DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment msps and F54A3.2

DIOPT Version :9

Sequence 1:	NP_001247129.1	Gene:	msps / 41952	FlyBaseID:	FBgn0027948	Length:	2082	Species:	Drosophila melanogaster
Sequence 2:	NP_494219.4	Gene:	F54A3.2 / 186196	WormBaseID:	WBGene00018781	Length:	748	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	177/754 - (23%)
Similarity:	318/754 - (42%)	Gaps:	163/754 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 IDPMDLLDPVDILSKMPKDFYDKLEE--KKWTLRKESLEVLEKLLTDHPKLENGE---YGALVSA 323
            :|....||.||:|:|.|.:....:.|  .||..|||.||.|...:..:|:|....   ||.|:..
Worm     1 MDEWQFLDEVDVLAKWPAEHKKAVLEPGAKWKERKEGLEALNTQIEQNPRLSTSTMTIYGELMDE 65

  Fly   324 LKKVITKDSNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAIDAI 388
            |:|::.::||:|:|..|.:.:.|||:|:.:||:.:....||.|:::.|:||.||..|:..|:.|:
Worm    66 LRKILDRESNIVVVTTAIRTVELLARGIRQRFAGFIGMVVPFLIKRAKDKKKNVRDAILAAMGAV 130

  Fly   389 YASTSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDP 453
            ..:|:.|..|:.:::.....:|..| :|.|....|....|.|. :.:.:|.:...:||..:|.|.
Worm   131 ADTTTSERLQKDLIDWFGIPSPESK-KTLLHFLYAYFCRQCTP-DIQFIKTIAPLIVKASSESDV 193

  Fly   454 TVRDSSAEALGTLIKLMGDKAVTPLLADV--DPLKMAKIKECQEKAEIKIKVAGPKKETRPASAP 516
            ||||.:.:|||::.:|:|| .:|..:..:  :..|:.||.:.|::|..:.|   ..:||:|.:..
Worm   194 TVRDKACQALGSIKRLIGD-TITAFIGPISTETAKIEKINQYQQEAAEEFK---KFQETQPKAGG 254

  Fly   517 TAKAAAPAKTVAGSVD--PKPVTRPATTGARKVLKKPATVSGGGATSAPTAALKAGGKPLATERE 579
            ...|...|:.:..:.:  |:...:|....|.::|:
Worm   255 DGGAENSAENLDENQENSPEKAEKPQVLDAWELLE------------------------------ 289

  Fly   580 ITPEELQEKSEEILPAEILNGLVDSNWKNRLAAVEQL------LGEISGFDAKQAGISQILIRTI 638
              ||:..:|.::.:..:    |:|.|||.|||..|.:      .|.|. ...:...||::|::.:
Worm   290 --PEDCSKKIDKSVETQ----LIDKNWKERLAGAENVKKSMENAGRIE-ISERLTEISKLLMKIV 347

  Fly   639 SGRKPGLKEMNFQVLKFKLDIIRSVAEN-----YPLTTTTVDLVINEIIEKLADAKNG------- 691
            .      |::|..|......|:..:|:.     .||......:|.:::.:|.|..::.
Worm   348 E------KDVNVNVGAISAQILAEIAKKSRFSFAPLALRAFPVVFDKLKDKKAILRDALVEFCDE 406

  Fly   692 AAAADVLSAFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQPKT------- 749
            ||....|||::||         |:: |...|:|:.:.:...:::|    |..:..|||
Worm   407 AANTTPLSAYSEA---------VIT-ALSNKNPQARQQTALFLSR----FFAKNDPKTVETEAVK 457

  Fly   750 -LIEDVRKGVQSTNPTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPK 813
             |.|.:.|.....:..||.:|:::|..:...:|:.:         |.:...:|..||...||.|.
Worm   458 QLAEHILKTSNDADKEVREAALRIVAAVQKCLGEGV---------AKRLLAEVYDDKLKAEKLPP 513

  Fly   814 PVRGVQRSSGGTA-------------GNSPDNEDDDGGAAGEEE------------PINMADL-- 851
            .:..:::..|.:|             |.|..:......|||..:            |.:.|..
Worm   514 LIEELEKEFGSSASPEMLRLAKHYKIGASSTSAPPKTTAAGAPKRPSSAVAPRRAPPASAAPTRR 578

  Fly   852 --LPRVDI--------APQITEALLKEMSDKDWKTR-NEGLTKLQAIISEARLIKPSIGDLAPAL 905
              .|:..:        :|:...|.:..:..|.:..| .....|.:|.::.||  .|.|...|||.
Worm   579 APSPKAPVVAPTRRAPSPKAPVASVAPVKPKPFVARPAPSFGKPRAAVAPAR--APQITQRAPAA 641

  Fly   906 AHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFP 944
            ..   .|.:.|..|.:|             .|.|||..|
Worm   642 TR---PSTSAIRVTPIA-------------PNVVRNGAP 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	11/30 (37%)
		HEAT repeat	361..387	CDD:293787	10/25 (40%)
		HEAT repeat	398..466	CDD:293787	20/67 (30%)
		HEAT repeat	860..891	CDD:293787	5/31 (16%)
		HEAT repeat	900..929	CDD:293787	7/28 (25%)
		HEAT repeat	939..968	CDD:293787	4/6 (67%)
F54A3.2	NP_494219.4	HEAT repeat	103..132	CDD:293787	11/28 (39%)
		HEAT repeat	138..164	CDD:293787	5/26 (19%)
		HEAT repeat	177..206	CDD:293787	12/28 (43%)
		HEAT repeat	301..325	CDD:293787	9/27 (33%)
		HEAT repeat	335..371	CDD:293787	8/41 (20%)
		HEAT repeat	380..402	CDD:293787	3/21 (14%)
		Treslin_N	<387..>489	CDD:291938	25/115 (22%)
		HEAT repeat	413..442	CDD:293787	10/42 (24%)
		HEAT repeat	453..485	CDD:293787	7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166783
Domainoid	1	1.000	106	1.000	Domainoid score	I4124
eggNOG	1	0.900	-	-		E1_KOG1820
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D28390at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14167
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12609
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R51
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.880