DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and GAT1

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_116632.1	Gene:	GAT1 / 850523	SGDID:	S000001873	Length:	510	Species:	Saccharomyces cerevisiae

Alignment Length:	441	Identity:	95/441 - (21%)
Similarity:	155/441 - (35%)	Gaps:	146/441 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   599 HNSSLED-GYGSPRSSHSGGGGGGTLPAFQRIAYPN------SGSVERYAPITNYRGQNDTWFDP 656
            |:..|.| ...|.|:||:..|            :||      |.|.:.:...||          .
Yeast   166 HSDLLNDMDSASQRASHNASG------------FPNFLDTSCSSSFDDHFIFTN----------N 208

  Fly   657 LSYATSSSGQAQLGVGVGAGVVSNVIRNGRAISAANAAAAAAADGTTGRVDPGTFLSASASLSAM 721
            |.:..::|             ::|   |....|:.|..:.:.|:.|....:..|..|.:.:...:
Yeast   209 LPFLNNNS-------------INN---NHSHNSSHNNNSPSIANNTNANTNTNTSASTNTNSPLL 257

  Fly   722 AAESGGDFYKPNSFNVGGGGRSKANTSGAASSYSCPGSNATSAATSAVASGTAATAATTLDEHVS 786
            .........||.         |:.|:|.....   |......::||..:|.|..:
Yeast   258 RRNPSPSIVKPG---------SRRNSSVRKKK---PALKKIKSSTSVQSSATPPS---------- 300

  Fly   787 RANSRRLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRK 851
                   :.|....:.||||.|:.|.|||::|.|.|:||||||:.|||.|.|||::|.|.|:||:
Yeast   301 -------NTSSNPDIKCSNCTTSTTPLWRKDPKGLPLCNACGLFLKLHGVTRPLSLKTDIIKKRQ 358

  Fly   852 RK-----------PKGTKSEKSKSKSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDDMKPQL 905
            |.           |..:.:..:..|.||...::  :.|...|..|:...|.|..:.:.....|
Yeast   359 RSSTKINNNITPPPSSSLNPGAAGKKKNYTASV--AASKRKNSLNIVAPLKSQDIPIPKIASP-- 419

  Fly   906 DLKPYNSYSSQPQQQLPQYQQQQQLLMADQHSSAASSP---------------------HSMGST 949
                          .:|||     |....:|..::|.|                     |:..::
Yeast   420 --------------SIPQY-----LRSNTRHHLSSSVPIEAETFSSFRPDMNMTMNMNLHNASTS 465

  Fly   950 SLSPSAM---------SHQHQTHPHQQQQQQLCSGLDMSPNSNYQMSPLNM 991
            |.:..|.         .|...|:|:        |.::.:||.|..:..||:
Yeast   466 SFNNEAFWKPLDSAIDHHSGDTNPN--------SNMNTTPNGNLSLDWLNL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	27/48 (56%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	30/50 (60%)
GAT1	NP_116632.1	GAT1	1..495	CDD:227928	90/426 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	57	1.000	Domainoid score	I2679
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		mtm9213
orthoMCL	1	0.900	-	-		OOG6_107467
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.800