DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAe and GATA5

DIOPT Version :9

Sequence 1:	NP_650516.2	Gene:	GATAe / 41945	FlyBaseID:	FBgn0038391	Length:	746	Species:	Drosophila melanogaster
Sequence 2:	NP_536721.1	Gene:	GATA5 / 140628	HGNCID:	15802	Length:	397	Species:	Homo sapiens

Alignment Length:	404	Identity:	111/404 - (27%)
Similarity:	159/404 - (39%)	Gaps:	106/404 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 YADLGN-AYAP-------FPPSSSFSSNSYAATLQ---QGNTIYSVPGTGQFLAKSESGLNQTGL 402
            |||.|: .:||       .||:...|..||.:..:   |...:.:.||..|......|..
Human    16 YADSGSFLHAPGAGSPMFVPPARVPSMLSYLSGCEPSPQPPELAARPGWAQTATADSSAF----- 75

  Fly   403 LRQTGPAT-FQTISFEGGNGIEPLWASPAPP------------EYQSV-----QFS--------N 441
                ||.: ....:...|....|...||:.|            .||..     ||:        .
Human    76 ----GPGSPHPPAAHPPGATAFPFAHSPSGPGSGGSAGGRDGSAYQGALLPREQFAAPLGRPVGT 136

  Fly   442 FHPQVIDEYGSGNMSTSHWPPASSIGQYDGSL-----------VTASSTSSPNHELKCENCHG-- 493
            .:......|.|.:::.| |    :.|.:|||:           |:......|....:|.||..
Human   137 SYSATYPAYVSPDVAQS-W----TAGPFDGSVLHGLPGRRPTFVSDFLEEFPGEGRECVNCGALS 196

  Fly   494 -PFLRKG--SEYFCPNCPAFMRMAPRITQRQAKPKAAAAPNNRRNGVTCANCQTNSTTLWRRNNE 555
             |..|:.  ..|.|..|..:.:| ..:.:...:|:...: ::||.|:.|.||.|.:|||||||:|
Human   197 TPLWRRDGTGHYLCNACGLYHKM-NGVNRPLVRPQKRLS-SSRRAGLCCTNCHTTNTTLWRRNSE 259

  Fly   556 GNPVCNACGLYYKLHNMNRPLSMKKEGIQKRKRKPK------NNGGAPMHRAPLPS-MSQGVNLM 613
            |.|||||||||.|||.:.|||:||||.||.||||||      .:.|:..:.:..|| ::...:..
Human   260 GEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKARGSSGSTRNASASPSAVASTDSSA 324

  Fly   614 ANSPLYPSQVPVSMLNSQLNSQQNSSPELHDMSTTGQAGGQRVVSI--------------SLNAT 664
            |.|...||.               :||.....|...||.||...|:              :..:|
Human   325 ATSKAKPSL---------------ASPVCPGPSMAPQASGQEDDSLAPGHLEFKFEPEDFAFPST 374

  Fly   665 APPTPDGTLNMSAR 678
            | |:|...|..:.|
Human   375 A-PSPQAGLRGALR 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAe	NP_650516.2	ZnF_GATA	534..583	CDD:214648	34/48 (71%)
GATAe	NP_650516.2	ZnF_GATA	538..589	CDD:238123	36/50 (72%)
GATA5	NP_536721.1	GATA-N	1..170	CDD:283099	35/167 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..116		12/76 (16%)
		ZnF_GATA	184..229	CDD:214648	9/45 (20%)
		ZnF_GATA	188..232	CDD:238123	10/44 (23%)
		ZnF_GATA	<253..293	CDD:238123	30/39 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..356		27/89 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12499
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.770