DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and gata5

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_571310.2	Gene:	gata5 / 30482	ZFINID:	ZDB-GENE-980526-340	Length:	383	Species:	Danio rerio

Alignment Length:	405	Identity:	112/405 - (27%)
Similarity:	159/405 - (39%)	Gaps:	122/405 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   559 NQHQHHNSSSSSPGPAGLHHSSSSAATAAAVAAATAAVNGHNSSLEDGYGSPRSSHSGGGGGGTL 623
            :.||.|..||        ||:.....|             .|||.     :|.|.|...|
Zfish    52 SSHQAHGISS--------HHAWPQTGT-------------DNSSF-----NPGSPHPPPG----- 85

  Fly   624 PAFQRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSNVIRNGRAI 688
                 .:|.:|      .|:::..|::..:.:||  ..|:.|:|.   ..|:.:|.:|   |.:.
Zfish    86 -----FSYSHS------PPVSSSTGRDAAYQNPL--MLSNGGRAD---QYGSALVRSV---GGSY 131

  Fly   689 SAANAAAAAAADGTTGRVDPGTFLSASASLSAMAAESGGDFYKPNSFNVGGGGRSKANTSGAASS 753
            |:..||..:....|:.  .||.|             .||        .:|..|| :....|..||
Zfish   132 SSPYAAYMSPEMATSW--TPGPF-------------DGG--------MIGLQGR-QGTLPGRRSS 172

  Fly   754 YS------CPGSNATSAATSAV----ASGTAATAATT---------LDEHVSRANSRRLSASKRA 799
            ..      |.|....:..:.:.    ..||.......         ::..:.:...|..|.|:||
Zfish   173 IDMLDDLPCEGRECVNCGSISTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQKRLQSTSRRA 237

  Fly   800 GLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRKRKPKGTKSEKSKS 864
            ||.|:||||:.|:|||||..|||||||||||.|||.|||||.|||::||.||||||..|::.|..
Zfish   238 GLCCTNCHTSTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKMPKTKSSSG 302

  Fly   865 ---------------------KSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDDMKPQLDLK 908
                                 ||:.::.|...:|..|.:.......|||:.       ...:|:|
Zfish   303 STVSGATSPTSLPVSENASTIKSEPSIAASPYAGQTVVSVTQASTQLDSAS-------SAHVDIK 360

  Fly   909 PYNSYSSQPQQQLPQ 923
             |..|:..|....||
Zfish   361 -YEDYTYTPTSIAPQ 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	37/48 (77%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	37/50 (74%)
gata5	NP_571310.2	GATA-N	1..173	CDD:283099	42/194 (22%)
		ZnF_GATA	182..228	CDD:214648	3/45 (7%)
		ZnF_GATA	185..236	CDD:238123	5/50 (10%)
		ZnF_GATA	236..285	CDD:214648	37/48 (77%)
		ZnF_GATA	241..291	CDD:238123	37/49 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840