DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msps and T08D2.8

DIOPT Version :9

Sequence 1:	NP_001247129.1	Gene:	msps / 41952	FlyBaseID:	FBgn0027948	Length:	2082	Species:	Drosophila melanogaster
Sequence 2:	NP_001368073.1	Gene:	T08D2.8 / 353486	WormBaseID:	WBGene00011613	Length:	388	Species:	Caenorhabditis elegans

Alignment Length:	353	Identity:	97/353 - (27%)
Similarity:	145/353 - (41%)	Gaps:	86/353 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 LEVLEKLLTDHPKLENGEYGALVSALKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACV 363
            :|:.|: ||:..|:           |.|::.||.||.:.|::.:.||.:||.....||..|....
Worm     7 IEISER-LTEISKI-----------LMKIVEKDVNVNVGAISAQILAEIAKKSRFSFSALALRAF 59

  Fly   364 PSLLEKFKEKKPNVVTALREAIDAIYASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQ 428
            |.:.:|.|:|...:..||.|..|....:|.|.|..|:   .||||||..:.:||||::|...:..
Worm    60 PVVFDKLKDKNAILRDALVEFCDEAANTTPLSAYSEA---GLSNKNPQARQQTALFLSRFFAKND 121

  Fly   429 PTALNKKLLKLLTTSLVKTLNEPDPTVRDSSAEALGTLIKLMGDKAVTPLLADV--DPLKMAK-- 489
            |..:..:.:|.|...::||.|:.|..||.::...:..:.|.:|:.....|||:|  |.||..|
Worm   122 PKIVETEEVKQLAEHILKTSNDADKEVRKAALRIVAAVQKCLGEGVAKRLLAEVYHDKLKTEKLP 186

  Fly   490 --IKECQEKAEI------------------------KIKVAGPKK----------------ETR- 511
              |:|.:::.|.                        |.....||:                .||
Worm   187 PLIEELEKEFESSASPEMLRLAKHYKIGSSSTSAPPKTAAGAPKRLSSAVAPRRAPPASAAPTRR 251

  Fly   512 ------PASAPTAKAAAPAKTVA--GSVDPKP-VTRPATT-GARKVLKKPA-----TVSGGGATS 561
                  |..|||.:|.:|...||  ..|.||| |.|||.. |..:....||     |.....||.
Worm   252 APSPKAPVVAPTRRAPSPKAPVAPVAPVKPKPFVARPAPNFGKPRAAVAPARAPQITQRAPAATR 316

  Fly   562 APTAALKA---------GGKPLATEREI 580
            ..|:|::.         .|.|.|..:.|
Worm   317 PATSAIRVIPIAPNVVRNGAPAAPRKPI 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	10/30 (33%)
		HEAT repeat	361..387	CDD:293787	7/25 (28%)
		HEAT repeat	398..466	CDD:293787	21/67 (31%)
		HEAT repeat	860..891	CDD:293787
		HEAT repeat	900..929	CDD:293787
		HEAT repeat	939..968	CDD:293787
T08D2.8	NP_001368073.1	YCG1	101..>165	CDD:227543	18/63 (29%)
T08D2.8	NP_001368073.1	PHA03247	<219..361	CDD:223021	33/126 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1820
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R51
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.770