DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msps and dis1

DIOPT Version :9

Sequence 1:	NP_001247129.1	Gene:	msps / 41952	FlyBaseID:	FBgn0027948	Length:	2082	Species:	Drosophila melanogaster
Sequence 2:	NP_587785.1	Gene:	dis1 / 2539505	PomBaseID:	SPCC736.14	Length:	882	Species:	Schizosaccharomyces pombe

Alignment Length:	888	Identity:	210/888 - (23%)
Similarity:	357/888 - (40%)	Gaps:	155/888 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KLWKARVDGYEEAA-KIFRELDDEK---SPEWSKFAGLIKKMVVDSNALAQEKGLEAALIFVENS 79
            |.||.|.:.||... .:.|.|||..   .| |.....|.|:.:.|||...||..:::...|::.|
pombe    17 KSWKVRFEAYESLLHALNRALDDSDVCFQP-WIHDPALWKQGLCDSNVPTQEHAVKSLRCFLDKS 80

  Fly    80 GLAG--RTVGDVMTGIVQKCIAAPKTKTKELSVQVALMYVEIEKQEAVVEELVKGMEAKNPKIVS 142
            ...|  .....|:..:::||:.:|:...::.|.|..|:..:.:..:.|:|.|......|:||...
pombe    81 RQKGVNSAKSFVVAPLLEKCLPSPRQSIRDASHQALLILAKSDALDYVLEGLFSAARVKHPKQAV 145

  Fly   143 ACVAATTLALREFGHKVIGVKPLIKKLAPLMSDRDKTVRDEGKQLAVEIYRWIGAAMKAQI-STL 206
            |.:......|..||...:...|..|.:..|.:..||.:|.|...|::.:|.|:|.|.|..: ..|
pombe   146 ASIKELNSLLENFGIPALSPIPFYKLIPTLFAQSDKNIRQEASNLSITLYAWVGNAFKTHVFPQL 210

  Fly   207 PQVTLKELEDEFDKLK-----------------------GERVEPSRYLKSQQEKQAKIADAAAT 248
            .|:.:.:||..|..:.                       ....:|..:|.|:...|......:.:
pombe   211 KQIQVSDLEASFQNVTSRTTTGGHISNSLNTQEVVLPSFSSNAKPKPHLSSKSSSQGNTLQRSTS 275

  Fly   249 ------EDAYNEDDGEAGVEE--IDPMDLL---DPVDILSKMPKDFYDKLEEKKWTLRKESLEVL 302
                  .......|..|....  :.|...:   .|||:|||:..:|:..|...||..|||:||.:
pombe   276 SFSTPNRKVSQPSDFSASPSRSIVSPAKNIVGSTPVDVLSKLTPEFHTALSSPKWKDRKEALESM 340

  Fly   303 EKLLTDHPKLENGEYGALVSALKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLL 367
            ..:.: :|..:.|:|..|:..:.|.: ||:|||:|.:|...|..:||.|.|.|..|....:|||.
pombe   341 VPVCS-NPVYQEGDYSELLRVIAKSL-KDANVVVVGVAALLLTHIAKALRKGFLPYTGIVLPSLF 403

  Fly   368 EKFKEKKPNVVTALREAIDAIYASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQ--PT 430
            ::|||:|.::|.:|.:|.:||:.|..|....:..:|.|.:|||.||:||..::.|.|..|.  |.
pombe   404 DRFKERKSSLVHSLLDAANAIFESCGLNDIMDETLEFLKHKNPQVKTETLRWLNRCLQLTDVCPP 468

  Fly   431 ALNKKLLKLLTTSLVKTLNEPDPTVRDSSAEALGTLIKLMGDKAVTPLLADVDPLKMAKIKECQE 495
            ..:.:.|..|..:|:....||   ||.::...|.||:::.....::..:..:||.|:.||.|..:
pombe   469 RASLETLCSLCVTLINDTFEP---VRMATTNVLATLVQIFSQPVLSKYIVGLDPKKLPKILELSK 530

  Fly   496 KAEIKIKVAGPKKETRPASAPTAKAAAPAKTVAGSVDPKPVTRPATTGARKVLKKPATVSGGGAT 560
            ...:.   |.|.:.:||.   ..:.|:|.||       .||....|..|...|          .:
pombe   531 DITVN---AHPNQPSRPR---LPRVASPLKT-------SPVKLAVTPQAPSPL----------PS 572

  Fly   561 SAPTAALKAGGKPLATEREITPEELQEKSEEILPA-------EILNGLVDSNWKNRLAAVEQLLG 618
            |.|:.|            .:|.|.|..:|....|:       .::|....|..|   |......|
pombe   573 SNPSQA------------SLTEESLSTRSSPTKPSTTSLRSQSLVNRFASSTLK---APSSSSKG 622

  Fly   619 EISGFDAKQAGISQILIRTISGRKPGLKEMNFQVLKFKLDIIRSVAENYPLTTTTVDLVINEIIE 683
            ..:...:||:..|          .|.:.:        ||:..|...:..|.:|......:.|..:
pombe   623 VSNAASSKQSFPS----------SPSISK--------KLETSRLSTKKLPGSTMKAASALKEYPQ 669

  Fly   684 KLADAKNGAAAADVLSAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQPK 748
            : ...|:|....|.|.....:.|:|      |....|:|:.:...||.:           .|:.:
pombe   670 Q-QSMKSGGEKQDNLVTITMSEKVE------LDLLREEKAIRQVQEAED-----------ALERE 716

  Fly   749 TLIEDVRKGVQSTNPTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQ---VEFDK----- 805
            .|..:: ..:|..|..::....:...|:|  ..:..:....:||..|.:::|   :|.:|
pombe   717 RLFREI-NDLQIQNAEMKEQVYEKESTIS--QKEVEITSLRNEKDRLSTRLQQVLLELEKQHETN 778

  Fly   806 ----NVGEKPPKP---VRGVQRSSGGTAGNSPDNEDDDGGAAG 841
                ::..|.|:.   .|...|::..||       .|:.|.||
pombe   779 EEAMDIDLKVPESGAIGRVTTRATATTA-------MDESGNAG 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	11/30 (37%)
		HEAT repeat	361..387	CDD:293787	10/25 (40%)
		HEAT repeat	398..466	CDD:293787	21/69 (30%)
		HEAT repeat	860..891	CDD:293787
		HEAT repeat	900..929	CDD:293787
		HEAT repeat	939..968	CDD:293787
dis1	NP_587785.1	HEAT repeat	399..423	CDD:293787	10/23 (43%)
		HEAT repeat	433..464	CDD:293787	11/30 (37%)
		HEAT repeat	474..504	CDD:293787	10/32 (31%)
		Spc7_N	<535..673	CDD:292045	36/194 (19%)
		SMC_prok_A	<663..>793	CDD:274009	26/150 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1820
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003733
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101795
Panther	1	1.100	-	-	O	PTHR12609
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810