Protein Alignment msps and zyg-9

DIOPT Version :10

• Sequence 1: NP_001247129.1
• Gene: msps / 41952
• FlyBaseID: FBgn0027948
• Length: 2082
• Species: Drosophila melanogaster
• Sequence 2: NP_495784.1
• Gene: zyg-9 / 174350
• WormBaseID: WBGene00006994
• Length: 1415
• Species: Caenorhabditis elegans
• Alignment Length: 1916
• Identity: 417/1916 - (21%)
• Similarity: 720/1916 - (37%)
• Gaps: 608/1916 - (31%)

  Fly   268 DLLDPVDILSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLE-NGEYGALVSALKKVITKD 331
            |.||.||||.|:|.:|.:..|.|||..|||:||.|.|:|||:.:|. ...|..|:..|:.|:.||
 Worm     5 DYLDEVDILPKLPPNFDELRESKKWQERKEALEALLKVLTDNERLSTKASYAELIGHLQMVLAKD 69

  Fly   332 SNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAI-----DAIYAS 391
            :|:...|:|.||:...|.||..:||::|...:|.:.||.|||||    .|||.:     :.....
 Worm    70 ANINCQALAAKCIGKFATGLRAKFSSFAGPLLPVIFEKMKEKKP----MLREPLVDCSNEVGRTM 130

  Fly   392 TSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDPTVR 456
            .|||..||.|:.:|:..||.:|.:||||:||.|....|....|..:|.:.....|...:.|..||
 Worm   131 QSLETGQEDILAALAKPNPQIKQQTALFVARQLDLVVPAKQPKGFIKAVVPVFGKLTGDADQDVR 195

  Fly   457 DSSAEALGTLIKLMGDKAVTPLLADV--DPLKMAKIKECQEK-----AEIKIKVAGPKKETRPAS 514
            ::|.:.||.:.:::|||.|..||.|.  |..||.||.|..||     ||.:.|.|.|...|  :|
 Worm   196 EASLQGLGAVQRIIGDKNVKNLLGDASSDEGKMKKIGEYAEKSTASFAEEQAKNAPPVAPT--SS 258

  Fly   515 APTAKAAAPAKTVAGSVDPKPVTRPATTGARKVLKKPATVSGGGATSAPTAALKAGGKPLATERE 579
            .|:|.||        |.||                     |||.||     |:.:.|.|:|   |
 Worm   259 TPSASAA--------SGDP---------------------SGGTAT-----AVVSSGAPVA---E 286

  Fly   580 ITPEELQEKSEEI--LPAEILNGLVDSNWKNRLAAVEQLLGEISG---FDAKQAGISQILIRTIS 639
            ..|.:..:..:.:  :|......:....|:.|..|:|.||..|:.   .|.| |....::.|.
 Worm   287 ADPWDFLDAFDVLSKMPDGFDTNIESKKWQERKEALEGLLQLITANPKLDPK-ANYGALVERL-- 348

  Fly   640 GRKPGLKEMNFQVLKFKLDIIRSVAEN-----YPLTTTTVDLVINEIIEKLADAKNGAAAADVLS 699
             :|...|:.|..|.....:.|..:|..     .|...:...::..:..||....::...|.  :.
 Worm   349 -QKVLEKDANINVAALAANCITGIANGLRTKFQPFAVSVTPIIFEKFKEKKPTLRDPLVAC--ID 410

  Fly   700 AFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQP----KTLIEDVRKGVQS 760
            |....|.|| .||:::..|..:.:|.::::...::.|..::...|..|    ||||..:.|....
 Worm   411 AVVATTNLE-AVGEIVLAALGKPNPSIKTQTDLFLQRCFMKLNSQTMPKKTLKTLIPSLIKHSGD 474

  Fly   761 TNPTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPKPVRGVQRSSGGT 825
            ::..||.::...:|.|...:|         |||:|:.
 Worm   475 SDSEVREASYAAMGAMMRAIG---------EKPSLQL---------------------------- 502

  Fly   826 AGNSPDNEDDDGGAAGEEEPINMADLLPRVDIAPQITEALLKEMSDKDWKTRNEGLTKLQAIISE 890
                                  :||:     .:..:..:.:||...|
 Worm   503 ----------------------LADI-----ASDNLKMSKIKEFHQK------------------ 522

  Fly   891 ARLIKPSIGDLAPALAHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFPGFLHALGDNKS 955
                  ::.:..||....:|.|..|
 Worm   523 ------ALDEAGPAEIAEMVKSIHK---------------------------------------- 541

  Fly   956 FVRAAALNCINSFGEKGGYKEFFESEMIADALKGGSPALKTELWAWLADKLPGLPPKSVSKEDIH 1020
                                        |||....:|..||            .|||...:::
 Worm   542 ----------------------------ADAPPAAAPPKKT------------APPKKQPEDE-- 564

  Fly  1021 SMVPHLYAHICDRNADVRKNANEAVLGIMIHLGFDAMNRALDKQKPASKKDILAALEKARPNLPV 1085
                           :|.:..:|                                        |:
 Worm   565 ---------------EVVEEEDE----------------------------------------PL 574

  Fly  1086 KPLPKGKHQAPIPEEPKLKTVRGGGAGGAPGIQKSATARVAGGQDKQVPARKKDEDID--TSP-- 1146
            ||.|                                     |.:.|:||.::.:|:..  .:|
 Worm   575 KPPP-------------------------------------GDKKKKVPVKENEENEPPVVAPKA 602

  Fly  1147 --LLCANSAKNQRLLDEQKMKVLKWTFVTPREEFTELLRDQMMTANVNK-ALIANMFHDDFRYHL 1208
              ||..|..|.||:.:|:::|::||.|..|.:|....|  |.:..|..| :|::.:||.||:.||
 Worm   603 ELLLSDNEDKKQRIKEEKQLKLVKWNFQAPTDEHISQL--QTLLGNQAKVSLMSQLFHKDFKQHL 665

  Fly  1209 KVIEQLSEDLAGNSKALVCNLDLILKWLTLRFYDTNPSVLIKGLEYLVQVFQVLIDEEYILAENE 1273
            ..::.|......:.::|:.|.||:|||.||||::|||:.|||.||....:.:::.|.|..:::.|
 Worm   666 AALDSLVRLADTSPRSLLSNSDLLLKWCTLRFFETNPAALIKVLELCKVIVELIRDTETPMSQEE 730

  Fly  1274 GSSFVPHLLLKIGDPKDAVRNGVRRVLRQVILVFPFVKVFGYVMEGLKSKNARQRTECLDELTFL 1338
            .|:|||:||||.|:.||.:|..||.::..:..|...:|:...:::.|||||||||:|||..:.:.
 Worm   731 VSAFVPYLLLKTGEAKDNMRTSVRDIVNVLSDVVGPLKMTPMLLDALKSKNARQRSECLLVIEYY 795

  Fly  1339 IESYGMN-ICPQSAVREIARQISDRDNSVRNAALNCIVQVFFLSGEKTYKMIGHLNEKDLSMLDE 1402
            |.:.|:: :...|..:.:|..:.|:|.:|||||:|.:|..|...|::.:|..|.:.:||.|:::|
 Worm   796 ITNAGISPLKSLSVEKTVAPFVGDKDVNVRNAAINVLVACFKFEGDQMWKAAGRMADKDKSLVEE 860

  Fly  1403 RIKR-------AKKTKKPTPPPSVDVPAPQRHDSIEIEDAEVGNGCDELPPPDEDGLQRELNARG 1460
            ||||       ...|..||..|.:.||                                    :.
 Worm   861 RIKRTGVKPGSGVVTSPPTGGPKILVP------------------------------------QQ 889

  Fly  1461 QNNMTDRSATNVVAYLSSLTRQATFDQAPSSQLLLLQQQLQQLQQQAQQQKPSGPFGLDSQVISE 1525
            |.::..|.|          :|..|.:..|..    :|.....::|.....|.|..:.|...|.|.
 Worm   890 QGSVVRRPA----------SRSRTREPEPEE----VQSDTFTIRQDTMPPKTSSRYALRDDVFSS 940

  Fly  1526 IEKDWVRVDQMEQKPLLNVDISSLDEPIKVRPTRAGIHYPQEKFDRLISRQHYMQQTLTTSPSST 1590
            .                   :..||....:.|.:....:....|          |...|.|.||.
 Worm   941 A-------------------MGRLDGTQVITPPQPVNGWSNNTF----------QMKRTNSSSSI 976

  Fly  1591 AGMTSGVSPYRSPMRLQHQQPQQQLENNIPNLADVLPKHDPQLVKVIKGVSSTDTLKARAAINEL 1655
            :.:.:.            .|.|:.:.|...:||||                      |:.|:.::
 Worm   977 SSIDTS------------DQIQRSINNISSSLADV----------------------AQDAMFQV 1007

  Fly  1656 AAIIEAPEKQAVL-RDYEEIF------IQNVLAQF---KNLSQIPSAQSVVVY------------ 1698
            ..::..||::.:: |..:.:|      :..|:.:|   :::|....|.:.:::
 Worm  1008 TYVLNQPEQRHLVDRRADLVFRASAAQLDLVIEEFNAGRDVSGTMDACTQMLFILMGGVETEHGL 1072

  Fly  1699 QPLLSILYTFFHANILGKTLSVACIKNLMSALLNLMADPKLAVGD-DSQYN--KVINGICLKVLD 1760
            :||               ..|...:|.::|::|..:    :.:|: :|.|.  :.:|.:.::::.
 Worm  1073 EPL---------------NASPDTVKAIISSVLRCI----IQIGNTESGYGMARSLNRLAMRLIY 1118

  Fly  1761 KVDFTNLNCALIRLLRETCPEAKLPKFTDLLMKCIWRNVKMLPERSNELNYDAVILEVHEF-MLA 1824
            :|:.:||.|.||..:.|:.  ......|:|:.|...:....|.:|..:|....::...:.| :.|
 Worm  1119 RVELSNLLCGLILAMTESL--QMNTGITELVSKLSSKWCDELEKRRAQLRASDIVDSFNAFYVCA 1181

  Fly  1825 LPSTWWQNRPSDTPMRTIKTILHNMAKVKGNAILQHLNQIP-THSELHTYLIRILKNF------- 1881
            |  |..:...||:.:..:...|..:...:|:.:|....::. .|..|.:.:.:||:..
 Worm  1182 L--TELKMDISDSHILIVDNYLERVILQQGDVVLDAARRLSRPHMHLTSMINKILQMMRERKIDP 1244

  Fly  1882 -----------QKDGSA---SGIGASPQRAKEIASKRISHQTHDTVSQIFKLISDRDTKQQGLQK 1932
                       |:|.:.   ||:..|........|..:.|     :.|:..||:..|   :...:
 Worm  1245 IMPGTLEARMPQEDEAVVVRSGVQVSIDNILRDTSMAVKH-----IEQLNILIASSD---RSWNE 1301

  Fly  1933 LYDFKQQNPDIDLSTFLQGSSAPFHKYIEEGLAEIERNQNA--------GSTQDNRTAATRSYLT 1989
            ..::.:.||..:|...|.|..:. .|.|:..|:.:.::..|        |..|:.    .|...|
 Worm  1302 YMEYLKNNPMGELIKELVGECSR-KKRIDFNLSHVVKSSMAVFKAMAATGPVQEE----GRITPT 1361

  Fly  1990 DVNYQNNGPDPDFWMDRLQYHMTG-----GAAKLASARSADDGSHMLDNKVVDENLCLNGMNAQK 2049
            |:|             |:...:.|     |.|.:..||
 Worm  1362 DIN-------------RMDTMIVGTPLSRGDATITRAR--------------------------- 1386

  Fly  2050 ASLIKREKRDMSPNRLQHLQAKLAQIKKENH 2080
            .::|:.::..:|.:::.:::..|.::|  ||
 Worm  1387 GNMIRPKRTTLSRDQMANIRHTLDRVK--NH 1415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
msps	NP_001247129.1	HEAT repeat	319..350	CDD:293787	11/30 (37%)
		HEAT repeat	361..387	CDD:293787	11/30 (37%)
		HEAT repeat	398..466	CDD:293787	24/67 (36%)
		HEAT repeat	860..891	CDD:293787	3/30 (10%)
		HEAT repeat	900..929	CDD:293787	5/28 (18%)
		HEAT repeat	939..968	CDD:293787	0/28 (0%)
zyg-9	NP_495784.1	HEAT repeat	16..47	CDD:293787	16/30 (53%)
		HEAT repeat	57..88	CDD:293787	11/30 (37%)
		HEAT repeat	99..122	CDD:293787	11/26 (42%)
		HEAT repeat	133..161	CDD:293787	13/27 (48%)
		HEAT repeat	176..205	CDD:293787	8/28 (29%)