DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and GATA1

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_002040.1	Gene:	GATA1 / 2623	HGNCID:	4170	Length:	413	Species:	Homo sapiens

Alignment Length:	377	Identity:	115/377 - (30%)
Similarity:	144/377 - (38%)	Gaps:	100/377 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   568 SSSP--------GPAGLHHSSSSAATAAAVAAATAAVNGHNSSLEDGYGSPRSSHSGGGGGGTLP 624
            ||:|        ||.||..::||.|.:.|.|||.|.....::   :.|     .||        |
Human    25 SSTPESGVFFPSGPEGLDAAASSTAPSTATAAAAALAYYRDA---EAY-----RHS--------P 73

  Fly   625 AFQRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSNVIRNGRAIS 689
            .||  .||....:|.....:.|.|    |    :|..:           |....|.|... |..|
Human    74 VFQ--VYPLLNCMEGIPGGSPYAG----W----AYGKT-----------GLYPASTVCPT-REDS 116

  Fly   690 AANAAAAAAADGTTG--------RVDPGTFLSASA---SLSAMAAESGGDFYKPNSFNVGGGGRS 743
            ...|.......|:|.        |:.|.......|   ||....:..||..:....|:..|...:
Human   117 PPQAVEDLDGKGSTSFLETLKTERLSPDLLTLGPALPSSLPVPNSAYGGPDFSSTFFSPTGSPLN 181

  Fly   744 KANTSGAASSYSCPGSNAT-----SAATSAVASGTAATAATTLDE------------HVSRANSR 791
            .|       :||.|....|     ..|...|..|..||.....|.            |.....:|
Human   182 SA-------AYSSPKLRGTLPLPPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNR 239

  Fly   792 -------RLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQK 849
                   ||..|||||..|:||.||.|:|||||.:|:|||||||||||||.|.|||||:||.||.
Human   240 PLIRPKKRLIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQT 304

  Fly   850 RKRKPKGTKSEKSKSKSKNALNA---------IMESGSLVTNCHNV--GVVL 890
            |.||..| |.:|.:..|.....|         ::..||...||..|  |:.|
Human   305 RNRKASG-KGKKKRGSSLGGTGAAEGPAGGFMVVAGGSGSGNCGEVASGLTL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	36/48 (75%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	36/50 (72%)
GATA1	NP_002040.1	Interaction with MED1 and CCAR1. /evidence=ECO:0000269\|PubMed:24245781	200..330		58/130 (45%)
		ZnF_GATA	202..247	CDD:214648	7/44 (16%)
		ZnF_GATA	203..247	CDD:238123	7/43 (16%)
		Required for interaction with ZFPM1	203..222		5/18 (28%)
		Interaction with CALCOCO1. /evidence=ECO:0000269\|PubMed:24245781	249..315		45/66 (68%)
		ZnF_GATA	<268..308	CDD:238123	30/39 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..327		12/30 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140994
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.870