DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment srp and grn

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_001262366.1	Gene:	grn / 40962	FlyBaseID:	FBgn0001138	Length:	712	Species:	Drosophila melanogaster

Alignment Length:	821	Identity:	219/821 - (26%)
Similarity:	290/821 - (35%)	Gaps:	303/821 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   267 DLTSGSAAAAAAAAAAASHPHLFGQFSYPPSHHTPTQLYEHYPSTDPIMRNNFAFYSVYTGGGGG 331
            |:||   .|.|||.:....|.|.|..|                                :|||.|
  Fly     2 DMTS---TAEAAARSWYDSPRLGGGGS--------------------------------SGGGNG 31

  Fly   332 VGV-----GMTS------HEHLAAAAAAAAAVAQGTTPNIDEVIQDTLKDECFEDGHSTDYHVLT 385
            .||     |:.|      |.|.:.::.|::|   |::..:...:..       ..|...|
  Fly    32 GGVSPQTNGLGSAGSSLAHSHHSLSSGASSA---GSSVGVGSALGG-------GGGSGLD----- 81

  Fly   386 SVSDMHTLKDSSPYALT----HEQLHQQQHHHQQQL------------HHHQ------------- 421
             .|||     |:.|||.    |.:.:...|.|..::            |.|.
  Fly    82 -TSDM-----SAFYALESNGHHRRYYPSYHQHTSRMPSTHASPQVCRPHFHTPLSPWLTSEHKSF 140

  Fly   422 -------------QQQQQLYHQQQQQQQQQQHHHHHNNSTSSAGGDS------------------ 455
                         .|:.|:.|:..|..|..|        |::||..|
  Fly   141 APASAWSMGQFACPQEPQVEHKLGQMGQSHQ--------TTAAGQHSFPFPPTPPKDSTPDSVQT 197

  Fly   456 -PSSSHALSTLQSFTQLTSATQRDSLSPENDAYFAAAQLGSSLQNSSV--YAGSLLTQTANGIQY 517
             ||...|:.......|.|.:|.....|       .|..:..|:||.|.  .:||..|.|:
  Fly   198 GPSEYQAVMNAFMHQQATGSTSLTDAS-------CALDIKPSIQNGSASGSSGSGTTHTS----- 250

  Fly   518 GMQSPNQTQ--AHLQQQHHQQQQQQHQQHQQQQLQQQQQQHHHNQHQHHNSSSSSPGPAGLHHSS 580
               :|.|.:  |............|.||.||||.||||||...|.....|:|:|         ||
  Fly   251 ---TPKQREGTASTTNSSSNSSSSQQQQQQQQQQQQQQQQSSSNTTASSNTSAS---------SS 303

  Fly   581 SSAATAAAVAAATAAVNGHNSSLEDGYGSPRSS-HSGGGGGGTLPAFQRIAYPNSGSVERYAPIT 644
            ::||:.:|..||:||.:  ::.|.||.....|| .|||||||
  Fly   304 AAAASLSAAVAASAATS--SNGLFDGTAQAYSSGGSGGGGGG----------------------- 343

  Fly   645 NYRGQNDTWFDPLSYAT----SSSGQAQLGVGVGAGVVSNVIRNGRAISAA--NAAAAAAADGTT 703
               |.....:|..|||:    ::..||      .|...:|:.::....:||  ::.|||.|....
  Fly   344 ---GSGSGGYDTSSYASYHHAAAHHQA------AAVAAANMFQSSSVAAAAVRHSMAAAQAHHHH 399

  Fly   704 GRVDPGTFLSASAS-LSAMAAESGGDFYKPNSFNVGGGGRSKANTSGAA--SSYSCPGSNA---- 761
            .....|...|.|:| |..:....||         ..|.|....|:.||.  |.:|..||||
  Fly   400 HHHHSGHHHSGSSSGLHGLGGSVGG---------TAGMGSMSGNSGGAGSLSGHSGAGSNAGSNC 455

  Fly   762 -------TSAATSA-----VASGTAATAATTLD---EHVSRA----------------NSRRL-- 793
                   |...|||     |..|..:|.....|   .::..|                ..|||
  Fly   456 LDVKPVRTKPRTSAEGRECVNCGATSTPLWRRDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLTL 520

  Fly   794 ----SASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRKRKP 854
                ||:||||.||:||.||.|:|||||.:|||||||||||||||:|.|||||||:.||.|.||
  Fly   521 QSLQSAAKRAGTSCANCKTTTTTLWRRNASGEPVCNACGLYYKLHNVNRPLTMKKEGIQTRNRK- 584

  Fly   855 KGTKSEKSKSKSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDDMKPQLDLKPYNSYSSQPQQ 919
                 ..||||.|..|..         .|..:|..|...      |.||   |.|...:..
  Fly   585 -----LSSKSKKKKGLGG---------GCLPIGGHLGMG------DFKP---LDPSKGFGG---- 622

  Fly   920 QLPQYQQQQQLLMADQHSSAASSPHSMGSTSLSPSAMSHQH 960
                            ..||:.:.|...|:.|.| |.:|.|
  Fly   623 ----------------GFSASMAQHGHLSSGLHP-AHAHMH 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	38/48 (79%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	38/50 (76%)
grn	NP_001262366.1	ZnF_GATA	470..517	CDD:214648	5/46 (11%)
		ZnF_GATA	473..517	CDD:238123	5/43 (12%)
		ZnF_GATA	529..578	CDD:214648	38/48 (79%)
		ZnF_GATA	533..583	CDD:238123	38/49 (78%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438453
Domainoid	1	1.000	63	1.000	Domainoid score	I2907
eggNOG	1	0.900	-	-		E1_COG5641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		mtm9213
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.870