DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAe and gata4

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_001016949.1	Gene:	gata4 / 549703	XenbaseID:	XB-GENE-487458	Length:	394	Species:	Xenopus tropicalis

Alignment Length:	458	Identity:	131/458 - (28%)
Similarity:	189/458 - (41%)	Gaps:	133/458 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   283 HQHQAAAAASAA-AQTVHIAT------------SSHGGTVRFVTEDVRFTTAGPETSASNMYYDV 334
            :.|.|.||.|.. ..|..:::            ||..|:.  |:....:..||.|.||.|.
Frog    22 YMHSATAATSPVYVPTTRVSSMIPSLPYLQTSGSSQQGSP--VSGHNMWAQAGAEPSAYNP---- 80

  Fly   335 PVVDGSVHANESKTYADLGNAYAPFPPSSSFSSNSYAATLQQGNTIYSVPGTGQFLAKSESGLNQ 399
                              |.::.|..|..:|||:...:........||.|     ||.|.:|..|
Frog    81 ------------------GTSHPPVSPRFTFSSSPPISAASNREVPYSSP-----LAISANGREQ 122

  Fly   400 TGLLRQTGPATFQTISFEGGNGIEPLWASPAPPEYQSVQFSNFHPQVIDEYGSGNMSTSHWPPAS 464
            .|  |..| ||:               :||.|                 .|.|.:|..: |
Frog   123 YG--RALG-ATY---------------SSPYP-----------------AYMSPDMGAT-W---- 147

  Fly   465 SIGQYDGSLV-------TASSTSSPNHEL--------KCENCHG---PFLRKG--SEYFCPNCPA 509
            :...:|.|::       ..:::..||.|.        :|.||..   |..|:.  ..|.|..|..
Frog   148 TASPFDSSMLHNLQNRAGPAASRHPNIEFFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGL 212

  Fly   510 FMRMAPRITQRQAKPKAAAAPNNRRNGVTCANCQTNSTTLWRRNNEGNPVCNACGLYYKLHNMNR 574
            :.:| ..|.:...||:...:. :||.|::||||.|.:|||||||.||.|||||||||.|||.:.|
Frog   213 YHKM-NGINRPLIKPQRRLSA-SRRVGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPR 275

  Fly   575 PLSMKKEGIQKRKRKPKNNGGAPMHRAPLPSMSQGVNLMANSPLYPSQVPVSMLNS------QLN 633
            ||:|||||||.|||||||     :.::..|:   |.|  ::..|.||   .|..||      .:.
Frog   276 PLAMKKEGIQTRKRKPKN-----LSKSKTPT---GQN--SSDSLTPS---TSSTNSAGEEMRPIK 327

  Fly   634 SQQNSSPELHDMSTTGQAGGQRVVSISLNATAPPTPDGTLNMSARHHVTGESHSPYSQQSTPQSQ 698
            .:...||.....|:..||.   |:|.:.:..:...|..:|.:|.::|     ||..:  ::||:.
Frog   328 IEPGLSPPYGHSSSLSQAS---VLSTTTSHGSSSYPMSSLKLSPQNH-----HSTIN--TSPQAS 382

  Fly   699 SPH 701
            |.|
Frog   383 SKH 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	35/48 (73%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	38/50 (76%)
gata4	NP_001016949.1	GATA-N	1..174	CDD:283099	45/220 (20%)
		ZnF_GATA	181..228	CDD:214648	12/47 (26%)
		ZnF_GATA	185..235	CDD:238123	12/51 (24%)
		ZnF_GATA	237..284	CDD:214648	34/46 (74%)
		ZnF_GATA	239..290	CDD:238123	38/50 (76%)
		Peptidase_S64	293..>387	CDD:285411	27/116 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	42	1.000	Domainoid score	I12247
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910