFVENSGLAGRTVGDVMTGIVQKCIAAPKTKTKELSVQVALMYVEIEKQEAVVEELV 130
.|||||||::|||:.:||:|.|:|::|:|.|....||.|.|||.:::.|||:||||.|||.|||:
Human 66 LKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYIEIEKGEAVQEELL 130
Fly 131 KGMEAKNPKIVSACVAATTLALREFGHKVIGVKPLIKKLAPLMSDRDKTVRDEGKQLAVEIYRWI 195
||::.|||||:.||:.....||.|||.|:|.:||:||.|..|...|:|.||||.|.:||||||||
Human 131 KGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAVRDEAKLIAVEIYRWI 195
Fly 196 GAAMKAQISTLPQVTLKELEDEFDKLKGERVEPSRYLKSQQEKQAKI--ADAAATEDAYNEDDGE 258
..|::..:..:..|.|||||:|:.||......|:|:|:||||.:||: ..:|..:.....|||:
Human 196 RDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEAKLEQQQSAGGDAEGGGDDGD 260
Fly 259 AGVEEIDPMDLLDPVDILSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLENGEYGALVSA 323
. |.:||..:||:.|:||||:|||||||:|.|||..|||:||.:| :|..:||||.|:|..||.|
Human 261 E-VPQIDAYELLEAVEILSKLPKDFYDKIEAKKWQERKEALESVE-VLIKNPKLEAGDYADLVKA 323
Fly 324 LKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAIDAI 388
||||:.||:||:|||:|.|||..||.||.|:|..||...||::|||||||||.||.||:||||||
Human 324 LKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAI 388
Fly 389 YASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDP 453
:.:|:|:...|.::..:.||||::|.:|:|||||:......:.|.|.|||....:|:|.:|:..|
Human 389 FLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHINDSAP 453
Fly 454 TVRDSSAEALGTLIKLMGDKAVTPLLADVDPLKMAKIKECQEKAEI----KIKVAGPKKETRPAS 514
.|||::.|||||.:|::|:|||.|.|||||.||:.|||||.||.|: |..:|..|||.:|..
Human 454 EVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLP 518
Fly 515 APTAKAAAPAKTVAGSVDPKPVTRPATTGARKVLKKPATVSGG----GATSAPTAALKAG---GK 572
..||.:.| ||..|.|.::.| ..|..| |.||..:|| |..:||..|...| .|
Human 519 GRTAASGA-----AGDKDTKDISAP-KPGPLK--KAPAAKAGGPPKKGKPAAPGGAGNTGTKNKK 575
Fly 573 PLAT----EREITPEELQEKSEEILPAEILNGLVDSNWKNRLAAVEQLLGEISGFDAKQAGISQI 633
.|.| |.|::.|..:||:..:||...:..|..||||.|||.:|:....:...|..:.. .|.
Human 576 GLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELMDRTEMP-CQA 639
Fly 634 LIRTISGRKPGLKEMNFQVLKFKLDIIRSVAENYPLTTTTVDLVINEIIEKLADAKNGAAAADVL 698
|:|.:: :|||.||.||||::.||.|:..:|:....:.|:..:|::.:::|:.|.|.|..|.:.:
Human 640 LVRMLA-KKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAM 703
Fly 699 SAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQ-LQPKTLIEDVRKGVQSTN 762
:|.|||..|.:...:|:|.||.||:||.|||..||::.:|.||||. |..|..|.:|:..:.:||
Human 704 TAIAEACMLPWTAEQVVSMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATN 768
Fly 763 PTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPKPVRGVQR-SSGGTA 826
|.||.:||.::|.|.:|:|.:|.|||:.|||||.|||..||:|..|:.||.|.||:.: |:.||.
Human 769 PAVRTAAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFEKMQGQSPPAPTRGISKHSTSGTD 833
Fly 827 GNSPDNEDDDGGAAGEEEPINMADLLPRVDIAPQITEALLKEMSDKDWKTRNEGLTKLQAIISEA 891
.....:|.|||.. ::.|||||.:|:.:||..|:.::.||:||.|.|||.::..||::|
Human 834 EGEDGDEPDDGSN-------DVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDA 891
Fly 892 RLIKPSIGDLAPALAHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFPGFLHALGDNKSF 956
:.|:|:||:|..||..||.|||..:.|.||.|.:|||.|||...:.||:||....:..|||:|:.
Human 892 KFIQPNIGELPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNN 956
Fly 957 VRAAALNCINSFGEKGGYKEFFESEMIADALKGGSPALKTELWAWLADKLPGLPPKSVSKEDIHS 1021
||||||..:|::.|:.|.||:.|.|.:::.||..:|.|:.||..|||:|||.| ..:..|:..
Human 957 VRAAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTL---RSTPTDLIL 1018
Fly 1022 MVPHLYAHICDRNADVRKNANEAVLGIMIHLGFDAMNRALDKQKPASKKDILAALEKARPNLPVK 1086
.|||||:.:.|||.||||.|.:|:...|:|||::.|.:|..|.||.||..:||.||||:.|:|.|
Human 1019 CVPHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKVNMPAK 1083
Fly 1087 PLPKGKHQA---------------------------PIPEEPKLKTVRGGGAGGAPGIQKSATAR 1124
|.|..|..: |.|:..|.| |||:...|.:
Human 1084 PAPPTKATSKPMGGSAPAKFQPASAPAEDCISSSTEPKPDPKKAK---------APGLSSKAKS- 1138
Fly 1125 VAGGQDKQVPAR---KKDEDIDTSPLLCANSAKNQRLLDEQKMKVLKWTFVTPREEFTELLRDQM 1186
.|.|::|:: |:|||......:...:.|.||:.||:.:|||||.|.|||:|:.|.|:.||
Human 1139 ---AQGKKMPSKTSLKEDEDKSGPIFIVVPNGKEQRMKDEKGLKVLKWNFTTPRDEYIEQLKTQM 1200
Fly 1187 MTANVNKALIANMFHDDFRYHLKVIEQLSEDLAGNSKALVCNLDLILKWLTLRFYDTNPSVLIKG 1251
.:. |.|.|...|||.||::|.|.:..:.:.|....:.::..||||||||||||:|||.|||:|.
Human 1201 SSC-VAKWLQDEMFHSDFQHHNKALAVMVDHLESEKEGVIGCLDLILKWLTLRFFDTNTSVLMKA 1264
Fly 1252 LEYLVQVFQVLIDEEYILAENEGSSFVPHLLLKIGDPKDAVRNGVRRVLRQVILVFPFVKVFGYV 1316
||||..:|.:|.:|||.|.|||.|||:|:|::|:|:|||.:|..||.:|.::.||:|..|:|.::
Human 1265 LEYLKLLFTLLSEEEYHLTENEASSFIPYLVVKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFI 1329
Fly 1317 MEGLKSKNARQRTECLDELTFLIESYGMNIC---PQSAVREIARQISDRDNSVRNAALNCIVQVF 1378
|||.||||::||.|||:||..|:||||||:| |..|::|||..|.||||:|||||||.||.|:
Human 1330 MEGTKSKNSKQRAECLEELGCLVESYGMNVCQPTPGKALKEIAVHIGDRDNAVRNAALNTIVTVY 1394
Fly 1379 FLSGEKTYKMIGHLNEKDLSMLDERIKRAKKTKKPTPPPSVDVPAPQRHDSIEIEDAEVGNGCDE 1443
.:.|::.:|:||:|:|||:|||:|||||:.|.....|...|: ..|||..:|......:..|
Human 1395 NVHGDQVFKLIGNLSEKDMSMLEERIKRSAKRPSAAPIKQVE-EKPQRAQNISSNANMLRKG--- 1455
Fly 1444 LPPPDEDGLQRELNARGQNNMTDRSATNVVAYLSSLTRQATFDQAPSSQLLLLQQQLQQLQQQAQ 1508
|.|| :||...|| :.:....:.||
Human 1456 ---PAED-------------------------MSSKLNQA--------------RSMSGHPEAAQ 1478
Fly 1509 QQKPSGPFGLDSQVISEIEKD--WVRVDQMEQKPLLNVDISSLDEPIKVRPTRAGIHYPQEKFDR 1571
..:.. |.|| :.|||.| .||.:..| |:...:..:.||:.: |:.|.
Human 1479 MVRRE--FQLD---LDEIENDNGTVRCEMPE---LVQHKLDDIFEPVLI---------PEPKI-- 1524
Fly 1572 LISRQHYMQQTLTTSPSSTAGMTSGVSPYRSPMRLQHQQPQQQLENNIPNLADVLPKHDPQLVKV 1636
..|||:...|. .|.|..:. .:
Human 1525 -----------------------RAVSPHFDDMH--------------SNTASTIN-------FI 1545
Fly 1637 IKGVSSTDTLKARAAINELAAIIEAPEKQAVLRDYEEIFIQNVLAQFKNL----------SQIPS 1691
|..|:|.|...:..|:.::..::...:|...:..:.:.|: :|.|..| .::..
Human 1546 ISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFL---IATFMQLRLIYNTHMADEKLEK 1607
Fly 1692 AQSVVVYQPLLSILYTFFHANILGKTLSVACIKNLMSALLNLMADPKLA-VGDDSQYNKVINGIC 1755
.:.:.:|..::..:.:.|....|.:..|...:|:||..|:.||.|.::. :.:..|..:.:|.:.
Human 1608 DEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNLLV 1672
Fly 1756 LKVLDKVDFTNLNCALIRLLRET-CPEAKLPKFTDLLMKCIWRNVKMLPERSNELNYDAVILEVH 1819
:|||:|.|.||:..||:.||::: ...|..|||::|:|||:||.|::||:..|.:|.|.::|::|
Human 1673 VKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLDIH 1737
Fly 1820 EFMLALPSTWWQNRPSDTPMRTIKTILHNMAKVKGNAILQHLNQI--PTHSELHTYLIRILKNFQ 1882
.||...|....:...|:.|:||:||:||.:.|:||..||.||..| ...|||..:|.|::|:..
Human 1738 IFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKHSM 1802
Fly 1883 KDGSASGIGASPQRAKEIASKRISHQTHDTVSQIFKLISDRDTKQQGLQKLYDFKQQNPDIDLST 1947
....:.....:.:.|..|..|....:.:|.:::|||.|..::..::||.:||::|::..|.|:..
Human 1803 DQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDADIEP 1867
Fly 1948 FLQGSSAPFHKYIEEGLAEIERNQNAGSTQDNRT--------------AATRSYLTDVNYQNNGP 1998
||:.||..|..|:|.||..||..:.........| .:|.|.:.:.|.:..|
Human 1868 FLKNSSQFFQSYVERGLRVIEMEREGKGRISTSTGISPQMEVTCVPTPTSTVSSIGNTNGEEVG- 1931
Fly 1999 DPDFWMDRLQYHMTGGAAKLASARSADDGSHMLDNKVVDENLCLNGMNAQKASLIKREKRDMSPN 2063
|..:::|| |:...|.. |||...|:...|..:.::.|........||
Human 1932 -PSVYLERL---------KILRQRCG------LDNTKQDDRPPLTSLLSKPAVPTVASSTDM--- 1977
Fly 2064 RLQHLQAKLAQIK--KENH 2080
|.:||:|:: :|.|
Human 1978 ----LHSKLSQLRESREQH 1992
| 
