DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment srp and GATA5

DIOPT Version :9

Sequence 1:	NP_732100.2	Gene:	srp / 41944	FlyBaseID:	FBgn0003507	Length:	1264	Species:	Drosophila melanogaster
Sequence 2:	NP_536721.1	Gene:	GATA5 / 140628	HGNCID:	15802	Length:	397	Species:	Homo sapiens

Alignment Length:	417	Identity:	127/417 - (30%)
Similarity:	158/417 - (37%)	Gaps:	129/417 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   562 QHHNSSSSSPGPAGLHHSSSSAATAAAVAAATAAVNGHNSSLEDGYGSPRSSHSGGGGGGTLPAF 626
            |...:.||:.||...|      ..||....|||....|:.|      .|.|..|.||..|:  |:
Human    66 QTATADSSAFGPGSPH------PPAAHPPGATAFPFAHSPS------GPGSGGSAGGRDGS--AY 116

  Fly   627 QRIAYPNSGSVERYAPITNYRGQNDTWFDPLSYATSSSGQAQLGVGVGAGVVSNVIRNGRAISAA 691
            |....|.    |::|.             ||.....:|..|.....|...|             |
Human   117 QGALLPR----EQFAA-------------PLGRPVGTSYSATYPAYVSPDV-------------A 151

  Fly   692 NAAAAAAADGTTGRVDPG---TFLSASASLSAMAAESGGDFYKPNSFNVGGGGRSKANTSGAASS 753
            .:..|...||:.....||   ||:|              ||.:    ...|.||...| .||.|:
Human   152 QSWTAGPFDGSVLHGLPGRRPTFVS--------------DFLE----EFPGEGRECVN-CGALST 197

  Fly   754 ----------YSCPGSNATSAATSAVASGTAATAATTLDEHVSRAN------SRRLSASKRAGLS 802
                      |.|   ||..                 |...::..|      .:|||:|:||||.
Human   198 PLWRRDGTGHYLC---NACG-----------------LYHKMNGVNRPLVRPQKRLSSSRRAGLC 242

  Fly   803 CSNCHTTHTSLWRRNPAGEPVCNACGLYYKLHSVPRPLTMKKDTIQKRKRKPKG-TKSEKSKSKS 866
            |:|||||:|:|||||..|||||||||||.|||.|||||.|||::||.||||||. .|:..|...:
Human   243 CTNCHTTNTTLWRRNSEGEPVCNACGLYMKLHGVPRPLAMKKESIQTRKRKPKTIAKARGSSGST 307

  Fly   867 KNALNAIMESGSLVTNCHNVGVVLDSSQMDVNDDMKPQLDLKPYNSYSSQP----QQQLPQYQQQ 927
            :||    ..|.|.|.:       .|||.  .....||.|         :.|    ....||...|
Human   308 RNA----SASPSAVAS-------TDSSA--ATSKAKPSL---------ASPVCPGPSMAPQASGQ 350

  Fly   928 QQLLMADQHSSAASSPHSMGSTSLSPS 954
            :...:|..|......|......|.:||
Human   351 EDDSLAPGHLEFKFEPEDFAFPSTAPS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
srp	NP_732100.2	ZnF_GATA	798..847	CDD:214648	38/48 (79%)
srp	NP_732100.2	ZnF_GATA	802..853	CDD:238123	38/50 (76%)
GATA5	NP_536721.1	GATA-N	1..170	CDD:283099	35/147 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..116		19/63 (30%)
		ZnF_GATA	184..229	CDD:214648	13/65 (20%)
		ZnF_GATA	188..232	CDD:238123	10/64 (16%)
		ZnF_GATA	<253..293	CDD:238123	31/39 (79%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..356		28/96 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9610
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1745
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840