DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and Gata6

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_062058.2	Gene:	Gata6 / 29300	RGDID:	2666	Length:	587	Species:	Rattus norvegicus

Alignment Length:	619	Identity:	161/619 - (26%)
Similarity:	224/619 - (36%)	Gaps:	179/619 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   445 NNSTSSAGGD-SPSSSHALSTLQSFTQLTSATQRDS--LSPENDAYFAAAQ---------LGSSL 497
            ::|:.|.||| .|..:....|.|..|:..:.....|  |||.....||||.         .||:|
  Rat    42 SSSSCSRGGDRGPCGASNCRTPQLDTEAVAGPPGRSLLLSPYTSHPFAAAHGAAAPGVAGPGSAL 106

  Fly   498 QNSSVYAGSLL------TQTANGIQYGMQSPNQTQAHLQQQHHQQQQQQHQQHQQQQLQQQQQQH 556
               |.:...||      ..||:.:.:..:.     |.|.....:|.::.:|.
  Rat   107 ---STWEDLLLFTDLDQAATASKLLWSSRG-----AKLSPFAAEQPEEMYQT------------- 150

  Fly   557 HHNQHQHHNSSSSSPGPA-------GLHHSSSSAATAAAVAAA-----TAAVNGHNSSLE--DGY 607
                    .::.||.|||       |..||:::||.|||.|::     |..|......|.  .|.
  Rat   151 --------LAALSSQGPAAYDGAPGGFVHSAAAAAAAAAAASSPVYVPTTRVGSMLPGLPYLQGA 207

  Fly   608 GSPRSSHSGG------------------------------GGGGTLPAFQRIAYPNSGSVERYAP 642
            ||..|:|:||                              ||.|:..|.....:|.|.|    .|
  Rat   208 GSGPSNHAGGAGAHPGWPQASADSPPYGGGGAAGGGAAGPGGAGSATAHASARFPYSPS----PP 268

  Fly   643 ITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSN-----VIRNGRAISAANAAAAAAADGT 702
            :.|...:     ||..|..:.        |.|||.||.     ....||....::.:||...:||
  Rat   269 MANGAAR-----DPGGYVAAG--------GAGAGSVSGGGGSLAAMGGREHQYSSLSAARPLNGT 320

  Fly   703 -------------------TGRVDPGTFLSASASLSAMAAESGGDFYKPNSFNVGGGGRSKANTS 748
                               |.....|.|  .:..|.::.:.:|.....|.       |.|.....
  Rat   321 YHHHHHHHPTYSPYMGAPLTPAWPAGPF--ETPVLHSLQSRAGAPLPVPR-------GPSADLLE 376

  Fly   749 GAASSYSCPGSNATSAATSAVASGTAATAATTLD--EH--------VSRAN---------SRRLS 794
            ..:.|..|            |..|:..|.....|  .|        .|:.|         .:|:.
  Rat   377 DLSESREC------------VNCGSIQTPLWRRDGTGHYLCNACGLYSKMNGLSRPLIKPQKRVP 429

  Fly   795 ASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRKRKPKGTKS 859
            :|:|.||||:|||||.|:|||||..|||||||||||.|||.|||||.|||:.||.||||||....
  Rat   430 SSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMKKEGIQTRKRKPKNINK 494

  Fly   860 EKSKSKSKNALNAIMESGSLVTNC-HNVGVVLDSSQMDVNDDMKPQLDLKPYNSYSSQPQQQLPQ 923
            .|:.|.:.:.......|.|...:| .|......|:...|...:...:      ..|:.|:....:
  Rat   495 SKACSGNSSVPMTPTSSSSNSDDCTKNTSPPTQSTASGVGASVMSAV------GESANPENSDLK 553

  Fly   924 YQQQQQLLMADQHSSAASSPHSMGSTSLSPSAMS 957
            |..|..|.:....||.|....|:...|....|::
  Rat   554 YSGQDGLYIGVSLSSPAEVTSSVRQDSWCALALA 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	38/48 (79%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	39/50 (78%)
Gata6	NP_062058.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..73		9/30 (30%)
		GATA-N	147..371	CDD:283099	56/270 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..259		9/49 (18%)
		ZnF_GATA	382..429	CDD:214648	9/58 (16%)
		ZnF_GATA	383..428	CDD:238123	8/56 (14%)
		ZnF_GATA	435..482	CDD:214648	37/46 (80%)
		ZnF_GATA	437..488	CDD:238123	39/50 (78%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..532		15/51 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.830