DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msps and STU2

DIOPT Version :9

Sequence 1:	NP_001247129.1	Gene:	msps / 41952	FlyBaseID:	FBgn0027948	Length:	2082	Species:	Drosophila melanogaster
Sequence 2:	NP_013146.1	Gene:	STU2 / 850734	SGDID:	S000004035	Length:	888	Species:	Saccharomyces cerevisiae

Alignment Length:	986	Identity:	230/986 - (23%)
Similarity:	405/986 - (41%)	Gaps:	208/986 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EDTEYKKLPVEERCVHKLWKARVDGYEEAAKIFR------ELDDEKSPEWSKFAGLIKKMVVDSN 61
            |:.:|..||:|||..:||||||::.|:|..::||      ..||.....| :...|..:.:.|||
Yeast     5 EEVDYTTLPLEERLTYKLWKARLEAYKELNQLFRNSVGDISRDDNIQIYW-RDPTLFAQYITDSN 68

  Fly    62 ALAQEKGLEA--ALI--FVENSGLAGRTVGDVMTG---IVQKCIAAPK--TKTKELSVQVALMYV 117
            .:|||:.:.|  :||  |..:|......:..:.|.   :|:|.:.:.:  |||:.:|..::|..:
Yeast    69 VVAQEQAIVALNSLIDAFASSSLKNAHNITLISTWTPLLVEKGLTSSRATTKTQSMSCILSLCGL 133

  Fly   118 EIEKQEAVVEELVKGMEAKNPKIVSACVAATTLALREFGHKVIGVK----PLIKKLAPLMSDRDK 178
            :....:: ||.::...|.|.||:::|........:..||...:.|:    .|:|.:..|....|:
Yeast   134 DTSITQS-VELVIPFFEKKLPKLIAAAANCVYELMAAFGLTNVNVQTFLPELLKHVPQLAGHGDR 197

  Fly   179 TVRDEGKQLAVEIYRWIG--AAMKAQI--STLPQVTLKELEDEFDKLKGERVEPSRYL-----KS 234
            .||.:...|.||||:..|  :.:..:|  ..|..:.:|:|...|.|: |:....|:.|     :.
Yeast   198 NVRSQTMNLIVEIYKVTGNNSDLLEEILFKKLKPIQVKDLHKLFAKV-GDEPSSSKMLFEWEKRE 261

  Fly   235 QQEKQAKIADAAATEDAYNEDDGE----------AGVE------------EIDPMDLLDPVDILS 277
            .::|:::..:|...:...:.|:||          .|:|            :||...:|....||.
Yeast   262 LEKKRSQEEEARKRKSILSNDEGEYQIDKDGDTLMGMETDMPPSKQQSGVQIDTFSMLPEETILD 326

  Fly   278 KMPKDFYDKLEEKKWTLRKESLEVL-EKLLTDHPKLE--NGEYGALVSALKKVITKDSNVVLVAM 339
            |:||||.:::...||..|.|:||.. :.:|:...||:  :..|..|:.....:|.||:|:..||:
Yeast   327 KLPKDFQERITSSKWKDRVEALEEFWDSVLSQTKKLKSTSQNYSNLLGIYGHIIQKDANIQAVAL 391

  Fly   340 AGK-----CLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAI-------DAIYAST 392
            |.:     |..|...|.:|   :|.|.....||::.|||||:|:.|:|:|:       |.:.:|.
Yeast   392 AAQSVELICDKLKTPGFSK---DYVSLVFTPLLDRTKEKKPSVIEAIRKALLTICKYYDPLASSG 453

  Fly   393 SLEAQQESIVESLSNKNPSVKSE-TALFIARALTRTQP-TALNKKLLKLLTTSLVKTLNEPDPTV 455
            ..|...:.|:|.:.:|.|.::.| |.||.|........ :.|.:.|...:...:::.:|:..|.:
Yeast   454 RNEDMLKDILEHMKHKTPQIRMECTQLFNASMKEEKDGYSTLQRYLKDEVVPIVIQIVNDTQPAI 518

  Fly   456 RDSSAEALGTLIKLMGDKAVTPLLADVDPLKMAKIKECQEKAEIKIKVAGPKK----ETRPASAP 516
            |....|:...|||:.|.......|..:|.||..||:| ..|......:|....    ||...:.|
Yeast   519 RTIGFESFAILIKIFGMNTFVKTLEHLDNLKRKKIEE-TVKTLPNFSIASGSTHSTIETNKQTGP 582

  Fly   517 -------TAKAAAPAKTVAGSV---DPKPVTRPATTGARKVLKKPATVSGGGATSAPTAALKAGG 571
                   ...:..|:|.||.|.   |.|....|  .|:.....||:.|:....:.....:
Yeast   583 MENKFLLKKSSVLPSKRVASSPLRNDNKSKVNP--IGSVASASKPSMVAANNKSRVLLTS----- 640

  Fly   572 KPLATEREITPEELQEKSEEILPAEILNGLVDSNWKNRLAAVEQLLGEISGFDAKQAGISQILIR 636
            |.|||.:.:.... .:|:|:::          ..:|.||..::                :..:|.
Yeast   641 KSLATPKNVVANS-TDKNEKLI----------EEYKYRLQKLQ----------------NDEMIW 678

  Fly   637 TISGRKPGLKEMNFQVLKFKLDIIRSVAENYPLTTTTVDLVINEIIE---KLADAKNGAAAADVL 698
            | ..|:..|::|| ....:|:::|:.                ||::.   |.|.:|.......:.
Yeast   679 T-KERQSLLEKMN-NTENYKIEMIKE----------------NEMLREQLKEAQSKLNEKNIQLR 725

  Fly   699 SAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQPKTLIEDVRKGVQSTNP 763
            |...:..||.   .:|||...|.::.:::.                        |..|....||
Yeast   726 SKEIDVNKLS---DRVLSLENELRNMEIEL------------------------DRNKKRNDTN- 762

  Fly   764 TVRASAIQMVGTMSMY---------------MGKALMMFFDSEKPALKSQIQVE--FDKNVGEKP 811
                  :|.:||:|.|               :..|| .|.:.|....|..:..|  ..:::|:.|
Yeast   763 ------LQSMGTISSYSIPSSTVSSNYGVKSLSSAL-PFKEEEDVRRKEDVNYERRSSESIGDLP 820

  Fly   812 PK----PVRGVQRSSGGTAGNSPDNEDDDGGAAGEEEPINMADLLPRVDIAPQITEALLKEMSDK 872
            .:    .:|..:::..|.:..|.|.:.|...:...||....         |..:|..|...:...
Yeast   821 HRVNSLNIRPYRKNGTGVSSVSDDLDIDFNDSFASEESYKR---------AAAVTSTLKARIEKM 876

  Fly   873 DWKTRNEGLTK 883
            ..|:|.||.|:
Yeast   877 KAKSRREGTTR 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	10/35 (29%)
		HEAT repeat	361..387	CDD:293787	11/32 (34%)
		HEAT repeat	398..466	CDD:293787	15/69 (22%)
		HEAT repeat	860..891	CDD:293787	7/24 (29%)
		HEAT repeat	900..929	CDD:293787
		HEAT repeat	939..968	CDD:293787
STU2	NP_013146.1	PTZ00108	<655..888	CDD:240271	57/321 (18%)
STU2	NP_013146.1	Smc	<658..>760	CDD:224117	26/172 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1820
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5459
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003733
OrthoInspector	1	1.000	-	-		oto99236
orthoMCL	1	0.900	-	-		OOG6_101795
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R51
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.620