Protein Alignment srp and GATA4

DIOPT Version :9

• Sequence 1: NP_732100.2
• Gene: srp / 41944
• FlyBaseID: FBgn0003507
• Length: 1264
• Species: Drosophila melanogaster
• Sequence 2: NP_001295022.1
• Gene: GATA4 / 2626
• HGNCID: 4173
• Length: 443
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 144/496 - (29%)
• Similarity: 186/496 - (37%)
• Gaps: 176/496 - (35%)

  Fly   607 YGSPRSSHSGGGGGGTLPAFQRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGV 671
            :|.|..::..||.|    ||...|...|..|  |.|                  |.....:.||:
Human    11 HGPPPGAYEAGGPG----AFMHGAGAASSPV--YVP------------------TPRVPSSVLGL 51

  Fly   672 ----GVGAGVVSNVIRNGRAISAANAA-----------AAAAADG---TTGRVD-----PGTFLS 713
                |.|||..|.....|.:..||:.|           :.|.|||   |...|.     |||..|
Human    52 SYLQGGGAGSASGGASGGSSGGAASGAGPGTQQGSPGWSQAGADGAAYTPPPVSPRFSFPGTTGS 116

  Fly   714 ASASLSAMAAESGGDFYKPNSFNVGGG-------GRSKANTSGAASSYSCPGSNATSAATSAVAS 771
            .:|:.:|.||....      :::.|||       ||.:...:|.|.|||.| ..|..|...|..:
Human   117 LAAAAAAAAAREAA------AYSSGGGAAGAGLAGREQYGRAGFAGSYSSP-YPAYMADVGASWA 174

  Fly   772 GTAATAATTLDEHV-----SRAN------------------------------------------ 789
            ..||.:|...|..|     .|||
Human   175 AAAAASAGPFDSPVLHSLPGRANPAARHPNLVDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLC 239

  Fly   790 -------------------SRRLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHS 835
                               .||||||:|.||||:||.||.|:|||||..|||||||||||.|||.
Human   240 NACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHG 304

  Fly   836 VPRPLTMKKDTIQKRKRKPKGTKSEKSKSKSKNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDD 900
            |||||.|:|:.||.||||||.....|:.:....:.:....||: .:|..|       :....:::
Human   305 VPRPLAMRKEGIQTRKRKPKNLNKSKTPAAPSGSESLPPASGA-SSNSSN-------ATTSSSEE 361

  Fly   901 MKPQLDLKPYNSYSSQPQQQLPQYQQQQQLLMADQHSSAASSPHSMGSTSLSPSAMS-HQHQTHP 964
            |:|   :|.....||       .|          .|||:.|.       :.|.|||| |....||
Human   362 MRP---IKTEPGLSS-------HY----------GHSSSVSQ-------TFSVSAMSGHGPSIHP 399

  Fly   965 HQQQQQQLCSGLDMSPNSNYQMSPLNMQQHQQQQSCSMQHS 1005
                   :.|.|.:||..  ..||::    |..|:.|.|.|
Human   400 -------VLSALKLSPQG--YASPVS----QSPQTSSKQDS 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	36/48 (75%)
		ZnF_GATA	802..853	CDD:238123	37/50 (74%)
GATA4	NP_001295022.1	GATA-N	1..205	CDD:368398	60/224 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..107		12/46 (26%)
		ZnF_GATA	217..267	CDD:238123	6/49 (12%)
		ZnF_GATA	271..322	CDD:238123	37/50 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	315..379		20/91 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..429		7/24 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9610
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840