DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and Gata1

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_032115.1	Gene:	Gata1 / 14460	MGIID:	95661	Length:	413	Species:	Mus musculus

Alignment Length:	378	Identity:	120/378 - (31%)
Similarity:	152/378 - (40%)	Gaps:	108/378 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   570 SPGPAGLHHSSSSAATAAAVAAATAAVNGHNSSLEDGYGSPRSSHSGGGGGGTLPAFQRIAYPNS 634
            |.||.||..:|||.:..||.|||:|......:   :.|     .||        |.||  .||..
Mouse    35 SSGPEGLDAASSSTSPNAATAAASALAYYREA---EAY-----RHS--------PVFQ--VYPLL 81

  Fly   635 GSVERY---APITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSNVIRNGRAISAANAAAA 696
            .|:|..   :|                ||:.:.|:..|   ..|..|        ..|..:|.:.
Mouse    82 NSMEGIPGGSP----------------YASWAYGKTAL---YPASTV--------CPSHEDAPSQ 119

  Fly   697 AAADG------------TTGRVDP-----GTFLSASASLSAMAAESGGDFYKPNSFNVGGGGRSK 744
            |..|.            .|.|:.|     ||.|.||..::. :|..|.||..| .|:..|...|.
Mouse   120 ALEDQEGKSNNTFLDTLKTERLSPDLLTLGTALPASLPVTG-SAYGGADFPSP-FFSPTGSPLSS 182

  Fly   745 ANTSGAASSYSCP---GS--NATSAATSAVASGTAATAATTLDE------------HVSRANSR- 791
            |       :||.|   ||  .|...|...|..|..||.....|.            |.....:|
Mouse   183 A-------AYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRP 240

  Fly   792 ------RLSASKRAGLSCSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKR 850
                  |:..|||||..|:||.||.|:|||||.:|:|||||||||:|||.|.|||||:||.||.|
Mouse   241 LIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYFKLHQVNRPLTMRKDGIQTR 305

  Fly   851 KRKPKGTKSEKSKSKSKNALNA--------IMESGSLVTNCHNV--GVVLDSS 893
            .||..|...:|..|....|..|        ::...|...||..|  |:.|.::
Mouse   306 NRKASGKGKKKRGSNLAGAGAAEGPAGGFMVVAGSSSSGNCGEVASGLALGTA 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	35/48 (73%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	35/50 (70%)
Gata1	NP_032115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..49		8/13 (62%)
		Interaction with MED1 and CCAR1. /evidence=ECO:0000269\|PubMed:24245781	200..330		56/129 (43%)
		ZnF_GATA	203..249	CDD:238123	8/45 (18%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		5/18 (28%)
		Interaction with CALCOCO1. /evidence=ECO:0000269\|PubMed:24245781	249..315		43/65 (66%)
		ZnF_GATA	<268..308	CDD:238123	29/39 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		11/27 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830949
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870