DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GATAe and Gata1

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_036896.1	Gene:	Gata1 / 25172	RGDID:	2663	Length:	413	Species:	Rattus norvegicus

Alignment Length:	430	Identity:	115/430 - (26%)
Similarity:	162/430 - (37%)	Gaps:	114/430 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 VRFVTEDVRFTTAGPE---TSASNMYYDVPVVDGSVHA--NESKTYA--------DLGNAYAPFP 360
            |...::...|.::|||   |::|:...:......:..|  .|::.|.        .|.|:....|
  Rat    24 VSSTSDSAGFFSSGPESLDTASSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNSMEGIP 88

  Fly   361 PSSSFSSNSYAAT-LQQGNTIYSVPGTGQFLAKSESGLNQTGLLRQTGPATFQTISFEGGNG--- 421
            .||.::|.:|:.| |...:|:  .|.                  .:..|:  ||:....|..
  Rat    89 GSSPYASWAYSKTALYPASTV--CPS------------------HEDAPS--QTLEDPDGKNNNT 131

  Fly   422 -IEPLWASPAPPEYQSV--QFSNFHPQVIDEYGSGNMSTSHWPP--------ASSIGQYDGSLVT 475
             :|.|......|:..::  ......|.....||..:..:..:.|        |.|..::.|||..
  Rat   132 FLETLKTERLSPDLLTLGTALPTSLPVTSSAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPL 196

  Fly   476 ASSTSSPNHELKCENCHG---PFLRKG--SEYFCPNCPAFMRM----APRITQRQAKPKAAAAPN 531
            |     |....:|.||..   |..|:.  ..|.|..|..:.:|    .|.|     :||.....
  Rat   197 A-----PCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLI-----RPKKRMIV- 250

  Fly   532 NRRNGVTCANCQTNSTTLWRRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPKNNG-- 594
            ::|.|..|.||||.:|||||||..|:|||||||||||||.:||||:|:|:|||.|.||....|
  Rat   251 SKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKK 315

  Fly   595 -------GAPMHRAP-------------------LPSMSQGVNLMANSPLYPSQVPVSMLNSQLN 633
                   ||.....|                   .|.::.|.  ...:.||....||.:
  Rat   316 KRGSSLAGAGAAEGPAGGFMVVAGGSSSGNCGEVAPGLTLGT--AGTAHLYQGLGPVVL------ 372

  Fly   634 SQQNSSPELHDMSTTGQAGGQRVVSISLNATAP-PTPDGT 672
                |.|..|.||..|...|....|.   .|.| ||...|
  Rat   373 ----SGPVSHLMSFPGPLLGSPTASF---PTGPVPTTTST 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	34/48 (71%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	36/50 (72%)
Gata1	NP_036896.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		5/40 (13%)
		Interaction with MED1 and CCAR1. /evidence=ECO:0000250\|UniProtKB:P15976	200..330		56/135 (41%)
		ZnF_GATA	202..247	CDD:214648	13/49 (27%)
		ZnF_GATA	203..249	CDD:238123	13/50 (26%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		5/18 (28%)
		Interaction with CALCOCO1. /evidence=ECO:0000250\|UniProtKB:P15976	249..315		41/66 (62%)
		ZnF_GATA	<268..308	CDD:238123	29/39 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		10/27 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.910