DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment msps and zyg-9

DIOPT Version :9

Sequence 1:NP_001247129.1 Gene:msps / 41952 FlyBaseID:FBgn0027948 Length:2082 Species:Drosophila melanogaster
Sequence 2:NP_495784.1 Gene:zyg-9 / 174350 WormBaseID:WBGene00006994 Length:1415 Species:Caenorhabditis elegans


Alignment Length:1916 Identity:417/1916 - (21%)
Similarity:720/1916 - (37%) Gaps:608/1916 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 DLLDPVDILSKMPKDFYDKLEEKKWTLRKESLEVLEKLLTDHPKLE-NGEYGALVSALKKVITKD 331
            |.||.||||.|:|.:|.:..|.|||..|||:||.|.|:|||:.:|. ...|..|:..|:.|:.||
 Worm     5 DYLDEVDILPKLPPNFDELRESKKWQERKEALEALLKVLTDNERLSTKASYAELIGHLQMVLAKD 69

  Fly   332 SNVVLVAMAGKCLALLAKGLAKRFSNYASACVPSLLEKFKEKKPNVVTALREAI-----DAIYAS 391
            :|:...|:|.||:...|.||..:||::|...:|.:.||.|||||    .|||.:     :.....
 Worm    70 ANINCQALAAKCIGKFATGLRAKFSSFAGPLLPVIFEKMKEKKP----MLREPLVDCSNEVGRTM 130

  Fly   392 TSLEAQQESIVESLSNKNPSVKSETALFIARALTRTQPTALNKKLLKLLTTSLVKTLNEPDPTVR 456
            .|||..||.|:.:|:..||.:|.:||||:||.|....|....|..:|.:.....|...:.|..||
 Worm   131 QSLETGQEDILAALAKPNPQIKQQTALFVARQLDLVVPAKQPKGFIKAVVPVFGKLTGDADQDVR 195

  Fly   457 DSSAEALGTLIKLMGDKAVTPLLADV--DPLKMAKIKECQEK-----AEIKIKVAGPKKETRPAS 514
            ::|.:.||.:.:::|||.|..||.|.  |..||.||.|..||     ||.:.|.|.|...|  :|
 Worm   196 EASLQGLGAVQRIIGDKNVKNLLGDASSDEGKMKKIGEYAEKSTASFAEEQAKNAPPVAPT--SS 258

  Fly   515 APTAKAAAPAKTVAGSVDPKPVTRPATTGARKVLKKPATVSGGGATSAPTAALKAGGKPLATERE 579
            .|:|.||        |.||                     |||.||     |:.:.|.|:|   |
 Worm   259 TPSASAA--------SGDP---------------------SGGTAT-----AVVSSGAPVA---E 286

  Fly   580 ITPEELQEKSEEI--LPAEILNGLVDSNWKNRLAAVEQLLGEISG---FDAKQAGISQILIRTIS 639
            ..|.:..:..:.:  :|......:....|:.|..|:|.||..|:.   .|.| |....::.|.  
 Worm   287 ADPWDFLDAFDVLSKMPDGFDTNIESKKWQERKEALEGLLQLITANPKLDPK-ANYGALVERL-- 348

  Fly   640 GRKPGLKEMNFQVLKFKLDIIRSVAEN-----YPLTTTTVDLVINEIIEKLADAKNGAAAADVLS 699
             :|...|:.|..|.....:.|..:|..     .|...:...::..:..||....::...|.  :.
 Worm   349 -QKVLEKDANINVAALAANCITGIANGLRTKFQPFAVSVTPIIFEKFKEKKPTLRDPLVAC--ID 410

  Fly   700 AFAEATKLEYVVGKVLSFAFEQKSPKVQSEAFNWVNRSIIEFGFQLQP----KTLIEDVRKGVQS 760
            |....|.|| .||:::..|..:.:|.::::...::.|..::...|..|    ||||..:.|....
 Worm   411 AVVATTNLE-AVGEIVLAALGKPNPSIKTQTDLFLQRCFMKLNSQTMPKKTLKTLIPSLIKHSGD 474

  Fly   761 TNPTVRASAIQMVGTMSMYMGKALMMFFDSEKPALKSQIQVEFDKNVGEKPPKPVRGVQRSSGGT 825
            ::..||.::...:|.|...:|         |||:|:.                            
 Worm   475 SDSEVREASYAAMGAMMRAIG---------EKPSLQL---------------------------- 502

  Fly   826 AGNSPDNEDDDGGAAGEEEPINMADLLPRVDIAPQITEALLKEMSDKDWKTRNEGLTKLQAIISE 890
                                  :||:     .:..:..:.:||...|                  
 Worm   503 ----------------------LADI-----ASDNLKMSKIKEFHQK------------------ 522

  Fly   891 ARLIKPSIGDLAPALAHRLVDSNAKIAQTTLAICEQLATAMGAGCRNHVRNLFPGFLHALGDNKS 955
                  ::.:..||....:|.|..|                                        
 Worm   523 ------ALDEAGPAEIAEMVKSIHK---------------------------------------- 541

  Fly   956 FVRAAALNCINSFGEKGGYKEFFESEMIADALKGGSPALKTELWAWLADKLPGLPPKSVSKEDIH 1020
                                        |||....:|..||            .|||...:::  
 Worm   542 ----------------------------ADAPPAAAPPKKT------------APPKKQPEDE-- 564

  Fly  1021 SMVPHLYAHICDRNADVRKNANEAVLGIMIHLGFDAMNRALDKQKPASKKDILAALEKARPNLPV 1085
                           :|.:..:|                                        |:
 Worm   565 ---------------EVVEEEDE----------------------------------------PL 574

  Fly  1086 KPLPKGKHQAPIPEEPKLKTVRGGGAGGAPGIQKSATARVAGGQDKQVPARKKDEDID--TSP-- 1146
            ||.|                                     |.:.|:||.::.:|:..  .:|  
 Worm   575 KPPP-------------------------------------GDKKKKVPVKENEENEPPVVAPKA 602

  Fly  1147 --LLCANSAKNQRLLDEQKMKVLKWTFVTPREEFTELLRDQMMTANVNK-ALIANMFHDDFRYHL 1208
              ||..|..|.||:.:|:::|::||.|..|.:|....|  |.:..|..| :|::.:||.||:.||
 Worm   603 ELLLSDNEDKKQRIKEEKQLKLVKWNFQAPTDEHISQL--QTLLGNQAKVSLMSQLFHKDFKQHL 665

  Fly  1209 KVIEQLSEDLAGNSKALVCNLDLILKWLTLRFYDTNPSVLIKGLEYLVQVFQVLIDEEYILAENE 1273
            ..::.|......:.::|:.|.||:|||.||||::|||:.|||.||....:.:::.|.|..:::.|
 Worm   666 AALDSLVRLADTSPRSLLSNSDLLLKWCTLRFFETNPAALIKVLELCKVIVELIRDTETPMSQEE 730

  Fly  1274 GSSFVPHLLLKIGDPKDAVRNGVRRVLRQVILVFPFVKVFGYVMEGLKSKNARQRTECLDELTFL 1338
            .|:|||:||||.|:.||.:|..||.::..:..|...:|:...:::.|||||||||:|||..:.:.
 Worm   731 VSAFVPYLLLKTGEAKDNMRTSVRDIVNVLSDVVGPLKMTPMLLDALKSKNARQRSECLLVIEYY 795

  Fly  1339 IESYGMN-ICPQSAVREIARQISDRDNSVRNAALNCIVQVFFLSGEKTYKMIGHLNEKDLSMLDE 1402
            |.:.|:: :...|..:.:|..:.|:|.:|||||:|.:|..|...|::.:|..|.:.:||.|:::|
 Worm   796 ITNAGISPLKSLSVEKTVAPFVGDKDVNVRNAAINVLVACFKFEGDQMWKAAGRMADKDKSLVEE 860

  Fly  1403 RIKR-------AKKTKKPTPPPSVDVPAPQRHDSIEIEDAEVGNGCDELPPPDEDGLQRELNARG 1460
            ||||       ...|..||..|.:.||                                    :.
 Worm   861 RIKRTGVKPGSGVVTSPPTGGPKILVP------------------------------------QQ 889

  Fly  1461 QNNMTDRSATNVVAYLSSLTRQATFDQAPSSQLLLLQQQLQQLQQQAQQQKPSGPFGLDSQVISE 1525
            |.::..|.|          :|..|.:..|..    :|.....::|.....|.|..:.|...|.|.
 Worm   890 QGSVVRRPA----------SRSRTREPEPEE----VQSDTFTIRQDTMPPKTSSRYALRDDVFSS 940

  Fly  1526 IEKDWVRVDQMEQKPLLNVDISSLDEPIKVRPTRAGIHYPQEKFDRLISRQHYMQQTLTTSPSST 1590
            .                   :..||....:.|.:....:....|          |...|.|.||.
 Worm   941 A-------------------MGRLDGTQVITPPQPVNGWSNNTF----------QMKRTNSSSSI 976

  Fly  1591 AGMTSGVSPYRSPMRLQHQQPQQQLENNIPNLADVLPKHDPQLVKVIKGVSSTDTLKARAAINEL 1655
            :.:.:.            .|.|:.:.|...:||||                      |:.|:.::
 Worm   977 SSIDTS------------DQIQRSINNISSSLADV----------------------AQDAMFQV 1007

  Fly  1656 AAIIEAPEKQAVL-RDYEEIF------IQNVLAQF---KNLSQIPSAQSVVVY------------ 1698
            ..::..||::.:: |..:.:|      :..|:.:|   :::|....|.:.:::            
 Worm  1008 TYVLNQPEQRHLVDRRADLVFRASAAQLDLVIEEFNAGRDVSGTMDACTQMLFILMGGVETEHGL 1072

  Fly  1699 QPLLSILYTFFHANILGKTLSVACIKNLMSALLNLMADPKLAVGD-DSQYN--KVINGICLKVLD 1760
            :||               ..|...:|.::|::|..:    :.:|: :|.|.  :.:|.:.::::.
 Worm  1073 EPL---------------NASPDTVKAIISSVLRCI----IQIGNTESGYGMARSLNRLAMRLIY 1118

  Fly  1761 KVDFTNLNCALIRLLRETCPEAKLPKFTDLLMKCIWRNVKMLPERSNELNYDAVILEVHEF-MLA 1824
            :|:.:||.|.||..:.|:.  ......|:|:.|...:....|.:|..:|....::...:.| :.|
 Worm  1119 RVELSNLLCGLILAMTESL--QMNTGITELVSKLSSKWCDELEKRRAQLRASDIVDSFNAFYVCA 1181

  Fly  1825 LPSTWWQNRPSDTPMRTIKTILHNMAKVKGNAILQHLNQIP-THSELHTYLIRILKNF------- 1881
            |  |..:...||:.:..:...|..:...:|:.:|....::. .|..|.:.:.:||:..       
 Worm  1182 L--TELKMDISDSHILIVDNYLERVILQQGDVVLDAARRLSRPHMHLTSMINKILQMMRERKIDP 1244

  Fly  1882 -----------QKDGSA---SGIGASPQRAKEIASKRISHQTHDTVSQIFKLISDRDTKQQGLQK 1932
                       |:|.:.   ||:..|........|..:.|     :.|:..||:..|   :...:
 Worm  1245 IMPGTLEARMPQEDEAVVVRSGVQVSIDNILRDTSMAVKH-----IEQLNILIASSD---RSWNE 1301

  Fly  1933 LYDFKQQNPDIDLSTFLQGSSAPFHKYIEEGLAEIERNQNA--------GSTQDNRTAATRSYLT 1989
            ..::.:.||..:|...|.|..:. .|.|:..|:.:.::..|        |..|:.    .|...|
 Worm  1302 YMEYLKNNPMGELIKELVGECSR-KKRIDFNLSHVVKSSMAVFKAMAATGPVQEE----GRITPT 1361

  Fly  1990 DVNYQNNGPDPDFWMDRLQYHMTG-----GAAKLASARSADDGSHMLDNKVVDENLCLNGMNAQK 2049
            |:|             |:...:.|     |.|.:..||                           
 Worm  1362 DIN-------------RMDTMIVGTPLSRGDATITRAR--------------------------- 1386

  Fly  2050 ASLIKREKRDMSPNRLQHLQAKLAQIKKENH 2080
            .::|:.::..:|.:::.:::..|.::|  ||
 Worm  1387 GNMIRPKRTTLSRDQMANIRHTLDRVK--NH 1415

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mspsNP_001247129.1 HEAT repeat 319..350 CDD:293787 11/30 (37%)
HEAT repeat 361..387 CDD:293787 11/30 (37%)
HEAT repeat 398..466 CDD:293787 24/67 (36%)
HEAT repeat 860..891 CDD:293787 3/30 (10%)
HEAT repeat 900..929 CDD:293787 5/28 (18%)
HEAT repeat 939..968 CDD:293787 0/28 (0%)
zyg-9NP_495784.1 HEAT repeat 16..47 CDD:293787 16/30 (53%)
HEAT repeat 57..88 CDD:293787 11/30 (37%)
HEAT repeat 99..122 CDD:293787 11/26 (42%)
HEAT repeat 133..161 CDD:293787 13/27 (48%)
HEAT repeat 176..205 CDD:293787 8/28 (29%)
HEAT repeat 344..373 CDD:293787 6/31 (19%)
HEAT repeat 385..411 CDD:293787 3/27 (11%)
HEAT repeat 420..450 CDD:293787 5/29 (17%)
HEAT repeat 461..490 CDD:293787 8/28 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1820
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S5459
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D28390at33208
OrthoFinder 1 1.000 - - FOG0003733
OrthoInspector 1 1.000 - - otm14167
orthoMCL 1 0.900 - - OOG6_101795
Panther 1 1.100 - - O PTHR12609
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R51
SonicParanoid 1 1.000 - - X4162
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.760

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