DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GATAe and Gata6

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_062058.2	Gene:	Gata6 / 29300	RGDID:	2666	Length:	587	Species:	Rattus norvegicus

Alignment Length:	615	Identity:	167/615 - (27%)
Similarity:	235/615 - (38%)	Gaps:	155/615 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 EPSTNASNASSGSASDSHIEYQRSAHQSP-GATHYVQMAPRNAEVTEQVGAAAGAPPGTIFAYPI 200
            |||:..|..||.|:|.|     |...:.| ||::.     |..::..:  |.||.|..::...|.
  Rat    31 EPSSPLSPISSSSSSCS-----RGGDRGPCGASNC-----RTPQLDTE--AVAGPPGRSLLLSPY 83

  Fly   201 ICN----GDDVAAIKIETLEKGEATGESQQQQQQLQQHQHQQQQQCPTPNGASYGETIVISSEAE 261
            ..:    ....||..:.......:|.|.......|.|              |:....::.||...
  Rat    84 TSHPFAAAHGAAAPGVAGPGSALSTWEDLLLFTDLDQ--------------AATASKLLWSSRGA 134

  Fly   262 ALQHHHQQQQQHQQQQHQQQHHQ-------------HQAAAAASAAA---QTVHIAT-------- 302
            .|.....:|.:...|.......|             |.|||||:|||   ..|::.|
  Rat   135 KLSPFAAEQPEEMYQTLAALSSQGPAAYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLP 199

  Fly   303 ------------SSHGGTVRFVTEDVRFTTAG-----PETSASNMYYD----------VPVVDGS 340
                        |:|.|            .||     |:.||.:..|.          .|...||
  Rat   200 GLPYLQGAGSGPSNHAG------------GAGAHPGWPQASADSPPYGGGGAAGGGAAGPGGAGS 252

  Fly   341 VHANESKTYADLGNAYAPFPPSSSFSSNSYAATLQQGNT-IYSVPGTGQFLAKSESGLNQTGLLR 404
            ..|:.|..:     .|:|.||.::.::......:..|.. ..||.|.|..||......:|...|.
  Rat   253 ATAHASARF-----PYSPSPPMANGAARDPGGYVAAGGAGAGSVSGGGGSLAAMGGREHQYSSLS 312

  Fly   405 QTGP--ATFQ-------TISFEGGNGIEPLWASPAPPEYQSVQFSNFHPQVIDEYGSGNMSTSHW 460
            ...|  .|:.       |.|...|..:.|.|  ||.|         |...|:....|...:....
  Rat   313 AARPLNGTYHHHHHHHPTYSPYMGAPLTPAW--PAGP---------FETPVLHSLQSRAGAPLPV 366

  Fly   461 PPASSIGQYDGSLVTASSTSSPNHELKCENC---HGPFLRKG--SEYFCPNCPAFMRMAPRITQR 520
            |...|          |......:...:|.||   ..|..|:.  ..|.|..|..:.:| ..:::.
  Rat   367 PRGPS----------ADLLEDLSESRECVNCGSIQTPLWRRDGTGHYLCNACGLYSKM-NGLSRP 420

  Fly   521 QAKPKAAAAPNNRRNGVTCANCQTNSTTLWRRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQK 585
            ..||: ...|::||.|::||||.|.:|||||||.||.|||||||||.|||.:.|||:|||||||.
  Rat   421 LIKPQ-KRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQT 484

  Fly   586 RKRKPKN---------NGGAPMHRAPLPSMSQGVNLMAN-SPLYPSQVPVSMLNSQLNSQ--QNS 638
            |||||||         |...||  .|..|.|...:...| ||  |:|...|.:.:.:.|.  :::
  Rat   485 RKRKPKNINKSKACSGNSSVPM--TPTSSSSNSDDCTKNTSP--PTQSTASGVGASVMSAVGESA 545

  Fly   639 SPELHDMSTTGQAGGQRVVSISLNATAPPT 668
            :||..|:..:||.|  ..:.:||::.|..|
  Rat   546 NPENSDLKYSGQDG--LYIGVSLSSPAEVT 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	35/48 (73%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	38/50 (76%)
Gata6	NP_062058.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..73		16/53 (30%)
		GATA-N	147..371	CDD:283099	54/251 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..259		13/61 (21%)
		ZnF_GATA	382..429	CDD:214648	11/48 (23%)
		ZnF_GATA	383..428	CDD:238123	11/46 (24%)
		ZnF_GATA	435..482	CDD:214648	34/46 (74%)
		ZnF_GATA	437..488	CDD:238123	38/50 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..532		22/55 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11378
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.860