DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GATAe and GATA6

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_005248.2	Gene:	GATA6 / 2627	HGNCID:	4174	Length:	595	Species:	Homo sapiens

Alignment Length:	647	Identity:	153/647 - (23%)
Similarity:	243/647 - (37%)	Gaps:	203/647 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 EPSTNASNASSGSASDSHIEYQRSAHQSPGATHYVQMAPRNAEVTEQVGAAAGAPPGTIF----- 196
            ||||..|..||.|:|.|     |...:.||..........:.|      ||||.|..::.
Human    31 EPSTPPSPISSSSSSCS-----RGGERGPGGASNCGTPQLDTE------AAAGPPARSLLLSSYA 84

  Fly   197 AYPI-----------------ICNGDDV----------AAIKIETLEKG-EATGESQQQQQQLQQ 233
            ::|.                 :.:.:|:          .|.|:....:| :.:..:.:|.:::.|
Human    85 SHPFGAPHGPSAPGVAGPGGNLSSWEDLLLFTDLDQAATASKLLWSSRGAKLSPFAPEQPEEMYQ 149

  Fly   234 HQHQQQQQCPTPNGASYGETIVISSEAEALQHHHQQQQQHQQQQHQQQHHQHQAAAAASAAAQTV 298
            .......|.|.....:.|..:                           |....|||||:||:..|
Human   150 TLAALSSQGPAAYDGAPGGFV---------------------------HSAAAAAAAAAAASSPV 187

  Fly   299 HIATSSHGGTVRFVTEDVRFTTAG--------------PETSASNMYYDV-----------PVVD 338
            ::.|:..|..:..:...::.:.:|              |:.||.:..|..           |...
Human   188 YVPTTRVGSMLPGLPYHLQGSGSGPANHAGGAGAHPGWPQASADSPPYGSGGGAAGGGAAGPGGA 252

  Fly   339 GSVHANESKTYADLGNAYAPFPPSSSFSSNSYAATLQQGNTIYSVPGTGQFLAKSESGLNQTGLL 403
            ||..|:.|..:     .|:|.||.::      .|..:.|.  |:..|:|     ...|::..|
Human   253 GSAAAHVSARF-----PYSPSPPMAN------GAAREPGG--YAAAGSG-----GAGGVSGGG-- 297

  Fly   404 RQTGPATFQTISFEGGNGIEPLWASPAPPEYQSVQFS--------------NFHPQVIDEYGSGN 454
                    .:::..||.          .|:|.|:..:              :.||.....| .|.
Human   298 --------SSLAAMGGR----------EPQYSSLSAARPLNGTYHHHHHHHHHHPSPYSPY-VGA 343

  Fly   455 MSTSHWPPASSIGQYDGSLVTASSTSS---------PNHEL--------KCENC---HGPFLRKG 499
            ..|..||    .|.::..::.:..:.:         |:.:|        :|.||   ..|..|:.
Human   344 PLTPAWP----AGPFETPVLHSLQSRAGAPLPVPRGPSADLLEDLSESRECVNCGSIQTPLWRRD 404

  Fly   500 --SEYFCPNCPAFMRMAPRITQRQAKPKAAAAPNNRRNGVTCANCQTNSTTLWRRNNEGNPVCNA 562
              ..|.|..|..:.:| ..:::...||: ...|::||.|::||||.|.:|||||||.||.|||||
Human   405 GTGHYLCNACGLYSKM-NGLSRPLIKPQ-KRVPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNA 467

  Fly   563 CGLYYKLHNMNRPLSMKKEGIQKRKRKPKN-----------NGGAPMHRAPLPSMSQGVNLMANS 616
            ||||.|||.:.|||:|||||||.|||||||           |...||......|.|...:...:.
Human   468 CGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINKSKTCSGNSNNSIPMTPTSTSSNSDDCSKNTSP 532

  Fly   617 PLYPSQ----VPVSMLNSQLNSQQNSSPELHDMSTTGQAGGQRVVSISLNATAPPT----PD 670
            ...|:.    .||     ...:.::::||..::..:||.|  ..:.:||.:.|..|    ||
Human   533 TTQPTASGAGAPV-----MTGAGESTNPENSELKYSGQDG--LYIGVSLASPAEVTSSVRPD 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	35/48 (73%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	38/50 (76%)
GATA6	NP_005248.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..71		15/50 (30%)
		GATA-N	147..377	CDD:283099	49/299 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..255		7/46 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..339		11/77 (14%)
		ZnF_GATA	388..435	CDD:214648	11/48 (23%)
		ZnF_GATA	389..434	CDD:238123	11/46 (24%)
		ZnF_GATA	441..488	CDD:214648	34/46 (74%)
		ZnF_GATA	443..494	CDD:238123	38/50 (76%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..561		24/83 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12499
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.770