DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msps and Ckap5

DIOPT Version :9

Sequence 1:	NP_001247129.1	Gene:	msps / 41952	FlyBaseID:	FBgn0027948	Length:	2082	Species:	Drosophila melanogaster
Sequence 2:	XP_006500405.1	Gene:	Ckap5 / 75786	MGIID:	1923036	Length:	2040	Species:	Mus musculus

Alignment Length:	2166	Identity:	847/2166 - (39%)
Similarity:	1236/2166 - (57%)	Gaps:	252/2166 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEDTEYKKLPVEERCVHKLWKARVDGYEEAAKIFRELDDEKSPEWSKFAGLIKKMVVDSNALAQ 65
            |.:|:|:.||||:::|.|||||||:.|||||.|||:::.|||||||||:.|||||.|.||||:.|
Mouse     1 MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKYLGLIKKFVTDSNAVVQ 65

  Fly    66 EKGLEAALIFVENSGLAGRTVGDVMTGIVQKCIAAPKTKTKELSVQVALMYVEIEKQEAVVEELV 130
            .|||||||::|||:.:||:|.|:|::|:|.|....||.|.|||.:::.||||||||.|:|.|||:
Mouse    66 LKGLEAALVYVENAHVAGKTTGEVVSGVVSKVFNQPKAKAKELGIEICLMYVEIEKGESVQEELL 130

  Fly   131 KGMEAKNPKIVSACVAATTLALREFGHKVIGVKPLIKKLAPLMSDRDKTVRDEGKQLAVEIYRWI 195
            ||::.|||||:.||:.....||.|||.|:|.:||:||.|..|...|||.||||.|..|:|||||.
Mouse   131 KGLDNKNPKIIVACIETLRKALSEFGSKIISLKPIIKVLPKLFESRDKAVRDEAKLFAIEIYRWN 195

  Fly   196 GAAMKAQISTLPQVTLKELEDEFDKLKGERVEPSRYLKSQQEKQAKI--ADAAATEDAYNEDDGE 258
            ..|:|..:..:..|.|||||:|:.||.....:|||:|:||||.:||:  ..:|..:.....|||:
Mouse   196 RDAVKHTLQNINSVQLKELEEEWVKLPTGAPKPSRFLRSQQELEAKLEQQQSAGGDAEGGGDDGD 260

  Fly   259 AGVEEIDPMDLLDPVDILSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLENGEYGALVSA 323
            . |.::|..:|||.|:||||:|||||||:|.|||..|||:||.:| :|..:||||.|:|..||.|
Mouse   261 E-VPQVDAYELLDAVEILSKLPKDFYDKIEAKKWQERKEALEAVE-VLVKNPKLEAGDYADLVKA 323

  Fly   324 LKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAIDAI 388
            ||||:.||:||:|||:|.|||..||.||.|:|..||...||::|||||||||.||.||:||||||
Mouse   324 LKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAGHVVPTILEKFKEKKPQVVQALQEAIDAI 388

  Fly   389 YASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDP 453
            :.:|:|:...|.::..:.||||::|.:|:|||||:......:.|.|.|||....:|:|.:|:..|
Mouse   389 FLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTSSTLPKSLLKPFCAALLKHINDSAP 453

  Fly   454 TVRDSSAEALGTLIKLMGDKAVTPLLADVDPLKMAKIKECQEKAEI----KIKVAGPKKETRPAS 514
            .|||::.|||||.:|::|:|:|.|.|||||.||:.:||||.||.|:    |..:|..|||::|..
Mouse   454 EVRDAAFEALGTALKVVGEKSVNPFLADVDKLKLDRIKECSEKVELVHGKKSGLATEKKESKPLP 518

  Fly   515 APTAKAAAPAKTVAGSVDPKPVTRPATTGARKVLKKPATVSGG----GATSAPTAALKAG---GK 572
            ...|.:.|     ||..|.|.|:.| ..|..|  |.|...:||    |.|:||..:..||   .|
Mouse   519 GRAAASGA-----AGDKDTKDVSGP-KPGPLK--KTPTAKAGGPSKKGKTTAPGGSASAGTKNKK 575

  Fly   573 PLAT----EREITPEELQEKSEEILPAEILNGLVDSNWKNRLAAVEQLLGEISGFDAKQAGISQI 633
            .|.|    |.|::.|..:||:..:||...:..|..||||.|||.:|:....:...:..:.. .|.
Mouse   576 GLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELMERTEMP-CQA 639

  Fly   634 LIRTISGRKPGLKEMNFQVLKFKLDIIRSVAENYPLTTTTVDLVINEIIEKLADAKNGAAAADVL 698
            |::.:: :|||.||.||||::.||.|:..:|:....:.|:..:|::.:::|:.|.|.|..|.:.:
Mouse   640 LVKMLA-KKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQIVLDGLVDKIGDVKCGNNAKEAM 703

  Fly   699 SAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGF-QLQPKTLIEDVRKGVQSTN 762
            :|.|||..|.:...:|:|.||.||:||.|||..||::.:|.|||| :|..|..|.:|:..:.:||
Mouse   704 TAIAEACMLPWTAEQVMSMAFSQKNPKNQSETLNWLSNAIKEFGFSELNVKAFISNVKTALAATN 768

  Fly   763 PTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPKPVRGVQRSSGGTAG 827
            |.||.|||.::|.|.:|:|.:|.|.|:.|||||.|||..||.|..|:.||.|.||:.:.|
Mouse   769 PAVRTSAITLLGVMYLYVGPSLRMIFEDEKPALLSQIDAEFQKMQGQSPPAPTRGIAKHS----- 828

  Fly   828 NSPDNEDDDGGAAGEEEPINMADLLPRVDIAPQITEALLKEMSDKDWKTRNEGLTKLQAIISEAR 892
            .|..:|.:||...||... ::.|||||::|:.:||..|:.::.||:||.|.|||.::..||:||:
Mouse   829 TSATDEGEDGEEPGEGGN-DVVDLLPRIEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINEAK 892

  Fly   893 LIKPSIGDLAPALAHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFPGFLHALGDNKSFV 957
            .|:|:||:|..||..||.|||..:.|.||.|.:|||.||||..|.||:||....:..|||:|:.|
Mouse   893 FIQPNIGELPTALKGRLNDSNKILVQQTLNILQQLAVAMGANIRQHVKNLGIPVITVLGDSKNNV 957

  Fly   958 RAAALNCINSFGEKGGYKEFFESEMIADALKGGSPALKTELWAWLADKLPGLPPKSVSKEDIHSM 1022
            |||||..:|::.|:.|.||:.|.|.:::.||..:|.|:.||..|||:|||.|   ..:..|:...
Mouse   958 RAAALATVNAWAEQTGMKEWLEGEDLSEELKKENPFLRQELLGWLAEKLPTL---RSTPTDLILC 1019

  Fly  1023 VPHLYAHICDRNADVRKNANEAVLGIMIHLGFDAMNRALDKQKPASKKDILAALEKARPNLPVKP 1087
            |||||:.:.|||.||||.|.:|:...|:|||::.|.:|..|.||.||..:||.||||:.|:|.||
Mouse  1020 VPHLYSCLEDRNGDVRKKAQDALPFFMMHLGYEKMAKATGKLKPTSKDQVLAMLEKAKANMPSKP 1084

  Fly  1088 LPKGKHQA------------PIP------------EEPKLKTVRGGGAGGAPGIQKSATARVAGG 1128
            ....|..:            |||            .:|.||..:      |||:...|.:    .
Mouse  1085 AAPAKAMSKPMGGSAPAKTQPIPAPVEDSVSSTIEAKPDLKKAK------APGVSSKAKS----V 1139

  Fly  1129 QDKQVPAR---KKDEDIDTSPLLCANSAKNQRLLDEQKMKVLKWTFVTPREEFTELLRDQMMTAN 1190
            |.|:||::   |:|:|......:...:.|.||:.||:.:|||||.|.|||:|:.|.|:.||.|.
Mouse  1140 QGKKVPSKTTLKEDDDKSGPIFIVVPNGKEQRMRDEKGLKVLKWNFTTPRDEYIEQLKTQMSTC- 1203

  Fly  1191 VNKALIANMFHDDFRYHLKVIEQLSEDLAGNSKALVCNLDLILKWLTLRFYDTNPSVLIKGLEYL 1255
            |.|.|...|||.||::|.|.:..:.:.|......::..||||||||||||:|||.|||:|.||||
Mouse  1204 VAKWLQDEMFHSDFQHHNKALAVMVDHLESEKDGVISCLDLILKWLTLRFFDTNTSVLMKALEYL 1268

  Fly  1256 VQVFQVLIDEEYILAENEGSSFVPHLLLKIGDPKDAVRNGVRRVLRQVILVFPFVKVFGYVMEGL 1320
            ..:|.:|.:|||.|.|||.|||:|:|:||:|:|||.:|..||.:|.::.||:|..|:|.::|||.
Mouse  1269 KLLFTLLSEEEYHLTENEASSFIPYLILKVGEPKDVIRKDVRAILNRMCLVYPASKMFPFIMEGT 1333

  Fly  1321 KSKNARQRTECLDELTFLIESYGMNIC---PQSAVREIARQISDRDNSVRNAALNCIVQVFFLSG 1382
            ||||::||.|||:||..||||||||:|   |..|::|||..|.||||:|||||||.||.|:.:.|
Mouse  1334 KSKNSKQRAECLEELGCLIESYGMNVCQPTPGKALKEIAIHIGDRDNAVRNAALNTIVTVYNVHG 1398

  Fly  1383 EKTYKMIGHLNEKDLSMLDERIKRAKKTKKPTPPPSVDVPAPQRHDSIEIEDAEVGNGCDELPPP 1447
            ::.:|:||:|:|||:|||:|||||:  .|:|:..|              ::.||      |.|
Mouse  1399 DQVFKLIGNLSEKDMSMLEERIKRS--AKRPSAAP--------------VKQAE------EKP-- 1439

  Fly  1448 DEDGLQRELNARGQNNM------TDRSATNVVAYLSSLTRQATFDQAPSSQLLLLQQQLQQLQQQ 1506
                 ||..|.....||      .|.|:...:.|.:...:..:....|.:..::.::
Mouse  1440 -----QRTQNINSNANMLRKGPAEDMSSKLKIMYRTYRIQARSLSGHPEAAQMVRRE-------- 1491

  Fly  1507 AQQQKPSGPFGLDSQVISEIEKD--WVRVDQMEQKPLLNVDISSLDEPIKVRPTRAGIHYPQEKF 1569
                     |.||   :.|||.|  .||.:..|   |:...:..:.||:.:         |:.|.
Mouse  1492 ---------FQLD---LDEIENDNGTVRCEMPE---LVQHKLDDIFEPVLI---------PEPKI 1532

  Fly  1570 DRLISRQHYMQQTLTTSPSSTAGMTSGVSPYRSPMRLQHQQPQQQLENNIPNLADVLPKHDPQLV 1634
                                     ..|||:...|.              .|.|..:.
Mouse  1533 -------------------------RAVSPHFDDMH--------------SNTASTIN------- 1551

  Fly  1635 KVIKGVSSTDTLKARAAINELAAIIEAPEKQAVLRDYEEIFIQNVLAQFKNLSQIPSA------- 1692
            .:|..|:|.|...:..|:.::..::...:|...:..:.:.|:   :|.|..|..|.|.
Mouse  1552 FIISQVASGDINTSIQALTQIDEVLRQEDKAEAMSGHIDQFL---IATFMQLRLIYSTHMADEKL 1613

  Fly  1693 ---QSVVVYQPLLSILYTFFHANILGKTLSVACIKNLMSALLNLMADPKLA-VGDDSQYNKVING 1753
               :.:.:|..::..:.:.|....|.:..|...:|:||..|:.||.|.::. :.:..|..:.:|.
Mouse  1614 DKDEIIKLYSCIIGNMISLFQIESLAREASTGVLKDLMHGLITLMLDSRIEDLEEGQQVIRSVNL 1678

  Fly  1754 ICLKVLDKVDFTNLNCALIRLLRET-CPEAKLPKFTDLLMKCIWRNVKMLPERSNELNYDAVILE 1817
            :.:|||:|.|.||:..||:.||::: ...|..|||::|:|||:||.|::||:..|.:|.|.::|:
Mouse  1679 LVVKVLEKSDQTNILSALLVLLQDSLLATASSPKFSELVMKCLWRMVRLLPDTINSINLDRILLD 1743

  Fly  1818 VHEFMLALPSTWWQNRPSDTPMRTIKTILHNMAKVKGNAILQHLNQI--PTHSELHTYLIRILKN 1880
            :|.||...|....:...|:.|:||:||:||.:.|:||..||.||..|  ...|||..:|.|::|:
Mouse  1744 IHIFMKVFPKEKLKQCKSEFPIRTLKTLLHTLCKLKGPKILDHLTMIDNKNESELEAHLCRMMKH 1808

  Fly  1881 FQKDGSASGIGASPQRAKEIASKRISHQTHDTVSQIFKLISDRDTKQQGLQKLYDFKQQNPDIDL 1945
            ......:.....:.:.|..|..|....:.:|.:::|||.|..::..::||.:||::|::..|.|:
Mouse  1809 SMDQTGSKSDKETEKGASRIDEKSSKAKVNDFLAEIFKKIGSKENTKEGLAELYEYKKKYSDTDI 1873

  Fly  1946 STFLQGSSAPFHKYIEEGLAEIERNQNAGSTQDNRT--------------AATRSYLTDVNYQNN 1996
            ..||:.||..|..|:|.||..||..:.:.......|              .:|.|.|.:.|.:..
Mouse  1874 EPFLKNSSQFFQSYVERGLRVIEMERESKGRIPTSTGISPQMEVTCVPTPTSTVSSLGNTNGEEV 1938

  Fly  1997 GPDPDFWMDRLQYHMTGGAAKLASARSADDGSHMLDNKVVDENLCLNGMNAQKASLIKREKRDMS 2061
            |  |..:::||         |:...|..      |||...|:...|..:.::.|........||
Mouse  1939 G--PSVYLERL---------KILRQRCG------LDNTKQDDRPPLTSLLSKPAIPPVASSTDM- 1985

  Fly  2062 PNRLQHLQAKLAQIK--KENH 2080
                  |.:||:|::  :|.|
Mouse  1986 ------LHSKLSQLRESREQH 2000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	20/30 (67%)
		HEAT repeat	361..387	CDD:293787	18/25 (72%)
		HEAT repeat	398..466	CDD:293787	28/67 (42%)
		HEAT repeat	860..891	CDD:293787	13/30 (43%)
		HEAT repeat	900..929	CDD:293787	14/28 (50%)
		HEAT repeat	939..968	CDD:293787	14/28 (50%)
Ckap5	XP_006500405.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849587
Domainoid	1	1.000	296	1.000	Domainoid score	I1470
eggNOG	1	0.900	-	-		E1_KOG1820
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8844
Inparanoid	1	1.050	1374	1.000	Inparanoid score	I126
Isobase	1	0.950	-	0	Normalized mean entropy	S5459
OMA	1	1.010	-	-		QHG54876
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003733
OrthoInspector	1	1.000	-	-		oto92618
orthoMCL	1	0.900	-	-		OOG6_101795
Panther	1	1.100	-	-	LDO	PTHR12609
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R51
SonicParanoid	1	1.000	-	-		X4162
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740