DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and gata3

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_571286.1	Gene:	gata3 / 30458	ZFINID:	ZDB-GENE-990415-82	Length:	438	Species:	Danio rerio

Alignment Length:	420	Identity:	117/420 - (27%)
Similarity:	172/420 - (40%)	Gaps:	113/420 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   563 HHNSSSSSPGP---AGLHHSSSSAATAAAVAAATAAVNGHNS---------SLEDGYGSPRSSHS 615
            ||::|..:.||   ..|||||....:....|::::...||:|         ..:|....|..|.|
Zfish    99 HHSTSPWNLGPFPKTSLHHSSPGPLSVYPPASSSSLSAGHSSPHLFTFPPTPPKDVSPDPAISTS 163

  Fly   616 GGGGGGTLPAFQRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSN 680
            |                 |||..|         |.|.  :.:.|..|.:...:|...
Zfish   164 G-----------------SGSSVR---------QEDK--ECIKYQVSLAESMKLDSA-------- 192

  Fly   681 VIRNGRAISAANAAAAAAADGTTGRVDPGTFLSASASLSAMAAESGGDFYKPNSFNVGG-----G 740
               :.|::::..|.|::|.             ...|:..:...:.|...:.|:|. :||     |
Zfish   193 ---HSRSMASIGAGASSAH-------------HPIATYPSYVPDYGPGLFPPSSL-IGGSSSSYG 240

  Fly   741 GRSKANTSGAASSYSCPGSNATSAAT-SAVASGTAATAATTLDEHVSRAN------SRRLSASKR 798
            .:::..|..::....|....|||... ....:|.....|..|...::..|      .|||||::|
Zfish   241 SKTRPKTRSSSEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARR 305

  Fly   799 AGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRKRKPKGTKSEKSK 863
            ||.||:||.||.|:|||||..|:|||||||||||||::.|||||||:.||.|.|| ..:||:|||
Zfish   306 AGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRK-MSSKSKKSK 369

  Fly   864 SKSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDDMKPQLDLKPYNSYSSQPQQQLPQYQQQQ 928
             ||.::    ||..|             .|.|:.|....|        :..|:.....|.:....
Zfish   370 -KSHDS----MEDFS-------------KSLMEKNSSFSP--------AALSRHMTSFPPFSHSG 408

  Fly   929 QLLMADQHSSAASSPHSMGSTSLSPSAMSH 958
            .:|         ::|..|..:|..|.|..|
Zfish   409 HML---------TTPTPMHPSSSLPFASHH 429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	36/48 (75%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	36/50 (72%)
gata3	NP_571286.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	100..173		23/98 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	232..255		4/22 (18%)
		ZnF_GATA	251..299	CDD:214648	8/47 (17%)
		ZnF_GATA	255..305	CDD:238123	13/49 (27%)
		ZnF_GATA	305..354	CDD:214648	36/48 (75%)
		ZnF_GATA	309..360	CDD:238123	36/50 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..378		16/33 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..438		7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573877
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.870