DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GATAe and Gata5

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_032119.2	Gene:	Gata5 / 14464	MGIID:	109497	Length:	404	Species:	Mus musculus

Alignment Length:	464	Identity:	119/464 - (25%)
Similarity:	184/464 - (39%)	Gaps:	144/464 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   285 HQAAAAASAAAQTVHIAT-----SSHGGTVRFVTEDVRFTTAGPETSASNMYYDVPVVDGSVHAN 344
            :|:.|.|.:..|..:..:     ||..|:..||. ..|..:..|...:.......|.:  :.|::
Mouse     2 YQSLALAQSPGQGTYADSGAFLHSSGTGSPVFVA-PTRMPSMLPYLPSCEPGSQAPAL--AAHSS 63

  Fly   345 ESKTYADLGNAY---APFPPSSSFSSNSYAATLQQGNTIY----SVPGTGQFLAKSESGLNQTG- 401
            .::..|...:|:   :|.||          |....|.|.:    |.||:|   :...:|:...|
Mouse    64 WTQAVAADSSAFGSGSPHPP----------AAHPPGATTFPFAHSPPGSG---SGGSAGVRDGGA 115

  Fly   402 -----LLRQTGPATFQTISFEGGNGIEPLWASPAPPEYQSVQFSNFHPQVIDEYGSGNMSTSHWP 461
                 |.|:..|....          .|:.||              :|.....|.|.:::
Mouse   116 FQGALLAREQYPTPLG----------RPMGAS--------------YPTTYPAYMSSDVA----- 151

  Fly   462 PASSIGQYDGSL----------VTASSTS--------SPNHELKCENCHG---PFLRKG--SEYF 503
            |:.:.|.:|.|:          :....||        .|....:|.||..   |..|:.  ..|.
Mouse   152 PSWTSGAFDSSILHGLQARPGGLPGRRTSFVPDFLEEFPGEGRECVNCGALSTPLWRRDGTGHYL 216

  Fly   504 CPNCPAFMRMAPRITQRQAKPKAAAAPNNRRNGVTCANCQTNSTTLWRRNNEGNPVCNACGLYYK 568
            |..|..:.:| ..:.:...:|:...: ::||:|:.|:||.|.:|||||||:||.|||||||||.|
Mouse   217 CNACGLYHKM-NGVNRPLVRPQKRLS-SSRRSGLCCSNCHTATTTLWRRNSEGEPVCNACGLYMK 279

  Fly   569 LHNMNRPLSMKKEGIQKRKRKPKNNGGAPMHRAPLPSMSQG-----VNLMANSPLYPSQVPVSML 628
            ||.:.|||:||||.||.|||||||           |:..:|     .|..|:||        ::|
Mouse   280 LHGVPRPLAMKKESIQTRKRKPKN-----------PAKIKGSSGSTANTTASSP--------TLL 325

  Fly   629 NSQLNSQQNSSPELHDMSTTGQAGGQRVVSISLNATAPPTPDGTLNMSARHHVTGESHSPYSQQS 693
            ||:            ..:||.:|..    |::....|.||            :|.::.||..:..
Mouse   326 NSE------------SSATTLKAES----SLASPVCAGPT------------ITSQASSPADESL 362

  Fly   694 TPQSQSPHL 702
            .    |.||
Mouse   363 A----SSHL 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	34/48 (71%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	36/50 (72%)
Gata5	NP_032119.2	GATA-N	1..181	CDD:368398	41/223 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..112		12/53 (23%)
		ZnF_GATA	195..239	CDD:238123	10/44 (23%)
		ZnF_GATA	250..300	CDD:238123	36/49 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..332		18/69 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	48	1.000	Domainoid score	I11848
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.770