Protein Alignment msps and F54A3.2

DIOPT Version :10

• Sequence 1: NP_001247129.1
• Gene: msps / 41952
• FlyBaseID: FBgn0027948
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_494219.4
• Gene: F54A3.2 / 186196
• WormBaseID: WBGene00018781
• Length: 748
• Species: Caenorhabditis elegans
• Alignment Length: 754
• Identity: 177/754 - (23%)
• Similarity: 318/754 - (42%)
• Gaps: 163/754 - (21%)

  Fly   264 IDPMDLLDPVDILSKMPKDFYDKLEE--KKWTLRKESLEVLEKLLTDHPKLENGE---YGALVSA 323
            :|....||.||:|:|.|.:....:.|  .||..|||.||.|...:..:|:|....   ||.|:..
 Worm     1 MDEWQFLDEVDVLAKWPAEHKKAVLEPGAKWKERKEGLEALNTQIEQNPRLSTSTMTIYGELMDE 65

  Fly   324 LKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAIDAI 388
            |:|::.::||:|:|..|.:.:.|||:|:.:||:.:....||.|:::.|:||.||..|:..|:.|:
 Worm    66 LRKILDRESNIVVVTTAIRTVELLARGIRQRFAGFIGMVVPFLIKRAKDKKKNVRDAILAAMGAV 130

  Fly   389 YASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDP 453
            ..:|:.|..|:.:::.....:|..| :|.|....|....|.|. :.:.:|.:...:||..:|.|.
 Worm   131 ADTTTSERLQKDLIDWFGIPSPESK-KTLLHFLYAYFCRQCTP-DIQFIKTIAPLIVKASSESDV 193

  Fly   454 TVRDSSAEALGTLIKLMGDKAVTPLLADV--DPLKMAKIKECQEKAEIKIKVAGPKKETRPASAP 516
            ||||.:.:|||::.:|:|| .:|..:..:  :..|:.||.:.|::|..:.|   ..:||:|.:..
 Worm   194 TVRDKACQALGSIKRLIGD-TITAFIGPISTETAKIEKINQYQQEAAEEFK---KFQETQPKAGG 254

  Fly   517 TAKAAAPAKTVAGSVD--PKPVTRPATTGARKVLKKPATVSGGGATSAPTAALKAGGKPLATERE 579
            ...|...|:.:..:.:  |:...:|....|.::|:
 Worm   255 DGGAENSAENLDENQENSPEKAEKPQVLDAWELLE------------------------------ 289

  Fly   580 ITPEELQEKSEEILPAEILNGLVDSNWKNRLAAVEQL------LGEISGFDAKQAGISQILIRTI 638
              ||:..:|.::.:..:    |:|.|||.|||..|.:      .|.|. ...:...||::|::.:
 Worm   290 --PEDCSKKIDKSVETQ----LIDKNWKERLAGAENVKKSMENAGRIE-ISERLTEISKLLMKIV 347

  Fly   639 SGRKPGLKEMNFQVLKFKLDIIRSVAEN-----YPLTTTTVDLVINEIIEKLADAKNG------- 691
            .      |::|..|......|:..:|:.     .||......:|.:::.:|.|..::.
 Worm   348 E------KDVNVNVGAISAQILAEIAKKSRFSFAPLALRAFPVVFDKLKDKKAILRDALVEFCDE 406

  Fly   692 AAAADVLSAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQPKT------- 749
            ||....|||::||         |:: |...|:|:.:.:...:::|    |..:..|||
 Worm   407 AANTTPLSAYSEA---------VIT-ALSNKNPQARQQTALFLSR----FFAKNDPKTVETEAVK 457

  Fly   750 -LIEDVRKGVQSTNPTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPK 813
             |.|.:.|.....:..||.:|:::|..:...:|:.:         |.:...:|..||...||.|.
 Worm   458 QLAEHILKTSNDADKEVREAALRIVAAVQKCLGEGV---------AKRLLAEVYDDKLKAEKLPP 513

  Fly   814 PVRGVQRSSGGTA-------------GNSPDNEDDDGGAAGEEE------------PINMADL-- 851
            .:..:::..|.:|             |.|..:......|||..:            |.:.|..
 Worm   514 LIEELEKEFGSSASPEMLRLAKHYKIGASSTSAPPKTTAAGAPKRPSSAVAPRRAPPASAAPTRR 578

  Fly   852 --LPRVDI--------APQITEALLKEMSDKDWKTR-NEGLTKLQAIISEARLIKPSIGDLAPAL 905
              .|:..:        :|:...|.:..:..|.:..| .....|.:|.::.||  .|.|...|||.
 Worm   579 APSPKAPVVAPTRRAPSPKAPVASVAPVKPKPFVARPAPSFGKPRAAVAPAR--APQITQRAPAA 641

  Fly   906 AHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFP 944
            ..   .|.:.|..|.:|             .|.|||..|
 Worm   642 TR---PSTSAIRVTPIA-------------PNVVRNGAP 664

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	11/30 (37%)
		HEAT repeat	361..387	CDD:293787	10/25 (40%)
		HEAT repeat	398..466	CDD:293787	20/67 (30%)
		HEAT repeat	860..891	CDD:293787	5/31 (16%)
		HEAT repeat	900..929	CDD:293787	7/28 (25%)
		HEAT repeat	939..968	CDD:293787	4/6 (67%)
F54A3.2	NP_494219.4	HEAT repeat	103..132	CDD:293787	11/28 (39%)
		HEAT repeat	138..164	CDD:293787	5/26 (19%)
		HEAT repeat	177..206	CDD:293787	12/28 (43%)
		PTZ00108	<220..529	CDD:240271	75/377 (20%)
		HEAT repeat	301..325	CDD:293787	9/27 (33%)
		HEAT repeat	335..371	CDD:293787	8/41 (20%)
		HEAT repeat	380..402	CDD:293787	3/21 (14%)
		HEAT repeat	413..442	CDD:293787	10/42 (24%)
		PHA03247	<541..741	CDD:223021	29/142 (20%)