DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAe and Gata1

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_032115.1	Gene:	Gata1 / 14460	MGIID:	95661	Length:	413	Species:	Mus musculus

Alignment Length:	420	Identity:	115/420 - (27%)
Similarity:	159/420 - (37%)	Gaps:	102/420 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 TEDVRFTTAGPE-----TSASNMYYDVPVVDGSVHANESKTYA--------DLGNAYAPFPPSSS 364
            ::...|.::|||     :|:::............:..|::.|.        .|.|:....|..|.
Mouse    28 SDSTGFFSSGPEGLDAASSSTSPNAATAAASALAYYREAEAYRHSPVFQVYPLLNSMEGIPGGSP 92

  Fly   365 FSSNSYAAT-LQQGNTIYSVPGTGQFLAKSESGLNQTGLLRQTGPATFQTISFEGGNGIEP--LW 426
            ::|.:|..| |...:|:  .|....  |.|::..:|.|....|...|.:|      ..:.|  |.
Mouse    93 YASWAYGKTALYPASTV--CPSHED--APSQALEDQEGKSNNTFLDTLKT------ERLSPDLLT 147

  Fly   427 ASPAPPEYQSVQFSNFHPQVIDEYGSGNMSTSHWPP--------ASSIGQYDGSLVTASSTSSPN 483
            ...|.|....|..|        .||..:..:..:.|        |.|..::.|||..|     |.
Mouse   148 LGTALPASLPVTGS--------AYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLA-----PC 199

  Fly   484 HELKCENCHG---PFLRKG--SEYFCPNCPAFMRM----APRITQRQAKPKAAAAPNNRRNGVTC 539
            ...:|.||..   |..|:.  ..|.|..|..:.:|    .|.|     :||..... ::|.|..|
Mouse   200 EARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLI-----RPKKRMIV-SKRAGTQC 258

  Fly   540 ANCQTNSTTLWRRNNEGNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPKNNG---------G 595
            .||||.:|||||||..|:|||||||||:|||.:||||:|:|:|||.|.||....|         |
Mouse   259 TNCQTTTTTLWRRNASGDPVCNACGLYFKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSNLAG 323

  Fly   596 APMHRAP-------LPSMSQG----------VNLMANSPLYPSQVPVSMLNSQLNSQQNSSPELH 643
            |.....|       ..|.|.|          :.....:.||....||.:          |.|..|
Mouse   324 AGAAEGPAGGFMVVAGSSSSGNCGEVASGLALGTAGTAHLYQGLGPVVL----------SGPVSH 378

  Fly   644 DMSTTGQAGGQRVVSISLNATAP-PTPDGT 672
            .|...|...|....|.   .|.| ||...|
Mouse   379 LMPFPGPLLGSPTTSF---PTGPAPTTSST 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	33/48 (69%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	35/50 (70%)
Gata1	NP_032115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..49		5/19 (26%)
		Interaction with MED1 and CCAR1. /evidence=ECO:0000269\|PubMed:24245781	200..330		55/135 (41%)
		ZnF_GATA	203..249	CDD:238123	13/50 (26%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		5/18 (28%)
		Interaction with CALCOCO1. /evidence=ECO:0000269\|PubMed:24245781	249..315		40/66 (61%)
		ZnF_GATA	<268..308	CDD:238123	28/39 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		10/27 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413		6/18 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910